History Series / APBio

* CoolLoser: Grace is pretty, friendly, upbeat and not particularly socially awkward, but, like the rest of Jack's class, is still considered to be an outcast within the student body.

* ADateWithRosiePalms: To prove a point, Jack asks his students to raise their hands if they masturbate. Naturally, only [[ButtMonkey Victor]] raises his.

** While Heather is initially characterized as a ShrinkingViolet {{Nerd}}, she quickly starts showing that she's surprisingly aggressive and kinky as well as an expert butcher.

* HotGuyUglyWife: An unmarried example. The tall and muscular Dan Decker has a mutual crush on the mousy and bizarre Heather.

* {{Nerd}}: Heather's look and initial characterization are a classic Hollywood nerd, with enormous NerdGlasses, outdated fashion, and a perpetually blank, open-mouth stare.

* MauveShirt: Marissa (the overweight girl with glasses who sits in the front row of Jack's class) gets a few lines and even attends Victor's house party, but otherwise does not receive any kind of focus or characterization. This puts her in a strange purgatory between the "major" students and the [[LivingProp "background"]] students. Season two gives a few more of the other LivingProp students dialogue, pushing them into this category as well, perhaps taking a cue from ''Series/TheOffice''.

* BittersweetEnding: Season 1 ends with one. In the season finale, Jack's shoe-in to fill in for Miles as the head of Philosophy at Stanford is revoked after the Dean fires Miles ([[BrickJoke as a result of the catfishing scheme]] [[HoistByHisOwnPetard that Jack pulled in the pilot]]) and decides that Jack, who Miles recommended, would be an unsuitable replacement, tainting Jack's career by proxy and forcing him to remain in Toledo and continue teaching AP Bio. [[AwLookTheyReallyDoLoveEachOther He is cheered up by his students]], who inspire him to expand their plot from simply getting revenge on Miles to getting revenge on [[UpToEleven every single thing in the world that bothers them]]. The episode ends with Jack enthusiastically (and happily) scribbling down new ideas for revenge targets with his class.

** While Heather is initially characterized as a ShrinkingViolet HollywoodNerd, she quickly starts showing that she's surprisingly aggressive and kinky as well as an expert butcher.

* HollywoodNerd: Heather's look and initial characterization are a classic Hollywood nerd, with enormous NerdGlasses, outdated fashion, and a perpetually blank, open-mouth stare.

* LoadsAndLoadsOfCharacters: Jack, his class (composed of nine major students), Principal Durban, Stef, Mary and Michelle appear in every single episode, as does Helen starting in the second season. Miles, Coach Novak and Meredith are recurring characters who appear frequently. Many of the students' parents have appeared multiple times, and many more characters make one-shot appearances.

* FictionalHoliday: The season 3 finale reveals that Toledoans celebrate Creator/KatieHolmes Day, a parody of Christmas during which the real-life actress who happens to be from Toledo is idolized to a bizarre, quasi-religious degree.

* ChildhoodBrainDamage: [[spoiler:Jack's almost-stepbrother Max displays behavior that is alternately violent, rude, oblivious and downright nonsensical, such as cheerfully trying to beat Jack up when he first meets him and dragging a large tree branch into the house to play with. At the end of the episode, Jack's father reveals he was left under an X-ray machine for too long as a small child by a negligent technician.]]

* TheDitz: Victor is quite clearly the dopiest kid in Jack's class, though Colin comes in a close second. The fact that they're both in an AP class implies that they have book smarts but have otherwise been coddled to the point of idiocy. Dale the janitor is also regularly shown to be a bumbling nincompoop who is so easily deceived that he's effortlessly tricked into believing that [[InsaneTrollLogic his missing mop was transformed into a dog by a magical dumpster]].

* FullNameBasis: Dan Decker is almost always referred to as Dan Decker.
* FunTShirt: Anthony wears a new one at least OncePerEpisode. A more subtle example, Colin seems to always wear Tee Turtle shirts under his button-downs.

** Heather's family runs a butcher shop, giving her an expert knowledge of pig anatomy.

* ShownTheirWork: The Toledo of this universe has the absurdly grandiose celebration Katie Holmes Day. There's also a separatist faction that honors Jamie Farr. Farr played a character on MASH who was from Toledo and Katie Holmes is actually from Toledo.

