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[[folder: Film - Live Action]]

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** Subverted with Sunny. Everyone thought she was disabled or deformed - her eyes are the wrong colour, she's too small, she doesn't have a stinger tail, and she just looks off - but she isn't. She's just a hybrid. Her father was [[spoiler:a [=NightWing=].]]

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** Subverted with Sunny. Everyone thought she was disabled or deformed - -- her eyes are the wrong colour, she's too small, she doesn't have a stinger tail, and she just looks off - -- but she isn't. She's just a hybrid. Her father was [[spoiler:a [=NightWing=].]]



* In ''WesternAnimation/MiloMurphysLaw,'' the title character and all the men in his family suffer from a HereditaryCurse that makes them BornUnlucky and TheJinx. This is presented as if it were a sort of weird medical condition, with the whole family having CrazyPrepared habits to deal with it.

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* In ''WesternAnimation/MiloMurphysLaw,'' ''WesternAnimation/MiloMurphysLaw'', the title character and all the men in his family suffer from a HereditaryCurse that makes them BornUnlucky and TheJinx. This is presented as if it were a sort of weird medical condition, with the whole family having CrazyPrepared habits to deal with it.
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** In Tuuri's flashback to her childhood settlement that wouldn't let the non-immune come and go freely, her combination of wanderlust and lack of immunity play out like a DreamCrushingHandicap.
** Tuuri and Reynir need to wear breathing masks when they venture too far from the tank.

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** In Tuuri's flashback to her childhood settlement that wouldn't let the non-immune come and go freely, her combination of wanderlust and lack of immunity play plays out like a DreamCrushingHandicap.
** Tuuri and Reynir need to wear breathing masks when they venture too far from the tank.tank, while the immune members of the crew can walk around without them.
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* In ''WesternAnimation/MiloMurphysLaw,'' the title character and all the men in his family suffer from a HereditaryCurse that makes them BornUnlucky and TheJinx. This is presented as if it were a sort of weird medical condition, with the whole family having CrazyPrepared habits to deal with it.
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[[folder:Anime & Manga]]
* Reki from ''Anime/HaibaneRenmei'' was born with [[spoiler:grey wings]] instead of [[spoiler:the normal white]] due to [[spoiler:being stuck in a Circle of Sin]]. This left her [[AllOfTheOtherReindeer ostrasized by others]]. She [[HideYourOtherness hides this]] deformity by [[spoiler:dyeing her wings]].
[[/folder]]
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** Starflight doesn't have the normal [=NightWing=] powers like being able to read other's minds. This is due [[spoiler:to him being hatched in a cave instead of in the light of the moons]].
** Subverted with Sunny. Everyone thought she was disabled or deformed - her eyes are the wrong colour, she's too small, she doesn't have a stinger tail, and she just looks off - but she isn't. She's just a hybrid. Her father was [[spoiler:a [=NightWing=].]]

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* The ''Literature/HarryPotter'' books treat [[OurWerewolvesAreDifferent lycanthropy]] like this. Lupin regularly takes medication to alleviate the worst effects of his condition and required extensive accommodations during his school years. When his wife becomes pregnant, he worries "WhatIfTheBabyIsLikeMe"

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* The ''Literature/HarryPotter'' books treat [[OurWerewolvesAreDifferent lycanthropy]] like this. Lupin regularly takes medication to alleviate the worst effects of his condition and required extensive accommodations during his school years. When his wife becomes pregnant, he worries "WhatIfTheBabyIsLikeMe""WhatIfTheBabyIsLikeMe".
* ''Literature/WingsOfFire'':
** Peril is a [=SkyWing=] born with a condition called "firescales". This means that she was born with too much fire in her body. Touching her causes burning and she can kill others if they hold her for too long. She needs to eat coal every day to survive. [[spoiler:That is actually a lie that her queen told her in order to make her more subservient to her]].
** Peril's twin brother was born with the opposite problem. He had too little fire in his body. He was killed not soon after being hatched.
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** The Dagrenning program in Iceland exists to let non-immune parents have children that are The Immune.
** In Tuuri's flashback to her childhood settlement that wouldn't let the non-immune come and go freely, her combination of wanderlust and lack of immunity play out like a Dream-Crushing Handicap.

