History Monster / MarvelVideoGames

* ''[[Film/X2XMenUnited X2]]: Wolverine's Revenge'': [[MadScientist The Professor]], real name Truett Hudson, is a mastermind behind the Weapon X project, an experiment designed to create the perfect killing machine. To this end, the Professor [[PlayingWithSyringes experiments]] on a least a dozen people, turning them into mindless feral mutants, before he gets his hands on Victor Creed, aka [[Characters/MarvelComicsSabretooth Sabretooth]], and Logan, aka [[Characters/XMenFilmSeriesWolverine Wolverine]]. Kidnapping the two, the Professor commits a number of painful experiments on them, wiping their minds and turning them into [[SuperSoldiers perfect soldiers]]. When Logan escapes and confronts the Professor, the latter informs him that he injected all Weapon X subjects with the Shiva Virus, which would kill them in a few years, leading to Logan starting to search for the cure several years later.

!!''Franchise/SpiderMan''

* ''VideoGame/SpiderMan3'' ([[UsefulNotes/PlayStation3 PS3]], [[UsefulNotes/Xbox360 360]], [[UsefulNotes/MicrosoftWindows PC]] version): [[CorruptCorporateExecutive Luke Carlyle]] is a former industrialist whose business crumbled after the Daily Bugle uncovered his corrupt practices. Seeking revenge against the city that ruined him, Carlyle adopted the identity of "Carlyle the MadBomber" and led a series of terrorist attacks across Manhattan. After destroying his old building, Carlyle had his men plant explosives throughout the city, focusing mostly on locations that would cause civilian casualties. When Spider-Man foils his plans, Carlyle launches an attack on the Daily Bugle and kidnaps J. Jonah Jameson. Carlyle places an [[ExplosiveLeash explosive collar]] around Jameson's neck and tosses him out of his helicopter in an attempt to kill him and Spider-Man. Carlyle ultimately escapes after Spider-Man takes out his helicopter, but not before [[YouHaveOutlivedYourUsefulness setting off the explosives he had rigged in each of his henchmen's suits]].

** [[UsefulNotes/MicrosoftWindows Windows]]; [[UsefulNotes/Xbox360 360]]; [[UsefulNotes/PlayStation3 PS3]]; UsefulNotes/{{Wii}} version: [[Characters/MarvelComicsVenom The Venom symbiote]] itself has grown so powerful that it has nearly completely overridden Eddie Brock's mind and become its own threat. Spreading symbiotes across New York while [[ToServeMan gorging itself on innocents]] and threatening Spider-Man's loved ones, the Venom symbiote transforms most of New York into an apocalyptic wasteland where almost all citizens have been turned into its symbiote zombies. Boarding a ComicBook/{{SHIELD}} Helicarrier, the Venom symbiote plans to traverse the globe and infect all life on Earth with its taint to assume absolute dominion.
** ''Amazing Allies Edition'' (UsefulNotes/{{PS2}} and [[UsefulNotes/PlayStationPortable PSP]]): [[Characters/MarvelComicsEddieBrock Eddie Brock]] himself is [[AdaptationalVillainy nothing]] like [[AntiVillain any]] of his [[AntiHero usual]] incarnations. Hating Spider-Man for untold reasons, Venom allows [[MadScientist Jackal]] to experiment on him in order to speed up his symbiote suit's growth rate, then spreads his symbiote across Manhattan, infecting hundreds of people, including Spider-Man's friends, and turning them into mindless, hate-filled zombies. After manipulating many of Spider-Man's foes into assisting him in destroying the Wall-Crawler, Venom reveals he plans to allow his symbiote to spread across the planet, infecting every human around the world once Spider-Man is dead.

* ''VideoGame/XMenOriginsWolverine'' (UsefulNotes/PlayStation2 & UsefulNotes/{{Wii}} version): [[BigBad Colonel William Stryker]] is a [[InsaneAdmiral high-ranking officer]] within the US Army and the head of the Weapon X project. Having assembled the team of mutants in the past, Stryker uses them to complete his own personal operations, at one point ordering them to massacre a militia within an African village, and then tries to torture information from innocent civilians there about the adamantium that located within the area. When Logan rebelled against him, Stryker knocked him out and then tried to [[NukeEm obliterate the village with a nuke]]. In the present, manipulating Logan to become his subject in the Weapon X program, Stryker [[PlayingWithSyringes experiments on countless humans]], transforming them into his mindless brutes [[AndIMustScream who suffer so much]] that they thank Logan for killing them.

