History Main / TheImmune

* ''Franchise/DeadRising'': Due to zombie-fighting nature of the series, none of the playable protagonist (or even [=NPCs=] to a lesser extent) ever get infected by zombie attacks during gameplay. It's used as a plot point in the first three games. Some people are more resistant to the zombie virus than others; such resistants include [[spoiler:Frank West and Tyrone King]]. [[VideoGame/DeadRising3 Chuck's]] apparent immunity, while unexplained, is a natural step up from that. Nick Ramos, protagonist of [[VideoGame/DeadRising3 3]] is immune due to [[spoiler:being a secret failsafe created by the mastermind behind the zombie outbreaks]].

* As an AntiFrustrationFeature, this is ''usually'' the case with anything involving zombies or similar creatures in video games. There are games where you have to manage your infection level, but they tend to be rare (examples include ''VideoGame/{{Extermination}}'' or ''VideoGame/ResidentEvilOutbreak''.)
** It's used as a plot point in both ''VideoGame/DeadRising'' games. Some people are more resistant to the zombie virus than others; such resistants include [[spoiler:Frank West and Tyrone King]]. Chuck's apparent immunity, while unexplained, is a natural step up from that.

* ThePlague in ''Webcomic/StandStillStaySilent'' attacks all mammals, but in every species, some percent is immune. For humans, in Year 90 it's about 9% in Iceland and 48% in the rest of Known World. All cats and non-mammalian species are immune as well. In spite of this, scientists are still looking for a cure, hinting that the discovery of immune people ultimately had limited impact on that particular venture.

* In ''Manga/AnatoliaStory'', Yuri proves to be immune to the plague ravaging the Hittite Empire when she spends an extended amount of time tending to the sick. Given that she's from modern times, Yuri believes her vaccinations have granted her immunity, while the people of the ancient time period just take this as further proof that Yuri is blessed by the gods. (A bit of ArtisticLicense there: the historical plague that swept through Anatolia is generally agreed to have been tularemia, which is not a general vaccination and is only administered to high-risk groups due to dangerous side effects. Not to mention that one of the historical figures Yuri is based on, [[https://en.wikipedia.org/wiki/Gassulawiya Gassulawiya]], did die to the plague.)

* It's not really brought up in the game, but some of the in-game documents in ''Videogame/{{Dishonored}}'' hint that all Serkonans are immune to the Rat Plague because they are the descendants of survivors of a Rat Plague outbreak on Serkonan who passed on their genetic immunity to their offspring. This would explain why Corvo and Daud, both Serkonans, never contract the Plague despite being exposed to it so often.

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* Lelouch becomes this in ''FanFic/KnightOfDeathAndRebirth'' as he’s the only one to [[spoiler:resist and even reverse the effects of demonic energy]].

* ''{{Series/Heroes}}'': Mohinder's blood carries the cure for the Shanti virus

* In ''Series/BeautyAndTheBeast1987'', a Russian immigrant ends up infecting the sewer-dwellers with a deadly disease. Vincent ends up having a natural immunity.

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* Discussed in a strip of ''ComicStrip/TheFamilyCircus'', in which Billy has Chicken Pox. One strip depicts Thel and Billy inside, with all the other kids outside talking to the neighbourhood kids, saying Thel is alright because she's "a mune".
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* In the post-apocalyptic "economic horror" RPG ''TabletopGame/RedMarkets'' some people are immune to the Blight that causes zombies, and others, called "latents", become carriers after being bitten and become zombies after dying for some other reason. Immunity or latency can be established at character creation or discovered after getting bitten and making a critical success or critical failure on the fort save, respectively.
** A drug called Suppressin K-7864 was produced by the DHQS from a mixture of immune marrow cells and antibiotics, it doesn't cure the Blight or prevent infection entirely, but instead turns the infectee latent. As a result Immune in the Recession under government control are subject to "medical conscription" for their cells and in the Loss cults like the Crusaders (who seek a cure) and the Holy Communion (who think the Immune are holy, and eat them) have a habit of claiming their own samples.

* [[spoiler: Tsugumi]] of ''VisualNovel/Ever17'', whose blood provides the cure for Tief Blau.

* Dairy farmers in the 18th century were found to be immune to smallpox, due to exposure to cowpox, which is caused by a very similar, closely-related virus but is far less virulent.

* José Saramago's ''Blindness'' follows the one woman immune to the plague of blindness.

** The episode "Tip of the Day" has Doofenshmirtz invent a Delete-From-My-Mind-inator, which erases whatever he is thinking of from the memories of everyone in the Tri-State Area. However, people who are ''not'' thinking about whatever he is thinking of at the moment will be unaffected, so when he unintentionally made everyone forget about [[WhatTheHeckIsAnAglet aglets]] (which was Phineas and Ferb's Big Idea for the episode), only Candace was not affected because she never bothered to learn the name.

** In "Cheers For Fears", Doof's Worst-Fear-inator makes [[YourWorstNightmare whatever is the worst fear of anyone]] who is zapped by it come to life. However, if the victim is fearless or has no fears at all (Perry for instance), it has no affect on them.

* ''WesternAnimation/PhineasAndFerb'': The episode "Tip of the Day" has Doofenshmirtz invent a Delete-From-My-Mind-inator, which erases whatever he is thinking of from the memories of everyone in the Tri-State Area. However, people who are ''not'' thinking about whatever he is thinking of at the moment will be unaffected, so when he unintentionally made everyone forget about [[WhatTheHeckIsAnAglet aglets]] (which was Phineas and Ferb's Big Idea for the episode), only Candace was not affected because she never bothered to learn the name.

