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* The generational sagas by author EdwardRutherfurd often use physical genetic quirks, such as webbed digits or SkunkStripe hair, to illustrate a bloodline's continuity down through the centuries.

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* The generational sagas by author EdwardRutherfurd Creator/EdwardRutherfurd often use physical genetic quirks, such as webbed digits or SkunkStripe hair, to illustrate a bloodline's continuity down through the centuries.
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** Kakashi and the BigBad both have mismatched eyes, with one of them being a sharingan- [[spoiler: turns out the BigBad is Obito Uchiha, whose left eye was transplanted to Kakashi when they were children! Side-effects include shared vision when they're near each other and having the same Mangekyou, [[PortalCut Kamui]]. Due to Mangekyou's power it is safe to say Obito would not have been beaten without Kakashi's presence. Good thing Obito gave him that eye all those years ago!]]
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* In ''SamuraiChamploo'', the villainous brothers Denkibou, Umanosuke and Toube all share pink sclera (their eye whites) on their left eyes. It's arguably the only physical trait they have in common.

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* In ''SamuraiChamploo'', ''Anime/SamuraiChamploo'', the villainous brothers Denkibou, Umanosuke and Toube all share pink sclera (their eye whites) on their left eyes. It's arguably the only physical trait they have in common.
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[[folder:Fanfic]]
* Two of the characters, a Granddaughter and Great-granddaughter of two of the protagonists - Lucy and Sarah Edmontons, in ''Fanfic/BringingMeToLife'' share heterochromia. One eye is dark-gray, while the other is dark-brown.
[[/folder]]
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* In ''ASongOfIceAndFire'', certain members of House Targaryen have a physical tolerance to high temperatures and fire; also, they all share a characteristic light-silver hair and violet eyes, a trait of the peoples of Old Valyria.
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** In ''SamuraiChamploo'', the villainous brothers Denkibou, Umanosuke and Toube all share pink sclera (their eye whites) on their left eyes. It's arguably the only physical trait they have in common.

to:

** * In ''SamuraiChamploo'', the villainous brothers Denkibou, Umanosuke and Toube all share pink sclera (their eye whites) on their left eyes. It's arguably the only physical trait they have in common.
Is there an issue? Send a MessageReason:
None

Added DiffLines:

** In ''SamuraiChamploo'', the villainous brothers Denkibou, Umanosuke and Toube all share pink sclera (their eye whites) on their left eyes. It's arguably the only physical trait they have in common.
Is there an issue? Send a MessageReason:
None


* In ''VideoGame/TalesOfGraces'', this is a sign that [[spoiler:Lambda]] is inside somebody's body. It happens to Richard and later [[spoiler:Asbel]], and this carries into ''Tales pf Graces F''. [[spoiler:When Lambda is inside Richard, his other eye is [[RedEyesTakeWarning red]], but when it happens to Asbel, it's actually ''purple'', signaling that Lambda has a different relationship with Asbel than Richard.]]

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* In ''VideoGame/TalesOfGraces'', this is a sign that [[spoiler:Lambda]] is inside somebody's body. It happens to Richard and later [[spoiler:Asbel]], and this carries into ''Tales pf of Graces F''. [[spoiler:When Lambda is inside Richard, his other eye is [[RedEyesTakeWarning red]], but when it happens to Asbel, it's actually ''purple'', signaling that Lambda has a different relationship with Asbel than Richard.]]
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An unusual physical trait that ties two characters together. The physical trait can be heterochromia, [[YouGottaHaveBlueHair unusual hair colours]], deformities or other odd traits. It could be something that's passed down from one generation to the next. These traits can be used to identify twins, [[MarkOfTheBeast possessed people]], clones, or a once-unknown connection between two people that indicates they are related.

to:

An unusual physical trait that ties two characters together. The physical trait can be heterochromia, [[YouGottaHaveBlueHair unusual hair colours]], deformities or other odd traits. It could could also be something that's passed down from one generation to the next. These traits can be used to identify twins, [[MarkOfTheBeast possessed people]], clones, or a once-unknown connection between two people that indicates they are related.
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None


* Luki and Noki from ''DOGSBulletsAndCarnage'' have very weird eyes (gold with a black iris, black with a gold iris, with the actual which-eye-is-which swapped between twins). They're [[EnfantTerrible enfants terribles]].

