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* [[TheHero Red]] and [[TheMafia Giovanni]] in ''Manga/PokemonSpecial'' are the most important. Also Yellow and Lance.
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* [[TheHero Red]] and [[TheMafia Giovanni]] in ''Manga/PokemonSpecial'' are the most important. Also Also, Yellow and Lance.Lance, with a dash of EvilCounterpart for good measure. The ''only'' reason Petrel managed to get the drop on Lance in the HGSS arc is because he took the appearance of the person who disturbs Lance the most -- Yellow.
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** Izaya isn't all that fond of [[spoiler:Nakura]] either.
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** Zorin Blitz is this to Seras, [[spoiler: ''especially'' after she kills [[LoveInterest Pip]]]].
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** Zorin Blitz is this to Seras, [[spoiler: ''especially'' after she kills [[LoveInterest Pip]]]].The two organizations they work for, Hellsing and Iscariot respectively, are arch enemies ''and'' [[TheRival rivals]].
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* Neo Saiba to Taichi Yagami in ''Manga/{{Digimon V-Tamer 01}}''.
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* Neo Saiba to Taichi Yagami in ''Manga/{{Digimon V-Tamer 01}}''.''Manga/DigimonVTamer01''.
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** Gaara's was his father, at least until he died. Ironically, Gaara wasn't the one who killed him (though, there is no doubt he probably wished he was at the time) -- Orochimaru was. By the time they finally had their fight (via Edo Tensei), Gaara had already forgiven him.
*** Ichigo also had one in Grimmjow, though that was mostly by the latter's insistence. Ichigo himself seemed to have mixed feelings on the matter.
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** [[spoiler:Chapter 764 implies that those bearing the D. initial are this to the World Nobles -- to the point that they're nicknamed "God's Natural Enemy". In hindsight, this wasn't really surprising at all, considering how much practically every D. in the series constantly chafed against the World Government and the World Nobles in particular.]]
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*** [[spoiler:Though he was unaware of it at the time, Doflamingo's own brother Rocinante (aka Corazon, Law's idol) held great enmity for him. While the exact circumstances are unknown, Doflamingo would end up murdering him, which would earn him Law's hatred.]]
** [[spoiler:Chapter 764 implies that those bearing the D. initial are this to the World Nobles -- to the point that they're nicknamed "God's Natural Enemy". In hindsight, this wasn't really surprising at all, considering how much practically every D. in the series constantly chafed against the World Government and the World Nobles in particular. Law's conflict with Doflamingo just happened to be another example, albeit one we weren't entirely aware of first, while Luffy's actions speak for themselves.]]
** [[spoiler:Chapter 764 implies that those bearing the D. initial are this to the World Nobles -- to the point that they're nicknamed "God's Natural Enemy". In hindsight, this wasn't really surprising at all, considering how much practically every D. in the series constantly chafed against the World Government and the World Nobles in particular. Law's conflict with Doflamingo just happened to be another example, albeit one we weren't entirely aware of first, while Luffy's actions speak for themselves.]]
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** As a whole, Frieza is this to Goku. He's one of the few villains who've crossed the MoralEventHorizon so much that even [[AllLovingHero Goku]] can't forgive him.
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** As a whole, Frieza is this to Goku. He's one of the most iconic [[BigBad Big Bads]] in the entire show, and one of the few villains who've crossed the MoralEventHorizon so much far that even [[AllLovingHero Goku]] can't forgive him.him.
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** For the series as a whole, Frieza is this to Goku. He's one of the few villains who've crossed the MoralEvenHorizon so much that even [[AllLovingHero Goku]] can't forgive him.
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** For the series as As a whole, Frieza is this to Goku. He's one of the few villains who've crossed the MoralEvenHorizon MoralEventHorizon so much that even [[AllLovingHero Goku]] can't forgive him.
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** For the series as a whole, Frieza is this to Goku. He's one of the few villains who've crossed the MoralEvenHorizon so much that even [[AllLovingHero Goku]] can't forgive him.
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* In {{HunterxHunter}}, Hisoka is this to Gon. He has an unnerving obssession with Gon and anticipates the day he "ripens to his full potential" just so he can have the chance to fight and possibly kill him. Gon also had a desire to fight Hisoka earlier in the series for hurting his pride.
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* In {{HunterxHunter}}, [[Manga/HunterXHunter Hunter x Hunter]], Hisoka is this to Gon. He has an unnerving obssession with Gon and anticipates the day he "ripens to his full potential" just so he can have the chance to fight and possibly kill him. Gon also had a desire to fight Hisoka earlier in the series for hurting his pride.
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** Chrollo Lucifer is Kurapica's arch-enemy, due to being the leader of the group responsible for [[LastofHisKind slaughtering his entire clan]].
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** Chrollo Lucifer is Kurapica's arch-enemy, Arch Enemy, due to being the leader of the group responsible for [[LastofHisKind slaughtering his entire clan]].
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** Chrollo Lucifer is Kurapica's Arch Enemy, due to being the leader of the group responsible for killing his clan.
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** Chrollo Lucifer is Kurapica's Arch Enemy, arch-enemy, due to being the leader of the group responsible for killing [[LastofHisKind slaughtering his clan.entire clan]].
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** Zorin blitz is this to Seras, [[spoiler: ''especially'' after she kills [[LoveInterest Pip]]]].
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** Zorin blitz Blitz is this to Seras, [[spoiler: ''especially'' after she kills [[LoveInterest Pip]]]].
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** Zorin blitz is this to Seras, [[spoiler: ''especially'' after she kills [[LoveInterest Pip]]]].
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** [[spoiler:Chapter 764 implies that those bearing the D. initial are this to the World Nobles -- to the point that they're nicknamed "God's Natural Enemy".]]
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** [[spoiler:Chapter 764 implies that those bearing the D. initial are this to the World Nobles -- to the point that they're nicknamed "God's Natural Enemy". In hindsight, this wasn't really surprising at all, considering how much practically every D. in the series constantly chafed against the World Government and the World Nobles in particular.]]
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** Nel and Nnoitra have incompatible philosophies. She believes in never fighting without reason and avoiding it if possible, he believes fighting itself is a reason to fight. He hates women, especially women in positions of authority over him, as Nel used to be and Harribel is. Nel dismisses his philosophy and refuses to see him as a warrior. As a result, she feels he needs to be watched over to prevent himself from getting into more trouble than he can handle. Eventually, he rips off her fraccions' masks, smashes her mask and throws her out of Las Noches.
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** [[spoiler:Chapter 764 implies that those bearing the D. initial are this to the World Nobles -- to the point that they're nicknamed "God's Natural Enemy".]]
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* Ranma of ''RanmaOneHalf'' had Happosai (outright stated to be Ranma Arch Enemy in the datebook)
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** In both the games and the anime, Groudon and Kyogre are this to each other.
* Ranma of ''RanmaOneHalf'' had Happosai (outright stated to beRanma Ranma's Arch Enemy in the datebook)
* Ranma of ''RanmaOneHalf'' had Happosai (outright stated to be
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*** Aokiji also has major beef with Akainu, though more from an ideological standpoint. However, their enmity and rivalry did not become so prevalent until Sengoku retired and both ended competing for the position of Fleet Admiral. Aokiji, normally indifferent, even somewhat adverse to the idea of inheriting such a tedious job, was completely against Akainu becoming Fleet Admiral. This feud between them, the first ever major conflict between admirals, became so heated that it eventually degenerated to a DuelToTheDeath on the barren island of Punk Hazard, with the winner becoming Fleet Admiral. The victor wound up being Akainu; but for all his ruthlessness, not even he could ignore the decades he and Aokiji served together as comrades and ended up sparing his opponent's life. However, Aokiji despised the idea of serving under his rival so much that he ''[[ScrewThisImOuttaHere ditched the Marines]]'' and gave up his position as an admiral.
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*** Aokiji also has major beef with Akainu, though more from an ideological standpoint. However, their enmity and rivalry did not become so prevalent until Sengoku retired and both ended competing competed for the position of Fleet Admiral. Aokiji, normally indifferent, even somewhat adverse to the idea of inheriting such a tedious job, was completely against Akainu becoming Fleet Admiral. This feud between them, the first ever major conflict between admirals, became so heated that it eventually degenerated to a DuelToTheDeath on the barren island of Punk Hazard, with the winner becoming Fleet Admiral. The victor wound up being Akainu; but for all his ruthlessness, not even he could ignore the decades he and Aokiji served together as comrades and ended up sparing his opponent's life. However, Aokiji despised the idea of serving under his rival so much that he ''[[ScrewThisImOuttaHere ditched the Marines]]'' and gave up his position as an admiral.
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*** Aokiji also has major beef with Akainu, though more from an ideological standpoint. However, their enmity and rivalry did not become so prevalent until Sengoku retired and both ended competing for the position of Fleet Admiral. Aokiji, normally indifferent, even somewhat adverse to the idea of inheriting such a tedious job, was completely against Akainu becoming Fleet Admiral. This feud between them, the first ever major conflict between admirals, became so heated that it eventually degenerated to a DuelToTheDeath on the barren island of Punk Hazard, with the winner becoming Fleet Admiral. The victor wound up being Akainu; but for all his ruthlessness, not even he could ignore the decades he and Aokiji served together as comrades and ended up sparing his opponent's life. However, Aokiji despised the idea of serving under his rival so much that he ''[[ScrewThisImOuttaHer ditched the Marines]]'' and gave up his position as an admiral.
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*** Aokiji also has major beef with Akainu, though more from an ideological standpoint. However, their enmity and rivalry did not become so prevalent until Sengoku retired and both ended competing for the position of Fleet Admiral. Aokiji, normally indifferent, even somewhat adverse to the idea of inheriting such a tedious job, was completely against Akainu becoming Fleet Admiral. This feud between them, the first ever major conflict between admirals, became so heated that it eventually degenerated to a DuelToTheDeath on the barren island of Punk Hazard, with the winner becoming Fleet Admiral. The victor wound up being Akainu; but for all his ruthlessness, not even he could ignore the decades he and Aokiji served together as comrades and ended up sparing his opponent's life. However, Aokiji despised the idea of serving under his rival so much that he ''[[ScrewThisImOuttaHer ''[[ScrewThisImOuttaHere ditched the Marines]]'' and gave up his position as an admiral.
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** [[GoodIsNotNice Yamamoto]]'s seems to be [[TheEmperor Yhwach]]. (who could be considered his EvilCounterpart, complete with a NotSoDifferent moment when the latter [[JerkassHasAPoint accuses the former]] of being a RetiredMonster) Notably, Yhwach is the only enemy that Yamamoto doesn't call "child", and he immediately unleashes his [[GodzillaThreshold incredibly destructive]] [[OneWingedAngel Bankai]] as soon as he shows up. The feeling is mutual - they've been at it for at least a millenium and it's pretty obvious that they really hate each other.
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** [[GoodIsNotNice Yamamoto]]'s seems to be [[TheEmperor Yhwach]]. Yhwach]] (who could be considered his EvilCounterpart, complete with a NotSoDifferent moment when the latter [[JerkassHasAPoint accuses the former]] of being a RetiredMonster) RetiredMonster). Notably, Yhwach is the only enemy that Yamamoto doesn't call "child", and he immediately unleashes his [[GodzillaThreshold incredibly destructive]] [[OneWingedAngel Bankai]] as soon as he shows up. The feeling is mutual - they've been at it for at least a millenium and it's pretty obvious that they really hate each other.
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*** Aokiji also has major beef with Akainu, though more from an ideological standpoint. However, their enmity and rivalry did not become so prevalent until Sengoku retired and both ended competing for the position of Fleet Admiral. Aokiji, normally indifferent, even somewhat adverse to the idea of inheriting such a tedious job, was completely against Akainu becoming Fleet Admiral. This feud between them, the first ever major conflict between admirals, became so heated that it eventually degenerated to a DuelToTheDeath on the barren island of Punk Hazard, with the winner becoming Fleet Admiral. The victor wound up being Akainu; but for all his ruthlessness, not even he could ignore the decades he and Aokiji served together as comrades and ended up sparing his opponent's life. However, Aokiji despised the idea of serving under his rival so much that he ''[[ScrewThisImOuttaHer ditched the Marines]]'' and gave up his position as an admiral.
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* In ''Manga/FistOfTheNorthStar'', main character Kenshiro's arch-nemeses were his adoptive older brothers [[BoisterousWeakling Jagi]] and [[BigBad Raoh]], who were both bitter over Ken being chosen as [[ThereCanBeOnlyOne the sole successor to]] Hokuto Shinken over them (and [[KungFuJesus Toki]] and , but he didn't really mind). Even though Raoh was the bigger rival in the story, Jagi gets special mention because he purposefully set out to ruin Ken's life and is personally responsible for the good majority of the plot. In the early part of the series, [[RivalTurnedEvil Shin]] fufilled this role, as he was the one who took Ken's fiance [[LoveInterest Yuria]] away from him and gave him his distinctive seven scars on his chest, though it could be considered subverted in the meta-sense because he was goaded into doing this by Jagi.
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* In ''Manga/FistOfTheNorthStar'', main character Kenshiro's arch-nemeses were his adoptive older brothers [[BoisterousWeakling Jagi]] and [[BigBad Raoh]], who were both bitter over Ken being chosen as [[ThereCanBeOnlyOne the sole successor to]] Hokuto Shinken over them (and [[KungFuJesus Toki]] and , Toki]], but he didn't really mind). Even though Raoh was the bigger rival in the story, Jagi gets special mention because he purposefully set out to ruin Ken's life and is personally responsible for the good majority of the plot. In the early part of the series, [[RivalTurnedEvil Shin]] fufilled this role, as he was the one who took Ken's fiance [[LoveInterest Yuria]] away from him and gave him his distinctive seven scars on his chest, though it could be considered subverted in the meta-sense because he was goaded into doing this by Jagi.
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** [[spoiler: Subverted when it turns out that Silver isn't being possessed by Deliora, he's actually [[OurZombiesAreDifferent a reanimated corpse]], and he just wanted to make Grey angry enough to kill him because he [[TakeUpMySword wants him to avenge his death and defeat Tartarus.]]]]
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** [[spoiler: Subverted when it turns out that Silver isn't being possessed by Deliora, he's actually [[OurZombiesAreDifferent a reanimated corpse]], and he just wanted to make Grey angry enough to kill him because he [[TakeUpMySword wants him to avenge his death and defeat Tartarus.]]]]]]]]
* In ''Manga/FistOfTheNorthStar'', main character Kenshiro's arch-nemeses were his adoptive older brothers [[BoisterousWeakling Jagi]] and [[BigBad Raoh]], who were both bitter over Ken being chosen as [[ThereCanBeOnlyOne the sole successor to]] Hokuto Shinken over them (and [[KungFuJesus Toki]] and , but he didn't really mind). Even though Raoh was the bigger rival in the story, Jagi gets special mention because he purposefully set out to ruin Ken's life and is personally responsible for the good majority of the plot. In the early part of the series, [[RivalTurnedEvil Shin]] fufilled this role, as he was the one who took Ken's fiance [[LoveInterest Yuria]] away from him and gave him his distinctive seven scars on his chest, though it could be considered subverted in the meta-sense because he was goaded into doing this by Jagi.
* In ''Manga/FistOfTheNorthStar'', main character Kenshiro's arch-nemeses were his adoptive older brothers [[BoisterousWeakling Jagi]] and [[BigBad Raoh]], who were both bitter over Ken being chosen as [[ThereCanBeOnlyOne the sole successor to]] Hokuto Shinken over them (and [[KungFuJesus Toki]] and , but he didn't really mind). Even though Raoh was the bigger rival in the story, Jagi gets special mention because he purposefully set out to ruin Ken's life and is personally responsible for the good majority of the plot. In the early part of the series, [[RivalTurnedEvil Shin]] fufilled this role, as he was the one who took Ken's fiance [[LoveInterest Yuria]] away from him and gave him his distinctive seven scars on his chest, though it could be considered subverted in the meta-sense because he was goaded into doing this by Jagi.
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** [[spoiler: Subverted when it turns out that Silver isn't being possessed by Deliora, he just wanted to make Grey angry enough to kill him because he [[ICannotSelfTerminate can't do it himself]].]]
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** [[spoiler: Subverted when it turns out that Silver isn't being possessed by Deliora, he's actually [[OurZombiesAreDifferent a reanimated corpse]], and he just wanted to make Grey angry enough to kill him because he [[ICannotSelfTerminate can't do it himself]].]][[TakeUpMySword wants him to avenge his death and defeat Tartarus.]]]]
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* In ''Manga/FairyTail'', the demon Deliora ruined Gray's life by wiping out his hometown, killing his parents, and forcing his mentor/surrogate mother Ur to sacrifice herself to defeat him. [[spoiler:When Gray encounters Deliora again when the latter is possessing the corpse of Gray's father Silver Fullbuster, Gray ''[[UnstoppableRage loses it]]''.]]
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* In ''Manga/FairyTail'', the demon Deliora ruined Gray's life by wiping out his hometown, killing his parents, and forcing his mentor/surrogate mother Ur to sacrifice herself to defeat him. [[spoiler:When Gray encounters Deliora again when the latter is possessing the corpse of Gray's father Silver Fullbuster, Gray ''[[UnstoppableRage loses it]]''.]]