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** The Dagrenning program in Iceland exists to let non-immune parents have children that are The Immune.
TheImmune.
** In Tuuri's flashback to her childhood settlement that wouldn't let the non-immune come and go freely, her combination of wanderlust and lack of immunity play out like a Dream-Crushing Handicap.DreamCrushingHandicap.
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* ''Webcomic/StandStillStaySilent'': Lack of immunity to the [[ThePlague Rash]] sometimes gets treated like a disability.
** The Dagrenning program in Iceland exists to let non-immune parents have children that are The Immune.
** In Tuuri's flashback to her childhood settlement that wouldn't let the non-immune come and go freely, her combination of wanderlust and lack of immunity play out like a Dream-Crushing Handicap.
** Tuuri and Reynir need to wear breathing masks when they venture too far from the tank.
** Tuuri and Reynir can't be left alone without an immune person for protection, and taking that role has been outright referred to as "baby-sitting" on two separate occasions.
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* Gems from ''WesternAnimation/StevenUniverse'' are an artificially created for specific purposes in their FantasticCasteSystem. At times however, the circumstances of their "birth" leave them with various defects of deformities, giving them different body-types and even differences in their powers, abilities and mindsets. These types of gems are referred to as "Off-Color." Due to the strict caste system, these gems are usually discarded, persecuted and even exterminated.

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* Gems from ''WesternAnimation/StevenUniverse'' are an artificially created for specific purposes in their FantasticCasteSystem. At times however, the circumstances of their "birth" leave them with various defects of deformities, giving them different body-types and even differences in their powers, abilities and mindsets. These types of gems are referred to as "Off-Color." Due to the strict caste system, these gems are usually discarded, persecuted and even exterminated.exterminated:

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* ''Webcomic/SlightlyDamned'': Buwaro's birth defect, which makes him psychologically and physiologically different from normal demons. [[spoiler:He's naturally always in a Berzerk State. His necklace is what keeps him in check.]]

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* ''Webcomic/SlightlyDamned'': ''Webcomic/SlightlyDamned'':
**
Buwaro's birth defect, which makes him psychologically and physiologically different from normal demons. [[spoiler:He's naturally always in a Berzerk State. His necklace is what keeps him in check.]]



* Scootaloo from ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' is a downplayed example. She's a pegasus filly who can't fly, even though her classmates can, but the show is deliberately vague about whether Scootaloo is permanently disabled or just a late bloomer.
* Tempest Shadow from ''WesternAnimation/MyLittlePonyTheMovie2017'' has a broken horn as a result of an accident as a filly. While it doesn’t negate her ability to use magic entirely, her magic is erratic and unfocused compared to a unicorn with a full horn.

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* ''WesternAnimation/MyLittlePonyFriendshipIsMagic'':
**
Scootaloo from ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' is a downplayed example. She's a pegasus filly who can't fly, even though her classmates can, but the show is deliberately vague about whether Scootaloo is permanently disabled or just a late bloomer.
* ** Tempest Shadow from ''WesternAnimation/MyLittlePonyTheMovie2017'' has a broken horn as a result of an accident as a filly. While it doesn’t negate her ability to use magic entirely, her magic is erratic and unfocused compared to a unicorn with a full horn.
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* The ''Literature/HarryPotter'' books treat [[OurWerewolvesAreDifferent lycanthropy]] like this. Lupin regularly takes medication to alleviate the worst effects of his condition and required extensive accommodations during his school years. When his wife becomes pregnant, he worries "WhatIfTheBabyIsLikeMe"
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None

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* Asher Mir in ''VideoGame/Destiny2'' had one of his arms and his Ghost converted into Vex technology after encountering the Vex Axis Mind Brakion in the Pyramidion on Io. Being a Guardian the process hasn't been as devastating as it could be, but his Vex arm seems to be fairly useless and is constantly curled against his torso, his Ghost is nowhere to be seen and is implied to have been absorbed into the greater Vex consensus, and he's even started to bleed Vex radiolaran fluid. It's not a matter of if his incomplete conversion is going to permanently kill him, but when.
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* Tempest Shadow from ‘’WesternAnimationMyLittlePonyTheMovie2017’’ has a broken horn as a result of an accident as a filly. While it doesn’t negate her ability to use magic entirely, her magic is erratic and unfocused compared to a unicorn with a full horn.