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* Luki and Noki from ''DOGSBulletsAndCarnage'' ''Manga/DogsBulletsAndCarnage'' have very weird eyes [[MarkOfTheSupernatural mismatched eyes]] (gold with a black iris, black with a gold iris, with the actual which-eye-is-which swapped between twins). They're [[EnfantTerrible enfants terribles]].also both powerful cyborg {{Child Soldier}}s.
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* All the clone "shatterlings" of Gentian Line in "House of Suns" by Creator/AlastairReynolds have one green eye and the other a "wintery jackdaw blue", since they're all [[OppositeSexClone male and female "facets"]] of Abigail Gentian. it is noted that since they have a bit of leeway from Abigail's exact appearance, in some shatterlings the mismatched eyes are toned down so much as to be unnoticeable.

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* All the clone "shatterlings" of Gentian Line in "House of Suns" "Literature/HouseOfSuns" by Creator/AlastairReynolds have one green eye and the other a "wintery jackdaw blue", since they're all [[OppositeSexClone male and female "facets"]] of Abigail Gentian. it is noted that since they have a bit of leeway from Abigail's exact appearance, in some shatterlings the mismatched eyes are toned down so much as to be unnoticeable.
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* In ''Literature/TheGodfather'', Sonny Corleone has a very large penis and can only have normal sex with Lucy Mancini, who has an abnormally large vagina.
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* All the clone "shatterlings" of Gentian Line in "House of Suns" by AlastairReynolds have one green eye and the other a "wintery jackdaw blue", since they're all [[OppositeSexClone male and female "facets"]] of Abigail Gentian. it is noted that since they have a bit of leeway from Abigail's exact appearance, in some shatterlings the mismatched eyes are toned down so much as to be unnoticeable.

to:

* All the clone "shatterlings" of Gentian Line in "House of Suns" by AlastairReynolds Creator/AlastairReynolds have one green eye and the other a "wintery jackdaw blue", since they're all [[OppositeSexClone male and female "facets"]] of Abigail Gentian. it is noted that since they have a bit of leeway from Abigail's exact appearance, in some shatterlings the mismatched eyes are toned down so much as to be unnoticeable.

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* Vivio from ''Anime/MagicalGirlLyricalNanohaStrikerS'' has red and green eyes because [[spoiler:the person from whom she was cloned]] also possesses those features.
** ''Manga/{{ViVid}}'' introduces Einhart Stratos, a descendant of another Emperor from the Belkan Age (just like the one from whom Vivio was cloned). She also has heterochromia, albeit blue and violet eyes.

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* ''Franchise/LyricalNanoha'':
**
Vivio from ''Anime/MagicalGirlLyricalNanohaStrikerS'' has red and green eyes because [[spoiler:the person from whom she was cloned]] also possesses those features.
** ''Manga/{{ViVid}}'' ''Manga/MagicalGirlLyricalNanohaViVid'' introduces Einhart Stratos, a descendant of another Emperor [[spoiler:Emperor from the Belkan Age (just like the one from whom Vivio was cloned).cloned)]]. She also has heterochromia, albeit blue and violet eyes.
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* In ''Manga/FullMetalAlchemist'', the fact that Ed, his brother Al, and their father Hohenheim all have gold eyes and gold hair (not blond, ''gold'') is an important plot point, as it [[spoiler:marks them as ethnically members of the lost Xerxes civilization. Hohenheim is an immortal survivor of the apocalypse]]. The first anime missed the memo and gave Al blue eyes, but it still mostly works.

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* In ''Manga/FullMetalAlchemist'', ''Manga/FullmetalAlchemist'', the fact that Ed, his brother Al, and their father Hohenheim all have gold eyes and gold hair (not blond, ''gold'') is an important plot point, as it [[spoiler:marks them as ethnically members of the lost Xerxes civilization. Hohenheim is an immortal survivor of the apocalypse]]. The first anime missed the memo and gave Al blue eyes, but it still mostly works.
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* In ''Literature/WarriorCats'', at one point Hollyleaf notes that Cinderheart always flicks her paw a certain way when grooming it. She notices Leafpool staring at Cinderheart, and Leafpool comments that Cinderpelt used to flick her paw like that. Cinderheart is a reincarnation of Cinderpelt, and while the reader already knows this, it's one of the first times the characters see the resemblance between the two.

