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* ''Anime/DragonBallZ'': [[MadScientist Dr. Gero]] places his brain in a robot body.
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* ''Anime/DragonBallZ'': [[MadScientist Dr. Gero]] places placed his brain in a robot body.body to [[ImmortalitySeeker live forever]] and to become strong enough to take revenge on Goku for destroying the Red Ribbon Army.
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* Dr. Nefarious from ''Franchise/RatchetAndClank'' used to be [[https://villains.fandom.com/wiki/File:Nefarious-1.png an organic alien]], but was later made into a robot. You wouldn't know that from [[https://static.wikia.nocookie.net/villains/images/0/02/Dr._Nefarious_Rift_Apart_render.webp/revision/latest?cb=20210614181220 looking at him]], though; he has no visible organic parts whatsoever, not even in the dome atop his head. The same thing may or may not also apply to his AlternateSelf, [[https://static.wikia.nocookie.net/villains/images/7/71/Emperor_Nefarious_from_RA_render.png/revision/latest?cb=20210720110028 Emperor Nefarious]].
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* ''TabletopGame/{{Shadowrun}}'' 2nd Edition supplement ''Cybertechnology''. It is possible to replace a person's arms, legs, torso, and skull with cybertech, with only their brain remaining from their original body. However, cybermancy magic must be used to allow the recipient to [[CyberneticsEatYourSoul survive the complete loss of all Essence]] (LifeEnergy).
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* ''TabletopGame/{{Shadowrun}}'' 2nd Edition supplement ''Cybertechnology''. It is possible to replace a person's arms, legs, torso, and skull with cybertech, with only their brain remaining from their original body. However, cybermancy magic must be used to allow the recipient to [[CyberneticsEatYourSoul survive the complete loss of all Essence]] (LifeEnergy).Essence]], and even then they become a [[ArtificialZombie cyberzombie]].
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* ''TabletopGame/{{Shadowrun}}'' 2nd Edition supplement ''Cybertechnology''. It is possible to replace a person's arms, legs, torso, and skull with cybertech, with only their brain remaining from their original body. However, cybermancy magic must be used to allow the recipient to [[CyberneticsEatsYourSoul survive the complete loss of all Essence]] (LifeEnergy).
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* ''TabletopGame/{{Shadowrun}}'' 2nd Edition supplement ''Cybertechnology''. It is possible to replace a person's arms, legs, torso, and skull with cybertech, with only their brain remaining from their original body. However, cybermancy magic must be used to allow the recipient to [[CyberneticsEatsYourSoul [[CyberneticsEatYourSoul survive the complete loss of all Essence]] (LifeEnergy).
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[[caption-width-right:336:"Lose over 99% body fat in less than one week using this simple procedure!"]]
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* ''TabletopGame/{{Shadowrun}}'' 2nd Edition supplement ''Cybertechnology''. It is possible to replace a person's arms, legs, torso, and skull with cybertech, with only their brain remaining from their original body. However, cybermancy magic must be used to allow the recipient to survive the complete loss of all Essence (LifeEnergy).
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* ''TabletopGame/{{Shadowrun}}'' 2nd Edition supplement ''Cybertechnology''. It is possible to replace a person's arms, legs, torso, and skull with cybertech, with only their brain remaining from their original body. However, cybermancy magic must be used to allow the recipient to [[CyberneticsEatsYourSoul survive the complete loss of all Essence Essence]] (LifeEnergy).
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** ''Literature/TheCyberDragonsTrilogy'' also has FullConversionCyborg bodies but they have become more common place with cheap knock offs and plastic versions replacing the extremely expensive ones from ''Literature/AgentG.'' They are still extremely expensive but no more so than extensive plastic surgery.
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Incorrect Example Indentation.
