Twilight Sparkle's big lecture on why each of her friends can bear the various Elements, with the kicker being her final burst of insight. The best part is that it was all genuinely in-character, so the DM can't do anything but accept it.
Rarity: Just put yourself in Fluttershy's position, dear! Her friends are all down, and that red dragon is gloating over them. Fluttershy might be feeling righteous outrage at what this dragon is doing to her friends. Imagine you are Fluttershy in that situation. What would you do? What would you say?
Rover: See?! The true hypocrisy of po-nies — hugs and friendship following lots of violence! Rarity: You tried to enslave me. * Beat Panel* Rover: Uh... It was supposed to be ironic?
Followed by her extending a very generous offer to the Diamond Dogs — with the underlying threat that they could 'bargain' with Rainbow Dash instead of they don't care to cooperate.
Rarity: You'll like her—she's not a hypocrite.
After a much-needed pep talk from her friends, Rainbow Dash gains the favor of the dice with a well-timed natural 20.
Then there's her proceeding to keep perfectly in-character while turning down the Wonderbolts: "I already HAVE a party."
The entire Sonic Rainboom sequence, starting with the GM saying that Dash needs two natural twenties in a row (out of three rolls) to succeed. She gets a natural 18 and then a natural 19, and Pinkie manages to fast-talk the GM by saying that Dash is accelerating, so a natural 20 now will still be enough. The GM tries to convince everyone not to get their hopes up... and Dash does it.
GM: So, all in all... the laws of physics are dead, and Rainbow Dash murdered them. Pinkie: Yep!
The entire fight with Blueblood. Presented for once, not in screencaps but in entirely new art, the Mane Six take on a horde of ninja mooks, pony versions of Imoen, Isabella, and Garett, and an Alicorn Amulet-empowered Blueblood. They, for once, manage to actually use their combat abilities, and pull them off to full effect. The visual representations of said powers are also epic and fit well with the characters.
Twilight pulls off incredible feats throughout, pulling off powerful spells that completely shake up the battle, as befits a min-maxer such as herself. The rest of the party is left in awe as she pulls off things like blocking the door with a Fountain of Flame, summoning a Magma Beast to fight for her, and using a Color Spray and Magic Missiles to clear out ninjas.
Fluttershy is initially out of her depth, unable to choose what to do. This is represented in-panel as Angel needing to help her. However, later into the fight she starts to get the hang of things, notably foiling Blueblood's attempt at turning invisible with a Vexing Overgrowth.
Pinkie puts her buffs to good use, changing bad luck to good with her various powers and enhancing her comrades. However, when it comes to her own abilities, she is less than stellar.
Rarity uses a Swift Parry to generate shields like her Equestria Girls counterpart, and finishes off Blueblood with a Backstab using her glass slipper.
Discord turns up and separates them, as in the show. The players also separated throughout the DM's house. Fluttershy's player went straight to the bathroom because she was terrified of the DM's old DM. But when it came to her character's turn being broken, she proceeds to lay into Discord's character so accurately that all the guy could do was just go straight to the curse.
Fluttershy: It doesn't really matter what I say, does it? Discord: W-what could you possibly mean by that? Of course, it matters what you say! Fluttershy: Oh, sorry. My mistake. What I say matters until the moment you find the right words to use against me. That's what this is all leading up to, isn't it? Same with the others? I had a feeling Discord was that kind of person when I heard you over the phone. I'm kind of relieved you're so obvious about it. He's basically a god, right? He doesn't need to fool me to hurt me. But by trapping and tricking me, he's trying to make me feel like it's my own "fault" for being punished, right? That way, when it comes time to point fingers, no one's blaming Discord. Only themselves and each other. Against something like that, my only defense, really... is to try and take the fun out of it. Discord: Rrrrgh, FINE. You "win." Here's your "prize."
Guest Comics
In the Smarmony Returns guest comic, the party averts TPK by dragon by exploiting each character's powers and clever rule abuse to enlarge a pet throwing rock to deal 24d6+12 damage. The kicker: the rock was named Thomas. Derpy puts it best.
Derpy: Look out, here comes Tom!!
In the second Story Time, a player was forced to bring out a back up character, leading to him playing as Erin, a Paladin who had sworn an oath to never strike a living creature; this made him the butt of the rest of the party's jokes. However, one day a Drow showed up in town and took Erin's mother hostage. Erin calmly approached the Drow who laughed him off as bluffing; unfortunately for the Drow, Erin had very high Will and a homebrew spell called Stunning Force, causing Erin's righteous fury to manifest as a vision. Said vision combined with a high enough roll and Erin's Will modifier to cause the Drow to have a heart attack from shock and die. Needless to say, no one made fun of Erin after that.
Same video opened with a villain who had basically won and mocked the heroes when one player run over, pointed a Rod of Wonder at the guy and on the third hit, summoned Karmic Ray, which forces the target to feel the collective effect of their actions on others. Given he was attempting to destroy the world, that was the end of him. For bonus points, the villain was gloating about how everything went All According to Plan and how he planned for anything, and then was taken down by the one thing he couldn't plan arround: sheer dumb luck.
out of thin air.GM: Did you just come up with that now?