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* ''VideoGame/DyztopiaPostHumanRPG'': The leader of the archangels, Slash, regrets [[spoiler:listening to Quot's request to spare Asterisk, since this just led to Asterisk continuing with his cycle of wiping out humanity and reviving them. Slash now believes the only way to atone for his failure is to stop the party from unwittingly delivering the Zodiac stones to Zazz's office, thus preventing the cycle from continuing]].
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* ''VideoGame/DyztopiaPostHumanRPG'': The leader of the archangels, Slash, regrets [[spoiler:listening to Quot's request to spare Asterisk, since this just led to Asterisk continuing with his cycle of wiping out humanity and reviving them. Slash now believes the only way to atone for his failure is to stop the party from unwittingly delivering the Zodiac stones to Zazz's office, thus preventing the cycle from continuing]].continuing. Quot herself regrets convincing Slash to spare Asterisk, since she is not only ostracized by the other angels, Asterisk dumps her anyways]].
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* ''VideoGame/DyztopiaPostHumanRPG'': The leader of the archangels, Slash, regrets [[spoiler:listening to Quot's request to spare Asterisk, since this just led to Asterisk continuing with his cycle of wiping out humanity and reviving them. Slash now believes the only way to atone for his failure is to stop the party from unwittingly delivering the Zodiac stones to Zazz's office, thus preventing the cycle from continuing]].
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* ''VideoGame/PhysicalExorcismSeries'': In ''VisualNovel/Case03TrueCannibalBoy'', Brucie reveals [[spoiler:that he feels guilt over Grete killing Hans in ''VisualNovel/Case00TheCannibalBoy'', who he [[EvenEvilHasLovedOnes genuinely loved]]. The Cannibal Boy of Mt. Candyhouse takes advantage of this by shapeshifting into Hans in order to make him hesitate]].
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* If you fail to save a patient in ''VideoGame/TraumaCenter'', the PlayerCharacter becomes so ashamed and depressed over their failure that they decide to resign from the medical field and they're never seen again, implying that they can't consider themselves as doctors nor face their colleagues after the failure they had.
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* ''VideoGame/SunHaven'' has Wornhardt, the doctor of the eponymous town. Though he's a capable and well-mannered medical professional, he's still haunted by [[spoiler:his failure to save a mayor's daughter from an illness he couldn't diagnose, leading to his hometown in the Southern Isles turning on him and Wornhardt leaving in shame.]]
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* ''VideoGame/EasternExorcist'' begins with the hero, Lu Yun-chuan, failing his mission to hunt down the demon lord known as King Mandrill, where two of his sworn brothers are killed by King Mandrill's forces while his last brother is mortally injured... all because Lu decides to spare a ''hulijing'' his brothers caught. According to his only surviving brother, Zhang Huai-zhou, the ''hulijing'' is one of King Mandrill's minions who then rats them out, leading to Lu Yun-chuan deciding to atone for his failures by completing the quest solo. [[spoiler:And then comes the last stage's revelation; the ''hulijing'' is actually innocent, his supposed sworn brother, Zhang, is the ''real'' traitor in league with the demons]].
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* ''VideoGame/{{Chest}}'':
** Raks, aka Rain Green, is haunted by one of his machines accidentally killing his brother, Right. Ever since then, thinking about this trauma causes him to fall asleep as part of his mental defense mechanism. He decides to become a royal scientist again when Anzi, a goddess, tells him that his brother in Heaven doesn't blame him.
** Rosy was unable to protect her brother from bullies, which is why she currently wants to become the strongest warrior in the world so she can protect everyone she loves.
** Raks, aka Rain Green, is haunted by one of his machines accidentally killing his brother, Right. Ever since then, thinking about this trauma causes him to fall asleep as part of his mental defense mechanism. He decides to become a royal scientist again when Anzi, a goddess, tells him that his brother in Heaven doesn't blame him.
** Rosy was unable to protect her brother from bullies, which is why she currently wants to become the strongest warrior in the world so she can protect everyone she loves.
