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1Fiend Folio is filled to the brim with fiendish friends and foes.
2
3!Playable Characters
4!!Normal Characters
5[[folder:Fiend]]
6!!Fiend
7[[quoteright:108:https://static.tvtropes.org/pmwiki/pub/images/fiend.png]]
8The star of the show. A genetically-modified ear of corn that somehow attained sentience and the appearance of a purple demon. Fiend is a GlassCannon character whose health bar can only hold Black Hearts and the Fiend Folio-exclusive Immoral Hearts. Whenever Fiend takes damage, all hearts of the same color adjacent to the damaged one are removed from his health bar and turn into familiars that rush down and deal contact damage to enemies. Once the room is clear, all of the familiars turn back into hearts for Fiend to pick up.\
9\
10Fiend begins each run with an innate Pyromancy item, which allows him to launch a fireball at his enemies by double tapping the fire keys.\
11\
12Fiend's Birthright grants his Pyromancy fireballs a homing effect and gives them a chance to spawn a heart minion.
13----
14* AmazingTechnicolorPopulation: For whatever reason, Fiend is ''purple''.
15* FlippingTheBird: This may as well be Fiend's trademark; it's his signature pose, what he does for "positive" actions in place of Isaac's thumbs-up, and official artwork usually has him giving the middle finger if his hands are visible.
16* GeniusBruiser: Fiend wrote the eponymous folio that the mod is named for, and is more than capable of obliterating everything it adds to the basement.
17* GlassCannon: Whenever Fiend takes damage, his health bar turns into familiars. More familiars means more damage dealt, but can potentially leave Fiend with only half a heart for defense.
18* LifeDrain: Enemies killed by Pyromancy's fireballs have a chance of dropping half Immoral Hearts.
19* LovableRogue: Fiend's an asshole, but it's hard to not root for him.
20* TheMinionMaster
21* PlayingWithFire: Can be configured, but Fiend has the ability to conjure up fireballs and fling them at his foes.
22* RuderAndCruder: Fiend's equivalent to Isaac's thumbs up pose has him flip the bird instead. Fiend also swears up a storm when he takes damage, as seen when he picks up the Mime Degree.
23[[/folder]]
24
25[[folder:Golem]]
26!!Golem
27[[quoteright:102:https://static.tvtropes.org/pmwiki/pub/images/golem_41.png]]
28A LivingStatue who focuses on collecting and smelting trinkets, with the twist that all trinkets are replaced with rock trinkets (mostly) unique to Golem. By entering the Subway, he can interact with various [=NPCs=] that perform services like smelt his rocks, trade unwanted rocks for Soul Hearts, or roll them into other rocks. Golem's rock trinkets come in three forms: Normal rocks that merely act like normal trinkets; Geodes, which give a greater bonus if Golem's other trinket slot is another geode; and Fossils, which have unique effects when crushed.\
29\
30Golem starts every run with an inherent Mom's Purse effect, allowing him to carry two trinkets at once. He also begins with the Dirt Clump and Rolling Rock trinkets.\
31\
32Golem's Birthright effect gives him +2 Luck and causes tinted rocks to drop rock trinkets instead of Soul Hearts.
33----
34* DiminishingReturnsForBalance: Smelted rock trinkets grant less of an effect than if they were held in one of his trinket slots. Smelted geodes also don't grant their bonus effect unless both of Golem's trinket slots contain geodes.
35* {{Golem}}: Obviously.
36* HubLevel: Golem's Subway has doors that lead to the Treasure Room, Boss Room, Secret Room, and Shop, [[DoorToBefore but they only function once Golem has already entered the room in question]].
37* LivingStatue
38* UniqueProtagonistAsset: Golem's Subway is entirely unique to him and contains several [=NPC=]s that perform services relevant to Golem's Trinket-heavy playstyle.
39** '''Sourpuss''' the pig will smelt one of Golem's rocks in exchange for 1.5 Soul Hearts, but only appears on even-numbered floors.
40** '''Sweetpuss''' the pig will take a rock and reroll it into a fossil. If the rock he's given is already a fossil, he instead crushes it and activates its crush effect three times.
41** '''Babi''' the demon sells rare-quality rocks in exchange for heart containers, similar to a devil deal.
42** The '''Unfinished Golem''' only appears on odd-numbered floors, but drops a rock trinket when bombed.
43** The '''Bismuth Golem''' will crush one of Golem's rocks, spawning 1-1.5 Soul Hearts, plus a bonus effect if the rock was a fossil.
44** The '''Mining Machine''' costs 3 cents to use and will grind one of Golem's rocks, rerolling it into another, different rock.