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* ''VideoGame/BioShock'': This is essentially what a Big Daddy is, albeit in a proto-DieselPunk version. A Big Daddy is created by selecting a criminal or other person on the fringe of society, grafting their organs into a huge metal diving suit, and mentally conditioning them to protect [[CreepyChild the Little Sisters]]. Point Prometheus features a lengthy section where [[spoiler:Jack undergoes the process]].[[note]] although seemingly not the non-reversible elements, as seen in the endings where Jack is seen conspicuously suitless. This still doesn't explain what that machine did to his voice box, though.[[/note]]
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* ''VideoGame/BioShock'': ''VideoGame/BioShock'':
** ''VideoGame/BioShock1'': This is essentially what a Big Daddy is, albeit in a proto-DieselPunk version. A Big Daddy is created by selecting a criminal or other person on the fringe of society, grafting their organs into a huge metal diving suit, and mentally conditioning them to protect [[CreepyChild the Little Sisters]]. Point Prometheus features a lengthy section where [[spoiler:Jack undergoes the process]].[[note]] although seemingly not the non-reversible elements, as seen in the endings where Jack is seen conspicuously suitless. This still doesn't explain what that machine did to his voice box, though.[[/note]]
** ''VideoGame/BioShock1'': This is essentially what a Big Daddy is, albeit in a proto-DieselPunk version. A Big Daddy is created by selecting a criminal or other person on the fringe of society, grafting their organs into a huge metal diving suit, and mentally conditioning them to protect [[CreepyChild the Little Sisters]]. Point Prometheus features a lengthy section where [[spoiler:Jack undergoes the process]].[[note]] although seemingly not the non-reversible elements, as seen in the endings where Jack is seen conspicuously suitless. This still doesn't explain what that machine did to his voice box, though.[[/note]]
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* ''VideoGame/BioShock'': This is essentially what a Big Daddy is, albeit in a proto-DieselPunk version. A Big Daddy is created by selecting a criminal or other person on the fringe of society, grafting their organs into a huge metal diving suit, and mentally conditioning them to protect [[CreepyChild the Little Sisters]]. Point Prometheus features a lengthy section where [[spoiler:Jack undergoes the process]].[[note]] although seemingly only the non-reversible elements, as seen in the endings where Jack is seen conspicuously suitless. This still doesn't explain what that machine did to his voice box, though.[[/note]]
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* ''VideoGame/BioShock'': This is essentially what a Big Daddy is, albeit in a proto-DieselPunk version. A Big Daddy is created by selecting a criminal or other person on the fringe of society, grafting their organs into a huge metal diving suit, and mentally conditioning them to protect [[CreepyChild the Little Sisters]]. Point Prometheus features a lengthy section where [[spoiler:Jack undergoes the process]].[[note]] although seemingly only not the non-reversible elements, as seen in the endings where Jack is seen conspicuously suitless. This still doesn't explain what that machine did to his voice box, though.[[/note]]
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* ''VideoGame/BioShockInfinite'': The Handymen retain only a few of their original organs in their massive steampunk bodies, most prominently their heads and hearts -- which can be seen via a porthole in their torsos and [[AttackItsWeakPoint shot by wily players]]. Given the powerful but clumsy tech that was used to [[WeCanRebuildHim remake them]], Handymen find this condition ''agonizing.''
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*
**''VideoGame/BioShockInfinite:'' The Handymen retain only a few of their original organs in their massive steampunk bodies, most prominently their heads and hearts -- which can be seen via a porthole in their torsos and [[AttackItsWeakPoint shot by wily players]]. Given the powerful but clumsy tech that was used to [[WeCanRebuildHim remake them]], Handymen find this condition ''agonizing.''
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* ''Literature/AgentG'' by Creator/CTPhipps: These are called "Shells" (as in Ghost in the). Notably, Shells look identical to human beings on the outside and are seemingly able to live normal lives in-between missions. They are also ImplaccableMan killing machines in the service of the government or PrivateMilitaryContractors.
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* ''Literature/AgentG'' by Creator/CTPhipps: These are called "Shells" (as in Ghost in the). Notably, Shells look identical to human beings on the outside and are seemingly able to live normal lives in-between missions. They are also ImplaccableMan ImplacableMan killing machines in the service of the government or PrivateMilitaryContractors.
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* ''Literature/AgentG'' by Creator/CTPhipps: These are called "Shells" (as in Ghost in the). Notably, Shells look identical to human beings on the outside and are seemingly able to live normal lives in-between missions. They are also ImplaccableMan killing machines in the service of the government or PrivateMilitaryContractors.
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* ''Franchise/MetalGear'': In between ''VideoGame/MetalGearSolid2'' and ''VideoGame/MetalGearSolid4'', Raiden was converted into a full-body cyborg. He usually leaves his mechanical parts uncovered, with only his face looking consistently organic. [[VideoGame/MetalGearRisingRevengeance Four years later]], full-body cyborgs, such as the [[QuirkyMinibossSquad Winds of Destruction]] and assorted EliteMooks, are much more common. [[spoiler:[[TheDragon Sundowner]] is trying to use the process on ''children'' to turn them into ChildSoldiers, using Raiden's experiences as a template.]]