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* Tempest Shadow from ‘’WesternAnimationMyLittlePonyTheMovie2017’’ ''WesternAnimation/MyLittlePonyTheMovie2017'' has a broken horn as a result of an accident as a filly. While it doesn’t negate her ability to use magic entirely, her magic is erratic and unfocused compared to a unicorn with a full horn.
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None

Added DiffLines:

* Tempest Shadow from ‘’WesternAnimationMyLittlePonyTheMovie2017’’ has a broken horn as a result of an accident as a filly. While it doesn’t negate her ability to use magic entirely, her magic is erratic and unfocused compared to a unicorn with a full horn.
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* Everyone in ''VideoGame/WeHappyFew'' is required to take Joy, a FantasticDrug that elevates mood and suppresses memories of [[NoodleIncident The Very Bad Thing]] that traumatized the entire city, Wastrels are immune to Joy's positive effects, and taking the drug only makes their mental issues worse.

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* Everyone in ''VideoGame/WeHappyFew'' is required to take Joy, a FantasticDrug that elevates mood and suppresses memories of [[NoodleIncident The Very Bad Thing]] that traumatized the entire city, city. Wastrels are immune to Joy's positive effects, and taking the drug only makes their mental issues worse.

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[[folder: Fanfic]]

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[[folder:Comic Books]]
* Due to a childhood illness, ComicBook/{{Starfire}}'s sister Blackfire is the only member of her species who can't absorb ultraviolet radiation. This leaves her unable to fly.
[[/folder]]

[[folder: Fanfic]]Fan Works]]
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* Tavi, the main character of ''Literature/CodexAlera'', is unable to furycraft when every single other human in the world can. [[spoiler: This turns out to be a result of his mother stunting his abilities to avoid people realizing he's the heir to the throne. Given a few years to recover, he quickly gains enough power to make him a PersonOfMassDestruction.]]
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* Tavi, the main character of ''Literature/CodexAlera'', is unable to furycraft when every single other human in the world can. [[spoiler: This turns out to be a result of his mother stunting his abilities to avoid people realizing he's the heir to the throne. Given a few years to recover, he quickly gains enough power to make him a PersonOfMassDestruction.]]
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* Maria Robotnik from ''Franchise/SonicTheHedgehog'' was an IllGirl who was dying from Neuro-Immune Deficiency Syndrome (NIDS), though her actual death was caused by being shot. NIDS weakens both the nervous system and the immune system. The disease has similar side effects to AIDS.
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* In ''Literature/TheLaundryFiles'', Krantzberg syndrome is the result of attempting to do magic using one's brain (instead of something like a [[MagicFromTechnology smartphone or desktop computer]]). It's caused by [[EldritchAbomination Eldritch Abominations]] literally eating away at the brains of such people, producing symptoms similar to dementia or Alzheimer's.

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* In ''VideoGame/{{Overwatch}}'', Tracer was displaced in time by an experimental aircraft she was test-piloting. She must wear (or at least be nearby) a device called a chronological accelerator to avoid simply fading out of existence. While this leaves her CursedWithAwesome (since it gives her the ability to teleport around or reverse time), it leaves her with a glaring weakness (as Doomfist demonstrated in his trailer when he damaged the accelerator and left Tracer to start uncontrollably shifting through time).

