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Yeah, I forgot that the guy who changed his mind about the Mi-go was just a puppeted corpse.

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* In Creator/HPLovecraft's "Literature/TheWhispererInDarkness" the Mi-Go have a tendency to put [[BrainInAJar brains in jars]] and at least claim they can easily put them back in bodies, not necessarily their original ones.
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This may be the case somewhere in the expanded universe/mythos, but it's not in the actual original story.


* In Creator/HPLovecraft's "Literature/TheWhispererInDarkness" the Mi-Go have a tendency to put [[BrainInAJar brains in jars]] and can easily put them back in bodies, not necessarily their original ones. [[spoiler:Even brains of their species in human bodies.]]
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* In Creator/HPLovecraft's "The Whisperer in Darkness" the Mi-Go have a tendency to put [[BrainInAJar brains in jars]] and can easily put them back in bodies, not necessarily their original ones. [[spoiler: Even brains of their species in human bodies.]]

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* In Creator/HPLovecraft's "The Whisperer in Darkness" "Literature/TheWhispererInDarkness" the Mi-Go have a tendency to put [[BrainInAJar brains in jars]] and can easily put them back in bodies, not necessarily their original ones. [[spoiler: Even [[spoiler:Even brains of their species in human bodies.]]
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* ''WesternAnimation/IAmWeasel''. In "I, Architect," an accident results in both Weasel and Baboon having their skulls cracked open and their brains falling out. Because Weasel's brain is so massive and Baboon's is so tiny, the surgeons place the smaller brain into Weasel's smaller head and the large brain into Baboon's larger head. As a result, when awaken, Weasel [[TookALevelInDumbass becomes an idiot]] and the changes he makes to the city are chaotic, whereas Baboon continues to move up in society and plans to stop Weasel from destroying the city with his stupidity.

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* ''WesternAnimation/IAmWeasel''. In "I, Architect," an accident results in both Weasel and Baboon having their skulls cracked open and their brains falling out. Because Weasel's brain is so massive and Baboon's is so tiny, the surgeons place the smaller brain into Weasel's smaller head and the large brain into Baboon's larger head. As a result, when awaken, Weasel [[TookALevelInDumbass becomes an idiot]] and the Baboon (in Weasel's body) starts making all sorts of chaotic changes he makes to the city are chaotic, city, whereas Baboon continues Weasel (in Baboon's body) has to move up in from the bottom of society and plans in order to stop Weasel from destroying the city with his stupidity.Baboon's nonsense.
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* Another film, ''Film/TheAtomicBrain'', deals with an old rich woman who seeks to cheat death by having her brain put into the body of a young, healthy woman. The scientist in charge of doing this does a number of tests on dead bodies, which makes them mindless bodies, but doing so with live bodies works wonders. The woman's plan gets [[SpannerInTheWorks derailed]] due to her initial choice getting mauled, her companion attempting to betray her and the scientist putting her in a ''cat's'' body.
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* ''TabletopGame/Warhammer40K''. One of the reasons ork paindoks are feared is that they occasionally replace a patient's brain with that of a squig, leaving them comatose for a while while they adapt, then leaving them semifunctional zombies only fit to follow the dok's orders.

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* ''TabletopGame/Warhammer40K''.''TabletopGame/Warhammer40000''. One of the reasons ork paindoks are feared is that they occasionally replace a patient's brain with that of a squig, leaving them comatose for a while while they adapt, then leaving them semifunctional zombies only fit to follow the dok's orders.
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* ''Series/OutOfJimmysHead'' has this happen to the eponymous character, using the brain of a MrAltDisney. However, the retention of the [ArtisticLicenseBiology "personality gland"]] lets Jimmy keep everything that's himself.

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* ''Series/OutOfJimmysHead'' has this happen to the eponymous character, using the brain of a MrAltDisney. However, the retention of the [ArtisticLicenseBiology [[ArtisticLicenseBiology "personality gland"]] lets Jimmy keep everything that's himself.
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* ''Series/OutOfJimmysHead'' has this happen to the eponymous character, using the brain of a MrAltDisney. However, the retention of the personality gland" lets Jimmy keep everything that's himself.

