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* ''Film/NoTimeToDie'': Safin's henchman Cyclops has one eye that's quite a bit bigger than the other. Justified, as it's cybernetic, and it's not even his (apparently, it once belonged to Ernst Stavro Blofeld), so it wasn't properly sized for him. Unfortunately, because the eye is cybernetic, this makes it an easy target for Bond's EMP watch.
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* Having a literal Mad Eye is OlderThanPrint: Cuchulain, the [[Myth/CelticMythology Irish]] folk hero. Whenever he went into one of his unstoppable rages, one of his eyes would get smaller and the other would get bigger. " ... he sucked one eye so deep into his head that a wild crane couldn't probe it onto his cheek out of the depths of his skull; the other eye fell out along his cheek." Now ''thats'' a Mad Eye.
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* Having a literal Mad Eye is OlderThanPrint: Cuchulain, the [[Myth/CelticMythology Irish]] folk hero. Whenever he went into one of his unstoppable rages, one of his eyes would get smaller and the other would get bigger. " ... he sucked one eye so deep into his head that a wild crane couldn't probe it onto his cheek out of the depths of his skull; the other eye fell out along his cheek." Now ''thats'' ''that's'' a Mad Eye.
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* ''VideoGame/ShantaeAndTheSevenSirens'': Golems have one big yellow eye with tiny pupil and one rectangular eye socket much larger than the other small, yellow, pupilless eye.
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* [[{{Cloudcuckoolander}} Jason]] from WebVideo/ElementAnimation's ''The Crack'' has heterochromia, with one eye having a green iris. Also accentuated by his permanent case of red sclerae.
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* [[{{Cloudcuckoolander}} Jason]] from WebVideo/ElementAnimation's WebAnimation/ElementAnimation's ''The Crack'' has heterochromia, with one eye having a green iris. Also accentuated by his permanent case of red sclerae.
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* ''LightNovel/SwordArtOnline'': Sugou Nobuyuki/Oberon's right eye [[http://www.nerd-age.com/wp-content/uploads/2012/11/Sword-Art-Online-episode-18-Oberon.png bugs out]] while he's gloating to Asuna in episode 18. That same eye later gets this treatment in the real world after Kirito [[EyeScream stabs him through it]] with the Pain Absorber [[YourMindMakesItReal set to zero]]; [[https://swordartonline.wikia.com/wiki/File:Nobuyuki_Sugou_eye.jpg it's permanently bloodshot, with visible veins/scarring extending in all directions from it]].
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* ''LightNovel/SwordArtOnline'': ''Literature/SwordArtOnline'': Sugou Nobuyuki/Oberon's right eye [[http://www.nerd-age.com/wp-content/uploads/2012/11/Sword-Art-Online-episode-18-Oberon.png bugs out]] while he's gloating to Asuna in episode 18. That same eye later gets this treatment in the real world after Kirito [[EyeScream stabs him through it]] with the Pain Absorber [[YourMindMakesItReal set to zero]]; [[https://swordartonline.wikia.com/wiki/File:Nobuyuki_Sugou_eye.jpg it's permanently bloodshot, with visible veins/scarring extending in all directions from it]].
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* ''VideoGame/PizzaTower'' has Peppino, whose eyes are regularly drawn mismatched to reflect how he is either [[NervousWreck crippled by anxiety]] or [[UnstoppableRage insane with fury]].
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* [[{{Cloudcuckoolander}} Jason]] from WebAnimation/ElementAnimation's ''The Crack'' has heterochromia, with one eye having a green iris. Also accentuated by his permanent case of red sclerae.
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* [[{{Cloudcuckoolander}} Jason]] from WebAnimation/ElementAnimation's WebVideo/ElementAnimation's ''The Crack'' has heterochromia, with one eye having a green iris. Also accentuated by his permanent case of red sclerae.
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None
Added DiffLines:
* [[{{Cloudcuckoolander}} Jason]] from WebAnimation/ElementAnimation's ''The Crack'' has heterochromia, with one eye having a green iris. Also accentuated by his permanent case of red sclerae.
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* when being sarcastic or angry, characters in Big Nate often display a Mad Eye
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* when When being sarcastic or angry, characters in Big Nate often display a Mad Eye