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* In ''Literature/WarriorCats'', at one point Hollyleaf notes that Cinderheart always flicks her paw a certain way when grooming it.herself. She notices Leafpool staring at Cinderheart, and Leafpool comments that Cinderpelt used to flick her paw like that. Cinderheart is a reincarnation of Cinderpelt, and while the reader already knows this, it's one of the first times the characters see the resemblance between the two.
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* In ''Literature/WarriorCats'', at one point Hollyleaf notes that Cinderheart always flicks her paw a certain way when grooming it. She notices Leafpool staring at Cinderheart, and Leafpool comments that Cinderpelt used to flick her paw like that. Cinderheart is a reincarnation of Cinderpelt, and while the reader already knows this, it's one of the first times the characters see the resemblance between the two.

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Crosswicking.


[[folder:Live Action TV]]

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[[folder:Live Action [[folder:Live-Action TV]]


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* In the ''Series/MurdochMysteries'' episode "Belly Speaker", the victim and his son (who's a ventriloquist) both have mismatched eyes, one blue and one brown. The son's DemonicDummy, modelled after him, has mismatched eyes as well. It's later revealed that he had a twin brother who also had such eyes.
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* One ''Literature/{{Goosebumps}}'' book has the main character's best friend be a girl with heterochromia. This becomes a plot point when she mysteriously disappears and he starts seeing a dog with MismatchedEyes around the neighborhood.

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* One ''Literature/{{Goosebumps}}'' book has the main character's best friend be a girl with heterochromia. This becomes a plot point when she mysteriously disappears and he starts seeing a dog with MismatchedEyes heterochromia around the neighborhood.
Is there an issue? Send a MessageReason:
None


* In ''Manga/FullMetalAlchemist'', the fact that Ed, his brother Al, and their father Hohenheim all have gold eyes and gold hair (not blonde, ''gold'') is an important plot point, as it [[spoiler:marks them as ethnically members of the lost Xerxes civilization. Hohenheim is an immortal survivor of the apocalypse]]. The first anime missed the memo and gave Al blue eyes, but it still mostly works.

to:

* In ''Manga/FullMetalAlchemist'', the fact that Ed, his brother Al, and their father Hohenheim all have gold eyes and gold hair (not blonde, blond, ''gold'') is an important plot point, as it [[spoiler:marks them as ethnically members of the lost Xerxes civilization. Hohenheim is an immortal survivor of the apocalypse]]. The first anime missed the memo and gave Al blue eyes, but it still mostly works.

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[[folder:Live Action TV]]
* On ''Series/KyleXY'', one of the first things that tips Kyle off to Jesse's connection to him is the fact that neither of them has a [[BellyButtonless belly button]].
[[/folder]]


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[[folder:Live Action TV]]
* On ''Series/KyleXY'', one of the first things that tips Kyle off to Jesse's connection to him is the fact that neither of them has a [[BellyButtonless belly button]].
[[/folder]]
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** ''{{ViVid}}'' introduces Einhart Stratos, a descendant of another Emperor from the Belkan Age (just like the one from whom Vivio was cloned). She also has heterochromia, albeit blue and violet eyes.

to:

** ''{{ViVid}}'' ''Manga/{{ViVid}}'' introduces Einhart Stratos, a descendant of another Emperor from the Belkan Age (just like the one from whom Vivio was cloned). She also has heterochromia, albeit blue and violet eyes.
Is there an issue? Send a MessageReason:
None


** ''{{Vivid}}'' introduces Einhart Stratos, a descendant of another Emperor from the Belkan Age (just like the one from whom Vivio was cloned). She also has heterochromia, albeit blue and violet eyes.

to:

** ''{{Vivid}}'' ''{{ViVid}}'' introduces Einhart Stratos, a descendant of another Emperor from the Belkan Age (just like the one from whom Vivio was cloned). She also has heterochromia, albeit blue and violet eyes.
Is there an issue? Send a MessageReason:
None


** ''Vivid'' introduces Einhart Stratos, a descendant of another Emperor from the Belkan Age (just like the one from whom Vivio was cloned). She also has heterochromia, albeit blue and violet eyes.