* A ''[[WesternAnimation/TheSimpsons Simpsons]]'' Halloween special had Bart immune to the zombifying effects of the Krusty Burger. The survivors of the outbreak wanted to eat Bart, but they compromised by having Bart taking a bath with their food.

* In the television version of the ''WesternAnimation/XMen'' "Legacy Virus" storyline, Cable came back in time to ensure that {{Wolverine}} would be infected with the titular virus, because his healing factor would both render him immune and lead to the creation of certain antibodies that would protect mutants from later plagues.

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Note that this trope is completely different from the RealLife term "asymptomatic carrier" (that's TyphoidMary) - A person who is immune will not have the disease or virus in the body even if they contract it (and thus unable to spread the virus or disease), while a asymptomatic carrier will have the person will carrying the virus or disease in the body, but show no symptoms of the virus or disease (and have same potential to spread the virus or disease). However, these two concepts have been used interchangeably and often misused.

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* Alice in ''Film/ResidentEvilExtinction''. It doesn't have any actual bearing on the plot, mind; it's just exposited by the White Queen at the end.
** Given Umbrella bonded her with the T-Virus at the end of ''Film/ResidentEvilApocalypse'', it makes sense that she is immune. She's ''already'' infected.

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* The ''Series/StargateSG1'' episode "The Broca Divide", where [[spoiler:Dr. Fraiser is immune to the virus due to the [[ImprobableAntidote strong antihistamines]] she takes for allergies]].
** Daniel Jackson was temporarily immune for the same reasons until he was trapped off-world and no longer had access to his medication.

* ''Series/TeenWolf'''s Lydia Martin is the only known person who is immune to the bite of a werewolf and the venom of a Kanima. The reason behind this is currently unknown, but it's implied to have something to do with her unexplained ability to sense the supernatural.
** As of Season 3, we know it's because [[spoiler: she is a Wailing Woman, otherwise known as a banshee]].

* This is part of ''Series/{{The 100}}'''s backstory. When the nuclear bombs fell, certain people had a natural resistance to radiation, allowing them to survive while the rest of humanity died out. Their radiation immunity was passed on to their descendants, who became the Grounders.
** This becomes a problem in the second season in particular; the residents of Mount Weather, cut off from the outside world for almost a century, lacked any natural immunity to radiation, and were thus desperate to capture the Grounders or the Ark residents due to their heightened immunity (the Grounders from their time on the surface and the Ark residents through residual exposure to cosmic radiation).

** In ''{{VideoGame/Halo 4}}'': [[spoiler:the Master Chief is exposed to the Libarian's memories, rendering him immune to the Composer.]]

* The baby in ''The Pitt'' {{DLC}} of ''VideoGame/{{Fallout 3}}'' is immune to harmful mutations caused by nuclear radiation. She is also resistant to 'Troglodyte Degeneration Contagion', a condition caused by radiation and industrial toxins that turns humans into sub-human monsters.
* [[spoiler: Tsugumi]] of ''VisualNovel/{{Ever17}}'', whose blood provides the cure for Tief Blau.

* ''Franchise/DragonAge''

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* In ''ComicBook/{{Venomized}}'', the Anti-Venom symbiote proves not only immune to Poison infestation, but [[TouchOfDeath instantly lethal to the smaller Poisons and able to one-shot even the huge ones with effort]]. Unfortunately, it is only immune to ''infestation''; other Poison weapons still work on it - as shown when he starts getting smug about it, and Poison Thanos immediately slams an energy blast into him.

* In ''TheLordOfTheRings'', Tom Bombadil is the only being completely unaffected by the One Ring (it cannot even make him vanish when he puts it on his finger), implied to be because there is nothing he desires in the world that the Ring can tempt him with. The Council of Elrond considers giving the Ring into his keeping because of this, but the problem is that the very cause of this immunity means he wouldn't be a good guardian--he wouldn't be able to appreciate how important the Ring is and would casually toss it aside and forget about it.
** As Tom doesn't seem to fit anywhere into Middle-Earth's greater cosmology (only really becomes apparent if you read The Silmarillion, where the connectedness of everything else is laid out), it's possible that the Ring doesn't work on him because he is somehow ''outside'' its influence.

* Indigenous populations in areas where malaria is a concern are often prone to sickle-cell anaemia, a genetic disorder characterized by malformed sickle-shaped blood cells. Two copies of the defective gene sickle all blood cells (which is lethal without constant care and debilitating with it), but having one good and one defective gene only sickles one-third of the cells, which hinders the development of any one of the [[FourIsDeath four]] protozoan species responsible for malaria. So this comes out as a situational evolutionary advantage [[PowerAtACost at a cost of]] lower physical power and a higher chance of stillborn or disabled offspring. Besides, due to modern medicine, malaria is treatable and a lesser concern.

* Indigenous populations in areas where malaria is a concern are often prone to sickle-cell anaemia, a genetic disorder characterized by malformed sickle-shaped blood cells. Two copies of the defective gene sickle all blood cells, but having one good and one defective gene only sickles one-third of the cells, which hinders the development of any one of the [[FourIsDeath four]] protozoan species responsible for malaria, so it comes out as an evolutionary advantage overall. However, due to modern medicine, malaria is treatable and a lesser concern.

* In ''TabletopGame/MagicTheGathering'', several members of the Mirran Resistance against New Phyrexia are immune to [[TheVirus Phyresis]], the most notable one being the Sylvok outcast Melira, who was born without any metal in her body, as most beings on Mirrodin were (and Phyresis affects metal).