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[[folder:Web Original]]
* Patient Zero for the Eurasian pandemic of SPID ([[CallARabbitASmeep AIDS by another name]]) in the Website/AlternateHistoryDotCom story ''Literature/ForAllTime'' was [[spoiler: a Soviet soldier who contracted it from a blood transfusion while in the Congo, then unwittingly spread it by donating his blood every three weeks.]]
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* ''ComicBook/{{PS238}}'': An AlienInvasion targets humanity with a contagious virus intended to [[TheVirus turn humanity into more of themselves]], but due to a lack of NoBiochemicalBarriers the virus had to be tailored to the specific body of the first human the aliens abducted, which turns out to be [[spoiler:Tyler. Luckily, he is put into stasis fast enough, and is later cured by a blood transfusion from someone with IdealIllnessImmunity.]]
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* Although he was [[https://www.eurekalert.org/pub_releases/2016-10/uoc-nr102416.php eventually exonerated]] as being the true Patient Zero, [[http://en.wikipedia.org/wiki/Gaetan_Dugas Gaetan Dugas]] was widely reported as being Patient 0 of the HIV/AIDS epidemic, at least in the western world, especially after the book ''And The Band Played On'' was published and placed a large amount of blame on him for the virus' spread in North America. He was actually labeled as Patient ''O'', meaning "Out(side)-of-California" which was mistaken for a number due to a typographical error. The True Patient Zero, whose identity remains unknown (and will likely remain so) originated from Africa, where a mutation of a Simian Immunodeficiency Virus (SIV) from the White-collared monkey jumped the species barrier either when someone ate meat from an infected monkey or (more likely) when blood from an infected monkey found its way into a cut on a human (most likely while hunting or butchering a monkey for meat).

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* Although he was [[https://www.eurekalert.org/pub_releases/2016-10/uoc-nr102416.php eventually exonerated]] as being the true Patient Zero, [[http://en.wikipedia.org/wiki/Gaetan_Dugas Gaetan Dugas]] was widely reported as being Patient 0 of the HIV/AIDS epidemic, at least in the western world, especially after the book ''And The Band Played On'' was published and placed a large amount of blame on him for the virus' spread in North America. He was actually labeled as Patient ''O'', meaning "Out(side)-of-California" which was mistaken for a number due to a typographical error. The True Patient Zero, whose identity remains unknown (and will likely remain so) originated was from somewhere in Africa, most likely in the basin of the River Congo, where a mutation of a Simian Immunodeficiency Virus (SIV) from the White-collared white-collared monkey jumped the species barrier either when someone ate meat from an infected monkey or (more likely) when blood from an infected monkey found its way into a cut on a human (most likely while hunting or butchering a monkey for meat).
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* Although he was [[https://www.eurekalert.org/pub_releases/2016-10/uoc-nr102416.php eventually exonerated]] as being the true Patient Zero, [[http://en.wikipedia.org/wiki/Gaetan_Dugas Gaetan Dugas]] was widely reported as being Patient 0 of the HIV/AIDS epidemic, at least in the western world, especially after the book ''And The Band Played On'' was published and placed a large amount of blame on him for the virus' spread in North America. He was actually labeled as Patient ''O'', meaning "Out(side)-of-California" which was mistaken for a number due to a typographical error. The True Patient Zero, whose identity remains unknown (and will likely remain so) originated from Africa, where a mutation of a Simian Immunodeficiency Virus (SIV) from the White-collared monkey jumped the species barrier when the monkey's meat was consumed by a human.

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* Although he was [[https://www.eurekalert.org/pub_releases/2016-10/uoc-nr102416.php eventually exonerated]] as being the true Patient Zero, [[http://en.wikipedia.org/wiki/Gaetan_Dugas Gaetan Dugas]] was widely reported as being Patient 0 of the HIV/AIDS epidemic, at least in the western world, especially after the book ''And The Band Played On'' was published and placed a large amount of blame on him for the virus' spread in North America. He was actually labeled as Patient ''O'', meaning "Out(side)-of-California" which was mistaken for a number due to a typographical error. The True Patient Zero, whose identity remains unknown (and will likely remain so) originated from Africa, where a mutation of a Simian Immunodeficiency Virus (SIV) from the White-collared monkey jumped the species barrier either when the monkey's someone ate meat was consumed by from an infected monkey or (more likely) when blood from an infected monkey found its way into a human.cut on a human (most likely while hunting or butchering a monkey for meat).
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* In the film ''Film/{{Zombieland}}'', Patient Zero is said to have been a person who ate a bad hamburger. Mad cow disease then became mad human disease.