* ''VideoGame/GhostRider2007'' ([[UsefulNotes/GameBoyAdvance GBA]] version): {{Mephisto|pheles}} is behind all the evil in the game. Seeking to expand his hellish kingdom, Mephisto decides to create a HellOnEarth by drawing a glyph that would break the seal between Hell and Earth and trigger [[TheEndOfTheWorldAsWeKnowIt the apocalypse]]. Choosing Johnny Blaze to become the Ghost Rider, Mephisto [[YouKilledMyFather has Blaze's dad killed]], and orders Vengeance to kill his girlfriend Roxanne when Blaze refuses to serve him. Once the glyph has been drawn into the Earth by Johnny, Mephisto tries to kill Johnny so that nobody can stop him.

** [[Characters/SpiderManInsomniacVenom The Venom symbiote]] is an [[AdaptationalAbomination extraterrestrial entity]] that arrived on Earth in a spiral-marked meteor with the intent of conquering it for the Hive. Costing Curt Connors his arm when it tried to bond to him, it was captured by Oscorp and used as an experimental treatment for Harry Osborn's terminal illness. Deeming Spider-Man--Peter Parker--a superior host, it tries to abandon Harry to bond to Spidey several times before Harry willingly relinquishes it to save Peter's life. [[TheCorrupter Making Peter increasingly aggressive]] even towards his loved ones, the symbiote takes over him while he sleeps and viciously attacks [[Characters/MarvelComicsKravenTheHunter Kraven]]'s Hunters before trying to kill Mary Jane when she attempts to shock Peter awake. Attempting to goad Peter into killing Kraven, the symbiote fully takes over Peter and tries to kill [[Characters/MarvelComicsMilesMorales Miles Morales]] before being defeated. Rejected by Peter, the symbiote re-bonds to Harry and twists his dream of healing the world to further its own goals--{{gaslighting}} him by impersonating his late mother. Influencing--if not outright controlling--Harry as Venom, the symbiote causes him to brutally kill dozens of Oscorp's security forces and Kraven's Hunters; kill Kraven by devouring his head; infect Mary Jane Watson with the Scream symbiote out of spite at Peter; and use the spiral meteor to unleash a horde of symbiotes to conquer the Earth. When Peter refuses to join it and resists its attempts to forcibly corrupt him, the Venom symbiote fully takes over Harry and tries to kill Peter and his loved ones.

''[[AC:Franchise/SpiderMan]]''