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* ''Series/OutOfJimmysHead'' has this happen to the eponymous character, using the brain of a MrAltDisney. However, the retention of the personality gland" [ArtisticLicenseBiology "personality gland"]] lets Jimmy keep everything that's himself.
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* ''Series/DoctorWho'': In "The Return of Doctor Mysterio", the aliens have their brains transplanted into human hosts by a team of scary surgeons.

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* ''Manga/BlackJack'', being a series that applies ToonPhysics to the MedicalDrama genre, unsurprisingly has this on occasion.
** In one notable case he gave an artist who had been painting landscapes on an island during an H-bomb test a new body to save him from radiation poisoning. He died anyway from brain cancer but not before completing one last painting.
** Another chapter had a horse's brain put in a man's body to incriminate his owner's killer.



* ''Manga/BlackJack'', being a series that applies AnimePhysics to the MedicalDrama genre, unsurprisingly has this on occasion.
** In one notable case he gave an artist who had been painting landscapes on an island during an H-bomb test a new body to save him from radiation poisoning. He died anyway from brain cancer but not before completing one last painting.
** Another chapter had a horse's brain put in a man's body to incriminate his owner's killer.
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-->'''Baloney:''' "Now, where did you get the brain of a two-year-old?"
-->'''Dr. Fruitcake:''' "Trust me, Baloney, you don't want to know."

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-->'''Baloney:''' "Now, Now, where did you get the brain of a two-year-old?"
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two-year-old?\\
'''Dr.
Fruitcake:''' "Trust Trust me, Baloney, you don't want to know."



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[[caption-width-right:350:A mind is a terrible thing to cut-and-paste.]]
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* ''Franchise/GhostInTheShell'':
** Brain Transplants in general are quite common in all GITS works, often from one artificial body to another. In [[Anime/GhostInTheShell the movie]] the Major muses that she has no real way of knowing if she even has a brain in her current body.

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* ''Franchise/GhostInTheShell'':
**
''Franchise/GhostInTheShell'': Brain Transplants in general are quite common in all GITS works, often from one artificial body to another. another.
**
In [[Anime/GhostInTheShell the first movie]] the Major muses that she has no real way of knowing if she even has a brain in her current body.



* ''Manga/BlackJack'', being a series that applies AnimePhysics to the MedicalDrama genre, unsurprisingly has this on occasion. In one notable case he gave an artist who had been painting landscapes on an island during an H-bomb test a new body to save him from radiation poisoning. He died anyway from brain cancer but not before completing one last painting.

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* ''Manga/BlackJack'', being a series that applies AnimePhysics to the MedicalDrama genre, unsurprisingly has this on occasion. occasion.
**
In one notable case he gave an artist who had been painting landscapes on an island during an H-bomb test a new body to save him from radiation poisoning. He died anyway from brain cancer but not before completing one last painting.
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Split animated films and live-action films.


[[folder: Film ]]

* At the end of ''Film/TheManWithTwoBrains'', Dr Hfuhruhurr, inventor of "cranial screw-top brain surgery", transplants the BrainInAJar he's been dating into the body of his evil wife.
* This has been a staple of ''Franchise/{{Frankenstein}}'' films ever since the [[Film/{{Frankenstein 1931}} 1931]] film where the monster received the brain of a violent criminal.
* In ''Film/TheGhostOfFrankenstein'' Ygor makes Dr. Frankenstein transplant his (Ygor's) brain into the monster's body so they'll be "together forever." Unfortunately they don't have the same blood type so Ygor!Monster is blind, leading to the eyes closed/arms outstretched shuffle that the Monster is Flanderized into having.
* In ''Film/AbbottAndCostelloMeetFrankenstein'' Dracula's plan involves transplanting Costello's brain into the monster.
* In ''Film/TheBrainThatWouldntDie'', a young, mad scientist's girlfriend is beheaded in a car accident. He takes her head back to his lab and keeps it alive with his mad science. Then he searches for another girl who won't be missed, so he can chop her head off and transplant his girlfriend's head on.