* In ''Film/TheKillerThatStalkedNewYork'', a 1950 film {{Very Loosely Based|OnATrueStory}} on the [[https://en.wikipedia.org/wiki/1947_New_York_City_smallpox_outbreak 1947 New York City smallpox outbreak]], patient zero is Sheila Bennet, a diamond smuggler who brings smallpox into New York City from Cuba. The authorities scramble to find her after the outbreak has started in order to keep her from spreading the disease to even more people and to be able to find out who she has already been in contact with. This is quite a change from the RealLife outbreak, where patient zero was not a smuggler but a regular tourist, did not get infected in Cuba but in Mexico, and was not the subject of a contact-tracing manhunt but was rather admitted to hospital before the outbreak really began.



* In ''Film/ProWrestlersVsZombies'', killing the two zombies raised by ritual seemingly causes all of the other zombies to vanish.
* The memorable opening scene of ''Film/ResidentEvilAfterlife'' with the J Pop Girl with ThousandYardStare standing in the rain at the Shibuya Scramble Crossing who [[DeadlyLunge suddenly chomps]] on a passing Japanese salaryman, followed by the lights going out across Tokyo and [[SpreadingDisasterMapGraphic then the rest of the world]].



* In ''Film/ProWrestlersVsZombies'', killing the two zombies raised by ritual seemingly causes all of the other zombies to vanish.
* The memorable opening scene of ''Film/ResidentEvilAfterlife'' with the J Pop Girl with ThousandYardStare standing in the rain at the Shibuya Scramble Crossing who [[DeadlyLunge suddenly chomps]] on a passing Japanese salaryman, followed by the lights going out across Tokyo and [[SpreadingDisasterMapGraphic then the rest of the world]].

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* In ''Film/ProWrestlersVsZombies'', killing the two zombies raised by ritual seemingly causes all of the other zombies film ''Film/{{Zombieland}}'', Patient Zero is said to vanish.
* The memorable opening scene of ''Film/ResidentEvilAfterlife'' with the J Pop Girl with ThousandYardStare standing in the rain at the Shibuya Scramble Crossing
have been a person who [[DeadlyLunge suddenly chomps]] on ate a passing Japanese salaryman, followed by the lights going out across Tokyo and [[SpreadingDisasterMapGraphic bad hamburger. Mad cow disease then the rest of the world]]. became mad human disease.
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* Typhoid Mary, who caused many outbreaks of [[ExactlyWhatItSaysOnTheTin Typhoid Fever]].

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* Typhoid Mary, TyphoidMary, who caused many outbreaks of [[ExactlyWhatItSaysOnTheTin Typhoid Fever]].
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* In ''Literature/FelicityFlooVisitsTheZoo'', Felicity is the one who initially has a cold (or possibly the flu), but then she spreads it to all the animals.
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* In ''WesternAnimation/{{Futurama}}'' episode "Cold Warriors", Fry is patient zero of the common cold which had been eradicated for centuries. He carried the virus after been frozen for a thousand years spreading to the Planet Express crew and Manhattan.

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* In the ''WesternAnimation/{{Futurama}}'' episode "Cold Warriors", Fry is patient zero of the common cold which had been eradicated for centuries. He carried the virus after been being frozen for a thousand years spreading to the Planet Express crew and Manhattan.
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* In ''WesternAnimation/{{Futurama}}'' episode "Cold Warriors", Fry is patient zero of the common cold which had been eradicated for centuries having carried the virus after been frozen for a thousand years.

