- Agamemnon Tiberius Vacuum claims Brooke Brodack is his nemesis (a claim she embraces). What exactly the past relationship between the two that lead to this is, is still unclear.
- The AlternateHistory.com timeline A More Personal Union has Henri III, the King of France, and his cousin Ferdinand of Uceda, the Prince of Spain. They have an utter hatred of each other starting from facing off on the battlefield in the Second Franco-Spanish War, which only grows over time.
- The Angry Video Game Nerd and The Nostalgia Critic were like this for a while, until it culminated in one of the most awesome battles ever.
- The Angry Video Game Nerd has two, a real-life example and an In-Universe one. For real his nemesis is LJN Toys, who were responsible for producing more terrible games than any one other company, while in-universe is the programmer Fred Fucks.
- Dr. Louis Zandor has General Dark Onward. Dr. Zandor is former Area 51 employee who put a map of Area 51 in the Eee Tee game and stole spaceship metal from the government. General Dark Onward was involved for recalling the Eee Tee games to cover up Area 51, and seeks to have him captured to retrieve the metal Zandor stole.
- Mara Wilson also seems to view the Critic as one after his brutal A Simple Wish review. She's notably disappointed when told that he's dead, stating that the chemistry between them was "organic".
- M. Night Shyamalan (or ShyamAmon) became one for the Critic post-uncancellation, having been the evil mastermind behind three separate reviews.
- The Annoying Orange:
- Liam the Leprechaun tends to be this to Orange at times. In one episode, Liam puts Orange on trial for being too annoying.
- Orange also has an antagonistic relationship with Grapefruit. In Grapefruit's first episode, he and Orange are rivals for Passion Fruit's affections. In another episode, Grapefruit returns as the head of the monster Frankenfruit, and prepares to attack Orange and Pear before being attacked himself by the Halloweenie. In The High Fructose Adventures of Annoying Orange episode "The Fruit-Venger", Orange, Grapefruit, Pear, Little Apple, Marshmallow, and Passion Fruit gain superpowers, with Grapefruit becoming a supervillain who goes on a rampage, while Orange and his friends become superheroes to oppose him.
- Atop the Fourth Wall and The Spoony Experiment — Dr. Insano was both Spoony One's and Linkara's nemesis. Lately though, Linkara's moved on to new enemiesnote , and Insano is now more of an annoyance to Spoony.
- Mechakara is a better example, as he is Linkara's most determined enemy. He has been destroyed twice and came back stronger then ever. Plus, he's the star villain of The Movie, and has nearly outmaneuvered Linkara twice through his adaptability.
- Lately though, Linkara's new archnemesis has become Lord Vyce. He was the first true example of Serial Escalation for Linkara in bringing in a cosmic enemy. Then after his first defeat, Vyce became VERY personal for Linkara, leading to Pollo's near death and Nimue's near shut down. Further, Vyce hates Linkara for stealing his ship and stopping his crusade against The Entitynote
- Ranger and Ice in Comic Fury Werewolf. It's pretty funny.
- Dr. Horrible's Sing-Along Blog — Johnny Snow claims to be Dr. Horrible's nemesis. Similar to the Buffy example above, Dr. Horrible does not take him very seriously, considering Captain Hammer to be his actual nemesis. For his part, Captain Hammer thinks of Dr. Horrible as just another villain that he regularly defeats, and a fairly pathetic one at that.Dr. Horrible "OK. Dude. You're not my nemesis. My nemesis is Captain Hammer. Captain Hammer, corporate tool! He dislocated my shoulder last week. Again."
- From Froghand:
- Froge is always willing to take pot-shots at Undertale, especially when compared against games that he thinks are better than Undertale, such as this section from LISA Session 03 Review
:The one thing that Undertale will never understand is that you cannot make the audience enjoy your work by throwing them into tangentially related situations, and expecting them to feel exactly what you expect to feel. You cannot make them laugh when you throw in the obligatory funny scene with the rock. You cannot make them feel sad by making them kill somebody who could have been avoided by sneaking out while they're asleep. You cannot throw your character into a world without any cohesion to it, and still expect your audience to feel something in regards to that world. That's emotional manipulation - and the only people you've manipulated are those too ignorant of the arts to see through your charade. - Valve Software has been this for years, with Froge blaming the loss of four years of his life to a carefully-plotted business structure on Valve's part to addict him, and others, into playing their games for as long as possible, as detailed in the 21,000 word article The Industrial Steamworks.You don't understand what addiction can do to you, until you take a step back and realise just how much damage it's done. I'll never get that time back. 3,500 hours could do a lot of good for a person... but I'll never get that time back. Not me. Not anybody else. Because it's gone. And all the money that you spent gonna be gone... That's why it's such a big deal to me. Not because I'm a white knight who wants an easy target. But because it's important to me that nobody follows the same path I did and makes the same mistakes I did. Four years of bullshit... It wasn't worth the weight.
