The Take That! comics George and Harold draw making fun of Melvin in Big Bad Battle of the Bionic Booger Boy and The Revenge of the Ridiculous Robo-Boogers.
So many moments in Return of Tippy Tinkletrousers:
Kindergartner George saving kindergartner Harold from Kipper Krupp and his goons.
First, a little context: little Harold was hiding behind the display sign of Billy Bill's gas station while trying to hide from Kipper and his thugs on his way to school. Billy Bill saw this, grabbed him, and handed him over to those aforementioned bullies because he thought little Harold was messing with the sign when he clearly wasn't, and was seen to "enjoy watching" the blatant bullying occurring in front of him.
George then stands up to the bullies by whipping them with his tie, Indiana Jones-style. While Mr. Krupp shows up to Kipper's cries to drag the two kindergarteners to detention for 'bullying' and 'lying', this ends up solidifying their friendship.
In Captain Underpants and the Revolting Revenge of the Radioactive Robo-Boxers:
The wordless comic George and Harold make to convince the cavepeople to help them fight Tippy.