to:

** ''Vivid'' ''{{Vivid}}'' introduces Einhart Stratos, a descendant of another Emperor from the Belkan Age (just like the one from whom Vivio was cloned). She also has heterochromia, albeit blue and violet eyes.
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An unusual physical trait that ties two characters together. The physical trait can be [[MismatchedEyes heterochromia]], [[YouGottaHaveBlueHair unusual hair colours]], deformities or other odd traits. It could be something that's passed down from one generation to the next. These traits can be used to identify twins, [[MarkOfTheBeast possessed people]], clones, or a once-unknown connection between two people that indicates they are related.

to:

An unusual physical trait that ties two characters together. The physical trait can be [[MismatchedEyes heterochromia]], heterochromia, [[YouGottaHaveBlueHair unusual hair colours]], deformities or other odd traits. It could be something that's passed down from one generation to the next. These traits can be used to identify twins, [[MarkOfTheBeast possessed people]], clones, or a once-unknown connection between two people that indicates they are related.
Is there an issue? Send a MessageReason:
None


An unusual physical trait that ties two characters together. The physical trait can be heterochromia, unusual hair colours, deformities or other odd traits. It could be something that's passed down from one generation to the next. These traits can be used to identify twins, [[MarkOfTheBeast possessed people]], clones, or a once-unknown connection between two people that indicates they are related.

to:

An unusual physical trait that ties two characters together. The physical trait can be heterochromia, [[MismatchedEyes heterochromia]], [[YouGottaHaveBlueHair unusual hair colours, colours]], deformities or other odd traits. It could be something that's passed down from one generation to the next. These traits can be used to identify twins, [[MarkOfTheBeast possessed people]], clones, or a once-unknown connection between two people that indicates they are related.
Is there an issue? Send a MessageReason:
None


Examples:

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Examples:
!!Examples:

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An unusual physical trait that ties two characters together. The physical trait can be anything from heterochromia, unusual hair colours, deformities and other odd traits. It could something that's passed down from one generation to another. These traits can be used to identify twins, [[MarkOfTheBeast possessed]], clones, or a once unknown connection between two people that indicate they are related.

Related to FamilyEyeResemblance when the eyes shows a familial relationship. See also SharedFamilyQuirks for when family members share similar behaviors or personalities and MarkOfTheBeast when the trait is a sign of possession.

to:

An unusual physical trait that ties two characters together. The physical trait can be anything from heterochromia, unusual hair colours, deformities and or other odd traits. It could be something that's passed down from one generation to another. the next. These traits can be used to identify twins, [[MarkOfTheBeast possessed]], possessed people]], clones, or a once unknown once-unknown connection between two people that indicate indicates they are related.

Related to FamilyEyeResemblance when the eyes shows show a familial relationship. See also SharedFamilyQuirks for when family members share similar behaviors or personalities personalities, and MarkOfTheBeast when the trait is a sign of possession.




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Examples:



* In Manga/{{Claymore}} every claymore warrior for the most part looks human, however their one distinct feature, least before they start tapping in their Yoma powers, is their silver eyes. In one episode the main character, Clare, who's a claymore is task with hunting down a Yoma in a city that doesn't allow claymores. To get into the city she takes a pill that limits her powers but make her appear human just by turning her eyes brown.
* Vivio from Anime/MagicalGirlLyricalNanohaStrikerS has red and green eyes because [[spoiler:the person she was cloned from]] also possesses those features.
** ''Vivid'' introduces Einhart Stratos, a descendant of another Emperor from the Belkan Age (just like the one Vivio was cloned from). She also has heterochromia, albeit blue and violet eyes.

to:

* In Manga/{{Claymore}} ''Manga/{{Claymore}}'', every claymore warrior for the most part looks human, however their one distinct feature, least before they start tapping in their Yoma powers, is their silver eyes. In one episode the main character, Clare, who's a claymore is task with hunting down a Yoma in a city that doesn't allow claymores. To get into the city she takes a pill that limits her powers but make her appear human just by turning her eyes brown.
* Vivio from Anime/MagicalGirlLyricalNanohaStrikerS ''Anime/MagicalGirlLyricalNanohaStrikerS'' has red and green eyes because [[spoiler:the person from whom she was cloned from]] cloned]] also possesses those features.
** ''Vivid'' introduces Einhart Stratos, a descendant of another Emperor from the Belkan Age (just like the one from whom Vivio was cloned from).cloned). She also has heterochromia, albeit blue and violet eyes.