- Froge is always willing to take pot-shots at Undertale, especially when compared against games that he thinks are better than Undertale, such as this section from LISA Session 03 Review
- Achmed Frollo to Judge Claude Frollo in The Frollo Show.
- Played for Laughs on Game Grumps, where Arin's arch-enemy is said to be clams. During their playthrough of The Legend of Zelda: Ocarina of Time Arin infamously had tons of trouble facing the Shell Blades of the Water Temple and his anguished, desperate cries of "THIS STUPID FUCKING CLAM!!!" more or less became a meme. Then, during their playthrough of The Legend of Zelda: Majora's Mask, it happens again when he ends up in a fish tank with a Shell Blade that, once again, kicks the crap out of him while he screams in frustrated agony and fruitlessly hurls ineffective attacks at it. Much later down the road when they are playing The Legend of Zelda: Twilight Princess and they encounter that game's version of Shell Blades, Dan wastes no time mocking Arin for it:Dan: Hey, look! It's your arch-nemesis The Clam!
- Cassidy Cain & Deus are a Classy Cat-Burglar vs. Phantom Thief version of this in Grandmaster of Theft. Which is just what Deus wants.
- In the Hitler Rants parody, Hitler's archnemesis is resident trickster Hermann Fegelein... the former is always at the butt end of the rivalry.
- In The Intercontinental Union of Disgusting Characters, Peter Perfect is Ringman's arch enemy, and Sick Sword is Omnion's arch enemy.
- In the second sequel, Ringman actually becomes Tiamat's arch enemy, even though he personally never laid a glove on her; then because of his bid to free the centaurs, Ringman even becomes the Dungeon Master's arch enemy.
- In The John Dredge Nothing To Do With Anything Show's Human League of Justice sketches, Phil Oakey and Gary Numan are portrayed as arch-enemies. In the first episode, Numan wants to regain the top of the charts by using a Number-One-Alyser-Ray. In the next episode, he's taken Susan Ann Sulley and turned her into a "Numanoid" in order to defeat the Human League and steal their fan base from under their noses.
- John Wolfe has HQ Residential House, a downright disgustingly overused stock 3D environment that appears in tons upon tons of the terrible, low-quality horror games he plays. He calls it out when it appears on-sight, has played it so many times he has the entire layout memorized, has expressed interest in hosting a Game Jam where you are tasked with using that asset but "in a good and creative way", and has made not one, not two, but three separate video compilations of terrible games that feature that house. His enmity with that object is best summed up in one of his video intros:"This is the story of a house. But not just any house. This is the story of HQ Residential House. A popular asset sold on the Unity Store. According to legend, HQ Residential House is not just any old Unity asset. It's haunted. It is said that once you play a game featuring the house, it will continue to appear in every game from that moment until the day you die..."
- By the end of KateModern, Ax-Crazy Phlebotinum Rebel Terrence has become the Arch Enemy of the K-Team.
- Madness Combat: Hank J. Wimbleton has the Auditor, the founder and leader of a Nebulous Evil Organization outright named the Agency Against Hank Wimbleton.
- Mahu: In "Crownless Eagle", the Swedish Empire is this to the Polish Commonwealth Republic. The war between the two 18th century nations lasts years and sees thousands of dead, including the near-destruction of the Swedish capital after a brutal siege which breaks the Swedish army and kills some of the Commonwealth's best generals.
- McJuggerNuggets: Jesse Ridgway has Jeffrey Ridgway, Sr. (his abusive father who keeps destroying his possessions), Jeffrey Ridgway, Jr. (his Big Brother Bully), and Aunt Melissa (who turned Jesse's own mother against him).
- In his Minecraft Let's Plays, the Evil Chicken is this to Gronkh. It's uncertain whether he considers Evil Chicken a specific creature which keeps reappearing to ambush him, or the chickenhood is not only evil but his personal arch enemy.
- Prefessor CGI is this to Hewy in Mr. Coat and Friends.
- MrRepzion is arch-enemies with the YouTuber Onision. At one point, they frequently clashed and made videos against each other. They have stopped making videos, but are still Arch-Enemies.
- The Nostalgia Chick — The Chick treats both Michael Bay and The Little Mermaid as her sworn enemies.
- Oancitizen's seems to be Harmony Korine, as Kyle has apparently reviewed more of his movies than any other film-maker, and it's obvious from said reviews that Kyle haaaaates this guy.
- OMFGcata's Jesse Cox has declared that Husky Starcraft is his arch enemy (replacing Inanimate Objects and TotalBiscuit, in order of previous priority) from the results of the second TheGameStation podcast.
- Phelous has Phelous D1, his recurring Evil Twin.
- Red vs. Blue: Carolina has the Director, her Archnemesis Dad.
- RWBY:
- Ruby and Torchwick. By the time they meet again in "Heroes and Monsters", Torchwick is so fed up with "Little Red" getting herself involved with his plans that he's reduced to angrily whacking poor Ruby with his cane in frustration while punctuating the beating with a vicious Why Won't You Die? Motive Rant, rubbing in exactly what he thinks of her heroics. Unfortunately for Torchwick, doing this while surrounded by a horde of monsters which are attracted to negativity results in him being Swallowed Whole.