45** The '''Geode Golem''' will take a rock and reroll it into a geode. If the rock Golem gives it is already a geode, it will duplicate it instead.
46** The '''Midarizer''' costs 10 cents to use, and will turn one of Golem's rocks into its golden version.
47* VisualPun: Golem's equivalent to Isaac's thumbs-up pose is a devil horn hand gesture. He's telling you to ''rock on''.
48[[/folder]]
49
50!!Tainted Characters
51[[folder:Fiend, the Bastard]]
52!!Fiend
53[[quoteright:108:https://static.tvtropes.org/pmwiki/pub/images/taintedfiend.png]]
54[[caption-width-right:108: [[DoppelgangerAttack STRENGTH IN NUMBERS]]]]
55Fiend corrupted and tainted by the horrors in the basement. His body has degraded into black sludge. The Bastard is a character focused on the DoppelgangerAttack. By using his pocket slot Malice item, the Bastard launches himself as an invincible projectile, dealing damage to enemies and splitting his body into miniature copies when he hits a solid object. The Bastard can only have Black Hearts in his health bar, and enemies killed by Malice have a chance of dropping Half Black Hearts. The Bastard gains one mini-copy per heart in his health bar, but is only able to hold a maximum of six hearts.\
56\
57Using Malice a second time while split will cause all of the Bastard's duplicates to fuse back into one.\
58\
59The Bastard's Birthright effect grants a greatly increased chance for enemies to drop Black Hearts when killed by Malice, and gives each of his copies a hat that alters their stats in various ways.
60----
61* AntiFrustrationFeatures: While split up, each of his copies has only one health. But when one dies, the rest gain MercyInvincibility.
62** Additionally, unlike Jacob & Esau, or any of the items that give a temporary extra character, the player only controls one of the Bastard's copies while split up, with the other copies automatically clustering around the player-controlled copy. This, plus their small size, makes it less likely for the other copies to get caught on objects.
63* BlobMonster: The Bastard's body is made up of nothing more than black sludge.
64* DoppelgangerAttack: His main gameplay mechanic.
65* PullingThemselvesTogether: Using Malice while split causes the Bastard's copies to fuse back together.
66* ShoutOut: Some of the hats given by Birthright include [[{{VideoGame/Pikmin}} Captain Olimar's helmet, a flower]], [[Franchise/SuperMarioBros Mario's hat]] (but with an "F" in place of the "M"), [[VideoGame/TeamFortress2 the Ghastly Gibus, the Tyrant's Helm]], and a pair of [[Franchise/DespicableMe googly-eyed goggles]].
67* WeakButSkilled: The Bastard has an inherent 20% damage penalty, which is further decreased to about 50% while split up, but makes up for it by having [[MoreDakka up to six bodies to shoot with]].
68[[/folder]]
69
70!!Challenge Characters
71[[folder:China]]
72!!China
73[[quoteright:114:https://static.tvtropes.org/pmwiki/pub/images/china_4.png]]
74Fiend's girlfriend. China is a genetically-modified apple who is only available in the Handle With Care challenge or if the player dies with the Cursed Urn trinket. Much like the Lost, China has no hearts. Instead, when China takes damage, she instead gains a Broken Heart. Seems simple enough, except China is also incredibly fragile and takes damage if she so much as brushes up against a solid object.\
75\
76China has a 15% chance to find a Horse Push-Pop after clearing a room, which will remove one of her broken hearts. Additionally, she has a 20% smaller hitbox and an innate 25% faster fire rate.\
77\
78China's Birthright grants her the Horse Paste item in her pocket slot, which allows her to remove a broken heart once every eight rooms.
79----
80* BlessedWithSuck: The design document for Fiend's gang describes her fragility as being her "special ability".
81* EdgeGravity: Averted. China can fall into the pits that other characters treat as walls, damaging her.
82* FragileSpeedster: She has an inherently faster firing speed than other characters, but takes damage very, ''very'' easily.
83* LiterallyShatteredLives: Dying causes China to shatter into pieces.
84* MeaningfulName: China as in "fine china", another term for porcelain.
85* ObviousRulePatch: To accommodate China not being able to press up against objects without taking damage, she's able to interact with doors and key blocks from a short distance away.
86* TrademarkFavoriteFood: Horses. [[PasteEater Horse glue heals her]], and if Fiend Folio's joke "Stable Mode" is activated, China will eat any horse enemy that touches her.