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* At the end of ''Film/TheManWithTwoBrains'', Dr Hfuhruhurr, inventor of "cranial screw-top brain surgery", transplants the BrainInAJar he's been dating into the body of his evil wife.
* This has been a staple of ''Franchise/{{Frankenstein}}'' films ever since the [[Film/{{Frankenstein 1931}} 1931]] film where the monster received the brain of a violent criminal.
* In ''Film/TheGhostOfFrankenstein'' Ygor makes Dr. Frankenstein transplant his (Ygor's) brain into the monster's body so they'll be "together forever." Unfortunately they don't have the same blood type so Ygor!Monster is blind, leading to the eyes closed/arms outstretched shuffle that the Monster is Flanderized into having.
* In ''Film/AbbottAndCostelloMeetFrankenstein'' Dracula's plan involves transplanting Costello's brain into the monster.
* In ''Film/TheBrainThatWouldntDie'', a young, mad scientist's girlfriend is beheaded in a car accident. He takes her head back to his lab and keeps it alive with his mad science. Then he searches for another girl who won't be missed, so he can chop her head off and transplant his girlfriend's head on.
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* Played for laughs in ''Film/YoungFrankenstein''. The monster is supposed to receive the brain of a supersmart person but Igor drops the jar and secretly replaces the brain with one that is marked ''abnormal''. The actual brain transplant is executed in an OffscreenMomentOfAwesome. When the monster awakes, of course it turns out to be a moron.

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* Played for laughs in ''Film/YoungFrankenstein''. The monster is supposed to receive the brain of a supersmart person but Igor drops the jar and secretly replaces the brain with one that is marked ''abnormal''. The actual brain transplant is executed in an OffscreenMomentOfAwesome. When the monster awakes, of course it turns out to be a moron.


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[[folder: Films -- Live-Action ]]

* At the end of ''Film/TheManWithTwoBrains'', Dr Hfuhruhurr, inventor of "cranial screw-top brain surgery", transplants the BrainInAJar he's been dating into the body of his evil wife.
* This has been a staple of ''Franchise/{{Frankenstein}}'' films ever since the [[Film/{{Frankenstein 1931}} 1931]] film where the monster received the brain of a violent criminal.
* In ''Film/TheGhostOfFrankenstein'' Ygor makes Dr. Frankenstein transplant his (Ygor's) brain into the monster's body so they'll be "together forever." Unfortunately they don't have the same blood type so Ygor!Monster is blind, leading to the eyes closed/arms outstretched shuffle that the Monster is Flanderized into having.
* In ''Film/AbbottAndCostelloMeetFrankenstein'' Dracula's plan involves transplanting Costello's brain into the monster.
* In ''Film/TheBrainThatWouldntDie'', a young, mad scientist's girlfriend is beheaded in a car accident. He takes her head back to his lab and keeps it alive with his mad science. Then he searches for another girl who won't be missed, so he can chop her head off and transplant his girlfriend's head on.
* Played for laughs in ''Film/YoungFrankenstein''. The monster is supposed to receive the brain of a supersmart person but Igor drops the jar and secretly replaces the brain with one that is marked ''abnormal''. The actual brain transplant is executed in an OffscreenMomentOfAwesome. When the monster awakes, of course it turns out to be a moron.

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!Examples

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* This has been a staple of ''Film/{{Frankenstein}}'' films ever since the [[Film/{{Frankenstein1931}} 1931]] film where the monster received the brain of a violent criminal.

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* This has been a staple of ''Film/{{Frankenstein}}'' ''Franchise/{{Frankenstein}}'' films ever since the [[Film/{{Frankenstein1931}} [[Film/{{Frankenstein 1931}} 1931]] film where the monster received the brain of a violent criminal.
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** Another chapter had a horse's brain put in a man's body to incriminate his owner's killer.
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* In the first episode of ''Anime/GhostInTheShellStandAloneComplex'' a politician attempted to swap his cyberbrain (a brain enclosed in cybernetics, as common as cell phones) into a waitress gynoid, but a foreign agent instead put his own brain in the politician's body and tried to smuggle the politician's brain out of the country in a suitcase. And they did that all in a restaurant men's room.
** Brain Transplants in general are quite common in all renditions of GhostInTheShell, often from one artificial body to another. In [[Anime/GhostInTheShell the movie]] the Major muses that she has no real way of knowing if she even has a brain in her current body.