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* In ''WesternAnimation/{{Futurama}}'' episode "Cold Warriors", Fry is patient zero of the common cold which had been eradicated for centuries having centuries. He carried the virus after been frozen for a thousand years.years spreading to the Planet Express crew and Manhattan.
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* In ''WesternAnimation/{{Futurama}}'' episode "Cold Warriors", Fry is patient zero of the common cold which had been eradicated for centuries having carried the virus after been frozen for a thousand years.
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[[caption-width-right:330:[-Well, that escalated quickly!-] ]]

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[[caption-width-right:330:[-Well, [[caption-width-right:350:[-Well, that escalated quickly!-] ]]

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* The memorable opening scene of ''Film/ResidentEvilAfterlife'', where the first zombie attack is shown on a rainy night on the Shibuya Scramble Crossing, followed by the lights going out across Tokyo and [[SpreadingDisasterMapGraphic then the rest of the world]]. Retcons in later movies change whether this was indeed the first attack however.

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* The memorable opening scene of ''Film/ResidentEvilAfterlife'', where ''Film/ResidentEvilAfterlife'' with the first zombie attack is shown on a rainy night on J Pop Girl with ThousandYardStare standing in the rain at the Shibuya Scramble Crossing, Crossing who [[DeadlyLunge suddenly chomps]] on a passing Japanese salaryman, followed by the lights going out across Tokyo and [[SpreadingDisasterMapGraphic then the rest of the world]]. Retcons in later movies change whether this was indeed the first attack however.
world]].
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* The memorable opening scene of ''Film/ResidentEvilAfterlife'', where the first zombie attack is shown on a rainy night during the Shibuya Scramble, followed by the lights going out across Tokyo and [[SpreadingDisasterMapGraphic then the rest of the world]]. Retcons in later movies change whether this was indeed the first attack however.

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* The memorable opening scene of ''Film/ResidentEvilAfterlife'', where the first zombie attack is shown on a rainy night during on the Shibuya Scramble, Scramble Crossing, followed by the lights going out across Tokyo and [[SpreadingDisasterMapGraphic then the rest of the world]]. Retcons in later movies change whether this was indeed the first attack however.
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* The memorable opening scene of ''Film/ResidentEvilAfterlife'', where the first zombie attack is shown on a rainy night during the Shibuya Scramble, followed by the lights going out across Tokyo and [[SpreadingDisasterMapGraphic then the rest of the world]]. Retcons in later movies change whether this was indeed the first attack however.
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* In the film ''Film/{{Zombieland}}'', Patient Zero is said to have been a person who [[spoiler:ate a bad hamburger]]

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* In the film ''Film/{{Zombieland}}'', Patient Zero is said to have been a person who [[spoiler:ate ate a bad hamburger]]hamburger. Mad cow disease then became mad human disease.
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* In ''Series/{{Community}}'''s "[[CommunityS2E06Epidemiology Epidemiology]]", Patient Zero is Pierce, being the first person to eat the tainted "taco meat".

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* In ''Series/{{Community}}'''s "[[CommunityS2E06Epidemiology "[[Recap/CommunityS2E06Epidemiology Epidemiology]]", Patient Zero is Pierce, being the first person to eat the tainted "taco meat".
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* In ''VideoGame/StubbsTheZombie'' you play as a dead salesman reanimated by experimental fertilizer spread over his shallow grave as he turns a city into zombies.
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* In ''VideoGame/Hitman2016'', the GOTY Edition brought in the Patient Zero campaign, which has 47 and Diana race against the clock to stop a virus spreading. The campaign starts in a hotel in Bangkok, which has 47 kill the cult leader who has created the virus. However, 47's actions triggers a DeadMansSwitch, and he must get a vial of the virus from an author in Italy, Sapienza, who plans to give it away to a cult member. You then move onto Colorado to take out mercenaries via sniper rifle in a farm-turned military compound, and kills the doctor testing the virus on various mercenaries (whom you must also take out). Then we come to Hokkaido, Japan, to kill the man who wants to spread the virus. That last mission is called "Patient Zero" also. You also need to kill any other people infected.
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TheVirus has taken over the entire world/country/town. Almost always, there is a patient zero. This is the person that started it all, the very first person to be infected. Perhaps s/he carried the virus for a while without realizing s/he was a ZombieInfectee. Perhaps s/he was the one who created the virus.