87[[/folder]]
88
89[[folder:Slippy]]
90!!Slippy
91[[quoteright:108:https://static.tvtropes.org/pmwiki/pub/images/slippy_3.png]]
92A humanoid frog only available in the Frog Mode challenge, or if the player dies while holding the Frog Puppet or Tattered Frog Puppet trinkets. Slippy's gimmick is that she is constantly on the move. If the player stops inputting movement, Slippy will [[MeaningfulName slip]] in the last direction she moved, with solid objects merely changing what direction she moves. The only way for Slippy to stand still is to use her Golden Frog Head active item, which will cause her to stop moving while its attack charges.\
93\
94Slippy has an inherent triple shot much like the Keeper, and begins play with the aforementioned Golden Frog Head in her active slot. By holding the active item button, Slippy is forced to stand still and begins to charge up a [[{{Fartillery}} fart]] that grows in strength the longer the charge is held.\
95\
96Slippy's Birthright causes her Golden Frog Head farts to leave behind clouds of gas that poison enemies.
97----
98* ObviousRulePatch: Slippy is the only character who can't make an immediate 180 degree turn, to prevent players from circumventing her gimmick by pressing opposing movement keys. If the player wants to hold still, they'll need to either use the Golden Frog Head, or do fancy footwork with all four of the movement keys.
99* WingDingEyes: "X"es.
100[[/folder]]
101
102!!Hidden Characters
103[[folder:Fend]]
104
105A yellow imp who is Fiend's janitor and best friend. He can't normally be selected, but the player may "unlock" him by editing the 'players.xml' file
106----
107* AlmightyJanitor: Averted. He's literally a janitor, but he's not good at anything else.
108* JokeCharacter: Fend starts with the Spirit Sword (reskinned to look like a mop) and Lost Contact, but has an inherent ''.20x'' damage multiplier. He won't take much damage, but neither will his enemies.
109[[/folder]]
110
111[[folder:Fient]]
112
113An orange imp who is Fiend's weed supplier. Like Fend, he can only be played as by editing the 'players.xml' file
114
115----
116* MightyGlacier: Played with. His speed is quite average. But he might as well start with Polyphemus, as his damage and tears stats start at 14.20 and 0.97 respectively. The latter can be rectified by using Wavy Cap [[InterfaceScrew at a cost]]. He also starts with two Black Hearts and one of Fiend Folio's Morbid Hearts, which take 3 hits to deplete and spawn a tumor familiar upon doing so.
117* NumerologicalMotif: Fient is associated with the number [[FourTwentyBlazeIt 420]]. He starts with 14.20 damage, 4.20 range, a 0.420x shot speed multiplier, as well as 4 coins, 2 bombs, and 0 keys. Fitting, since he's...
118* TheStoner: He is heavily associated with weed, is Fiend's weed supplier, and starts with the [[MushroomSamba Wavy Cap]] item in his pocket slot.
119[[/folder]]
120
121[[folder:Peat]]
122A character made from low-res images of Peter Griffin from ''WesternAnimation/FamilyGuy''. Like Fend and Fient, he too can only be played by editing the game files.
123----
124* JokeCharacter: Even moreso than Fend. No attempt is made to make him fit the art style of ''The Binding of Isaac'', and he's completely unable to pick up items of any kind aside from hearts. Meaning he can't increase his stats except his health, and he's unable to fight ???, The Lamb, the Boss Rush, Mega Satan, Mother, or Dogma and the Beast since he can't pick up their associated quest items.
125[[/folder]]
126
127!Bosses
128!!Chapter 1
129[[folder:Buck]]
130!!Buck
131[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/buck_99.png]]
132->Debut: ''Fiend Folio''
133->Floor(s): Basement
134
135A large beggar wearing a burlap sack over his head.
136----
137* AngryEyebrows: The first thing Buck does after Isaac enters his boss room is draw a pair of eyebrows on his bag.
138* BagOfHolding: Buck's bag contains blood, bombs, and smaller bags (that turn into {{Mooks}}).
139* TheDividual: A close look at Buck reveals that he's actually two separate beings: A fat, headless corpse, and a shadow monster hiding inside the bag.
140* EasterEgg: Landing the killing blow on Buck using the Crafting Bag causes him to drop the Mystery Badge.
141* KingMook: To the Snagger enemies.
142* OffWithHisHead: Defeating him makes his bag mask fall off, revealing that he has no head.
143[[/folder]]
144
145[[folder:The Whispers]]
146!!The Whispers
147[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/whispers_2.png]]
148->Debut: ''Reheated''
149->Floor(s): Cellar
150
151A trio of ghosts found haunting the Cellar.
152----
153* TheDividual: All three ghosts share the same health pool. When one of them dies, they all die.
154* EasterEgg: Taking a photo of them with the Toy Camera item shows a fourth ghost that the other three orbit around.
