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The Main Trio

Luke Watson

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Dark and Troubled Past: Before moving to Scream Street Luke was made fun of and ridiculed because of his werewolf side, this caused him to not fit in and to presumably have no friends.

Resus Negative

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Classical Movie Vampire: Dresses this way, presumably to please his parents, but in keeping with rebel nature, he has Messy Hair instead a widow's peak, and wears sneakers.
Only Sane Man: He's usually the one the call out the bad situations that the others get them and himself into.
Promoted Fanboy: He temporally joined his favourite rock band Brain Drain in the episode "Resus Rocks" when one of the members was off due to his head falling off and going missing (typical zombie problems).

Cleo Farr

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Action Girl: She's skilled at fighting and is very agile, which is very useful for any adventures her and her friends go on.
Adaptational Attractiveness: Her original book design is just a plain and simple bandaged mummy with only a bit of jewellery, but in the show her design gained more detailed golden jewellery, lip-sick, eye-shadow, a bandage skirt and a bunch of bandages at the back of her head to represent a ponytail.
Meaningful Name: Her name (along with her gold jewellery and eye motif) is clearly inspired by the "Egyptian" Princess/Pharaoh Cleopatra
Older Than They Look: She's 4000 years old!
Teen Genius: While she's technically in terms of age not a teen, she definitely has a mentality of one. She's exceptionally good at playing musical instruments, a skilled fighter and she almost always get perfect scores on her tests. Well in her words, she did have YEARS to practise.

Residents of Scream Street

Luella Everwell

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Attention Deficit... Ooh, Shiny!: She has a hard time concentrating when Eefa tries to teach her spells, when she's running the shop, or when Resus is arround
Cute Witch: Her attire is a perfect mix of cute and gothic for this young witch.
Mad Love: Downplayed. While Resus is never downright horrible to Luella and Luella is far from crazy, she has down some pretty reckless things for a guy that hasn't and probably wont make as much of an effort for her.
Oblivious to Love: Resus to Luella. She's not exactly the most subtle when it comes to her feelings towards him, but he can't seem to take a hint.
Perky Goth: While her outfit is very goth inspired, she lacks the usual depressing and emo personality you'd expect from a typical goth.

Doug

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Surfer Dude: Doug exclusively talks in surfer speak and is a "go for the flow" type of dude. His dialect especially stands out since he's the only character in the show to have an American accent.

Dixon

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Adaptational Attractiveness: In the book, Dixon has long, greasy ginger hair, pale grey skin, drab clothing, a hunched back and yellow eyes. While in his new design he now has short green hair, a more presentable purple suit, normal looking eyes and a big chin.
Bumbling Sidekick: To Otto.
Butt-Monkey: Despite being loyal to Otto and being the main reason why alot of his plans succeed at first, Otto regularly makes snide remarks at him, jokes at his expense and (comedically) abuses him. There's also a lot of Slap Stick jokes at his expense.
Secondary Color Nemesis: Though he's not the primary antagonist (but he's still a pain in the neck for the main characters).
Shapeshifter: It's his primary ability.
Shapeshifter Guilt Trip: Subverted. In the episode "Tutan Kutie" Dixon (by order of Otto) shapeshifts into Cleo's long lost boyfriend to get close to her and steal her (literal) heart. He ends up feeling remorse in the end and returns it.
- In the same episode it's implied that Dixon may have developed feelings for Cleo as he enjoyed being her "boyfriend" and even asked Cleo whether or not she thought of him when they kissed (while Cleo was under the impression that she was with a old boyfriend). This could be seen as a Ship Tease.
Shapeshifting Trickster: He's constantly using his ability to trick the main characters and other scream residents (usually under Otto's command).
Thin Chin of Sin: He could probably impale someone with how pointy his chin is.