* TroubledButCute: Devin.

''A.P. Bio'' is a comedy series created by Mike O'Brien. Two seasons aired on NBC, and a [[UnCancelled revived third and fourth season]] was released on Creator/{{Peacock}}.

On December 6, 2021, Mike O'Brien [[https://twitter.com/MikeOBrienXOXO/status/1467933272260841474 announced on Twitter]] that the show had been cancelled and would not be getting a fifth season.

** Devin, the Satan-worshiping outcast, and Colin, the [[FatIdiot doofy]] sax player, vanish from the class in the second season without explanation. Their seats are taken by Caleb and Eduardo, who are treated [[RememberTheNewGuy as if they've always been there]].

* LighterAndSofter: Possibly to address criticisms about the first season being too dark, the second season features Jack showing off his HiddenHeartOfGold more regularly and pushes his obsession with revenge farther into the background.

* BookEnds: Season two begins with an early joke where Jack thinks that a girl in his class is new, only for her to state that she's been there the whole time. The season ends with Jack again mistaking her for a new student, causing her to make the same objection.

* NumberOneDime: In the season 4 finale, we learn that Jack is extremely protective and possessive about a seemingly ordinary Harvard University-branded pen that's been missing all school year. [[spoiler:The audience is first led to assume that it's simply a souvenir from his time teaching at Harvard, when in fact it was a going-away present from his now-deceased mother from when he first went off to college and the clip is engraved with the words "I love you".]]

''A.P. Bio'' is a comedy series created by Mike O'Brien. Two seasons aired on NBC, and a [[UnCancelled revived third season]] was released on Creator/{{Peacock}}. A fourth has been ordered.

** Jazz music. Rap music. Probably all music.

** Caleb's contrarian family refuses to celebrate Katie Holmes Day and instead celebrates Creator/JamieFarr Day because they think he's a better example of a famous actor from Toledo. They celebrate by eating baked beans directly out of the can, and the men dress up as his crossdressing character Corporal Klinger from ''Series/MASH''.

* FictionalHoliday: The season 3 finale reveals that Toledoans celebrate Creator/KatieHolmes Day, a parody of Christmas during which the real-life actress who happens to be from Toledo is idolized to a bizarre, quasi-religious degree. The story of her landing her StarMakingRole of Joey Potter on ''Series/DawsonsCreek'' by videotaping her audition and mailing it to Los Angeles is seen as an inspirational tale about achieving one's dreams; it's read to children as a bedtime story and live re-enactments of it are performed annually in the town square as the equivalent of a Christmas Nativity Play. The average Toledoan also knows an absurd amount of mundane details and minutiae about Katie Holmes' early life, such as the specifications of the Buick she drove as a teenager.

* FicionalHoliday: The season 3 finale reveals that Toledoans celebrate Creator/KatieHolmes Day, a parody of Christmas during which the real-life actress who happens to be from Toledo is idolized to a bizarre, quasi-religious degree. The story of her landing her StarMakingRole of Joey Potter on ''Series/DawsonsCreek'' by videotaping her audition and mailing it to Los Angeles is seen as an inspirational tale about achieving one's dreams; it's read to children as a bedtime story and live re-enactments of it are performed annually in the town square as the equivalent of a Christmas Nativity Play. The average Toledoan also knows an absurd amount of mundane details and minutiae about Katie Holmes' early life, such as the specifications of the Buick she drove as a teenager.

* RememberTheNewGuy: Eduardo and Caleb appear out of nowhere in [[ChuckCunninghamSyndrome Colin and Devin's]] seats in the season two premiere. The rest of the cast act as though he had been there the whole time.

* BandGeek: Colin is a classic example. He's an awkward pudgy red-haired kid who is really into playing the saxophone, despite not being especially good at it.

* TheUglyGuysHotDaughter: Inverted ''and'' gender-inverted with Colin and his mom. Colin is a goofy-looking, awkward and annoying BandGeek, while his mom is a beautiful and witty professional musician who [[AbsurdlyYouthfulMother looks far too young to have a teenage son]].

* ADayInTheLimelight: Several episodes in the first season focus on one student in particular: