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** Most of incarnations of ComicBook/LexLuthor. In the years since, he's also been a CorruptCorporateExecutive and a [[PresidentEvil villainous politician]]. He did return to being a mad scientist in ComicBook/PostCrisis after the ''ComicBook/SupermanUpUpAndAway'' storyline, where Clark Kent brings his VillainWithGoodPublicity status down through journalism. Most interpretations from the late 90's onward merge the corporate and scientist portrayals into one. Nowadays, Luthor is portrayed as building his company on his brilliant inventions, and he still gets actively involved in [=LexCorp=]'s development projects.
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** Most of incarnations of ComicBook/LexLuthor. In the years since, he's also been a CorruptCorporateExecutive and a [[PresidentEvil villainous politician]]. He did return to being a mad scientist in ComicBook/PostCrisis after the ''ComicBook/SupermanUpUpAndAway'' storyline, where Clark Kent brings his VillainWithGoodPublicity status down through journalism. Most interpretations from the late 90's onward merge the corporate and scientist portrayals into one. Nowadays, Luthor is portrayed as building his company on his brilliant inventions, and he still gets actively involved in [=LexCorp=]'s development projects.
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** In ComicBook/TheNewChampionOfShazam, Doctor Sivana's daughter, Georgia, is the main antagonist.
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** ComicBook/PoisonIvy is a botanist that became a plant-controlling metahuman following a freak accident. While she also qualify as a HotScientist due to using her [[TheVamp feminine wiles as a weapon]], she is still very much a mad scientist due to her disturbed unhinged love for plants outweighing humans.
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** ComicBook/PoisonIvy is a botanist that became a plant-controlling metahuman following a freak accident. While she also qualify as a HotScientist due to using uses her [[TheVamp feminine wiles as a weapon]], she is still very much a mad scientist due to her disturbed unhinged love for plants outweighing humans.
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** A large number of the Pre-Crisis Phantom Zone prisoners are scientists who got people hurt or caused environmental harm while testing various new inventions (a rocket system, new chemical processes, a cyrosleep device, an immortality potion, labor robots, etc.).
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** TheJoker is usually portrayed as something of a Mad Chemist, being able to invent and manufacture deadly chemical weapons, like his signature Joker Venom.
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** [[Characters/BatmanTheJoker The Joker]] is usually portrayed as something of a Mad Chemist, being able to invent and manufacture deadly chemical weapons, like his signature Joker Venom.
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** TheJoker is usually portrayed as something of a Mad Chemist, being able to invent and manufacture deadly chemical weapons, like his signature Joker Venom.
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** Mr. Freeze used to be one of these, with no real backstory, just the whole freezing schtick. Then came ''WesternAnimation/BatmanTheAnimatedSeries'' which gave him [[IncrediblyLamePun chillingly]] tragic backstory and motivation, turning him more into a villainous [[TheWoobie Woobie.]] This new version of the character was {{Retcon}}[[CanonImmigrant ned]] into the main DCU.
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** Mr. Freeze used to be one of these, with no real backstory, just the whole freezing schtick. Then came ''WesternAnimation/BatmanTheAnimatedSeries'' which gave him [[IncrediblyLamePun a [[{{Pun}} chillingly]] tragic backstory and motivation, turning him more into a villainous [[TheWoobie Woobie.]] WoobieDestroyerOfWorlds. This new version of the character was {{Retcon}}[[CanonImmigrant ned]] into the main DCU.
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** In 2015, Jor-El was turned into one. Rogol Zaar, a genetically-engineered, immensely powerful and ferocious creature [[ComicBook/ManOfSteel2018 revealed to be responsible]] for [[ComicBook/TheKillersOfKrypton the destruction of Krypton]], was later revealed to have been created by Jor-El in ''ComicBook/BrianMichaelBendisSuperman'', who "set him loose into the galaxy" to do his bidding as his mercenary. All to further the agenda of the Circle, a secret organization of galactic leaders who pulled the strings from behind the scenes.
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** In 2015, Jor-El was turned into one. Rogol Zaar, a genetically-engineered, immensely powerful and ferocious creature [[ComicBook/ManOfSteel2018 revealed to be responsible]] for [[ComicBook/TheKillersOfKrypton the destruction of Krypton]], was later revealed to have been created by Jor-El in ''ComicBook/BrianMichaelBendisSuperman'', ''ComicBook/SupermanBrianMichaelBendis'', who "set him loose into the galaxy" to do his bidding as his mercenary. All to further the agenda of the Circle, a secret organization of galactic leaders who pulled the strings from behind the scenes.
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!!Franchise/TheDCU
* The DCU comic ''ComicBook/FiftyTwo'' had a secret conspiracy who was kidnapping Mad Scientists, good and evil, for a nefarious goal.