155* ShoutOut: Their movement pattern is based on the Boo Buddies in ''VideoGame/SuperMarioWorld''. Also, their laugh is a sped up version of Satan's laugh, similar to how Boos use a sped up Bowser laugh in ''VideoGame/SuperMario64''
156[[/folder]]
157
158[[folder:Honeydrop]]
159!!Honeydrop
160[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/honeydrop.png]]
161->Debut: ''The Devil's Harvest''
162->Floor(s): Cellar
163
164A colossal bee found in the Cellar.
165----
166* BeeAfraid: Honeydrop is relentless. After losing half of her health, she launches her stinger and continues fighting anyway.
167* BullfightBoss: In phase 2 of the fight, Honeydrop chases after Isaac, but she can be stunned if the player tricks her into running into a wall.
168* FlunkyBoss: Honeydrop constantly summons other bee enemies.
169* KingMook: Of the various bee enemies Fiend Folio added to the Cellar.
170[[/folder]]
171
172[[folder:Griddle Horn]]
173!!Griddle Horn
174[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/griddle_horn.png]]
175->Debut: ''Fiend Folio''
176->Floor(s): Burning Basement
177
178A thoroughly-scorched Little Horn variant whose attacks are now more incendiary than explosive.
179----
180* EasterEgg: Using the White Pepper on Griddle Horn instantly kills him and drops the Spatula Badge.
181* EyeScream: Compared to his living counterpart, Griddle Horn's eyes have melted away leaving just the sockets.
182* FingerSnapLighter: If there's any gunpowder in the room when Griddle Horn snaps his fingers, it'll catch fire. Otherwise, it creates gunpowder creep under Isaac.
183* PlayingWithFire: Griddle Horn coughs up clumps of burning coal, which can ignite the gunpowder his other attacks leave behind.
184* PowderTrail: A variation without explosives. The gunpowder catching fire serves as the hazard instead.
185[[/folder]]
186
187[[folder:Buster]]
188!!Buster & His Commission
189[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/buster_8.png]]
190->Debut: ''Fiend Folio''
191->Floor(s): Burning Basement
192
193A large fly with burnt skin who attacks alongside his minions known as "Commissions".
194----
195* BadBoss: Some of Buster's attacks involve setting his Commissions on fire, and chewing them up to spit at Isaac.
196* EasterEgg: Using the Defuse card after defeating Buster instantly detonates his corpse and causes him to drop the Commissioned Badge.
197* EyelessFace: Buster lacks eyes, unlike most of the fly enemies.
198* KingMook: To the Boom Flies.
199* MadeOfExplodium: When defeated, Buster begins ticking and eventually explodes, which can damage Isaac if he's too close.
200* PlayingWithFire: Leaves behind a trail of fire when he charges.
201* WildTake: Nearby Commissions' [[OhCrap understandable reaction]] once Buster starts ticking.
202[[/folder]]
203
204[[folder:Meltdown]]
205!!Meltdown
206[[quoteright:200:https://static.tvtropes.org/pmwiki/pub/images/meltdown.png]]
207->Debut: ''Reheated''
208->Floor(s): Burning Basement
209
210One of the Modern Horsemen of the Apocalypse, representing nuclear winter.
211----
212* BadBoss: Meltdown punches his horse mount to attack, and when going into phase two, he tosses it to the ground in anger.
213* BodyHorror: Meltdown's body looks as though it's melting, so much that he's effectively fused to his horse mount, and his flesh sloughs off into Falafel minions as he takes damage. His skeleton reveals that he doesn't have legs.
214* DemBones: Reduced to a skeleton in phase two.
215* DidntThinkThisThrough: After losing half his health, Meltdown blames his horse and throws it on the ground in frustration, not realizing that throwing around something that's carrying a ''nuclear bomb'' in its mouth isn't a good idea until it starts beeping.
216* EarlyBirdCameo: Defeating Meltdown three times in a file unlocks two Flea trinkets, revealing the existence of Deluge, chapter 2's as-of-yet unreleased Modern Horseman.
217* FamilyUnfriendlyDeath: Even moreso compared to the other bosses. His death animation stands out as surprisingly gruesome, having the boss emit a wail not unlike a shutting-down machine as his jaw falls to the floor due to the radiation he spreads.
218* SicklyGreenGlow: In phase two, Meltdown's head is engulfed in green fire.
219[[/folder]]
220
221!!Chapter 1.5
222[[folder:Ghostbuster]]
223!!Ghostbuster & His Emissions
224[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/ghostbuster.png]]
225->Debut: ''Reheated''
226->Floor(s): Downpour
227A posthumous Buster, now a ghost who attacks with his ghostly minions known as "Emissions".
228----
229* FireWaterJuxtaposition: In contrast to the living Buster's fire attacks, Ghostbuster instead uses water.