** [[spoiler: Subverted when it turns out that Silver isn't being possessed by Deliora, he just wanted to make Grey angry enough to kill him because he [[ICannotSelfTerminate can't do it himself]].]]
** [[spoiler: Subverted when it turns out that Silver isn't being possessed by Deliora, he just wanted to make Grey angry enough to kill him because he [[ICannotSelfTerminate can't do it himself]].]]
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* Griffith to Guts in ''{{Berserk}}''. The Skull Knight also has one in Void, the leader of the Godhand.
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* Griffith to Guts in ''{{Berserk}}''. ''Manga/{{Berserk}}''. Griffith ''claims'' not to care much one way or the other about Guts [[spoiler: after Griffith [[AGodAmI ascends to the God Hand]],]] but his actions give it the lie. The Skull Knight also has one in Void, the leader of the Godhand.Godhand. Zodd considers the Skull Knight his, although [[FanNickName Skully]] doesn't seem to take their rivalry quite as personally, considering him a WorthyFoe but not much more.
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* Alucard and Alexander Anderson from {{Hellsing}}. Both regard the other as a WorthyOpponent.
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* Alucard and Alexander Anderson from {{Hellsing}}.''Manga/{{Hellsing}}''. Both regard the other as a WorthyOpponent.
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* ''OnePiece'': While for the most part subverted due to the ArcVillain formula, there have been exceptions.
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* ''OnePiece'': ''Manga/OnePiece'': While for the most part subverted due to the ArcVillain formula, there have been exceptions.
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*** Luffy, who may be one of the most forgiving people in the series (read: Robin), had been aided several of his enemies, including Buggy and Mr. 3, but immediately had his live-and-let-live tendencies shut down the very ''moment'' he met Crocodile again while in Impel Down. Luffy would have never let him out of his cell had it not been for Ivankov.
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*** Luffy, who may be one of the most forgiving people in the series (read: Robin), had been series, has aided several of his enemies, including Buggy and Mr. 3, but immediately had his live-and-let-live tendencies shut down the very ''moment'' he met Crocodile again while in Impel Down. Luffy would have never let him out of his cell had it not been for Ivankov.
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* In ''Anime/DragonBallZ'', Vegeta is this to Goku until his HeelFaceTurn.
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* In ''Anime/DragonBallZ'', Vegeta is this to Goku until his HeelFaceTurn. Before the transition to the "Z" era, Piccolo was a strong contender.
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* In ''Anime/DragonBallZ'', Vegeta is this to Goku until his HeelFaceTurn.
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* In ''Anime/DragonBallZ'', Vegeta is this to Goku until his HeelFaceTurn.HeelFaceTurn.
* In ''Manga/FairyTail'', the demon Deliora ruined Gray's life by wiping out his hometown, killing his parents, and forcing his mentor/surrogate mother Ur to sacrifice herself to defeat him. [[spoiler:When Gray encounters Deliora again when the latter is possessing the corpse of Gray's father Silver Fullbuster, Gray ''[[UnstoppableRage loses it]]''.]]
* In ''Manga/FairyTail'', the demon Deliora ruined Gray's life by wiping out his hometown, killing his parents, and forcing his mentor/surrogate mother Ur to sacrifice herself to defeat him. [[spoiler:When Gray encounters Deliora again when the latter is possessing the corpse of Gray's father Silver Fullbuster, Gray ''[[UnstoppableRage loses it]]''.]]
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** ''[[Anime/MobileSuitZetaGundam Zeta Gundam]]'': While Paptimus Scirocco might be the BigBad and Yazan Gable the resident HeroKiller, it's [[StateSec Titans]]' AcePilot and former JerkJock Jerid Messa who is Kamille Bidan's archetypal archnemesis. The two of them essentially go back and forth on killing one another's friends and loved ones (Jerid kills Kamille's mother, girlfriend, and one of his friends; Kamille Jerid's crush, his BigBrotherMentor, his girlfriend, and a truckload of his subordinates), until the rivalry had turned deeply personal, especially on Jerid's part; by the end all he wants is Kamille's head on a pike.