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* In ''VideoGame/{{Overwatch}}'', ''VideoGame/{{Overwatch}}'':
**
Tracer was displaced in time by an experimental aircraft she was test-piloting. She must wear (or at least be nearby) a device called a chronological accelerator to avoid simply fading out of existence. While this leaves her CursedWithAwesome (since it gives her the ability to teleport around or reverse time), it leaves her with a glaring weakness (as Doomfist demonstrated in his trailer when he damaged the accelerator and left Tracer to start uncontrollably shifting through time).time).
** Bastion has a robotic analogue to PTSD, in that [[TraumaButton anything that reminds it]] of the [[RobotWar Omnic Crisis]] causes it to revert to its KillerRobot programming (notably in the "The Last Bastion" short, the machine-gun like sound of a woodpecker causes it to panic and destroy a large amount of trees with its minigun). Slightly different to PTSD in humans, in that its caused by what remains of Bastion's original programming, rather than a trauma induced trigger.
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* In ''TabletopGame/{{Pathfinder}}'', [[OurGnomesAreWeirder gnomes]] originate from fae spirits of the [[LandOfFaerie First World]] and never completely acclimated to the mundane world. If they don't maintain a certain level of whimsy and excitement in their lives, they begin to suffer "the Bleaching", a fatal degenerative condition where their bodies fade to stark white as their minds fall apart. A rare few survive the experience and are [[DisabilitySuperpower rewarded with]] DissonantSerenity and [[TheAgeless agelessness]].
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* In ''VideoGame/TheElderScrollsIVOblivion'', "Stunted Magicka" is a condition that prevents people from regenerating their {{Mana}} reserves naturally, instead forcing them to absorb it from outside sources. It can be congenital, notably for those born under the Atronach [[FictionalZodiac star sign]], but can also be inflicted by a magical disease.
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** Buwaro's adoptive sister Sakido is a [[AirborneMook wind demon]] who's wings were crippled [[spoiler:in an angel attack that also left her an [[MissingMom orphan]]]], she was completely flightless until [[spoiler:Darius gave her his [[AmuletOfConcentratedAwesome Sun]] [[PowerGivesYouWings Pendant]] which repaired her wings and even made them larger.]]
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* The beginning of the {{Cyberpunk}} novel ''Literature/{{Neuromancer}}'' describes protagonist Case as a once-talented computer hacker who was rendered unable to access [[{{Cyberspace}} virtual cyberspace networks]], after his central nervous system was damaged with a mycotoxin as punishment for stealing from his employers. An offer Case receives to fix this damage is what sets the rest of the story's plot in motion.

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* The beginning of the {{Cyberpunk}} novel ''Literature/{{Neuromancer}}'' describes the protagonist Case as a once-talented computer hacker who was rendered unable to access [[{{Cyberspace}} virtual cyberspace networks]], networks]] after his central nervous system was damaged with a mycotoxin as punishment for stealing from his employers. An offer Case receives to fix this damage is what sets the rest of the story's plot in motion.



* Webcomic/SlightlyDamned: Buwaro's birth defect, making him psycho / physio-logically different from normal demons. [[spoiler:He's naturally always in a Berzerk State. His necklace is what keeps him in check.]]

to:

* Webcomic/SlightlyDamned: ''Webcomic/SlightlyDamned'': Buwaro's birth defect, making which makes him psycho / physio-logically psychologically and physiologically different from normal demons. [[spoiler:He's naturally always in a Berzerk State. His necklace is what keeps him in check.]]
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None

Added DiffLines:

* The beginning of the {{Cyberpunk}} novel ''Literature/{{Neuromancer}}'' describes protagonist Case as a once-talented computer hacker who was rendered unable to access [[{{Cyberspace}} virtual cyberspace networks]], after his central nervous system was damaged with a mycotoxin as punishment for stealing from his employers. An offer Case receives to fix this damage is what sets the rest of the story's plot in motion.
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[[folder: Live Action Television]]

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[[folder: Live Action Live-Action Television]]



* In ''VideoGame/DeusExHumanRevolution'', the inventor of cybernetics, Hugh Darrow, has a rare condition that causes his body to reject any cybernetics all together (most people's bodies reject them to some degree, but this can be [[PhlebotinumPills controlled with medication]]). This means that he must walk with a cane. [[spoiler: His bitterness over this is why he takes part in the EvilPlan to turn the public against cybernetics.]]
* In ''VideoGame/{{Overwatch}}'', Tracer was displaced in time by an experimental aircraft she was test-piloting. She must wear (or at least be nearby) a device called a chronological accelerator to avoid simply fading out of existence. While this leaves her CursedWithAwesome (since it gives her the ability to teleport around or reverse time), it leaves her with a glaring weakness (as Doomfist demonstrated in his trailer).