- Adam is this to Blake and Yang over the course of the series. He tells Blake during the battle of Beacon that he plans on making her suffer for betraying him by abandoning the White Fang. He insists that he will destroy everything she loves; when Yang tries to rescue Blake moments later, Adam keeps his promise by defeating Yang with a single swing of his sword, amputating her right arm in the process. By the time of their final confrontation in Volume 6, Adam tells Blake that none of the pain and scarring he's experienced in his life hurt him as much as she did because she left him. When he realises she wants him to let go of the past, he vows to never let her get away from him again. He considers Yang unfinished business and is happy to fight her when she intervenes before he can kill Blake. Seeing her shaking from the PTSD flashbacks she has to the night he cut off her arm, he accuses Yang of cowardice and demands to know what Blake even sees in her. In the end, the final fight rests on the fact that he's alienated and alone while his attempts to isolate the pair from each other only succeed in making them stronger through unity, mutual trust and teamwork.
- Ozma and Salem have been engaged in a Secret War for many years, with him trying to unite humanity and her trying to destroy everything Ozma has ever worked to create. Salem acknowledges that Ozma is correct to believe a united humanity is extremely powerful and therefore seeks to divide humanity destroy the ability of both Ozma and humanity itself to have hope for a better future. She is also aware he has placed his faith in a "smaller, more honest soul", and she implies that she sees the destruction of that soul's optimism as the key to destroying Ozma. The "soul" concerned is strongly implied to be the ever-optimistic Ruby. The two finally confront each other in Volume 8, when Ozma is inhabiting Oscar Pine. Oscar stands no chance against Salem, but eventually manages to temporarily defeat her when her minion Hazel betrays her and holds her down long enough for him to use the Long Memory on her, leaving her incapacitated for several hours.
- Qrow Branwen and Tyrian Callows, the right-hand men to Ozpin and Salem respectively. The first time they met, Qrow humiliated Tyrian by ruining his mission to capture Ruby, a fight that ended with Qrow poisoned and on the brink of death, and Tyrian having his tail cut off, and crawling back to Salem in defeat. The second time was even worse as Tyrian forms a temporary truce with Qrow so they can both fight Clover - the first real friend Qrow has had since Team STRQ disbanded - before murdering Clover with Qrow's own sword. Suffice it to say, the pair well and truly hate each other.
- The MLP Abridged Series Scootertrix the Abridged, make a Running Gag out of this, with various characters unexpectedly turning out to have an arch-nemesis. Celestia claims to have five, four of which have been revealed so far: King Sombra, Queen Chrysalis, Spike, and Kevin Bacon.
- When it comes to other Let's Players: squids to Sky Does Minecraft, barrels to PewDiePie, creepy mannequins/suits of armor and creepy things pertaining to children or babies to Markiplier, the list goes on...
- Supermarioglitchy4's Super Mario 64 Bloopers:
- Some Jerk with a Camera treats It’s A Small World and Randy Moore as this.
- Spikerbleeper — Arch Enemy of Mr. TARDIS.
- [[STAR]] has a huge hatred for sentries, but what he hates the most is the Mini-Sentry from Team Fortress 2. Justified since it's the no. 1 thing that ruins EVERYTHING for him. The worst thing that happened to him was playing the perfect loadout to get ruined by a Mini-Sentry.
- In Survival of the Fittest, both the winner of V1 and the winner of V2 have their own arch enemies. The V1 Winner, Adam Dodd, has Cody Jenson, who killed his girlfriend, raped one of his friends, and beat his other friend into unconsciousness. The V2 Winner, Bryan Calvert, has Mariavel Varella, who killed his girlfriend after swearing vengeance on Bryan for killing her boyfriend. Neil Sinclair (who was not the winner, but definitely the hero) of V3 had Danya himself.
- Nightmares the Clown is the archenemy of Frank and Sadie Doyle in The Thrilling Adventure Hour. A Monster Clown that thrives off fear. He was Frank's childhood boogeyman and Frank remained afraid of him even in adulthood until Nightmares came face to face with Sadie's utter inability to take even Monster Clowns seriously. Nightmares would go on to threaten them numerous times and each time failing before Frank and Sadie until, upon his defeat in the final "Beyond Belief" segment, he realizes that he fears Frank and Sadie.
- From the Yogscast:
- Sjin and Kim Richards have this dynamic after the end of his stint as The Mentor in "The Apprentice" series on the latter's channel. Sjin also has a feud with Knight of Cerebus Strawfingers in Feed the World, since the latter is trying to blow up Sjin's farm.
- Rythian considers Sjin and Duncan Jones to be this throughout Blackrock Chronicle, since they destroyed the old world and routinely harass him. They eventually reconcile.