* In one film version of ''Literature/TheHoundOfTheBaskervilles'' Sherlock Holmes realizes that Stapleton is a member of the Baskerville family because both he and a portrait of patriarch Hugo Baskerville have webbed hands. (In the original novel, Holmes points out that Stapleton is facially a dead ringer for the portrait of Hugo when you block out of view the antiquated clothing Hugo is wearing.)

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* In one film version of ''Literature/TheHoundOfTheBaskervilles'' Sherlock Holmes ''Literature/TheHoundOfTheBaskervilles'', SherlockHolmes realizes that Stapleton is a member of the Baskerville family because both he and a portrait of patriarch Hugo Baskerville have webbed hands. (In the original novel, Holmes points out that Stapleton is facially a dead ringer for the portrait of Hugo when you block out of view the antiquated clothing Hugo is wearing.)



* On Series/KyleXY, one of the first things that tips Kyle off to Jesse's connection to him is the fact that neither of them have a [[BellyButtonless belly button.]]

to:

* On Series/KyleXY, ''Series/KyleXY'', one of the first things that tips Kyle off to Jesse's connection to him is the fact that neither of them have has a [[BellyButtonless belly button.]]button]].



* All the clone "shatterlings" of Gentian Line in "House of Suns" by AlastairReynolds have one green eye and the other a "wintery jackdaw blue", since they're all [[OppositeSexClone male and female "facets"]] of Abigail Gentian. it is noted that since they have a bit of leeway from Abigail's exact appearance, in some shatterlings the mismatched eyes are toned down so much as to be unnoticeable

to:

* All the clone "shatterlings" of Gentian Line in "House of Suns" by AlastairReynolds have one green eye and the other a "wintery jackdaw blue", since they're all [[OppositeSexClone male and female "facets"]] of Abigail Gentian. it is noted that since they have a bit of leeway from Abigail's exact appearance, in some shatterlings the mismatched eyes are toned down so much as to be unnoticeableunnoticeable.



* In ''VideoGame/TalesOfGraces'', this is a sign that [[spoiler:Lambda]] is inside somebody's body. It happens to Richard and later [[spoiler:Asbel]], and this carries into VideoGame/TalesOfGraces F. [[spoiler: When Lambda is inside Richard, his other eye is [[RedEyesTakeWarning red]], but when it happens to Asbel, it's actually ''purple'', signaling that Lambda has a different relationship with Asbel than Richard.]]
* In ''VideoGame/DevilMayCry 3'', Lady and Arkham [[spoiler:and Jester]] both have one blue and one red eye. This serves as a visual clue that [[spoiler:they're father and daughter.]]
* Iris and her twin sister also named Iris from VideoGame/RuneFactory both have green and red eyes. They used to be one person but were magically split into two entities.

to:

* In ''VideoGame/TalesOfGraces'', this is a sign that [[spoiler:Lambda]] is inside somebody's body. It happens to Richard and later [[spoiler:Asbel]], and this carries into VideoGame/TalesOfGraces F. [[spoiler: When ''Tales pf Graces F''. [[spoiler:When Lambda is inside Richard, his other eye is [[RedEyesTakeWarning red]], but when it happens to Asbel, it's actually ''purple'', signaling that Lambda has a different relationship with Asbel than Richard.]]
* In ''VideoGame/DevilMayCry 3'', Lady and Arkham [[spoiler:and Jester]] both have one blue and one red eye. This serves as a visual clue that [[spoiler:they're father and daughter.]]
daughter]].
* Iris and her twin sister sister, also named Iris Iris, from VideoGame/RuneFactory ''VideoGame/RuneFactory'' both have green and red eyes. They used to be one person woman but were magically split into two entities.



* In ''VisualNovel/FateStayNight'' homunculi made by the Einzbern family have distinctly silver hair and red eyes. This applies to Ilyasviel, her mother Irisviel, and the homunculus the two former are based on, Justeaze.