to:

* In ''VideoGame/DeusExHumanRevolution'', the inventor of cybernetics, Hugh Darrow, has a rare condition that causes his body to altogether reject any cybernetics all together (most people's bodies reject them to some degree, but this can be [[PhlebotinumPills controlled with medication]]). This means that he must walk with a cane. [[spoiler: His bitterness over this is why he takes part in the EvilPlan to turn the public against cybernetics.]]
* In ''VideoGame/{{Overwatch}}'', Tracer was displaced in time by an experimental aircraft she was test-piloting. She must wear (or at least be nearby) a device called a chronological accelerator to avoid simply fading out of existence. While this leaves her CursedWithAwesome (since it gives her the ability to teleport around or reverse time), it leaves her with a glaring weakness (as Doomfist demonstrated in his trailer).trailer when he damaged the accelerator and left Tracer to start uncontrollably shifting through time).






* Scootaloo from ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' is a downplayed example. She's a pegasus filly who can't fly, even though her classmates can. But the show is deliberately vague about whether Scootaloo is permanently disabled, or just a late bloomer.

to:

* Scootaloo from ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' is a downplayed example. She's a pegasus filly who can't fly, even though her classmates can. But can, but the show is deliberately vague about whether Scootaloo is permanently disabled, disabled or just a late bloomer.
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* ''TabletopGame/{{Warhammer}}'': Teclis is the greatest mage the Elves have ever produced (and one of the greatest mages in world history). He is also a ''ridiculously'' SquishyWizard, requiring healing potions just to stay alive, and having a limp uncurable by magic. By contrast, his brother Tyrion is an unpeered swordmaster.

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* ''TabletopGame/{{Warhammer}}'': Teclis is the greatest mage the Elves have ever produced (and one of the greatest mages in world history). He is also a ''ridiculously'' SquishyWizard, requiring healing potions just to stay alive, and having a limp uncurable incurable by magic. By contrast, his brother Tyrion is an unpeered swordmaster.



* ''VideoGame/KidIcarus'': Pit has the classic [[WingsDoNothing "flying being that cannot fly" disability]] for some unexplained reason. It's quite the sore spot for him. In ''VideoGame/KidIcarusUprising'', Palutena can grant Pit the Power of Flight to guide him places as if he were flying, but not for more than five minutes at a time, or else Pit's wings will come aflame. By contrast, his EvilKnockoff Dark Pit gained limitless flight under his own power by slaying Pandora and plundering her powers [[spoiler: until he traveled to the Rewind Spring, where Pandora revived herself from said powers]].

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* ''VideoGame/KidIcarus'': Pit has the classic [[WingsDoNothing "flying being that cannot fly" disability]] for some unexplained reason. It's quite the sore spot for him. In ''VideoGame/KidIcarusUprising'', Palutena can grant Pit the Power of Flight to guide him places as if he were flying, but not for more than five minutes at a time, or else Pit's wings will come aflame. By contrast, his EvilKnockoff Dark Pit gained limitless flight under his own power by slaying Pandora and plundering her powers [[spoiler: until he traveled travelled to the Rewind Spring, where Pandora revived herself from said powers]].



* In ''WesternAnimation/BatmanTheAnimatedSeries, Baby Doll suffers from "systemic hypoplasia"[[note]]Real medical terminology for a non-existent condition (hypoplasia is when someone is born with an organ that isn't properly developed)[[/note]], [[NotGrowingUpSucks meaning that she can never grow]], and resembles a little girl despite being well into adulthood.

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* In ''WesternAnimation/BatmanTheAnimatedSeries, ''WesternAnimation/BatmanTheAnimatedSeries'', Baby Doll suffers from "systemic hypoplasia"[[note]]Real medical terminology for a non-existent condition (hypoplasia is when someone is born with an organ that isn't properly developed)[[/note]], [[NotGrowingUpSucks meaning that she can never grow]], grow up]], and resembles a little girl despite being well into adulthood.