* [[VideoGame/SpiderManInsomniac Insomniac series]]:
** [[VideoGame/SpiderManPS4 Original game]]'s ''The City That Never Sleeps'' {{DLC}}: [[BigBad Hammerhead]], real name Joseph [[BilingualBonus Martello]], is a sadistic [[TheDon Maggia don]] who yearns for the "good old days" when mobsters like him ruled New York City with an iron fist, and the police knew to look the other way. When Sable International leaves their technology behind after the Devil's Breath incident, Hammerhead arms his men with as much as he can find--subsequently hoarding humanitarian supplies desperately needed by the war-torn country of Symkaria--and tears up the streets of New York with a brutal [[MobWar gang war]] against the other crime families so he can seize power, while attempting to have countless civilians killed through car bombings, assaults on witnesses and police escorts, and assassinations conducted by particularly brutal hitmen. When [[Characters/SpiderManInsomniacPeterParker Spider-Man]] and Yuri Watanabe attempt to stop him, Hammerhead provokes Yuri into shooting him by [[CopKiller massacring numerous cops]] before having other crime bosses slowly [[CementShoes drowned in cement]], trying to broadcast their deaths across the city. When that fails, he goes into hiding and has himself converted into a cyborg using the dangerous Project Olympus armor, forcing an Oscorp scientist to upgrade his men as well without care to the many that die from the procedure. When Hammerhead resurfaces, he tortures Silver Sable with a power drill until she gives him the most dangerous Sable Tech in her arsenal.
** ''[[VideoGame/SpiderManMilesMorales Miles Morales]]'': [[ManipulativeBastard Simon Krieger]] is the [[CorruptCorporateExecutive sociopathic head of the research and development at Roxxon]]. Placed in charge of the Nuform Project, Krieger has Rick Mason develop Nuform, only for it to make civilians horribly sick, with Krieger choosing to distribute it anyways, ignoring the risks out of pure greed. When Rick Mason tries to stop the project, Krieger kills him, resulting in Rick's sister, Phin, becoming the Tinkerer. When Phin steals the Nuform, Krieger has his enforcer, Rhino, capture both Miles and Phin, [[ILied going back on his deal with Prowler to let Miles go]], and has them both tortured for information, with Krieger implying that he plans on dissecting Miles for his powers. Knowing that Phin plans to destroy Roxxon Plaza, Krieger has the Nuform reactor sabotaged so it will destroy all of Harlem instead of just Roxxon Plaza while Krieger hides in his bunker to survive the blast, planning on painting himself as an victim of a terrorist attack, before [[InTheirOwnImage remaking Harlem in his own image]]. A cruel and corrupt businessman with [[LackOfEmpathy no regard towards human life]], Krieger will murder anyone just for the sake of money.
** ''[[VideoGame/MarvelsSpiderMan2 Spider-Man 2]]'':
*** [[Characters/SpiderManInsomniacVenom The Venom symbiote]] is an [[AdaptationalAbomination extraterrestrial entity]] that arrived on Earth in a spiral-marked meteor with the intent of conquering it for the Hive. Costing Curt Connors his arm when it tried to bond to him, it was captured by Oscorp and used as an experimental treatment for Harry Osborn's terminal illness. Deeming Spider-Man--Peter Parker--a superior host, it tries to abandon Harry to bond to Spidey several times before Harry willingly relinquishes it to save Peter's life. [[TheCorrupter Making Peter increasingly aggressive]] even towards his loved ones, the symbiote takes over him while he sleeps and viciously attacks [[Characters/MarvelComicsKravenTheHunter Kraven]]'s Hunters before trying to kill Mary Jane when she attempts to shock Peter awake. Attempting to goad Peter into killing Kraven, the symbiote fully takes over Peter and tries to kill [[Characters/MarvelComicsMilesMorales Miles Morales]] before being defeated. Rejected by Peter, the symbiote re-bonds to Harry and twists his dream of healing the world to further its own goals--{{gaslighting}} him by impersonating his late mother. Influencing--if not outright controlling--Harry as Venom, the symbiote causes him to brutally kill dozens of Oscorp's security forces and Kraven's Hunters; kill Kraven by devouring his head; infect Mary Jane Watson with the Scream symbiote out of spite at Peter; and use the spiral meteor to unleash a horde of symbiotes to conquer the Earth. When Peter refuses to join it and resists its attempts to forcibly corrupt him, the Venom symbiote fully takes over Harry and tries to kill Peter and his loved ones.
*** "[[Characters/MarvelComicsCletusKasady Cletus Kasady]]" is the alias of a [[AxCrazy psychopathic]] cult leader who has a noted history of gathering followers--often by kidnapping and brainwashing innocent people, gaslighting them into believing he cares about them, using them to commit heinous acts of violence and destruction, and ultimately [[ManipulativeBastard manipulating them]] into killing themselves both to dispose of them when [[YouHaveOutlivedYourUsefulness they've outlived their usefulness]] and for his own sadistic amusement. As "the Flame", he seeks to bring about the Crimson Hour--burning the world down one city at a time--by having his current group of followers commit arson and plant explosives in areas where mass civilian casualties will occur, such as a hospital or apartment block. Taunting Yuri Watanabe over her failure to stop him from disposing of his previous cult, the Flame lures her and Spider-Man into several traps, tries to burn Spider-Man alive, and then steals a surviving sample of the Venom symbiote--declaring his intent to use it to bring about the Crimson Hour by becoming the embodiment of [[Characters/MarvelComicsCarnage Carnage]].

''[[AC:Franchise/XMen]]''

[[AC:Franchise/MarvelCinematicUniverse non-canon tie-in games]]

[[AC:Other Games]]

** [[VideoGame/SpiderManPS4 Original game]]'s ''The City That Never Sleeps'' {{DLC}}: [[BigBad Hammerhead]] is a sadistic [[TheDon Maggia don]] who yearns for the "good old days" where mobsters like him ruled New York City with an iron fist, and the police knew to look the other way. When Sable International leaves their technology behind after the Devil's Breath incident, Hammerhead arms his men with as much as he can find and tears up the streets of New York with a brutal [[MobWar gang war]] against the other crime families so he can seize power from them, attempting to have numerous civilians killed. When [[Characters/SpiderManInsomniacPeterParker Spider-Man]] and his cop ally Yuri Watanabe attempt to stop him, he provokes Yuri into shooting him by [[CopKiller killing numerous cops]] while stealing the dangerous Project Olympus armor before having other crime bosses slowly [[CementShoes drowned in cement]], trying to broadcast their deaths across the city. When that fails, he goes into hiding and has himself converted into a cyborg, forcing an Oscorp scientist into upgrading his men with cybernetic enhancement, not caring that some of his men would die due to the procedure. When he resurfaces, he tortures Silver Sable with a power drill until she gives him the most dangerous Sable Tech in her arsenal.