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* ''Franchise/MetalGear'': In between ''VideoGame/MetalGearSolid2'' ''VideoGame/MetalGearSolid2SonsOfLiberty'' and ''VideoGame/MetalGearSolid4'', ''VideoGame/MetalGearSolid4GunsOfThePatriots'', Raiden was converted into a full-body cyborg. He usually leaves his mechanical parts uncovered, with only his face looking consistently organic. [[VideoGame/MetalGearRisingRevengeance Four years later]], full-body cyborgs, such as the [[QuirkyMinibossSquad Winds of Destruction]] and assorted EliteMooks, are much more common. [[spoiler:[[TheDragon Sundowner]] is trying to use the process on ''children'' to turn them into ChildSoldiers, using Raiden's experiences as a template.]]
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fix run-on sentence
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* ''Series/StarTrekDiscovery'': BridgeBunny Airiam, who appears to be an android, is revealed to be one in [[Recap/StarTrekDiscoveryS2E09ProjectDaedalus "Project Daedalus"]]. After suffering injuries in a shuttle crash, to the point where even parts of her brain have had to be replaced with computer memory that she has to download to offline storage periodically or run out of space. [[spoiler:This allows her body to be taken over by the rogue AI Control, forcing Burnham to MercyKill her via [[ThrownOutTheAirlock airlock]].]]
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* ''Series/StarTrekDiscovery'': BridgeBunny Airiam, who appears to be an android, is revealed to be one in [[Recap/StarTrekDiscoveryS2E09ProjectDaedalus "Project Daedalus"]]. After suffering catastrophic injuries in a shuttle crash, she had to be cyberized to the point where even parts of her brain have had to be were replaced with computer memory that she has to download to offline storage periodically or run out of space. [[spoiler:This allows her body to be taken over by the rogue AI Control, forcing Burnham to MercyKill her via [[ThrownOutTheAirlock airlock]].]]
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unnecessary to spoil that part
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* ''Series/StarTrekDiscovery'': BridgeBunny Airiam, who appears to be an android, is revealed to be one in [[Recap/StarTrekDiscoveryS2E09ProjectDaedalus "Project Daedalus"]] [[spoiler:After suffering injuries in a shuttle crash, to the point where even parts of her brain have had to be replaced with computer memory that she has to download to offline storage periodically or run out of space. This allows her body to be taken over by the rogue AI Control, forcing Burnham to MercyKill her via [[ThrownOutTheAirlock airlock]].]]
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* ''Series/StarTrekDiscovery'': BridgeBunny Airiam, who appears to be an android, is revealed to be one in [[Recap/StarTrekDiscoveryS2E09ProjectDaedalus "Project Daedalus"]] [[spoiler:After Daedalus"]]. After suffering injuries in a shuttle crash, to the point where even parts of her brain have had to be replaced with computer memory that she has to download to offline storage periodically or run out of space. This [[spoiler:This allows her body to be taken over by the rogue AI Control, forcing Burnham to MercyKill her via [[ThrownOutTheAirlock airlock]].]]
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* ''VideoGame/DaemonXMachina'': The player character, known only as the Rookie, can become one by upgrading themselves, with each upgrade replacing more and more of their organic body with cybernetics until barely anything organic remains.
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** "[[Recap/LoveDeathAndRobotsGoodHunting Good Hunting]]": [[spoiler:Yan, a Huli Jing, is forced against her will to become a steampunk cyborg to appeal to the mayor's sexual desires. After killing him, she approaches her human friend, who uses his mechanical prowess to revert her back to her fox form.]]
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** "[[Recap/LoveDeathAndRobotsGoodHunting Good Hunting]]": [[spoiler:Yan, a [[AsianFoxSpirit Huli Jing, Jing]], is forced against her will to become a steampunk cyborg to appeal to the mayor's sexual desires. After killing him, she approaches her human friend, who uses his mechanical prowess to revert give her back an upgraded body able to transform into a mechanical version of her fox form.]]
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* ''Manga/BattleAngelAlita'': Many cyborgs are little more than a head on a cyborg body, including the titular character. [[spoiler: Citizens of Zalem are often the inverse, their brains replaced with a chip in an otherwise organic body.]] Akita herself is a particularly extreme example, where as a child the only part of her that was organic was her head. As a young adult, only her brain was organic - and in ''Last Order'', Nova points out that her glial cells have been replaced with a polymer resin that can harden instantly to protect the brain from sudden shock or heat. Only her neurons are organic - less than 3% of her brain. [[spoiler:Eventually, even that 3% is replaced with cybernetics, though she remains human in her consciousness at least.]]