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Indices:
* {{Indexitis}}
* OthernessTropes
* ThisIndexHasHadAHardLife
* DisabilityTropes

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Created from YKTTW

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Indices:
* {{Indexitis}}
* OthernessTropes
* ThisIndexHasHadAHardLife
* DisabilityTropes

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This trope covers characters who have some sort of disability that doesn't exist in the real world. This can include, but is by no means limited to:

# Some sort of illness triggered by or connected to magic or technology that doesn't exist in the real world (much in the same way that electronic devices with flashing lights can trigger epilepsy or sensory overload in people who would likely never have had to worry about such things before they existed). For example, an allergy to GreenRocks, PhlebotinumPills, or SuperSerum.
# [[WoundThatWillNotHeal Injuries and deformities that are aggravated or caused by magic or technology]], preventing the magic or technology of the setting from healing them (e.g. a character who was mauled by a creature whose wounds cannot be healed with magic, or a character who lost a leg to an illness which prevents her from having a new one cloned).
# Difficulty learning to use magic or technology in the setting (when it's explicitly because of some sort of disability, rather than the character just being uninterested or never being given the option of doing so), being treated something like dyslexia and other learning disorders.
# Disabilities in non-humans with BizarreAlienBiology.
# Any fantastical condition which inhibits the character (e.g. not having a shadow; infestations of fictional germs or parasites).

This can still include conditions that end up being a DisabilitySuperpower or DisabilityImmunity, as long as the condition itself is still debilitating.

This trope can be used as a way to write disabled characters in settings which have magic or technology which would otherwise fix it, or to explore the social consequences of the magic and technology existing (although this can lead to a SpaceWhaleAesop; "Don't invent faster computers or people will lose the ability to eat plant matter!"). {{Cyberpunk}} and other social science fiction settings love using both variations, since including characters who can't benefit from the technology is a fascinating way of analysing its effect on society.

SuperTrope to UnSorcerer, whose disability is the lack of a setting's ubiquitous super powers and ScienceRelatedMemeticDisorder (where being a MadScientist is treated as a disorder) -- examples of both belong on their respective pages. Compare KryptoniteFactor and PowerIncontinence, which can be combined with this trope and NeurodiversityIsSupernatural, where mental disorders are given fictional supernatural origins.

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!!Examples:

[[foldercontrol]]

[[folder: Fanfic]]
* ''FanFic/ScootalooAndTheCabinetOfSeers'': Scootaloo worries so much about her possibly being never able to fly, she wants Twilight to consult the greatest {{Seer}}s of their world about it.
* ''Fanfic/OversaturatedWorld'': In ''[[https://www.fimfiction.net/story/323071/2/group-precipitation/launch-error-by-fome Launch Error]]'', it's shown that Human!Scootaloo can't fly even when she gets the magical wings that let other Pegasus Aspects fly.
* ''Fanfic/SpellboundFireflies'': Scootaloo can't fly like other pegasi 'cause she was never taught how until Rainbow Dash teaches her.
* ''Fanfic/TriptychContinuum'': In [[Recap/TriptychContinuumScootalift Scootalift]], Snowflake diagnoses Scootaloo with being a slow / late developer, so she will take longer than other pegasi to be able to fly.
* ''FanFic/RainbowFactory'': Scootaloo, Orion, and Aurora all fail their final flight test and get sent into the Pegasus Device, which [[spoiler:kills them to make rainbows]], just like all other weak fliers that fail the final test, like Fluttershy and Derpy.
[[/folder]]

[[folder: Film - Live Action]]
* In ''Film/StarTrekIITheWrathOfKhan'' Kirk has to wear antique reading glasses, because he's allergic to the drug that most people take to correct their vision.
[[/folder]]

[[folder: Live Action Television]]
* The ''Series/DeepSpaceNine'' episode "Melora" featured the eponymous character being from a planet with very low gravity. Most Elaysians never leave their homeworld for this reason. Melora adapting to "standard" gravity requires a special chair. It's treated as if it were a disability. She starts treatment that would make it possible for her to function completely normally in standard gravity, but decides not to go through with it as it means she'd never be able to return to her homeworld.
[[/folder]]