[[caption-width-right:250:"What a [[Characters/SpiderManPeterParker lovely]] couple [[Characters/MarvelComicsMaryJaneWatson you]] make. A shame [[Characters/MarvelComicsTheKingpin I]] didn't bring my camera. But I'll always remember you just like this."]]

** [[UsefulNotes/MicrosoftWindows Windows]]; [[UsefulNotes/Xbox360 360]]; [[UsefulNotes/PlayStation3 PS3]]; UsefulNotes/{{Wii}} version: [[Characters/VenomTheSymbiote The Venom symbiote]] itself has grown so powerful that it has nearly completely overridden Eddie Brock's mind and become its own threat. Spreading symbiotes across New York while [[ToServeMan gorging itself on innocents]] and threatening Spider-Man's loved ones, the Venom symbiote transforms most of New York into an apocalyptic wasteland where almost all citizens have been turned into its symbiote zombies. Boarding a ComicBook/{{SHIELD}} Helicarrier, the Venom symbiote plans to traverse the globe and infect all life on Earth with its taint to assume absolute dominion.
** ''Amazing Allies Edition'' (UsefulNotes/{{PS2}} and [[UsefulNotes/PlayStationPortable PSP]]): [[Characters/VenomEddieBrock Eddie Brock]] himself is [[AdaptationalVillainy nothing]] like [[AntiVillain any]] of his [[AntiHero usual]] incarnations. Hating Spider-Man for untold reasons, Venom allows [[MadScientist Jackal]] to experiment on him in order to speed up his symbiote suit's growth rate, then spreads his symbiote across Manhattan, infecting hundreds of people, including Spider-Man's friends, and turning them into mindless, hate-filled zombies. After manipulating many of Spider-Man's foes into assisting him in destroying the Wall-Crawler, Venom reveals he plans to allow his symbiote to spread across the planet, infecting every human around the world once Spider-Man is dead.

* ''[[VideoGame/SpiderManEdgeOfTime Edge of Time]]'': [[MadScientist Walker Sloan]] is a sociopathic industrialist from the 2099 future, functioning as the catalyst behind the game's events. [[AmbitionIsEvil Chafing under his lowly position]] in Alchemax, Sloan travels back in time and [[MakeWrongWhatOnceWentRight changes history]] to one where Alchemax has asserted control over most of Earth. Under Sloan's banner, Alchemax performs [[PlayingWithSyringes mass human experimentation]] on civilians with monstrous results, and runs the state of humanity into the ground under its dystopic heels. Personally experimenting on [[Characters/VenomEddieBrock Eddie Brock]] and implanting [[MindControlDevice mind control chips]] into him so as to command his alter ego "Anti-Venom", Sloan sends him on a rampage that endangers innocents while torturing him into further savage mutations, hoping to annihilate Spider-Man and gain even more control of time until Sloan can rewrite all reality.

* ''[[VideoGame/SpiderManPS4 Marvel's Spider-Man]]'':
** ''The City that Never Sleeps'' {{DLC}}: [[BigBad Hammerhead]] is a sadistic [[TheDon Maggia don]] who yearns for the "good old days" where mobsters like him ruled New York City with an iron fist, and the police knew to look the other way. When Sable International leaves their technology behind after the Devil's Breath incident, Hammerhead arms his men with as much as he can find and tears up the streets of New York with a brutal [[MobWar gang war]] against the other crime families so he can seize power from them, attempting to have numerous civilians killed. When [[Characters/SpiderManPS4PeterParker Spider-Man]] and his cop ally Yuri Watanabe attempt to stop him, he provokes Yuri into shooting him by [[CopKiller killing numerous cops]] while stealing the dangerous Project Olympus armor before having other crime bosses slowly [[CementShoes drowned in cement]], trying to broadcast their deaths across the city. When that fails, he goes into hiding and has himself converted into a cyborg, forcing an Oscorp scientist into upgrading his men with cybernetic enhancement, not caring that some of his men would die due to the procedure. When he resurfaces, he tortures Silver Sable with a power drill until she gives him the most dangerous Sable Tech in her arsenal.