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* In the first episode of ''Anime/GhostInTheShellStandAloneComplex'' a politician attempted to swap his cyberbrain (a brain enclosed in cybernetics, as common as cell phones) into a waitress gynoid, but a foreign agent instead put his own brain in the politician's body and tried to smuggle the politician's brain out of the country in a suitcase. And they did that all in a restaurant men's room.
''Franchise/GhostInTheShell'':
** Brain Transplants in general are quite common in all renditions of GhostInTheShell, GITS works, often from one artificial body to another. In [[Anime/GhostInTheShell the movie]] the Major muses that she has no real way of knowing if she even has a brain in her current body.
** In the first episode of ''Anime/GhostInTheShellStandAloneComplex'' a politician attempted to swap his cyberbrain (a brain enclosed in cybernetics, as common as cell phones) into a waitress gynoid, but a foreign agent instead put his own brain in the politician's body and tried to smuggle the politician's brain out of the country in a suitcase. And they did that all in a restaurant men's room.
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** Brain Transplants in general are quite common in all renditions of GhostInTheShell, often from one artificial body to another. In [[Anime/GhostInTheShell the movie]] the Major muses that she has no real way of knowing if she even has a brain in her current body.
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* The TV movie ''[[Series/OutOfJImmysHead Re-Animated]]'' has the main character needing an emergency brain transplant with the brain of cartoonist [[MrAltDisney Milt Appleday]], resulting in him being able to see his cartoon creations.

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* The TV movie ''[[Series/OutOfJImmysHead Re-Animated]]'' has the main character needing an emergency brain transplant with the brain of cartoonist [[MrAltDisney Milt Appleday]], resulting in him being able to see his cartoon creations.



* ''Series/OutOfJimmysHead'' has this happen to the eponymous character. However, the retention of the personality gland" lets Jimmy keep everything that's himself.

to:

* ''Series/OutOfJimmysHead'' has this happen to the eponymous character.character, using the brain of a MrAltDisney. However, the retention of the personality gland" lets Jimmy keep everything that's himself.
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* The TV movie ''[[Series/OutOfJImmysHead Re-Animated]]'' has the main character needing an emergency brain transplant with the brain of cartoonist [[MrAltDisney Milt Appleday]], resulting in him being able to see his cartoon creations.
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* ''Manga/BlackJack'', being a series that applies AnimePhysics to the MedicalDrama genre, unsurprisingly has this on occasion. In one notable case he gave an artist who had been painting landscapes on an island during an H-bomb test a new body to save him from radiation poisoning. He died anyway from brain cancer but not before completing one last painting.
Is there an issue? Send a MessageReason:
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* Referenced in ''Film/ToyStory'': while Sid swaps the heads of his sister's doll and a toy pterodactyl, he role-plays like he's a surgeon performing a dangerous "double-bypass brain transplant".

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* Referenced in ''Film/ToyStory'': ''WesternAnimation/ToyStory'': while Sid swaps the heads of his sister's doll and a toy pterodactyl, he role-plays like he's a surgeon performing a dangerous "double-bypass brain transplant".
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* ''WesternAnimation/KimPossible''. In one episode, Ron dreams that he is on work expereince at a hospital, when Kim is brought in from a mission. Ron goes to the ward where Kim is taken where he and the other doctors see that she has caught a disease that has paralysed her into making do a really goofy smile on her face. It is discovered that to cure Kim of the disease, she must be given someone else's brain, so one of the doctors unscrews his own skull and volunteers his brain for transplant. All of a sudden, everyone else in the room (except for Ron) catches the disease, so Ron has to take the brain from the doctor and insert into Kim's head.