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* ''Manga/BattleAngelAlita'': Many cyborgs are little more than a head on a cyborg body, including the titular character. [[spoiler: Citizens of Zalem are often the inverse, their brains replaced with a chip in an otherwise organic body.]] Akita Alita herself is a particularly extreme example, where as a child the only part of her that was organic was her head. As a young adult, only her brain was organic - and in ''Last Order'', Nova points out that her glial cells have been replaced with a polymer resin that can harden instantly to protect the brain from sudden shock or heat. Only her neurons are organic - less than 3% of her brain. [[spoiler:Eventually, even that 3% is replaced with cybernetics, though she remains human in her consciousness at least.]]
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* ''Franchise/SuperSentai''
** ''Series/ChoujuuSentaiLiveman'': Doctor Mazenda gradually replaces her body parts with mechanical appendages throughout the series, with the goal of giving herself a fully robotic body to preserve her beauty. [[spoiler:She eventually fully roboticizes herself, but only as a last resort to keep her brain from being extracted, as by that point she'd come to [[BeCarefulWhatYouWishFor regret forfeiting her humanity]].]]
** In ''Series/TensouSentaiGoseiger'', [[spoiler:[[EmperorScientist Robogog]] turns out to be one of these, having transplanted his brain into a robotic body.]]
** ''Series/ChoujuuSentaiLiveman'': Doctor Mazenda gradually replaces her body parts with mechanical appendages throughout the series, with the goal of giving herself a fully robotic body to preserve her beauty. [[spoiler:She eventually fully roboticizes herself, but only as a last resort to keep her brain from being extracted, as by that point she'd come to [[BeCarefulWhatYouWishFor regret forfeiting her humanity]].]]
** In ''Series/TensouSentaiGoseiger'', [[spoiler:[[EmperorScientist Robogog]] turns out to be one of these, having transplanted his brain into a robotic body.]]
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* ''Manga/PandoraInTheCrimsonShellGhostUrn'': The main character Nene is noted to be one among the few people in the world to use a full body prosthetic, in her case in order to deal with a nasty disease that was eating away at her original body. Clarion is another one who is similarly almost fullt mechanical but seems to take the robotic aspects even further. They look mostly human, just with some obvious joints.
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* ''Manga/PandoraInTheCrimsonShellGhostUrn'': The main character Nene is noted to be one among the few people in the world to use a full body prosthetic, in her case in order to deal with a nasty disease that was eating away at her original body. Clarion is another one who is similarly almost fullt fully mechanical but seems to take the robotic aspects even further. They look mostly human, just with some obvious joints.
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** Darth Vader is a {{downplayed}} example. Due to becoming a quadruple amputee in lightsaber duels (right arm to Count Dooku in ''Film/AttackOfTheClones'', remaining limbs to Obi-wan Kenobi in ''Film/RevengeOfTheSith'') and being badly burned by lava on Mustafar, his distinctive suit is [[DarkLordOnLifeSupport as much life-support system as armor]]. His skin was replaced with an artificial substitute, and his VaderBreath comes from a respirator that supplements his borderline-nonfunctional lungs. He's also had some of his vertebrae replaced with artificial substitutes, seen in ''Film/ReturnOfTheJedi'' as a result of XRaySparks from Palpatine's Force lightning.
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** Darth Vader is a {{downplayed}} example. Due to becoming a quadruple amputee in lightsaber duels (right arm to Count Dooku in ''Film/AttackOfTheClones'', remaining limbs to Obi-wan Obi-Wan Kenobi in ''Film/RevengeOfTheSith'') and being badly burned by lava on Mustafar, his distinctive suit is [[DarkLordOnLifeSupport as much life-support system as armor]]. His skin was replaced with an artificial substitute, and his VaderBreath comes from a respirator that supplements his borderline-nonfunctional lungs. He's also had some of his vertebrae replaced with artificial substitutes, seen in ''Film/ReturnOfTheJedi'' as a result of XRaySparks from Palpatine's Force lightning.
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* [[Fanfic/AbraxasHrodvitnon AbraxasVerse Timeline]]: The official timeline by the author reveals that Kiryu MK I, a HumongousMecha built by Monarch and [[spoiler:[[PeaceAndLoveIncorporated Apex Cybernetics]]]] to fight on Godzilla's side, was built around the ancient bones of Dagon from ''Film/Godzilla2014'', using said bones as an endoskeletal framework. Kiryu consequently becoming possessed by Dagon's resurrected consciousness is a [[https://hrodvitnon.tumblr.com/tagged/kiryu%21dagon recurring headcanon entertained by others on the author's Tumblr]], and the RecursiveFanfiction sequel ''[[https://archiveofourown.org/works/38446570/ Abraxas: The Clash of Silver]]'' furthermore portrays both Kiryu ''and'' [[spoiler:the second Mechagodzilla]] using tissue from [[HalfHumanHybrid the Zmeyevich]] as a telepathic control system with the effect of giving Zmeyevich the potential to control either machine.