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* In ''VisualNovel/FateStayNight'' ''VisualNovel/FateStayNight'', homunculi made by the Einzbern family have distinctly silver hair and red eyes. This applies to Ilyasviel, Ilyasviel; her mother mother, Irisviel, and the homunculus on which the two former are based on, based, Justeaze.



[[/folder]]

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[[/folder]][[/folder]]
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** ''Vivid'' introduces Einhart Stratos, a descendant of another Emperor from the Belkan Age (just like the one Vivio was cloned from). She also has heterochromia, albeit blue and violet eyes.
Is there an issue? Send a MessageReason:
None

Added DiffLines:

An unusual physical trait that ties two characters together. The physical trait can be anything from heterochromia, unusual hair colours, deformities and other odd traits. It could something that's passed down from one generation to another. These traits can be used to identify twins, [[MarkOfTheBeast possessed]], clones, or a once unknown connection between two people that indicate they are related.

Related to FamilyEyeResemblance when the eyes shows a familial relationship. See also SharedFamilyQuirks for when family members share similar behaviors or personalities and MarkOfTheBeast when the trait is a sign of possession.
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[[foldercontrol]]

[[folder:Anime & Manga]]
* [[{{Cloudcuckoolander}} Nenene]] and [[HandsomeLech Toki]] from ''Manga/CodeBreaker'' both have one blue and one brown eye. This almost gets Nenene killed when fire controller Oogami mistakes her for his despised teammate Toki [[spoiler: who is Nenene's long-lost brother. Nenene does not seem to notice the resemblance, even when Toki is standing in front of her while Sakura says "This is your brother!"]]
* In ''Manga/FullMetalAlchemist'', the fact that Ed, his brother Al, and their father Hohenheim all have gold eyes and gold hair (not blonde, ''gold'') is an important plot point, as it [[spoiler:marks them as ethnically members of the lost Xerxes civilization. Hohenheim is an immortal survivor of the apocalypse]]. The first anime missed the memo and gave Al blue eyes, but it still mostly works.
* The Count D from ''Manga/PetShopOfHorrors'' has heterochromia, one eye being purple and the other, whom he hides under his hair, is golden. In the manga, it's explained that [[spoiler:this is meant to be representative not only for his non-human nature, but also for his inheritance: his father and grandfather have golden and purple eyes, respectively. Since each one has a very different personality, and D has personality traits from ''both'', his heterochromia symbolizes this dual nature]].
* ''Manga/RozenMaiden'': Suiseiseki has red and green eyes, and was originally nicknamed "Boatlights-chan" by fans before she became known as simply "[[VerbalTic Desu]]". Her twin sister Souseiseki, introduced later, has the same eye colors but reversed. Appropriately, they are {{foil}}s for each other.
* Luki and Noki from ''DOGSBulletsAndCarnage'' have very weird eyes (gold with a black iris, black with a gold iris, with the actual which-eye-is-which swapped between twins). They're [[EnfantTerrible enfants terribles]].
* BigBad (of at least one arc) Rido Kuran of ''Manga/VampireKnight'' has one blue eye and one crimson eye, a trait that shows up in the people he possesses. This is the first clue to Rima Touya that something's [[NotHimself not quite right]] about Shiki...
* In Manga/{{Claymore}} every claymore warrior for the most part looks human, however their one distinct feature, least before they start tapping in their Yoma powers, is their silver eyes. In one episode the main character, Clare, who's a claymore is task with hunting down a Yoma in a city that doesn't allow claymores. To get into the city she takes a pill that limits her powers but make her appear human just by turning her eyes brown.
* Vivio from Anime/MagicalGirlLyricalNanohaStrikerS has red and green eyes because [[spoiler:the person she was cloned from]] also possesses those features.
* In ''Anime/GurrenLagann'', some character's pupils (specifically: [[spoiler:Lord Genome, Kittan, and Simon]]) take on spiral form to indicate their mastery of the Spiral Energy.
* Misaki Shokuhou from ''LightNovel/ACertainMagicalIndex'' has stars in her eyes. The same stars appear in the eyes of [[MindControlEyes those who she's using her mind control powers on]].
* Certain ninja clans in ''Manga/{{Naruto}}'' will have this. Most consistent are the Hyuga, all of whom possess white eyes called the ''Byakugan.'' Other examples include the Uchiha and their ''Sharingan'', and the overweight Akimichi clan.
[[/folder]]