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* ''WesternAnimation/KimPossible''. In one episode, Ron dreams that he is on work expereince experience at a hospital, when Kim is brought in from a mission. Ron goes to the ward where Kim is taken where he and the other doctors see that she has caught a disease that has paralysed paralyzed her into making do a really goofy smile on her face. It is discovered that to cure Kim of the disease, she must be given someone else's brain, so one of the doctors unscrews his own skull and volunteers his brain for transplant. All of a sudden, everyone else in the room (except for Ron) catches the disease, so Ron has to take the brain from the doctor doctor, who voluntarily offers it up, and insert into Kim's head.
head. [[RuleOfFunny Despite having someone else's brain, she acts as if she was the same as before.]]
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* The ''VideoGame/SamAndMaxTheDevilsPlayhouse'' episode ''They Stole Max's Brain'' has Sam put the preserved brain of the child-pharaoh Sammun-Mak in Max's emptied head so someone can move it while he looks for the original. [[spoiler:Then Sammun-Mak [[SixthRangerTraitor turns traitor]] once he gets his hands on the Toys of Power, keeping Max's body until his brain is forcefully removed by the Molemen.]]
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* In ''Series/KamenRiderGaim'', Ryoma Sengoku at one point transplants his brain into [[Film/KikaiderReboot Hakaider]]'s robot body, fights against Gaim and Kikaider, and then transplants his brain back to his own body with no apparent lasting effects.
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* ''WesternAnimation/KimPossible''. In one episode, Ron dreams that he is on work expereince at a hospital, when Kim is brought in from a mission. Ron goes to the ward where Kim is taken where he and the other doctors see that she has caught a disease that has paralysed her into making do a really goofy smile on her face. It is discovered that to cure Kim of the disease, she must be given someone else's brain, so one of the doctors unscrews his own skull and volunteers his brain for transplant. All of a sudden, everyone else in the room (except for Ron) catches the disease, so Ron has to take the brain from the doctor and insert into Kim's head.
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* The closest thing that has been done in real life is [[http://en.wikipedia.org/wiki/Head_transplant Head Transplants]] on test animals like dogs and monkeys. They were quadriplegic because their spinal cords in the head and torso could not attach, but they could breathe and eat, though [[AndIMustScream vocalization is unlikely]]. Fortunately, to our knowledge it has never been attempted with humans.

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* The closest thing that has been done in real life is [[http://en.wikipedia.org/wiki/Head_transplant Head Transplants]] on test animals like dogs and monkeys. They were quadriplegic because their spinal cords in the head and torso could not attach, but they could breathe and eat, though [[AndIMustScream vocalization is unlikely]]. Fortunately, to our knowledge it has never been attempted with humans.humans.
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* In the 1970s ''Series/WonderWoman'' episode "Gault's Brain", that was the BrainInAJar's plan, stealing the body of an athletic young man.
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Kind of an older trope, now largely superseded by BrainUploading. A Brain Transplant is what happens when a MadScientist saws open your skull, removes your brain, and puts it in someone else's body. The details, such as how the transplanted brain interfaces with the new body's nervous system, or how immune rejection is bypassed, tend to be HandWaved. In RealLife we don't yet have the technology to connect a brain from one person to the spinal cord of another, so at best this would result in an "AndIMustScream" situation.

Often involves a BrainInAJar at some point.

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!Examples

[[AC: {{Anime}} and {{Manga}}]]
* In the first episode of ''Anime/GhostInTheShellStandAloneComplex'' a politician attempted to swap his cyberbrain (a brain enclosed in cybernetics, as common as cell phones) into a waitress gynoid, but a foreign agent instead put his own brain in the politician's body and tried to smuggle the politician's brain out of the country in a suitcase. And they did that all in a restaurant men's room.

