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* The original version of [[MadScientist Singed, the Mad Chemist]], started off as the deranged BastardUnderstudy to Warwick, using innocent people--[[ProfessorGuineaPig or himself, whenever he was in short supply of victims]]--as subjects for his [[PlayingWithSyringes agonizing experiments]]. After Warwick was transformed into a beast by Soraka, Singed eagerly stepped into his erstwhile master's role as Noxus' chief MadScientist. Singed used the invasion of Ionia as the chance to perfect his chemical weapons, which horrifically killed countless people, Ionian and Noxian alike. Among these casualties were Riven's old unit and Master Yi's entire village. After the League forces Runeterra into an uneasy truce, Singed spends his time dabbling in things like "pest control", where his street-melting pesticides invariably prove worse than the initial infestations.

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