Can't Live Without You in Video Games.
- Played straight with Jacob and Esau in The Binding of Isaac. A player character who consists of two brothers controlled together. They each have a separate healthbar, but one dying ends the run even if the other has health remaining.
- In BioShock 2 it is revealed that if an Alpha Model Big Daddy (the Player Character in the second game, different from the Big Daddies encountered in the first game) is too far away from his Little Sister or the Sister's heart stops, he either dies or lapses into a coma.
- Alcatraz in Crysis 2 is only kept alive by the Nanosuit, and even then, just barely. At a couple of points in the game the player has to use the suit's defibrillator system to revive him. Though the suit ends up being less of a life support system and more of a symbiote over the course of the game.
- In Digimon Survive, if a human Tamer dies, their Digimon partner vanishes with them.
- Dragon Age: Origins: Wynne is dependent on a friendly Fade spirit to keep her alive.
- Similar but opposite to Pern cycle, the Bond in Drakan series connects the dragon and his rider in such way that if the dragon dies, so does the rider, but not vice-versa (justified by the fact that dragons are just that much more powerful). Arokh, for example, has outlived at least one rider already.
- In Drakengard, making a Pact not only binds a human with a magical entity for mutual power, but also takes a price branding a seal on what was taken.
- In Enslaved: Odyssey to the West, the player character is forcibly bonded to a Damsel in Distress Gadgeteer Genius via a Restraining Bolt that will crush his skull if he disobeys her or she dies, because she can't survive in the killbot-infested wasteland on their own. Near the end of the game, Trip deactivated the slave headband that she placed on Monkey, but Monkey urges her to turn it back on, indicating an emotional attachment that Monkey feels towards Trip.
- In the Dead Money DLC of Fallout: New Vegas, Elijah links the Explosive Leashes of you and your companions so that you don't try and betray each other.
- In Final Fantasy IV, the death of a summoned monster results in the death of the Summoner. This is how Rydia's mother dies early in the game. Once it returns to the realm of summoned monsters, the Summoner can no longer be harmed by its death. Which is likely why Rydia always has her monsters show up for a single attack and then teleport away.
- Late in Kid Icarus: Uprising Dark Pit discovers that if anything serious happens to Pit, he's affected by it too, and makes keeping Pit alive his top priority.
- In Knights of the Old Republic II: The Sith Lords, the player character and his mentor Kreia are linked by a Force Bond, gaining each other strengths and weaknesses. This isn't exactly convenient - in particular, the player is made aware of the bond when Kreia loses a hand fighting the apparent Big Bad Darth Sion to keep him at bay, and the player character half the ship away at this point immediately recoils in pain as if their hand got lopped off — so getting rid of it is one of the major plot points. In the end, when Kreia turns out to be The Man Behind the Man, she uses this as the player character's incentive to follow her to the final planet in the game — if they try to run or hide, Kreia will kill herself and thus also kill the PC no matter where they may be.
- In the ending for Tales of Destiny 2, Reala dies along with the final boss Elraine when Kyle destroys the huge lens, as it is the only way to ensure the demise of Elraine, much to the dismay of Kyle. Although in the restarted timeline, thanks to The Power of Love, Reala is miraculously reborn and reunited with Kyle at the place where they met for the first time.
- The Destiny Bond move from Pokémon means that if the opponent's next move causes you to faint then so will they.
- In the Super Smash Bros. series, there are several characters that have a "leader and follower" archetype: The Ice Climbers, Olimar/Alph, and Rosalina & Luma. If the leader character (Popo, Olimar/Alph, and Rosalina) is knocked out, the follower character (Nana, Pikmin, and Luma) will disappear.
- In Town of Salem 2, this is the gimmick of the Admirer role. The Admirer is able to propose to another player, and if said player accepts the proposal, whichever of the pair dies first will cause the other to die of a broken heart on the same night.
- In The World Ends with You, if a Player is erased, their partner is as well in seven minutes unless they make a new pact with a different denizen of the Underground.
- In Xenoblade Chronicles 2, if a Driver dies, then all Blades they've resonated with will return to their Core Crystals, never to remember their past lives upon reawakening ever again. If a Blade were to share a piece of their Core Crystal with their Driver or if they were to infuse human cells into their being to become Flesh Eaters, then they risk dying for good.
- In the second Zone of the Enders game, the protagonist Dingo is critically injured and linked to Jehuty so he can live, at the expense of not being able to survive outside of Jehuty.
- Planescape: Torment has two major examples:
- Mebbeth, Ei-Vene and Martha are all aspects of Ravel Puzzlewell, who have taken on lives of their own. They still cannot survive without their original so if Ravel dies, they begin fading away.
- The Transcendent One is The Nameless One's mortality, stripped from the rest of his being. While The Nameless One cannot die while The Transcendent One is separated from him (he literally has no concept of death), should he somehow 'cease to exist' anyway The Transcendent One will cease to exist as well since it has no existence of its own outside of being The Nameless One's mortality.
