The series, set in the shared Marvel Universe, is an Interquel set shortly after a 1991 arc in the original Fantastic Four (1961) series, in which the heroes briefly united as a replacement (of sorts) for the usual Fantastic Four team.
At this point in time the Hulk, in his grey-skinned 'Joe Fixit' incarnation, is working in Las Vegas - and the other three heroes are mysteriously drawn to Las Vegas as well, only to find a host of demons waiting for them. When things start to escalate, the original Fantastic Four team are also drawn into events...
The first issue was published June 22, 2022.
New Fantastic Four provides examples of the following tropes:
- Astral Projection: When Doctor Strange becomes aware that mystic threats may try to take advantage of the situation When the Planets Align, he projects himself into Four Freedoms Plaza to warn the Fantastic Four. His timing when he manifests in Reed and Sue's bedroom is a little unfortunate.
- The Bus Came Back: The demon Saturnine reappears for the first time since 2010's X-Men: Pixie Strikes Back.
- Demonic Possession: Asmodeus initially forces his demons to possess mortal hosts. They don't adapt to their new bodies fast enough for his liking, though (Ghost Rider mentions that most demons don't actually like possessing normal mortals, as proximity to human souls is uncomfortable for them), so he later calls up damned souls as possessors instead.
- Disposable Vagrant: Asmodeus starts by recruiting and possessing the homeless of Los Angeles, and nobody notices until one woman goes to Priest for help.
- Earpiece Conversation: Hulk outfits the team with hidden earpieces for two-way conversations, initially so that they can talk in his limo while the Ghost Rider rides alongside it.
- Emotion Eater: Saturnine is fuelled by the fear of the people of Las Vegas. He takes no action against the terrified crowd when he manifests, he just feeds on their reaction and grows.
- Flying Car: Near the end of the story, When the Planets Align, the Ghost Rider's Cool Bike temporarily acquires the ability to ride on air as well. As usual, it leaves a trail of fire behind it.
- Giant Foot of Stomping: The gigantic demon Saturnine is an Emotion Eater, a Sizeshifter fuelled by the fear he consumes. Once Priest cuts off that food supply, he shrinks to the point where the Ghost Rider can simply stomp on him.
- His Name Really Is "Barkeep": Father John Priest. Asmodeus, the demon he meets in the first issue, is very amused that his name is Priest.
- I'm Not Afraid of You: Priest's Make a Wish powers don't work on supernatural beings, but they do let him calm the crowd when the Emotion Eater Saturnine manifests. The demon starts shrinking without humanity's fear and panic, enabling its defeat.
- Interrupted Intimacy: The Astral Form of Doctor Strange appears in Reed and Sue's bedroom at Four Freedoms Plaza, just as the two of them are about to enjoy some "private time" to themselves.
- Interquel: The series is set shortly after the original 1991 Fantastic Four arc that gathered the four heroes as a team.
- Luke, I Am Your Father: When Mephisto meets John Priest, he reveals that he's actually Priest's father.
- Make a Wish: Priest starts to manifest the ability to change reality by wishing, initially by calling the superheroes to Las Vegas to confront Asmodeus. It doesn't work at all on supernatural beings, though.
- No-Sell: John Priest's new powers have zero effect on the Ghost Rider - or any other supernatural beings.
- Self-Made Orphan: After the reveal that his father is Mephisto, John Priest tries to use his Make a Wish powers to destroy the demon. Unfortunately, they don't work on supernatural beings.
- Sizeshifter: Saturnine is an Emotion Eater who grows larger as the people of Las Vegas panic in fear. He shrinks again once his food supply is cut off, becoming so small that the Ghost Rider can deal with him via a Giant Foot of Stomping.
- Speech Bubbles: The possessed Human Torch has purple speech bubbles with yellow borders and text.
- What Happened to the Mouse?: Asmodeus, who's the main villain at the start of the story, is the heroes' prisoner at the start of the last issue, and is with them in the street when the first part of his plan succeeds and Saturnine manifests. But he's never seen or mentioned after that point.
- When the Planets Align:
- The demonic plan is linked to the upcoming syzygy, when every planet in the solar system will be aligned. The syzygy is also why Priest's powers have started to manifest.
- A couple of pages in the final issue show the Ghost Rider riding on thin air, leaving flaming tracks behind him. Reed Richards comments that he didn't know the Ghost Rider's powers could do this - and, normally, they can't - only for the Ghost Rider to reply that during the syzygy all things are possible.