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* [[Fanfic/AbraxasHrodvitnon AbraxasVerse Timeline]]: AbraxasVerse]]: The official timeline by the author reveals that Kiryu MK I, a HumongousMecha built by Monarch and [[spoiler:[[PeaceAndLoveIncorporated Apex Cybernetics]]]] to fight on Godzilla's side, was built around the ancient bones of Dagon from ''Film/Godzilla2014'', using said bones as an endoskeletal framework. Kiryu consequently becoming possessed by Dagon's resurrected consciousness is a [[https://hrodvitnon.tumblr.com/tagged/kiryu%21dagon recurring headcanon entertained by others on the author's Tumblr]], and the RecursiveFanfiction sequel ''[[https://archiveofourown.org/works/38446570/ Abraxas: The Clash of Silver]]'' furthermore portrays both Kiryu ''and'' [[spoiler:the second Mechagodzilla]] using tissue from [[HalfHumanHybrid the Zmeyevich]] as a telepathic control system with the effect of giving Zmeyevich the potential to control either machine.
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* [[Fanfic/AbraxasHrodvitnon AbraxasVerse Timeline]]: The official timeline by the author reveals that Kiryu MK I, a HumongousMecha built by Monarch and [[spoiler:[[PeaceAndLoveIncorporated Apex Cybernetics]]]] to fight on Godzilla's side, was built around the ancient bones of Dagon from ''Film/Godzilla2014'', using said bones as an endoskeletal framework. Kiryu consequently becoming possessed by Dagon's resurrected consciousness is a [[https://hrodvitnon.tumblr.com/tagged/kiryu%21dagon recurring headcanon entertained by others on the author's Tumblr]], and the RecursiveFanfiction sequel ''[[https://archiveofourown.org/works/38446570/ Abraxas: The Clash of Silver]]'' furthermore portrays both Kiryu ''and'' [[spoiler:the second Mechagodzilla]] using tissue from [[HalfHumanHybrid the Zmeyevich]] as a telepathic control system with the effect of giving Zmeyevich the potential to control either machine.
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* ''Film/GodzillaVsKong'': [[Characters/MonsterVerseKingGhidorah Mechagodzilla]] looks on the surface like it's purely cybernetic, but it's ultimately revealed to be this trope: the neural transmitter which controls the Mecha's actions is using [[spoiler:the undead, telepathic upper-skull of Ghidorah's leftover severed head]] as its WetwareCPU, and Bernie Hayes furthermore speculates that there's likely a second piece of [[spoiler:Ghidorah's DNA (believed by Bernie in the movie and explicitly stated in the novelization to be a second skull, although neither version of the story explains where the hell a second skull came from [[NotEnoughToBury given the nature of Ghidorah's death]])]] integrated in the actual Mecha to act as the receiver. At first, Mechagodzilla is strictly under its builders' control, but once the Mecha is empowered with untested HollowEarth energy, [[spoiler:what's left of Ghidorah's consciousness re-emerges and takes control of the Mecha for itself]], ironically turning Godzilla's EvilKnockoff into [[spoiler:Godzilla's ArchEnemy [[{{Reincarnation}} reincarnated]] as a RoboticPsychopath]].
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* ''Franchise/PowerRangers'': An occasional occurrence, usually applying to TheStarscream.
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* ''Franchise/PowerRangers'': An occasional occurrence, usually applying to TheStarscream.
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* ''Manga/OnePiece'': In an SBS Oda shows that in a universe where Franky gave up on his dreams, by his 50s he's transformed himself completely into a robot instead of just a regular cyborg.
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mispelled name
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** Beilart Valance, in both ''ComicBook/StarWarsMarvel1977'' and in the new canon, is revealed to be this. Prior to 2018, the assumption was that he was a human with replaced parts.
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** Beilart Beilert Valance, in both ''ComicBook/StarWarsMarvel1977'' and in the new canon, is revealed to be this. Prior to 2018, the assumption was that he was a human with replaced parts.