[[folder:Film]]
* In one film version of ''Literature/TheHoundOfTheBaskervilles'' Sherlock Holmes realizes that Stapleton is a member of the Baskerville family because both he and a portrait of patriarch Hugo Baskerville have webbed hands. (In the original novel, Holmes points out that Stapleton is facially a dead ringer for the portrait of Hugo when you block out of view the antiquated clothing Hugo is wearing.)
* ''Film/X2XMenUnited'': Jason Stryker has differently-colored eyes, as does the illusory little girl he creates.
[[/folder]]

[[folder:Live Action TV]]
* On Series/KyleXY, one of the first things that tips Kyle off to Jesse's connection to him is the fact that neither of them have a [[BellyButtonless belly button.]]
[[/folder]]

[[folder:Literature]]
* The horribly inbred Martense clan from ''The Lurking Fear'' by Creator/HPLovecraft all have this as a distinguishing mark. They have brown-and-blue eyes apparently. [[spoiler:This is the tip-off that the swarm of [[HumanoidAbomination Humanoid Abominations]] haunting the area actually consists of their offspring]].
* All the clone "shatterlings" of Gentian Line in "House of Suns" by AlastairReynolds have one green eye and the other a "wintery jackdaw blue", since they're all [[OppositeSexClone male and female "facets"]] of Abigail Gentian. it is noted that since they have a bit of leeway from Abigail's exact appearance, in some shatterlings the mismatched eyes are toned down so much as to be unnoticeable
* One ''Literature/{{Goosebumps}}'' book has the main character's best friend be a girl with heterochromia. This becomes a plot point when she mysteriously disappears and he starts seeing a dog with MismatchedEyes around the neighborhood.
* The generational sagas by author EdwardRutherfurd often use physical genetic quirks, such as webbed digits or SkunkStripe hair, to illustrate a bloodline's continuity down through the centuries.
[[/folder]]

[[folder:Theatre]]
* The play ''Redwood Curtain'' is centered on a young Vietnamese girl who was adopted by an American family. She has "eyes like a husky dog" (one blue, one dark). When she meets a homeless Vietnam vet who has similarly mis-matched eyes, she starts wondering if he could be her biological father. He's not, but he knows who is.
[[/folder]]

[[folder:Video Games]]
* ''VideoGame/MortalKombatArmageddon'': The protagonist of Konquest Mode, Taven, is shown to be related to his brother and antagonist Daegon by a dragon tattoo on their faces, which are inverted mirror images of each other.
* In ''VideoGame/TalesOfGraces'', this is a sign that [[spoiler:Lambda]] is inside somebody's body. It happens to Richard and later [[spoiler:Asbel]], and this carries into VideoGame/TalesOfGraces F. [[spoiler: When Lambda is inside Richard, his other eye is [[RedEyesTakeWarning red]], but when it happens to Asbel, it's actually ''purple'', signaling that Lambda has a different relationship with Asbel than Richard.]]
* In ''VideoGame/DevilMayCry 3'', Lady and Arkham [[spoiler:and Jester]] both have one blue and one red eye. This serves as a visual clue that [[spoiler:they're father and daughter.]]
* Iris and her twin sister also named Iris from VideoGame/RuneFactory both have green and red eyes. They used to be one person but were magically split into two entities.
[[/folder]]

[[folder: Visual Novels]]
* In ''VisualNovel/FateStayNight'' homunculi made by the Einzbern family have distinctly silver hair and red eyes. This applies to Ilyasviel, her mother Irisviel, and the homunculus the two former are based on, Justeaze.
[[/folder]]

[[folder:Webcomics]]
* [[AuthorAvatar Christian Weston Chandler]] in ''Webcomic/{{Sonichu}}'' has heterochromatic eyes, though it's not at all striking. It's a feature of his EvilTwin (with inverted colors) and his Chris-Chan Sonichu form, too.
* When Abel of ''Webcomic/DanAndMabsFurryAdventures'' first enters the Succubus and Incubus Academy, he attracts interest because of his heterochromia and the dual batlike/birdlike nature of his wings. Both of these are traits of Quoar and his elusive clan members.
[[/folder]]

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