** [[BigBad Aldrich Killian]], after the events of the film, managed to [[BrainUploading download his consciousness into a new body]], becoming MODOK. As MODOK, intending to hurt Tony, he has [[Characters/MCUAim AIM]] lead attacks to take over Stark Industries' network, with his ultimate goal being to download himself into the network, start WorldWarIII using Tony's weapons, and [[DespotismJustifiesTheMeans rule over what's left]].

** [[BigBad Aldrich Killian]], after the events of the film, managed to [[BrainUploading download his consciousness into a new body]], becoming MODOK. As MODOK, intending to hurt Tony, he has [[Characters/MCUCompanies AIM]] lead attacks to take over Stark Industries' network, with his ultimate goal being to download himself into the network, start WorldWarIII using Tony's weapons, and [[DespotismJustifiesTheMeans rule over what's left]].

* ''[[VideoGame/MarvelFutureFight Future Fight]]'': [[BigBad MODOK]], head of ComicBook/{{AIM}}, is revealed to be the instigator of the collapse of reality in this game. He sends Jocasta into the past to distract the Avengers from [[TheChessmaster his plans]] to destroy the universe and remake it in his image by having Jocasta distract the Avengers from exposing MODOK's goals by making them focus by other villains such as Ultron, HYDRA and Fisk. This in turn leaves the Avengers with no time to stop reality from destroying itself. When the Avengers defeat their BadFuture counterparts in Chapter 8, MODOK reveals that he was responsible for sending Jocasta to the past to prevent the Avengers from stopping him, having done this 90,000 times in the past before, with each effort having the same outcome in facilitating the destruction of reality, with every reality being more unstable than the last. He subsequently orders Jocasta to reset the timeline, leaving the Avengers to their fate while he recreates the universe [[InTheirOwnImage in his own image]].

* ''VideoGame/MarvelsAvengers'': [[NotSoWellIntentionedExtremist Monica Rappaccini]] is the [[MadScientist sociopathic scientist]] and the right-hand woman of George "MODOK" Tarleton. Wanting to acquire a Terrigen crystal for her own purposes, Rappaccini [[ManipulativeBitch manipulates]] Tarleton to bring the crystal near the A-Day celebration, hiring Taskmaster to launch an attack to steal it and resulting in the deaths of thousands. After the attack, Rappaccini kidnaps hundreds of Inhumans to [[PlayingWithSyringes experiment on them]], exposing them to Dark Terrigen in order to produce Adaptoids, apathetic to the torment they suffer. In the wake of MODOK's defeat, Rappaccini usurps control of ComicBook/{{AIM}} as the Scientist Supreme, attempting to exploit the Cosmic Cube to ward off the Kree and lord over Earth for herself.

%% NOTE: Due to the controversial nature of this trope, any changes (additions, removals, edits) should be discussed [[https://tvtropes.org/pmwiki/posts.php?discussion=6vic3f9h1cy5qivsenw8llok here]].

* ''[[VideoGame/SpiderManEdgeOfTime Edge of Time]]'': [[MadScientist Walker Sloan]] is a sociopathic industrialist from the 2099 future, functioning as the catalyst behind the game's events. [[AmbitionIsEvil Chafing under his lowly position]] in Alchemax, Sloan travels back in time and changes history to one where Alchemax has asserted control over most of Earth. Under Sloan's banner, Alchemax performs [[PlayingWithSyringes mass human experimentation]] on civilians with monstrous results, and runs the state of humanity into the ground under its dystopic heels. Personally experimenting on [[Characters/VenomEddieBrock Eddie Brock]] and implanting [[MindControlDevice mind control chips]] into him so as to command his alter ego "Anti-Venom", Sloan sends him on a rampage that endangers innocents while torturing him into further savage mutations, hoping to annihilate Spider-Man and gain even more control of time until Sloan can rewrite all reality.