[[folder: Literature]]
*''Literature/{{Animorphs}}''
** In the novel "The Other", an Andalite named Mertil suffers from a condition that makes him unable to use the morphing technology, and his friend Gafinilan suffers from a painful disease known as Soola's Disease, which can only be gotten rid of by acquiring and morphing another Andalite.
** In "The Reaction", Rachel is revealed to have an allergy to her alligator morph, which causes her to morph uncontrollably whenever she experiences any strong emotions. She gets better by the end of the novel, though.
** In "The Proposal", Marco's emotional issues revolving around his dad deciding to marry his math teacher causes him to morph into freakish animal hybrids, such as a salmon with gorilla arms or a skunk/spider hybrid. Similarly, he gets better by the end.
* In ''Literature/TheCaseOfTheToxicSpellDump'', exposure to the magic equivalent of toxic waste can cause infants to be born without a soul and apparently simply stop existing after death--no afterlife, no nothing. The condition is called "apsychia", and is considered a birth defect; the protagonist meets a medical researcher who is working on an experimental procedure in which tiny pieces of many souls are fused into, essentially, a synthetic soul which can then be implanted in the apsychic child. Whether this will actually work is still unclear.
* On ''Literature/{{Discworld}}'' a yennork is a werewolf with permanent ShapeshifterModeLock as either a wolf or a human. This doesn't mean they ''are'' a wolf or a human, just a werewolf without the "switch".
[[/folder]]

[[folder: Tabletop Game]]
* ''TabletopGame/{{Warhammer}}'': Teclis is the greatest mage the Elves have ever produced (and one of the greatest mages in world history). He is also a ''ridiculously'' SquishyWizard, requiring healing potions just to stay alive, and having a limp uncurable by magic. By contrast, his brother Tyrion is an unpeered swordmaster.
[[/folder]]