230* NonHumanUndead: Ghostbuster is the ghost of a fly.
231* ShoutOut: To ''{{Franchise/Ghostbusters}}''.
232* VacuumMouth: Uses this to suck in his Emission minions, as well as Isaac. He also does it when defeated before exploding.
233[[/folder]]
234
235[[folder:Cacamancer]]
236!!Cacamancer
237[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/cacamancer.png]]
238 [[caption-width-right:192:some caption text]]
239->Debut: ''Reheated, returning from Devil's Harvest''
240->Floor(s): Dross
241A large mage made of pure poop.
242----
243%%* DungFu: Obviously.
244%%* FatBastard
245%%* {{Gasshole}}
246* LastDitchMove: Upon death, he fires out multiple projectile patterns, ending with an explosive shot that detonates the gas clouds he leaves behind.
247* ToiletHumor: He's made out of poop.
248* {{Whatevermancy}}: ''Caca''mancy.
249[[/folder]]
250
251!!Chapter 2
252[[folder:Battie]]
253!!Battie
254[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/battie.png]]
255->Debut: ''Fiend Folio''
256->Floor(s): Caves
257A large bat with an ill temper.
258----
259* EasterEgg: Using the Fiend Folio active item against Battie always creates a friendly Battie that defeats the boss instantly, which also rewards the player with the Baby Badge.
260* GroundPound: She flies into the air and slams down, creating shockwaves of stone.
261* KingMook: To the various bat enemies.
262* {{Wraparound}}: One of Battie's attacks has her charge across the room several times in this manner, leaving behind a trail of blood shots.
263[[/folder]]
264
265[[folder:Kingpin]]
266!!Kingpin
267[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/kingpin_3.png]]
268->Debut: ''Fiend Folio''
269->Floor(s): Caves
270A large worm who burrows in and out of the ground while chasing Isaac.
271----
272* BulletHell: Every time one of Kingpin's sections is destroyed, it leaves behind a set of stationary bullets that can quickly fill the room.
273* KingMook: To the Weavers.
274* NonIndicativeName: Despite having "Pin" in his name, Kingpin acts more like a cross between Larry Jr. and one of Fiend Folio's Weaver enemies.
275* SegmentedSerpent: Just like Larry Jr., killing one of Kingpin's center pieces causes him to split into two.
276[[/folder]]
277
278[[folder:Slinger]]
279!!Slinger
280[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/slinger_7.png]]
281->Debut: ''Reheated''
282->Floor(s): Catacombs
283A skinless humanoid creature with a spider egg sack for a head.
284----
285* TeethFlying: When Slinger first enters the room, he faceplants and leaves a tooth on the floor that generates red creep until it's destroyed.
286* UseYourHead: Slinger can spawn spiders by lobbing his head, which naturally grows back.
287[[/folder]]
288
289[[folder:Monsoon]]
290!!Monsoon
291[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/monsoon.png]]
292->Debut: ''Fiend Folio''
293->Floor(s): Flooded Caves
294A BlobMonster made entirely of water based on Monstro.
295----
296* EasterEgg: Using Flush against Monsoon's smaller form instantly kills him and drops the Dripping Badge.
297* IHaveManyNames: While "Monsoon" is the default, there are options to change his name to "Moistro", "Jack the Dripper", or "[[OverlyLongName Jack Moistro the Monsoon Dripper]]".
298* KillItWithWater: A water drop monster who sprays water and bubbles to attack.
299* KingMook: To the Drop enemies.
300* MythologyGag: Monsoon reuses Monstro's sound effects from the original Flash ''Binding of Isaac''.
301[[/folder]]
302
303[[folder:Aquagob]]
304!!Aquagob
305[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/aquagob.png]]
306->Debut: ''Reheated''
307->Floor(s): Flooded Caves
308A large blue severed head who spits water and bubbles at Isaac.
309----
310%%* KillItWithWater
311* KingMook: To the Horf enemies.
312* MookMaker: He can summon Horf variants called Aquababs, and some of his bubbles contain flies.
313[[/folder]]
314
315!!Chapter 3
316[[folder:The Organization]]
317!!The Organization (Chaser, Speedy, Bashful, and Pokey)
318[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/the_organisation.png]]
319->Debut: ''Fiend Folio''
320->Floor(s): Depths
321A quartet of ghosts, each possessing a single organ. They consist of Chaser (brain), Speedy (heart), Bashful (eye), and Pokey (intestines).
322----
323* AttackItsWeakPoint: Only Chaser's brain is vulnerable to damage. All of the other ghosts are invincible, including Chaser's brainless body when he throws it, and block Isaac's shots.