-->--'''Quentin "Mysterio" Beck''', after reassembling the Tablet of Order and Chaos, ''VideoGame/SpiderManShatteredDimensions''

** ''The City that Never Sleeps'' {{DLC}}: [[BigBad Hammerhead]] is a sadistic [[TheDon Maggia don]] who yearns for the "good old days" where mobsters like him ruled New York City with an iron fist, and the police knew to look the other way. When Sable International leaves their technology behind after the Devil's Breath incident, Hammerhead arms his men with as much as he can find and tears up the streets of New York with a brutal [[MobWar gang war]] against the other crime families so he can seize power from them, attempting to have numerous civilians killed. When Spider-Man and his cop ally Yuri Watanabe attempt to stop him, he provokes Yuri into shooting him by [[CopKiller killing numerous cops]] while stealing the dangerous Project Olympus armor before having other crime bosses slowly [[CementShoes drowned in cement]], trying to broadcast their deaths across the city. When that fails, he goes into hiding and has himself converted into a cyborg, forcing an Oscorp scientist into upgrading his men with cybernetic enhancement, not caring that some of his men would die due to the procedure. When he resurfaces, he tortures Silver Sable with a power drill until she gives him the most dangerous Sable Tech in her arsenal.

* ''Film/GhostRider2007'' ([[UsefulNotes/GameBoyAdvance GBA]] version): {{Mephisto|pheles}} is behind all the evil in the game. Seeking to expand his hellish kingdom, Mephisto decides to create a HellOnEarth by drawing a glyph that would break the seal between Hell and Earth and trigger [[TheEndOfTheWorldAsWeKnowIt the apocalypse]]. Choosing Johnny Blaze to become the Ghost Rider, Mephisto [[YouKilledMyFather has Blaze's dad killed]], and orders Vengeance to kill his girlfriend Roxanne when Blaze refuses to serve him. Once the glyph has been drawn into the Earth by Johnny, Mephisto tries to kill Johnny so that nobody can stop him.

* ''VideoGame/GhostRider2007'' ([[UsefulNotes/GameBoyAdvance GBA]] version): {{Mephisto|pheles}} is behind all the evil in the game. Seeking to expand his hellish kingdom, Mephisto decides to create a HellOnEarth by drawing a glyph that would break the seal between Hell and Earth and trigger [[TheEndOfTheWorldAsWeKnowIt the apocalypse]]. Choosing Johnny Blaze to become the Ghost Rider, Mephisto [[YouKilledMyFather has Blaze's dad killed]], and orders Vengeance to kill his girlfriend Roxanne when Blaze refuses to serve him. Once the glyph has been drawn into the Earth by Johnny, Mephisto tries to kill Johnny so that nobody can stop him.

* ''Film/IronMan3: [[https://marvel.fandom.com/wiki/Iron_Man_3:_The_Official_Game The Official Game]]'':

* ''VideoGame/MarvelVsCapcomInfinite'': [[Characters/MarvelComicsUltron Ultron]], upon {{fusi|onDance}}ng with Sigma, begins seeking the Infinity Stones to remake both the Marvel and Capcom universes [[InTheirOwnImage to his liking]]. Attacking Xgard, Ultron-Sigma uses the Sigma Virus to enslave its people, parading them in front of Thor before infecting him and forcing him to [[FightingYourFriend fight his friends]] while Ultron gloats. He also schemes with Grandmaster Meio to drop a virus-loaded bomb on Earth to infect all living things on the planet. When Dante tricks him with the Soul Stone, Ultron Omega attempts to slowly drain him of his life. Desiring nothing less than [[OmnicidalManiac the extinction of all souls]], Ultron is loathed by every hero and almost every villain.

* ''[[VideoGame/SpiderManWebOfShadows Web of Shadows]]'' has, depending on the version, different components of ComicBook/{{Venom}}:

* ''VideoGame/{{The Incredible Hulk|2008}}'': [[GeneralRipper Major Glenn Talbot]], a far cry from his [[Series/AgentsOfSHIELD later]] MCU [[SympatheticInspectorAntagonist characterization]], is a homicidal army major obsessed with taking down the Hulk, Bruce Banner, through any means necessary. Beginning his attacks on Hulk by launching numerous missile strikes on him, Talbot disregards his soldiers' objections that the missiles will impact many highly-populated areas of New York, and pins all the ensuing destruction on the Hulk. When press helicopters fly too close to his military base, Talbot orders them all shot down, hoping to silence the reporters' attempts to oust him as a madman. Showing no care for innocents, Talbot kidnaps both Hulk's best friend, Rick Jones, and his LoveInterest, Betty Ross, to use as hostages to draw him out, and, when the army turns on him after they learn of his crimes, Talbot responds by killing the soldiers sent after him, attempting to murder the Hulk, then setting his Hulkbuster armor to detonate, fully knowing it will wipe out most of the city, just to kill the Hulk. A sociopath who abused his power for no reason other than blind hatred and [[GreenEyedMonster jealousy]], Glenn Talbot stood out, even to Bruce Banner, as [[HeWhoFightsMonsters a truly wicked man whose hatred made him far worse than the "monsters" he claimed to be fighting]].