[[folder: Video Games]]
* In ''VideoGame/DeusExHumanRevolution'', the inventor of cybernetics, Hugh Darrow, has a rare condition that causes his body to reject any cybernetics all together (most people's bodies reject them to some degree, but this can be [[PhlebotinumPills controlled with medication]]). This means that he must walk with a cane. [[spoiler: His bitterness over this is why he takes part in the EvilPlan to turn the public against cybernetics.]]
* In ''VideoGame/{{Overwatch}}'', Tracer was displaced in time by an experimental aircraft she was test-piloting. She must wear (or at least be nearby) a device called a chronological accelerator to avoid simply fading out of existence. While this leaves her CursedWithAwesome (since it gives her the ability to teleport around or reverse time), it leaves her with a glaring weakness (as Doomfist demonstrated in his trailer).
* In ''Franchise/MassEffect'', Ardat-Yakshi is a genetic condition that causes the Asari's inherent mental abilities to kill anyone they mate with. Diagnosed Asari are either LockedAwayInAMonastery or executed because there is no cure for the condition, Ardat-Yakshi quickly get addicted to the sensation of killing their mates, and the worst-case scenario for an uncontrolled Ardat-Yakshi is a SerialKiller who roams the galaxy gleefully seducing and murdering everyone she can.
* The AcePilot Rena Hirose from ''VideoGame/AceCombat3Electrosphere'' suffers from the "Silverstone disease", meaning that her skins lacks any protection from UV sunlight radiation whatsoever. As a result, the only way she has to be outside during daytime is inside the fully-enclosed cockpit of her plane.
* In ''VideoGame/{{Runescape}}'', the [[RockMonster volcano-dwelling]] [=TzHaar=] sometimes hatch stunted "Ga'al" when their eggs become too cool: lacking [=TzHaar=] {{Genetic Memor|y}}ies, they have no [[FantasticCasteSystem caste]] and cannot communicate, so the [=TzHaar=] send them to die in honorable combat to speed them to their next {{reincarnation}}. One quest reveals, to some [=TzHaar=]'s [[MyGodWhatHaveIDone horror]], that the Ga'al are actually very precocious learners if anyone bothers to ''teach'' them.
* Everyone in ''VideoGame/WeHappyFew'' is required to take Joy, a FantasticDrug that elevates mood and suppresses memories of [[NoodleIncident The Very Bad Thing]] that traumatized the entire city, Wastrels are immune to Joy's positive effects, and taking the drug only makes their mental issues worse.
* ''VideoGame/KidIcarus'': Pit has the classic [[WingsDoNothing "flying being that cannot fly" disability]] for some unexplained reason. It's quite the sore spot for him. In ''VideoGame/KidIcarusUprising'', Palutena can grant Pit the Power of Flight to guide him places as if he were flying, but not for more than five minutes at a time, or else Pit's wings will come aflame. By contrast, his EvilKnockoff Dark Pit gained limitless flight under his own power by slaying Pandora and plundering her powers [[spoiler: until he traveled to the Rewind Spring, where Pandora revived herself from said powers]].
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[[folder:Web Comic]]
* In ''Webcomic/AlwaysHuman'', Austen has "Egan's Syndrome", an autoimmune condition that leaves her unable to use the BioAugmentation mods that are ubiquitous in the setting. Being ineligible for mods like memory boosters and physical augments forces her to put a lot of extra work into her studies and her health, and being thought of as InspirationallyDisadvantaged is a major pet peeve for her.
* Webcomic/SlightlyDamned: Buwaro's birth defect, making him psycho / physio-logically different from normal demons. [[spoiler:He's naturally always in a Berzerk State. His necklace is what keeps him in check.]]
* Snippy from ''Webcomic/RomanticallyApocalyptic'' is one of the 1% of people that the neural network that controls sleep can't connect to. Instead of browsing the web during his sleep he instead gets horrifying nightmares and is chronically sleep-deprived, as he can't afford to ''purchase'' more sleep with the money from his dead-end job.
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[[folder:Web Original]]
* ''Literature/WhateleyUniverse'': Roulette gets occasional burnouts, which is where the body cooks itself due to overuse of its mutant powers every once in a while, and each one changes her powers.
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[[folder:Western Animation]]
* Scootaloo from ''WesternAnimation/MyLittlePonyFriendshipIsMagic'' is a downplayed example. She's a pegasus filly who can't fly, even though her classmates can. But the show is deliberately vague about whether Scootaloo is permanently disabled, or just a late bloomer.
* Gems from ''WesternAnimation/StevenUniverse'' are an artificially created for specific purposes in their FantasticCasteSystem. At times however, the circumstances of their "birth" leave them with various defects of deformities, giving them different body-types and even differences in their powers, abilities and mindsets. These types of gems are referred to as "Off-Color." Due to the strict caste system, these gems are usually discarded, persecuted and even exterminated.
** Amethysts are quartz gems designed to be tall, buff intimidating soldiers. Amethyst from the Crystal Gems however did not finishing forming until long after the others, coming out just barely half the height of what an amethyst should be. This also applies to the various quartz gems at the zoo, such as Skinny and Carnelian. It is implied through Peridot's observation of the Beta kindergarten on Earth that many of the gems there were created under lax conditions in a hurry due to the war.
** Peridot is an era 2 peridot created under an environment where resources in creating gems on homeworld have dwindled. This is the explanation for why Peridot lacks many of the powers associated with gems (shapeshifting, super strength etc.) and possibly for her short stature. To compensate, era 2 peridots are equipped with technological limb enhancers. [[spoiler: Although it turns out that Peridot, at least, also has [[ExtraOreDinary ferrokinetic powers]].]]
** Sapphires are short aristocratic gems with the power to see ahead into the future (or at least a probable future). Padparadscha is an off-color sapphire who possesses retrocognition, blurting out events that have already happened. She lives on the run with the other Off-Colors in the long abandoned Homeworld kindergarten.
* In ''WesternAnimation/BatmanTheAnimatedSeries, Baby Doll suffers from "systemic hypoplasia"[[note]]Real medical terminology for a non-existent condition (hypoplasia is when someone is born with an organ that isn't properly developed)[[/note]], [[NotGrowingUpSucks meaning that she can never grow]], and resembles a little girl despite being well into adulthood.
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