* ''Franchise/{{Batman}}'':
** Mr. Freeze used to be one of these, with no real backstory, just the whole freezing schtick. Then came ''WesternAnimation/BatmanTheAnimatedSeries'' which gave him [[IncrediblyLamePun chillingly]] tragic backstory and motivation, turning him more into a villainous [[TheWoobie Woobie.]] This new version of the character was {{Retcon}}[[CanonImmigrant ned]] into the main DCU.
** Scarecrow is an expert psychologist who creates fear gas that preys on the target's most deeply seeded phobias.
** ComicBook/PoisonIvy is a botanist that became a plant-controlling metahuman following a freak accident. While she also qualify as a HotScientist due to using her [[TheVamp feminine wiles as a weapon]], she is still very much a mad scientist due to her disturbed unhinged love for plants outweighing humans.
** Hugo Strange is the most archetypal mad scientist. He's an expert in everything from chemistry and genetics to psychology, and uses it for evil. And with his typical wardrobe of lab coat and goggles, he dresses the part as well.
** StarterVillain Alfred Stryker experiments on guinea pigs in his spare time when he's not being a CorruptCorporateExecutive.
** "Monsters in the Closet", in the ''ComicBook/BatmanBlackAndWhite'' anthology series, features a one-off appearance by a mad scientist who kidnaps people and turns them into fish-person hybrids. One of them gets him in the end.
** In ''ComicBook/TheAttackOfTheAnnihilator'', Kenneth Anderson is turned into a psychic mutant as running experiments on alien energies, and decides to destroy Gotham and rebuild it in his image.
* Professor Merson, an American scientist working for Germany, was the source of countless [[StupidJetpackHitler Nazi superweapons]] (including the [[MonowheelMayhem War Wheel]]) in the 1982 ''ComicBook/{{Blackhawk}}'' revival. It can be hard to tell -- ''Blackhawk'' seems to feature gadgetry unbelievably ludicrous enough to fall under mad science in every issue, and frequently right on the cover.
* ''ComicBook/{{Shazam}}'':
** Doctor Sivana and his family are similarly the archenemies of Captain Marvel and friends. Sivana, in particular, may be the UrExample in comic books, predating Lex Luthor by several months. He's a five-foot-tall gnome of a man with a chrome dome, huge ScaryShinyGlasses, and more often than not a white lab coat. His stated goals (in no particular order): To become Rightful Ruler of the Universe in fact as well as in name; to spread evil, cruelty, and nastiness throughout the cosmos; and to humiliate, discredit, and ultimately ''KILL CAPTAIN MARVEL!''. The original version of the character was actually a benevolent man who was ruined by being rejected by the scientific community [[TheyCalledMeMad for his ideas]]. When his wife died, he blamed the world and turned into the crackpot we love to hate. This was the Pre-ComicBook/{{Crisis|on Infinite Earths}} origin, the current version seems to always have been mean.
** In ''[[ComicBook/TheMultiversity Thunderworld #1]]'', the Dr. Sivana of Earth-5 takes exception to being called 'mad'. He sees himself more as a radical genius.
* A heroic Mad Scientist in The DCU is Doctor Magnus, creator of the ComicBook/MetalMen. When off his meds he hallucinates and can accidentally create sentient robots without fully meaning to.
* ''Franchise/{{Superman}}'':
** Most of incarnations of ComicBook/LexLuthor. In the years since, he's also been a CorruptCorporateExecutive and a [[PresidentEvil villainous politician]]. He did return to being a mad scientist in ComicBook/PostCrisis after the ''ComicBook/SupermanUpUpAndAway'' storyline, where Clark Kent brings his VillainWithGoodPublicity status down through journalism. Most interpretations from the late 90's onward merge the corporate and scientist portrayals into one. Nowadays, Luthor is portrayed as building his company on his brilliant inventions, and he still gets actively involved in [=LexCorp=]'s development projects.
** Bertron, the alien scientist in ''ComicBook/SupermanDoomsdayHunterPrey'', who was responsible for the creation of Doomsday. He subjected the creature to the harsh environment of Krypton in the distant past, cloning it again and again every time it was destroyed either by the environment or by its resident creatures. Over the years it evolved into its current form, which would later be known as Doomsday. However, once the creature had reached the point where nothing on the planet could withstand him, he turned his attention on his creators and killed them and Bertron in the process.
** In 2015, Jor-El was turned into one. Rogol Zaar, a genetically-engineered, immensely powerful and ferocious creature [[ComicBook/ManOfSteel2018 revealed to be responsible]] for [[ComicBook/TheKillersOfKrypton the destruction of Krypton]], was later revealed to have been created by Jor-El in ''ComicBook/BrianMichaelBendisSuperman'', who "set him loose into the galaxy" to do his bidding as his mercenary. All to further the agenda of the Circle, a secret organization of galactic leaders who pulled the strings from behind the scenes.
** The Ultra-Humanite (arguably comics' first supervillain) who actually transferred his brain from the standard baldie-in-a-labcoat mad scientist's body into that of a beautiful woman. He was only another Mad Scientist in the [[UsefulNotes/TheGoldenAgeOfComicBooks Golden Age]] comics, but in the series ''ComicBook/TheGoldenAge'', he becomes the arch-villain, [[spoiler:[[VillainWithGoodPublicity posing as a hero and getting the medal of honor]]. He saved Hitler's brain, too. And put it in an invincible super-body]].
** Karmang from ''ComicBook/SupermanVsShazam'', who previously used his advanced science to make himself immortal, builds two devices to blow two Earths up.
* ''Franchise/WonderWoman'':
** Foe Byrna Brilyant is a scientist with no compulsions about stealing the work of others and then combining and modifying it for profit, generally by hiring herself out in her HumongousMecha capable of causing winter storms or holding things for ransom...with winter storms.
** ''ComicBook/WonderWoman1942'':
*** Paula von Gunther showed enormous promise as a horrific mad scientist focused on psychiatry and meddling with the human mind, along with figuring out a way to make herself invisible among other things while she was working for the Nazis. After it was revealed she was being forced to do so and having her daughter they'd been holding hostage rescued she proves an even more impressive and varied scientist steadfastly allied with Diana and the Allies for saving Gerta. The underling mindset seems to be genetic as her daughter Gerta, well meaning as she may be, accidentally creates a number of super-powered villains over the years.
*** Queen Atomia is a scientist who has figured out how to make a gas that shrinks those who breathe it to a microscopic scale, has created two machines that [[ReforgedIntoAMinion turn humans into her near mindless slaves]], and has a great interest in the potential uses for nuclear energy, and bombs.
** In ''ComicBook/WonderWoman1987'' Veronica Cale is a scientist and CEO who thinks it's a good idea to nab Doctor Psycho from prison in order to do experiments on how his mental powers work, and purchase the newest Silver Swan to learn more about the modifications done to the poor girls body. She also intends to find a way to mentally control both of the aforementioned villains to turn them into her own lackeys.
%% * [[Comicbook/TheMultiversity Earth 44's]] Doc Tornado (a combination of the Metal Men's Doc Magnus and Red Tornado) is another heroic Mad Scientist.
* The DCU comic ''ComicBook/FiftyTwo'' had a secret conspiracy who was kidnapping Mad Scientists, good and evil, for a nefarious goal.
* ''Franchise/{{Batman}}'':
** Mr. Freeze used to be one of these, with no real backstory, just the whole freezing schtick. Then came ''WesternAnimation/BatmanTheAnimatedSeries'' which gave him [[IncrediblyLamePun chillingly]] tragic backstory and motivation, turning him more into a villainous [[TheWoobie Woobie.]] This new version of the character was {{Retcon}}[[CanonImmigrant ned]] into the main DCU.
** Scarecrow is an expert psychologist who creates fear gas that preys on the target's most deeply seeded phobias.
** ComicBook/PoisonIvy is a botanist that became a plant-controlling metahuman following a freak accident. While she also qualify as a HotScientist due to using her [[TheVamp feminine wiles as a weapon]], she is still very much a mad scientist due to her disturbed unhinged love for plants outweighing humans.
** Hugo Strange is the most archetypal mad scientist. He's an expert in everything from chemistry and genetics to psychology, and uses it for evil. And with his typical wardrobe of lab coat and goggles, he dresses the part as well.
** StarterVillain Alfred Stryker experiments on guinea pigs in his spare time when he's not being a CorruptCorporateExecutive.
** "Monsters in the Closet", in the ''ComicBook/BatmanBlackAndWhite'' anthology series, features a one-off appearance by a mad scientist who kidnaps people and turns them into fish-person hybrids. One of them gets him in the end.
** In ''ComicBook/TheAttackOfTheAnnihilator'', Kenneth Anderson is turned into a psychic mutant as running experiments on alien energies, and decides to destroy Gotham and rebuild it in his image.
* Professor Merson, an American scientist working for Germany, was the source of countless [[StupidJetpackHitler Nazi superweapons]] (including the [[MonowheelMayhem War Wheel]]) in the 1982 ''ComicBook/{{Blackhawk}}'' revival. It can be hard to tell -- ''Blackhawk'' seems to feature gadgetry unbelievably ludicrous enough to fall under mad science in every issue, and frequently right on the cover.
* ''ComicBook/{{Shazam}}'':
** Doctor Sivana and his family are similarly the archenemies of Captain Marvel and friends. Sivana, in particular, may be the UrExample in comic books, predating Lex Luthor by several months. He's a five-foot-tall gnome of a man with a chrome dome, huge ScaryShinyGlasses, and more often than not a white lab coat. His stated goals (in no particular order): To become Rightful Ruler of the Universe in fact as well as in name; to spread evil, cruelty, and nastiness throughout the cosmos; and to humiliate, discredit, and ultimately ''KILL CAPTAIN MARVEL!''. The original version of the character was actually a benevolent man who was ruined by being rejected by the scientific community [[TheyCalledMeMad for his ideas]]. When his wife died, he blamed the world and turned into the crackpot we love to hate. This was the Pre-ComicBook/{{Crisis|on Infinite Earths}} origin, the current version seems to always have been mean.
** In ''[[ComicBook/TheMultiversity Thunderworld #1]]'', the Dr. Sivana of Earth-5 takes exception to being called 'mad'. He sees himself more as a radical genius.
* A heroic Mad Scientist in The DCU is Doctor Magnus, creator of the ComicBook/MetalMen. When off his meds he hallucinates and can accidentally create sentient robots without fully meaning to.
* ''Franchise/{{Superman}}'':
** Most of incarnations of ComicBook/LexLuthor. In the years since, he's also been a CorruptCorporateExecutive and a [[PresidentEvil villainous politician]]. He did return to being a mad scientist in ComicBook/PostCrisis after the ''ComicBook/SupermanUpUpAndAway'' storyline, where Clark Kent brings his VillainWithGoodPublicity status down through journalism. Most interpretations from the late 90's onward merge the corporate and scientist portrayals into one. Nowadays, Luthor is portrayed as building his company on his brilliant inventions, and he still gets actively involved in [=LexCorp=]'s development projects.
** Bertron, the alien scientist in ''ComicBook/SupermanDoomsdayHunterPrey'', who was responsible for the creation of Doomsday. He subjected the creature to the harsh environment of Krypton in the distant past, cloning it again and again every time it was destroyed either by the environment or by its resident creatures. Over the years it evolved into its current form, which would later be known as Doomsday. However, once the creature had reached the point where nothing on the planet could withstand him, he turned his attention on his creators and killed them and Bertron in the process.
** In 2015, Jor-El was turned into one. Rogol Zaar, a genetically-engineered, immensely powerful and ferocious creature [[ComicBook/ManOfSteel2018 revealed to be responsible]] for [[ComicBook/TheKillersOfKrypton the destruction of Krypton]], was later revealed to have been created by Jor-El in ''ComicBook/BrianMichaelBendisSuperman'', who "set him loose into the galaxy" to do his bidding as his mercenary. All to further the agenda of the Circle, a secret organization of galactic leaders who pulled the strings from behind the scenes.
** The Ultra-Humanite (arguably comics' first supervillain) who actually transferred his brain from the standard baldie-in-a-labcoat mad scientist's body into that of a beautiful woman. He was only another Mad Scientist in the [[UsefulNotes/TheGoldenAgeOfComicBooks Golden Age]] comics, but in the series ''ComicBook/TheGoldenAge'', he becomes the arch-villain, [[spoiler:[[VillainWithGoodPublicity posing as a hero and getting the medal of honor]]. He saved Hitler's brain, too. And put it in an invincible super-body]].
** Karmang from ''ComicBook/SupermanVsShazam'', who previously used his advanced science to make himself immortal, builds two devices to blow two Earths up.
* ''Franchise/WonderWoman'':
** Foe Byrna Brilyant is a scientist with no compulsions about stealing the work of others and then combining and modifying it for profit, generally by hiring herself out in her HumongousMecha capable of causing winter storms or holding things for ransom...with winter storms.
** ''ComicBook/WonderWoman1942'':
*** Paula von Gunther showed enormous promise as a horrific mad scientist focused on psychiatry and meddling with the human mind, along with figuring out a way to make herself invisible among other things while she was working for the Nazis. After it was revealed she was being forced to do so and having her daughter they'd been holding hostage rescued she proves an even more impressive and varied scientist steadfastly allied with Diana and the Allies for saving Gerta. The underling mindset seems to be genetic as her daughter Gerta, well meaning as she may be, accidentally creates a number of super-powered villains over the years.
*** Queen Atomia is a scientist who has figured out how to make a gas that shrinks those who breathe it to a microscopic scale, has created two machines that [[ReforgedIntoAMinion turn humans into her near mindless slaves]], and has a great interest in the potential uses for nuclear energy, and bombs.
** In ''ComicBook/WonderWoman1987'' Veronica Cale is a scientist and CEO who thinks it's a good idea to nab Doctor Psycho from prison in order to do experiments on how his mental powers work, and purchase the newest Silver Swan to learn more about the modifications done to the poor girls body. She also intends to find a way to mentally control both of the aforementioned villains to turn them into her own lackeys.
%% * [[Comicbook/TheMultiversity Earth 44's]] Doc Tornado (a combination of the Metal Men's Doc Magnus and Red Tornado) is another heroic Mad Scientist.