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* ''Anime/GalaxyExpress999''. Humans can put their minds in machine bodies, to achieve a form of immortality. It is very much a case of CyberneticsEatYourSoul. Some people, realizing this, or tiring of immortality, can return to their human bodies, which are stored on Pluto in the Graves of Ice.
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* ''Anime/GalaxyExpress999''. ''Manga/GalaxyExpress999'': Humans can put their minds in machine bodies, to achieve a form of immortality. It is very much a case of CyberneticsEatYourSoul. Some people, realizing this, or tiring of immortality, can return to their human bodies, which are stored on Pluto in the Graves of Ice.
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* ''Manga/BattleAngelAlita'': Many cyborgs are little more than a head on a cyborg body, including the titular character. [[spoiler: Citizens of Zalem are often the inverse, their brains replaced with a chip in an otherwise organic body.]] Akita herself is a particularly extreme example, where as a child the only part of her that was organic was her head. As a young adult, only her brain was organic - and in ''Last Order'', Nova points out that her glial cells have been replaced with a polymer resin that can harden instantly to protect the brain from sudden shock or heat. Only her neurons are organic - less than 3% of her brain. [[spoiler:Eventually, even that 3% is [[FullConversionCyborg replaced with cybernetics]], though she remains human in her consciousness at least.]]
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* ''Manga/BattleAngelAlita'': Many cyborgs are little more than a head on a cyborg body, including the titular character. [[spoiler: Citizens of Zalem are often the inverse, their brains replaced with a chip in an otherwise organic body.]] Akita herself is a particularly extreme example, where as a child the only part of her that was organic was her head. As a young adult, only her brain was organic - and in ''Last Order'', Nova points out that her glial cells have been replaced with a polymer resin that can harden instantly to protect the brain from sudden shock or heat. Only her neurons are organic - less than 3% of her brain. [[spoiler:Eventually, even that 3% is [[FullConversionCyborg replaced with cybernetics]], cybernetics, though she remains human in her consciousness at least.]]
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* ''Manga/BattleAngelAlita'': Many cyborgs are little more than a head on a cyborg body, including the titular character. [[spoiler: Citizens of Zalem are often the inverse, their brains replaced with a chip in an otherwise organic body.]] Akita herself is a particularly extreme example, where As a child the only part of her that was organic was her head. As a young adult, only her brain was organic - and in Last Order, Nova points out that her glial cells have been replaced with a polymer resin that can harden instantly to protect the brain from sudden shock or heat. Only her neurons are organic - less than 3% of her brain. [[spoiler:Eventually, even that 3% is replaced with cybernetics, though she remains human in her consciousness at least.]]
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* ''Manga/BattleAngelAlita'': Many cyborgs are little more than a head on a cyborg body, including the titular character. [[spoiler: Citizens of Zalem are often the inverse, their brains replaced with a chip in an otherwise organic body.]] Akita herself is a particularly extreme example, where As as a child the only part of her that was organic was her head. As a young adult, only her brain was organic - and in Last Order, ''Last Order'', Nova points out that her glial cells have been replaced with a polymer resin that can harden instantly to protect the brain from sudden shock or heat. Only her neurons are organic - less than 3% of her brain. [[spoiler:Eventually, even that 3% is [[FullConversionCyborg replaced with cybernetics, cybernetics]], though she remains human in her consciousness at least.]]
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* ''Manga/BattleAngelAlita'': Many cyborgs are little more than a head on a cyborg body, including the titular character. [[spoiler: Citizens of Zalem are often the inverse, their brains replaced with a chip in an otherwise organic body.]]
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* ''Manga/BattleAngelAlita'': Many cyborgs are little more than a head on a cyborg body, including the titular character. [[spoiler: Citizens of Zalem are often the inverse, their brains replaced with a chip in an otherwise organic body.]] Akita herself is a particularly extreme example, where As a child the only part of her that was organic was her head. As a young adult, only her brain was organic - and in Last Order, Nova points out that her glial cells have been replaced with a polymer resin that can harden instantly to protect the brain from sudden shock or heat. Only her neurons are organic - less than 3% of her brain. [[spoiler:Eventually, even that 3% is replaced with cybernetics, though she remains human in her consciousness at least.]]
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* ''Manga/PandoraInTheCrimsonShellGhostUrn'': The main character Nene is noted to be one among the few people in the world to use a full body prosthetic, in her case in order to deal with a nasty disease that was eating away at her original body. Clarion is another one who is similarly almost fullt mechanical but seems to take the robotic aspects even further. They look mostly human, just with some obvious joints.