The notable characters in Eyeshield 21.
- Deimon Devil Batsnote Sena Kobayakawa, Yoichi Hiruma, Ryokan Kurita, Mamori Anezaki, Tetsuo Ishimaru, Taro "Monta" Raimon, The Ha-Ha Brothers, Daikichi Komusubi, Manabu Yukimitsu, Natsuhiko Taki, Gen "Musashi" Takekura, Sakaki Doburoku, Suzuna Taki, Cerberus, Satake and Yamaoka, Futoshi Omosadake
- Ojo White Knightsnote Seijuro Shin, Haruto Sakuraba, Makoto Ootawara, Ichiro Takami, Daigo Ikari, Gunpei Shoji
- Shinryuji Naganote Agon Kongo, Unsui Kongo, Ikkyu Hosokawa, Gondayu Yamabushi, The Saiyuki Brigade
- Seibu Wild Gunmennote The Kid, Jo Tetsuma, Riku Kaitani, "Buffalo" Ushijima
- Taiyo Sphinxnote Mamoru Banba, Kiminari Harao, Niinobu Kasamatsu
- NASA Aliensnote Patrick "Panther" Spencer, Homer Fitzgerald, Jeremy Watt, The Gonzales Brothers (Nathan "Big Shit" Gonzales and Otto "Piss" Gonzales), Leonard Apollo
- Kyoshin Poseidonnote Shun Kakei, Kengo Mizumachi, Osamu Kobanzame, Hiroshi Onishi and Hiroshi Ohira
- Bando Spidersnote Hayato Akaba, Kotaro Sasaki, Juri "Julie" Sawai
- Hakushu Dinosaursnote Reiji "Marco" Maruko, Rikiya Gaou, Hiromi Kisaragi, Hanataka Tengu, Himuro "Maria" Maruko
- Teikoku Alexandersnote Takeru Yamato, Taka Honjo, Karin Koizumi, Kureji "Heracles" Hera, Reisuke "Achilles" Aki, Doujirou Tenma, Kirio Ibarada
- The Pentagramnote Clifford D. Louis, Bud Walker, Tatanka, Donald "Mr. Don" Oberman
- College and Semi-Pro Football Teamsnote Enma Fires, Saikyodai Wizards, Ojo Silver Knights, Shuei Doctor Fishes, Takekura Construction Babel, Zokuto Frilled Lizards
- Other Football Playersnote Players introduced in the Tournament (Kaoru Hatsujou, Rui Habashira, Megu Tsuyumine, Atsushi Munakata, Suguru Aoyanagi, Sasuke Kanagushi, Yamamoto Onihei, Taiga Kamiya), Players introduced in the World Youth Cup (Akira "Chuubou" Nakabou, Heinrich Schultz, Rodchenko, Team Militaria)
- Other Charactersnote Riku Kumabukuro, Riko Kumabukuro, "Machine Gun" Sanada, "Miracle" Ito, Torakichi