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*** Natalie X is a psychic mutant member of a team from a BadFuture that confronted the Fantastic Four in an attempt to save refugees from that future. After resolving it with a move to an artificial Earth, she took a serum to increase her telepathic powers that had the side effect of increasing the size of her brain. It's very grotesque; she eventually becomes the HiveQueen of the colony they established and her head becomes big enough to fill out ''[[Characters/MarvelComicsGalactus Galactus]]' helmet''.
*** Reed Richards did this to himself once in ''Fantastic Four: 1234'' by Creator/GrantMorrison. In order to defeat [[Characters/MarvelComicsDoctorDoom Doctor Doom]] in a [[SmartPeoplePlayChess 4-dimensional chess game]] that was threatening to destroy the Fantastic Four, Reed used his [[RubberMan stretching powers]] to literally grow new structures in his brain in order to out-think Doom.
*** Reed Richards did this to himself once in ''Fantastic Four: 1234'' by Creator/GrantMorrison. In order to defeat [[Characters/MarvelComicsDoctorDoom Doctor Doom]] in a [[SmartPeoplePlayChess 4-dimensional chess game]] that was threatening to destroy the Fantastic Four, Reed used his [[RubberMan stretching powers]] to literally grow new structures in his brain in order to out-think Doom.
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*** In ''ComicBook/FantasticFour1998'', Natalie X is a psychic mutant member of a team from a BadFuture that confronted the Fantastic Four in an attempt to save refugees from that future. After resolving it with a move to an artificial Earth, she took a serum to increase her telepathic powers that had the side effect of increasing the size of her brain. It's very grotesque; she eventually becomes the HiveQueen of the colony they established and her head becomes big enough to fill out ''[[Characters/MarvelComicsGalactus Galactus]]' helmet''.
*** Reed Richards did this to himself once in''Fantastic Four: 1234'' ''ComicBook/FantasticFour1234'' by Creator/GrantMorrison. In order to defeat [[Characters/MarvelComicsDoctorDoom Doctor Doom]] in a [[SmartPeoplePlayChess 4-dimensional chess game]] that was threatening to destroy the Fantastic Four, Reed used his [[RubberMan stretching powers]] to literally grow new structures in his brain in order to out-think Doom.
*** Reed Richards did this to himself once in
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*** And Batman actually. In ''World's Finest #151'', when an ancient Kryptonian device landed on Earth, it evolved Batman into a big-brained human from 800,000 years in the future.
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*** Muto, a villain of one of Superman's descendants, and who later appeared in the 2499 segment of ''ComicBook/TheDominusEffect''.
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*** Muto, a villain of one of Superman's descendants, and who later appeared in the 2499 segment of ''ComicBook/TheDominusEffect''.some few stories like ''ComicBook/ActionComics'' #338-339 and ''ComicBook/WorldsFinest1941'' #166, is a mutant with a giant, hairless yellow head and huge psychic powers as telekinesis and matter-transmutation.
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* ''VideoGame/TheLegendOfZeldaTheWindWaker'': The younger of the two retired swordfighting brothers, Sturgeon, has become a MiniatureSeniorCitizen a gigantic swollen head that's nearly 70% of his body's total mass. While he doesn't have any psychic powers, he's the more intelligent and well-learned of the two brothers, although Orca is actually a fair bit more calm than Sturgeon.
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* ''VideoGame/StarFox'': "Only I have the [[{{Pun}} brains]] to rule Lylat!" says Andross after assuming his giant brain form.
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* ''VideoGame/StarFox'': ''VideoGame/StarFox64'': "Only I have the [[{{Pun}} brains]] to rule Lylat!" says Andross after assuming his giant brain form.
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* Mad Rocket Slave "Grosshirn der Krankheit" from ''VideoGame/NineteenSeventeenTheAlienInvasionDX'', an alien giant whose forehead takes up most of his body. Fittingly he can use PsychicPowers to spam projectiles as a boss.
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* ''Anime/DoraemonNobitaAndTheTinLabyrinth'': The main villain, Professor Napogistra, have a huge brain that takes up around one-third of his entire body. Justified since his brain is a neural link to his entire robot army.
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* ''Anime/DoraemonNobitaAndTheTinLabyrinth'': The main villain, Professor Napogistra, have has a huge brain that takes up around one-third of his entire body. Justified since his brain is a neural link to his entire robot army.