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TheVirus has taken over the entire world/country/town. Almost always, there is a patient zero. This is the person that started it all, the very first person to be infected. Perhaps s/he they carried the virus for a while without realizing s/he was they were a ZombieInfectee. Perhaps s/he was they were the one who created the virus.
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* In ''ComicBook/XMen'', reference is made to 'Patient Zero' of the mutant-killing Legacy Virus, who was apparently a mutant who contracted the virus and released it into its airborne form when he used his power for the first time after becoming infected. Eventually, Beast was able to devise a cure, but the only way to release it on a large scale was to 'infect' someone else with the cure, which would kill the host just like the original virus killed Patient Zero (although Colossus chose to use it anyway).



* In one ComicBook/JusticeLeague story, a failed assassination attempt on Lex Luthor releases a virus from his lab that causes those with super powers to become very sick and gives super powers to normal people which eventually kill them. The original purpose of the virus was to take super powers away. The Justice League hunts down Patient Zero who has grown into a monster with multiple superpowers, hoping that they can make a cure from them, but this doesn’t work. Instead a cure is made from Superman who had antibodies against the virus because Lex Luthor had previously infected him with it but his immune system had fought it off and he hadn’t spread it to anyone.

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* In one ComicBook/JusticeLeague ''ComicBook/JusticeLeague'' story, a failed assassination attempt on Lex Luthor releases a virus from his lab that causes those with super powers to become very sick and gives super powers to normal people which eventually kill them. The original purpose of the virus was to take super powers away. The Justice League hunts down Patient Zero who has grown into a monster with multiple superpowers, hoping that they can make a cure from them, but this doesn’t work. Instead a cure is made from Superman who had antibodies against the virus because Lex Luthor had previously infected him with it but his immune system had fought it off and he hadn’t spread it to anyone.
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* ''Series/TheOuterLimits1995'': In an episode actually called "Patient Zero", the future humanity is ravaged by a plague. A man time travels to the present to kill the plague's patient zero to prevent the plague from happening. Because patient zero turns out to be a beautiful woman, the man can't bring himself to kill her, and instead decides to protect her and prevent her from getting sick in the first place. [[spoiler:Eventually, another time traveler shows up and reveals that in his efforts to prevent the girl from becoming sick, the man himself has become sick and become the new patient zero. The man agrees to be killed, which successfully stops the plague.]]
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* In the ''WesternAnimation/FamilyGuy'' episode "Halloween on Spooner Street", Quagmire is shown to have contracted every STD known to man, which includes being patient zero for gonorrhea.
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* In one ComicBook/JusticeLeague story, a failed assassination attempt on Lex Luthor releases a virus from his lab that causes those with super powers to become very sick and gives super powers to normal people which eventually kill them. The original purpose of the virus was to take super powers away. The Justice League hunts down Patient Zero who has grown into a monster with multiple superpowers, hoping that they can make a cure from them, but this doesn’t work. Instead a cure is made from Superman who had antibodies against the virus because Lex Luthor had previously infected him with it but his immune system had fought it off and he hadn’t spread it to anyone.
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* ''VideoGame/Vampyr2018'': The patient zero for the Skal epidemic (a plague that turns humans into mutated, feral vampires) is revealed to be [[spoiler:Harriet Jones, who was being experimented by Dr. Swansea using vampire blood to cure the Spanish influenza. What he didn't expect is that Jones was also an WalkingWasteland possessed by the [[BigBad Red Queen]] to spread disease and [[TheScourgeOfGod punish mankind for its inequities]]]].
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* ''ComicBook/ZombiesChristmasCarol'' had Scrooge contract the Hungry Death from a horse, which rotted after administering the bite, and then he became the carrier to the rest of the world.
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** In the episode "[[Recap/SouthParkS17E3WorldWarZimmerman World War Zimmerman]]", Cartman believes Token to be patient zero, but this is just Cartman's racism.

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