* ''(The Amazing) VideoGame/SpiderManVsTheKingpin'' ([[AdaptationExpansion Sega CD version]]): Wilson "[[Characters/MarvelComicsTheKingpin The Kingpin]]" Fisk frames Spider-Man for the theft and intended use of a nuclear bomb, which he himself intends to use to destroy New York City as part of a plan to TakeOverTheWorld and rid himself of Spider-Man once and for all; if the player runs out of time, the bomb goes off and destroys New York just as he planned. He additionally [[FrameUp frames Spider-Man]] for kidnapping and threatening to kill Mary Jane, part of a plan to lure him to his hideout for the final showdown. Should Spider-Man fail to save Mary Jane from [[HollywoodAcid acid]] in time, the Kingpin laughs and mockingly offers condolences, and if he gets defeated by Kingpin, the latter kills them both onscreen, savoring every moment. [[AdaptationalVillainy Lacking any of his comic counterpart's nobler traits]], this Kingpin is willing to do anything and everything to destroy Spider-Man and New York itself.

** [[BigBad Aldrich Killian]], after the events of the film, managed to [[BrainUploading download his consciousness into a new body]], becoming MODOK. As MODOK, intending to hurt Tony, he has [[Characters/MCUAdvancedIdeaMechanics AIM]] lead attacks to take over Stark Industries' network, with his ultimate goal being to download himself into the network, start WorldWarIII using Tony's weapons, and [[DespotismJustifiesTheMeans rule over what's left]].

** First game: [[ArcVillain Mephisto]] is the ruler of Mephisto's Realm. Striking a deal with [[Characters/MarvelComicsDoctorDoom Doctor Doom]], Mephisto gave Doom the powerful Twilight Sword in exchange for the soul of the X-Man Nightcrawler. When the heroes traveled to Mephisto's Realm to rescue Nightcrawler, Mephisto's equally depraved son, Blackheart, manages to capture Jean Grey for him. Mephisto then has both Nightcrawler and Jean Grey locked in separate cages hanging above the bottomless pit of the Infinite Vortex. The demon lord gives the heroes a SadisticChoice of freeing one of the X-Men, at the cost of letting the other plummet into the Vortex to their death. When finally confronted by the heroes, Mephisto [[BaddieFlattery congratulates them for surviving in his realm for so long]] and promises to reward them by resurrecting the soul of the sacrificed X-Men. However, Mephisto reveals that he had corrupted their soul into becoming his [[BrainwashedAndCrazy brainwashed puppet]], and sics them on the heroes so he could claim their souls as well. Despite the heroes managing to free the corrupted X-Men, they will still be forever bound as Mephisto's slave. Rather than live as his pawn and to give the heroes a chance to escape, the X-Man will perform a HeroicSacrifice to stop Mephisto. The deaths of the X-Man will result in [[MortonsFork two separate bad endings]] depending on the player's choice of who to sacrifice. In another bad ending, Mephisto will attempt to conquer our dimension resulting in cataclysmic destruction. Despite only appearing in one level, Mephisto stands out from the plethora of villains the game has to offer.

* ''VideoGame/GhostRider'' ([[UsefulNotes/GameBoyAdvance GBA]] version): [[BigBad Mephisto]] is behind all the evil in the game. Seeking to expand his hellish kingdom, Mephisto decides to create a HellOnEarth by drawing a glyph that would break the seal between Hell and Earth and trigger [[TheEndOfTheWorldAsWeKnowIt the apocalypse]]. Choosing Johnny Blaze to become the Ghost Rider, Mephisto [[YouKilledMyFather has Blaze's dad killed]], and orders Vengeance to kill his girlfriend Roxanne when Blaze refuses to serve him. Once the glyph has been drawn into the Earth by Johnny, Mephisto tries to kill Johnny so that nobody can stop him.