[[AC:Comic Books]]
* In the ''Bad Company'' series by ''ComicBook/TwoThousandAD'', Kano was taken prisoner by the alien Krool and subjected to a horrifying experiment: Half of his brain was switched with one from a Krool, and he went nearly insane until he met Mad Tommy and they founded Bad Company.
* At the end of the ''ComicBook/JudgeDredd'' story "America", the narrator Bennet Beeny witnesses his soulmate America Jara be gunned down by the Judges in a failed terrorist attack on the Statue of Liberty. After America is declared braindead, Beeny has his brain placed in America's body so they can still be together. In a later story, Beeny's new body begins to shut down because it's rejecting the implant.
* ''ComicStrip/{{Nero}}'': In the classic story ''Het Rattenkasteel'' (''The Rat Castle'') Nero and Detective Van Zwam enter a haunted castle where they are held captive in a dungeon by a MadScientist named Dr. Ratsjenko who plans to transplant their brains into those of rats to make rats even smarter. This is also shown in a very macabre ImagineSpot where Nero imagines Ratsjenko cutting open his head and removing the brain. He fails to do so with them, but later he does manage to steal a brain from a university laboratory and put it in a rat, who makes his rat compatriots rise to lead a rebellion against the humans.

[[AC:{{Film}}]]
* At the end of ''Film/TheManWithTwoBrains'', Dr Hfuhruhurr, inventor of "cranial screw-top brain surgery", transplants the BrainInAJar he's been dating into the body of his evil wife.
* This has been a staple of ''Film/{{Frankenstein}}'' films ever since the [[Film/{{Frankenstein1931}} 1931]] film where the monster received the brain of a violent criminal.
* In ''Film/TheGhostOfFrankenstein'' Ygor makes Dr. Frankenstein transplant his (Ygor's) brain into the monster's body so they'll be "together forever." Unfortunately they don't have the same blood type so Ygor!Monster is blind, leading to the eyes closed/arms outstretched shuffle that the Monster is Flanderized into having.
* In ''Film/AbbottAndCostelloMeetFrankenstein'' Dracula's plan involves transplanting Costello's brain into the monster.
* In ''Film/TheBrainThatWouldntDie'', a young, mad scientist's girlfriend is beheaded in a car accident. He takes her head back to his lab and keeps it alive with his mad science. Then he searches for another girl who won't be missed, so he can chop her head off and transplant his girlfriend's head on.
* Referenced in ''Film/ToyStory'': while Sid swaps the heads of his sister's doll and a toy pterodactyl, he role-plays like he's a surgeon performing a dangerous "double-bypass brain transplant".
-->'''Buzz Lightyear:''' I don't think that man's ever been to medical school.
* Played for laughs in ''Film/YoungFrankenstein''. The monster is supposed to receive the brain of a supersmart person but Igor drops the jar and secretly replaces the brain with one that is marked ''abnormal''. The actual brain transplant is executed in an OffscreenMomentOfAwesome. When the monster awakes, of course it turns out to be a moron.

[[AC: {{Literature}}]]
* In ''Literature/IWillFearNoEvil'' by Creator/RobertAHeinlein the protagonist has their brain transplanted into a woman's body, it doesn't end well. The event is later mentioned in ''Literature/TimeEnoughForLove'' when the possibility of being transferred into an OppositeSexClone is suggested to Lazarus Long, he rejects it.
* In [[https://www.fictionpress.com/s/3214035/1/SI S.I.]] the protagonist is awakened from cryonic suspension, and suffers severe ethylene glycol poisoning. Fortunately there happened to be a body nearby that lacked a central nervous system.
* In the ''Literature/{{Discworld}}'' novels, this is the ultimate expression of {{The Igor}}s' philosophy that "What cometh around goeth around". When an Igor dies, his relatives, in addition to sharing his body parts out to whoever needs them, preserve the brain. Eventually, ''someone'' will suffer brain death but have a body in good condition, and Igor will be back on someone's feet.
* In the ''Literature/VorkosiganSaga'', Jackson's Whole infamously hosts life extension clinics based on brain transplants into younger clones. The clone's brain is thrown away.
* In ''[[Literature/JohnCarterOfMars Mastermind of Mars]]'', the bulk of [[MadScientist Ras Thavas']] research involves swapping people's brains. He's even made a business out of it, transplanting the brains of the old and wealthy and/or powerful into younger bodies.
* This is possible, albeit risky, in the ''Franchise/StarWarsExpandedUniverse''. Monks of the B'Omarr order have their brains removed [[BrainInAJar and placed into life-support jars]] upon reaching enlightenment so they can continue to contemplate the universe forever. Less scrupulous B'Omarr initiates have been known to perform the operation on unwilling patients and even reverse it, implanting brains into other bodies. One of the short stories in ''Literature/TalesFromJabbasPalace'' implies that Bib Fortuna eventually manages to escape his AndIMustScream fate that way.
* In Creator/HPLovecraft's "The Whisperer in Darkness" the Mi-Go have a tendency to put [[BrainInAJar brains in jars]] and can easily put them back in bodies, not necessarily their original ones. [[spoiler: Even brains of their species in human bodies.]]
* In ''Fountain Society'', a dying scientist's brain is transplanted into a body of a younger man. He eventually rebels against the eponymous society, [[spoiler:and destroys their skyscraper by crashing a plane on it while the BigBad is going through the same operation]].