324* EasterEgg: They die in one hit to the Gamekid or Power Pill effect and drop the Haunted Badge. Which is appropriate, considering...
325* {{Expy}}: They're basically the ghosts from ''VideoGame/PacMan'', with their names and movement patterns taken from the original game: Chaser is Blinky's Japanese title, while Speedy, Bashful and Pokey are the English titles for Pinky, Inky, and Clyde.
326* {{Irony}}: Despite containing the quartet's guts, Pokey himself is ''[[DirtyCoward gutless]]''.
327* MeaningfulName: Chaser chases, Speedy is fast, Bashful is bashful, and Pokey is slow.
328* PunnyName: "Organization" is a play on how there's not only four ghosts, but that each of them contain an organ.
329[[/folder]]
330
331[[folder:Gutso the Great]]
332!!Gutso the Great
333[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/gutso.png]]
334->Debut: ''Reheated''
335->Floor(s): Depths
336A massive, overbloated humanoid figure the size of Gurdy, whose eponymous gut hides a nasty secret...
337----
338* BodyHorror: After taking enough damage, Gutso's stomach tears open and his innards begin attacking.
339* FatBastard: Gutso's so fat he can't even move.
340* MythologyGag: Gutso bears a resemblance to [[https://static.wikia.nocookie.net/bindingofisaacre_gamepedia/images/1/16/Boss_Mega_Fatty_Unused_ingame.png this]] unused sprite for Mega Fatty.
341[[/folder]]
342
343[[folder:Luncheon]]
344!!Luncheon and the Tapeworms (Petunia, Minkus, Greg, and Boris)
345[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/luncheon_4.png]]
346->Debut: ''Fiend Folio''
347->Floor(s): Necropolis
348A massive, sock puppet-like worm creature, from whose maw spill other, smaller worms.
349----
350* FlunkyBoss: Luncheon spits up tapeworms to fight on its behalf. After killing enough worms, Luncheon is defeated.
351* MixAndMatchCritters: The tapeworms Luncheon spawns have three segments that influence the worm's abilities: A head, a torso, and a tail. Each segment is taken from one of four possible tapeworms: The cheerful Petunia, the fearful Minkus, the aggressive Greg, and the spacey Boris.
352* MythologyGag: The tapeworms are based on ''Tapeworm'', a board game made by Edmund [=McMillen=].
353[[/folder]]
354
355[[folder:Pollution]]
356!!Pollution
357[[quoteright:200:https://static.tvtropes.org/pmwiki/pub/images/pollution.png]]
358->Debut: ''Fiend Folio''
359->Floor(s): Dank Depths
360One of Meltdown's colleagues among the Modern Horsemen, though HIS gimmick is evident from his name.
361----
362* BadassBiker: Pollution's horse is also a motorcycle.
363* BreathWeapon: His horse can breathe fire, which carries over into phase 2 when Pollution wears its head in place of his own.
364* CarFu: Pollution will run Isaac down on his horse-cycle, and when phase 2 of the fight begins, he kicks the horse's remains at Isaac.
365* DefeatEqualsExplosion: Pollution explodes when defeated. Unlike Buster, however, this can't damage Isaac.
366* EarlyBirdCameo: Defeating Pollution three times in a file unlocks two Flea trinkets, revealing the existence of Propaganda, chapter 4's as-of-yet unreleased Modern Horseman.
367* OffWithHisHead: The transition into phase 2 begins with Pollution losing his head and replacing it with his horse's.
368[[/folder]]
369
370[[folder:Tsar]]
371!!Tsar
372[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/tsar.png]]
373->Debut: ''Reheated''
374->Floor(s): Dank Depths
375The foulest-smelling entity in all of Fiend Folio, Tsar is a blob-like creature who can alter its bodily composition by absorbing a number of foul substances.
376----
377* GetBackHereBoss: Between hiding inside grates and bouncing out of range of Isaac's tears, there are few opportunities to deal damage to Tsar.
378* GroundPound: He can hover in the air and slam down, not only trying to smash Isaac, but also causing the pipes in his room to spread creep on the floor.
379* MuckMonster: Tsar's body is made up of not only tar, but sewage and corrosive sludge as well.
380* PunnyName: Normally tsar is pronounced with a silent T, but in this case the S is silent to make the word tar.
381* VomitIndiscretionShot: Upon his death Tsar vomits up his whole body, leaving him as just a withered skeleton.
382[[/folder]]
383
384[[folder:Junkstrap]]
385!!Junkstrap
386[[quoteright:186:https://static.tvtropes.org/pmwiki/pub/images/junkstrap.png]]
387->Debut: ''Monthiversary Update''
388->Floor(s): Dank Depths
389A massive skull armed with and protected by tar, trash and a massive football helmet.
