As a Moments subpage, all spoilers are unmarked as per policy. You Have Been Warned.
- The first game's memorable opening cinematic, taking William Birkin's slaughter of the Umbrella Ops team depicted in Resident Evil 2 and blending it with imagery suggestive of the T-Virus' effect on a host's cellular structure, set to music that is both haunting and beautiful at once.
- Badass Normal is the tenant of the heroes for most of the franchise, but the Outbreak crew shines best because unlike everyone else, they're not The Immune — every part of the game is one long Timed Mission until you finally Earn Your Happy Ending, as the T-Virus is ticking down and threatening to overtake and kill them. This makes any character that manages to make it through, especially on Very Hard, a prime candidate for being one of the toughest Action Survivor members of the franchise cast. And, if a news article in Resident Evil 7: Biohazard is anything to go by, Alyssa was confirmed to be one of them if she isn't the Sole Survivor.
- Special mention goes to the Outbreak scenario. Every other stage has a traditional boss monster you have to kill. Outbreak's boss? A sea of zombies that literally flood the main street of Raccoon City. Solution? Activate a series of explosives and blow them all up. Your character's holy shit reaction afterwards is quite justified.
- Decisions, Decisions with four special endings; in all but one case (which is more of a tearjerker), the two infected survivors are resigned to their fates and decide to kick zombie ass.
- Kevin and Jim face off against a revived Thanatos, who manages to either shrug off the Daylight cure's effects or survive being shot numerous times. While Jim is understandably bricking it, Kevin replies by grinning, cracking one last joke, then raising his signature pistol and opening fire on the charging Super Tyrant as the missiles rain down on Raccoon City.Jim: No. No way...
(Jim points behind Kevin; Thanatos-R is beginning to rise to its feet.)
Kevin: See? Never a dull moment. Now, let's finish this like men.
(Thanatos-R roars loudly and charges as the camera zooms in on Kevin and Jim's faces. Kevin fires a shot at the oncoming Thanatos-R, smiling; the missiles impact the city.) - Mark and David fix up a tank and decide to go all out on a zombie horde.
- Special mention goes to Alyssa and Yoko's special ending, where it's implied that Yoko told Alyssa everything, prompting Alyssa to publish everything she's been told in an article before destroying her computer, before standing with Yoko as the missiles begin to impact. Though it costs them both their lives, they still managed to get the last laugh on Umbrella by exposing their culpability in the Raccoon City disaster to the world.
- Kevin and Jim face off against a revived Thanatos, who manages to either shrug off the Daylight cure's effects or survive being shot numerous times. While Jim is understandably bricking it, Kevin replies by grinning, cracking one last joke, then raising his signature pistol and opening fire on the charging Super Tyrant as the missiles rain down on Raccoon City.
- David saving a scientist by clocking a zombie with a pipe in the introduction to End of the Road.
- In the same scenario, Carter utilizes Mr. X as your protector! Just watching him beat up the hunters with no effort is enough to make any Resident Evil/Biohazard fan smiling.
- In Desperate Times, a massive amount of zombies invade the police station and you are forced to defend it. Now, if you're playing online with 4 survivors on your group at the most difficult mode available, then get ready for one of the most thrilling experiences of the game.
- In End of the Road, the Eldritch Abomination Nyx is a monstrous Blob Monster capable of easily consuming and adding lifeforms to its bulk... and can even do so to a Tyrant. Unfortunately for the monster, said Tyrant was loaded with demolition charges, and while it's expected to use them against him, it's possible to hold on to the chance and instead wait until Nyx has eaten the still-struggling Tyrant to transmit the detonation signal, crippling it.