[[AC: LiveActionTV]]
* SoapWithinAShow example: In ''Series/{{Friends}}'', this is how Joey's character on ''Series/DaysOfOurLives'' "returns"; the brain of another character gets transplanted into his body. At some point, they [[ViewersAreGoldfish start ignoring this]] and he's just Dr Drake Ramoray again.
* In the ''Series/MetalHurlantChronicles'' episode "Long Live the King", the winner of the succession tournament has the dying king's brain transplanted into his skull. Presumably his brain was thrown out.
* Happened in a HalloweenEpisode of ''Series/TwoGuysAGirlAndAPizzaPlace'', complete with a Mad Scientist character, who switches Pete's brain with Ashley's brain and Berg's brain with Sharon's brain and the only one who can help them is Johnny.
* ''Series/OutOfJimmysHead'' has this happen to the eponymous character. However, the retention of the personality gland" lets Jimmy keep everything that's himself.

[[AC:PuppetShows]]
* In the ''Series/TheMrPotatoHeadShow'' episode, "Royal Pain", Dr. Fruitcake rebuilds his creation, Hammy the Ham Monster (who was destroyed by Baloney in the episode, "Aliens Dig Baloney"). To ensure Hammy is much more tame this time around, Dr. Fruitcake has given him the brain of a two-year old child.
-->'''Baloney:''' "Now, where did you get the brain of a two-year-old?"
-->'''Dr. Fruitcake:''' "Trust me, Baloney, you don't want to know."

[[AC: TabletopGames]]
* ''TabletopGame/Warhammer40K''. One of the reasons ork paindoks are feared is that they occasionally replace a patient's brain with that of a squig, leaving them comatose for a while while they adapt, then leaving them semifunctional zombies only fit to follow the dok's orders.

[[AC: Video Games]]
* ''VideoGame/SurgeonSimulator2013'' has a brain surgery mission. In which the entire brain is removed and a new brain is roughly placed in the same place.

[[AC: {{Webcomics}}]]
* In ''Webcomic/{{Narbonic}}'' after Dave's first death Dr. Narbon reanimates him, but being a zombie gets boring quickly so she is convinced eventually to clone him a new body and transplant his brain into it.

[[AC: WesternAnimation]]
* ''WesternAnimation/IAmWeasel''. In "I, Architect," an accident results in both Weasel and Baboon having their skulls cracked open and their brains falling out. Because Weasel's brain is so massive and Baboon's is so tiny, the surgeons place the smaller brain into Weasel's smaller head and the large brain into Baboon's larger head. As a result, when awaken, Weasel [[TookALevelInDumbass becomes an idiot]] and the changes he makes to the city are chaotic, whereas Baboon continues to move up in society and plans to stop Weasel from destroying the city with his stupidity.

[[AC: RealLife]]
* The closest thing that has been done in real life is [[http://en.wikipedia.org/wiki/Head_transplant Head Transplants]] on test animals like dogs and monkeys. They were quadriplegic because their spinal cords in the head and torso could not attach, but they could breathe and eat, though [[AndIMustScream vocalization is unlikely]]. Fortunately, to our knowledge it has never been attempted with humans.

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