390----
391* {{Expy}}: Visually, he resembles The Gate from base ''Isaac'', but made of garbage and wearing a football helmet.
392* KingMook: To Fiend Folio's Dope's Head enemies.
393* PunnyName: Junk + jock strap.
394* SpikesOfDoom: Junkstrap can line the edges of his boss room with spikes, which he'll try to push Isaac onto.
395[[/folder]]
396
397!!Chapter 3.5
398[[folder:Warp Zone]]
399!!WARP ZOOOOOOOOOONE!
400[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/warp_zone.png]]
401->Debut: ''The Devil's Harvest'' (as Mega Portal)
402->Floor(s): Mausoleum
403A sentient portal with an ill will and a propensity for tricks. Who knows what lurks on the other side...?
404----
405* BossRush: Part of Warp Zone's boss fight is dedicated to fighting warped versions of earlier bosses: Monstro, Larry Jr., and Gemini.
406* IHaveManyNames: Warp Zone's name can be changed to "Warp Zooooooooone" or "Mega Portal".
407* KingMook: To the Portal and Mini-Portal "enemies" from the base game.
408* KungFuProofMook: Warp Zone is one of the few bosses immune to the Chaos Card. Throwing it at him has him CatchAndReturn it, turning Isaac into The Lost if it hits.
409* ShoutOut: To ''VideoGame/SuperMeatBoy''. The "Warp Zooooooooone!" sound clip even plays during the VersusCharacterSplash.
410[[/folder]]
411
412[[folder:Dusk]]
413!!Dusk
414[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/dusk_0.png]]
415->Debut: ''Reheated''
416->Floor(s): Mausoleum
417A strange, bony, long-armed shadow creature with tricky effect tears and a mean streak a mile wide.
418----
419* CreepilyLongArms: Skeletal ones, at that. At least in his first phase.
420* DoppelgangerSpin: Dusk has two variants on this. One where he spawns a bunch of spectral versions of himself before lunging at Isaac, and one where he orbits Isaac alongside three copies that are colored differently than the true one.
421* FlyingFace: In phase two, Dusk is reduced to just his skull.
422* ShoutOut: To the boss of the same name from ''The Legend of Bum-bo''.
423* WingDingEyes: Violet spirals.
424[[/folder]]
425
426[[folder:Madomme]]
427!!Madomme
428[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/madomme.png]]
429->Debut: ''Spitshine Update''
430->Floor(s): Gehenna
431A fiendish dominatrix suit with a queenly taste for inflicting pain. Leads her loyal army of bitches into battle.
432----
433* BondageIsBad: Kinda goes with Gehenna as a whole, but Madomme refuses to be subtle about it.
434* ChessMotifs: Madomme and her bitches have this sort of motif going. G-Imps are Pawns, Horses are Knights, Castles are Rooks, Glorias are Bishops, Champ is the King, and Madomme herself the Queen.
435* {{Dominatrix}}: Madomme herself, who rules over her bitches with a leather-clad iron fist, and is a living leather suit. Even Champ, the "king", is kept locked in a cage for no reason other than Madomme's amusement (Champ at least seems okay with this arrangement).
436* EvilCounterpart: Madomme is the [[EvilerThanThou eviler]] counterpart to the Mausoleum's Siren, both being demonic women with large, curved horns and an emphasis on controlling minions.
437* HellBentForLeather: Exaggerated; Madomme is a ''sentient, demonic dom suit''. Played straight with all of her bitches, who only ''wear'' leather gear instead of ''being'' leather gear.
438* OverdrawnAtTheBloodBank: On top of using blood to attack Isaac, when she's defeated, Madomme's suit is unzipped and an absolute torrent of blood spills out of it.
439* RedAndBlackAndEvilAllOver: She's a Gehenna boss, did you expect anything different?
440* SlasherSmile: Half of Madomme's face is taken up by her ridiculously pointy teeth.
441* VideoGameCrueltyPunishment: Champ is normally harmless and invincible, but killing her using a Chaos Card or other instant death effect causes several G-Imps to spawn in retaliation.
442[[/folder]]
443
444!!Chapter 4
445[[folder:Basco]]
446!!Basco
447[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/basco.png]]
448->Debut: ''Reheated''
449->Floor(s): Womb
450A large, spiced-up poop monster with a penchant for rolling and a rather heated reaction to spicy food.
451----
452* FireBreathingDiner: Eating spicy food will cause Basco to speed up and spray fire for a short time.