* ''VideoGame/XMenLegendsII'': [[Characters/MarvelComicsApocalypse Apocalypse]] is once again presented as a extremely cruel SocialDarwinist. Apocalypse starts the game by conquering Genosha, locking all the Genoshan mutants in a makeshift prison so he can test them for [[MagicGenetics harmonic DNA]], a particular DNA type that will increase his own power. When the X-Men come to liberate Genohsa, Apocalypse attempts to destroy the [[BigDamPlot Genoshan Sea Wall]], which would have killed almost every mutant in Genosha. After Genosha is liberated, the X-Men track Apocalypse's forces to the Savage Land, where they attempt to destroy the technology that keeps the Savage Land in tropic temperatures; this would result in the inhabitants of the Savage Land freezing to death. Later Apocalypse manages to conquer New York City, dropping a bomb that flattens several neighborhoods, just to make room for his tower. Apocalypse again imprisons the mutants and tests them for harmonic DNA, while having his forces attempt to drive the human refugees into the sea, setting up anti-aircraft guns to prevent anyone from rescuing them. Apocalypse is such a powerful and cruel foe that the [[EnemyMine X-Men and the Brotherhood team up to stop him]].

* ''[[VideoGame/XMenLegends Legends]] II: Rise of Apocalypse'': [[Characters/MarvelComicsApocalypse Apocalypse]] is once again presented as a extremely cruel SocialDarwinist. Apocalypse starts the game by conquering Genosha, locking all the Genoshan mutants in a makeshift prison so he can test them for [[MagicGenetics harmonic DNA]], a particular DNA type that will increase his own power. When the X-Men come to liberate Genohsa, Apocalypse attempts to destroy the [[BigDamPlot Genoshan Sea Wall]], which would have killed almost every mutant in Genosha. After Genosha is liberated, the X-Men track Apocalypse's forces to the Savage Land, where they attempt to destroy the technology that keeps the Savage Land in tropic temperatures; this would result in the inhabitants of the Savage Land freezing to death. Later Apocalypse manages to conquer New York City, dropping a bomb that flattens several neighborhoods, just to make room for his tower. Apocalypse again imprisons the mutants and tests them for harmonic DNA, while having his forces attempt to drive the human refugees into the sea, setting up anti-aircraft guns to prevent anyone from rescuing them. Apocalypse is such a powerful and cruel foe that the [[EnemyMine X-Men and the Brotherhood team up to stop him]].

* ''VideoGame/ThePunisher'': [[InsaneAdmiral General Kreigkopf]] is the leader of [[TheMafiya the Russian Syndicate]] in the second portion of the game. An associate of [[TheMafia the Gnucci Family]], Kreigkopf would supply them with drugs and money from the harbor. When Castle attacks the harbor, he discovers Kreigkopf has been smuggling in weapons, including a tank and a nuke. Frank discovers that Kreigkopf is also part of a HumanTrafficking ring. Kreigkopf sends the Russian to attack Castle at his apartment. When Castle and Furry invade Grand Nixon Island, he prepares to [[NukeEm launch the nuke at New York City]], and manages to get it to the point it's supposedly irreversible before Frank kills him.

* ''VideoGame/MarvelVsCapcomInfinite'': [[AIIsACrapshoot Ultron]], upon {{fusi|onDance}}ng with Sigma, begins seeking the Infinity Stones to remake both the Marvel and Capcom universes [[InTheirOwnImage to his liking]]. Attacking Xgard, Ultron-Sigma uses the Sigma Virus to enslave its people, parading them in front of Thor before infecting him and forcing him to [[FightingYourFriend fight his friends]] while Ultron gloats. He also schemes with Grandmaster Meio to drop a virus-loaded bomb on Earth to infect all living things on the planet. When Dante tricks him with the Soul Stone, Ultron Omega attempts to slowly drain him of his life. Desiring nothing less than [[OmnicidalManiac the extinction of all souls]], Ultron is loathed by every hero and almost every villain.

* ''[[VideoGame/SpiderManWebOfShadows Web of Shadows]]-Amazing Allies'' ([[UsefulNotes/PlayStation2 PS2]] and [[UsefulNotes/PlayStationPortable PSP]]) ''Edition'': [[Characters/VenomEddieBrock Eddie Brock]], aka ComicBook/{{Venom}}, is the main antagonist of this alternate telling of the story, and is nothing like [[AntiVillain any]] of his [[AntiHero other]] incarnations. Hating Spider-Man for untold reasons, Venom allows [[MadScientist Jackal]] to experiment on him in order to speed up his symbiote suit's growth rate, then spreads his symbiote across Manhattan, infecting hundreds of people, including Spider-Man's friends, and turning them into mindless, hate-filled zombies. After manipulating many of Spider-Man's foes into assisting him in destroying the Wall-Crawler, Venom reveals he plans to allow his symbiote to spread across the planet, infecting every human around the world once Spider-Man is dead.