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* In the ''WesternAnimation/{{Rugrats}}'' "Passover" special, Moses (Tommy) unleashes plagues on Pharaoh (Angelica) to make her let the babies go. Of course, this being a kid's show, the plagues are downplayed to be mere annoyances to the Pharaoh while the more horrific ones aren't shown. The final plague is also played out different, with it being said that the first born of every household would be "[[NeverSayDie taken away]]"; upon realizing that this included ''her'', Pharaoh agreed to let everyone go if Moses called the plague off.
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* In ''Film/TheReaping'', the town of Haven claims to be suffering the biblical plagues of Egypt, which is the reason Katherine is there. [[spoiler:They are revealed to be Loren's angelic power.]]
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* ''VideoGame/NobodySavesTheWorld'': [[spoiler:As it turns out, not only does the Calamity [[EvilTaintedThePlace consume the land]], it also takes hold of the people as well, covering them in fungal growths and [[EyelessFace leaving them without any eyes]].]]