453* IAteWhat: Basco's "food" only superficially resembles actual food: Cherries are a pair of eyeballs on a stem, and the strawberry is a heart. Only the drumstick seems to be exactly what it looks like, but is [[ImAHumanitarian probably made of human meat]].
454* PowerUpFood: Basco will spawn several pieces of food every so often, which will either heal him or power him up depending on if they're "spicy" or not. Dealing enough damage to a healing food will cause it to rot and poison Basco when he eats it.
455%%* TalkingPoo
456[[/folder]]
457
458[[folder:The Sun]]
459!!The Sun
460[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/the_sun_0.png]]
461->Debut: ''Fiend Folio''
462->Floor(s): Utero
463A gilded cauldron filled with viscera who commands a solar system of organs to defend itself: Venus (brain), Earth (kidney), and Neptune (heart).
464----
465* BlackSpeech: Its voice is the same as Satan's[[note]]specifically, his prior Flash incarnation[[/note]], complete with constantly shouting Isaac's name in reverse.
466* EasterEgg: Similarly to Great Gideon, killing the Sun's body with the Chaos Card will both instantly end the fight and grant the player the Planet Badge.
467* KillOneOthersGetStronger: When one of the organs is destroyed, the other two gain enhanced attacks.
468* OrbitingParticleShield: Earth is orbited by a pair of kidney stones that can block shots and will fire back if hit.
469[[/folder]]
470
471[[folder:Peeping]]
472!!Peeping
473[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/peeping_6.png]]
474->Debut: ''Fiend Folio''
475->Floor(s): Utero
476A mobile eyelike creature with a nasty glare and its sights set on conflict.
477----
478* EyeScream: Peeping tears itself out of the floor to start the fight alongside its ocular nerves. In phase three, it tears itself from the nerves and begins [[PinballProjectile rolling around as just an eyeball]].
479* EyesDoNotBelongThere: In the first phase, Peeping has a mouth filled with other, smaller eyeballs. In phase two, he spits four of them onto stalks to aid him.
480%%* FacelessEye
481[[/folder]]
482
483[[folder:Cacophobia]]
484!!Cacophobia
485[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/cacophobia.png]]
486->Debut: ''Monthiversary Update''
487->Floor(s): Scarred Womb
488A strange collective consisting of Venus, a bandage-wrapped creature who acts as Cacophobia's avatar, but neither moves nor attacks; and Cacophobia's many, many eyes.
489----
490* ArcSymbol: Rorschach tests. They appear as her boss icon, her bestiary icon, and if you die to it, Isaac's Last Will gets replaced with one.
491* BodyHorror: Venus goes through a lot of it. From having her jaw broken, to her limbs cut off, to being bisected horizontally or vertically, and even reduced to LudicrousGibs.
492%%* BulletHell: Some room layouts feature this.
493* DroneOfDread: Cacophobia's fight replaces the normal boss theme with various droning sounds that change as the room does.
494* InterfaceScrew: If the player dies to Cacophobia, Isaac's last will is replaced with a Rorschach test.
495* JumpCut: Cacophobia's main gimmick. Every few seconds, the entire boss room is rearranged. As Cacophobia's health lowers, the more frequently the jump cuts happen.
496* TheLittleShopThatWasntThereYesterday: After Cacophobia is defeated, the game [[JumpCut jump cuts]] to a red field, then back to the boss room, with no evidence of Cacophobia ever having been there at all.
497* ShoutOut: Cacophobia as a whole is based on the works of Francis Bacon. Venus's design is based on Carsoro from ''[[{{VideoGame/Hylics}} Hylics 2]]'', while the mechanics of the fight itself are reminiscent of Sans in ''{{VideoGame/Undertale}}''.
498* SurprisinglyCreepyMoment: In a game full of BloodyHilarious BlackComedy, Cacophobia stands out by being a genuine horror monster with very little humor.
499%%* TheWallsHaveEyes: And they shoot at you.
500[[/folder]]
501
502!!Chapter 4.5
503[[folder:Mr. Dead]]
504!!Mr. Dead
505[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/mrdead.png]]
506->Debut: ''Fiend Folio''
507->Floor(s): Corpse
508A sentient Teratoma-like entity piloting the remains of Mr. Fred, in whose busted-open head it reclines.
509----
510* EyeScream: The tumor can pop Mr. Dead's eyes from their sockets to act as minions that bounce around the room.
511* MookMaker: He can spit up Bonies, as well as Tinytoma chunks that spawn Spiders or Small Maggots when destroyed.
512* OrbitingParticleShield: He often shields himself using Tinytomas.
513* PuppeteerParasite: The Teratoma-like entity reclining in Mr. Dead's head is in full control, with the rest of the body piloted by it.
514[[/folder]]

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