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** ''[[Anime/MobileSuitZetaGundam Zeta Gundam]]'': While Paptimus Scirocco might be the BigBad and [[SociopathicSoldier Yazan Gable Gable]] the resident HeroKiller, it's [[StateSec Titans]]' AcePilot and former JerkJock Jerid Messa who is protagonist [[InsufferableGenius Kamille Bidan's Bidan]]'s archetypal archnemesis. The two of them essentially go back and forth on killing one another's friends and loved ones (Jerid kills Kamille's mother, girlfriend, and one of his friends; Kamille Jerid's crush, his BigBrotherMentor, his girlfriend, and a truckload of his subordinates), until the rivalry had turned turns deeply personal, especially on Jerid's part; by personal. By the end all he wants that Jerid in particular is living for is his dream of seeing Kamille's head on a pike.
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** Madara Uchiha to ''everyone''. [[spoiler:Literally speaking, ''everything'' that went wrong in the 'verse that would eventually lead to the plot can be blamed on him. The fact that his ultimate goal is to destroy free will is what causes the entire ninja world, who has been in almost a constant state of war for the last ''century'', to unite and stand against him.]]
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** Madara Uchiha to ''everyone''. [[spoiler:Literally speaking, ''everything'' that went wrong in the 'verse that would eventually lead to the plot can be blamed on him. The fact that his ultimate goal is to destroy free will is what causes the entire ninja world, who has been in almost a constant state of war for the last ''century'', to unite and stand against him.him, speaks volumes about what kind of man Madara Uchiha is.]]
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* In ''Manga/{{Naruto}}'' it's a little hard to decide, but mostly earlier friends turn into enemies, such as Orochimaru and Jiraiya, or even Naruto and Sasuke (though, the latter is in a quite difficult situation). Also Sasuke considered Itachi his arch-nemesis for a long time [[spoiler:until learing the truth now turns to Naruto and the leaf village]]. Tobi and the Akatsuki to Naruto and his allies.
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* In ''Manga/{{Naruto}}'' it's a little hard to decide, but mostly earlier friends turn into enemies, such as Orochimaru and Jiraiya, or even Naruto and Sasuke (though, the latter is in a quite difficult situation). Also Sasuke considered Itachi his arch-nemesis for a long time [[spoiler:until learing the truth now turns to Naruto and the leaf village]]. Tobi and the Akatsuki to Naruto and his allies.allies is perhaps the primary one.
** Madara Uchiha to ''everyone''. [[spoiler:Literally speaking, ''everything'' that went wrong in the 'verse that would eventually lead to the plot can be blamed on him. The fact that his ultimate goal is to destroy free will is what causes the entire ninja world, who has been in almost a constant state of war for the last ''century'', to unite and stand against him.]]
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*** Luffy, may be one of the most forgiving people in the series (read: Robin), had been aided several of his enemies, including Buggy and Mr. 3, but immediately had his live-and-let-live tendencies shut down the very ''moment'' he met Crocodile again while in Impel Down. Luffy would have never let him out of his cell had it not been for Ivankov.
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*** Luffy, who may be one of the most forgiving people in the series (read: Robin), had been aided several of his enemies, including Buggy and Mr. 3, but immediately had his live-and-let-live tendencies shut down the very ''moment'' he met Crocodile again while in Impel Down. Luffy would have never let him out of his cell had it not been for Ivankov.
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* Light and L from ''Manga/DeathNote'' are each other's archenemies, {{foil}}s, and near intellectual equals.
** Near is Mello's Arch Enemy even though they're theoretically on the same side.
* Baikinman from ''Soreike! Franchise/{{Anpanman}}'' is Anpanman's Arch Enemy, who was born to fight Anpanman. However, Anpanman treats him as friendly as anyone else as long as he isn't causing trouble.
* In ''ShakuganNoShana'', Wilhelmina Carmel explicitly refer to Sabrac, The Destructive Blade, as her nemesis.
* Seto Kaiba in ''Anime/YuGiOh'' might qualify, though he could also be considered a rival to Yugi. He even invokes this trope in the [[WebVideo/YuGiOhTheAbridgedSeries abridged series]]:
--> Kaiba: After all, he's my arch rival. The [[Franchise/SherlockHolmes Sherlock Holmes to my Moriarty]], the [[Manga/{{Akira}} Kaneda to my Tetsuo]], the [[Anime/SpeedRacer Speed Racer to my Racer X]]. I could go on but I won't.
** [[TheSociopath Yami Bakura]] is this to Yami Yugi.
* ''VisualNovel/HigurashiNoNakuKoroNi'' [[spoiler: has Furude Rika and Miyo Takano, who have been at each others' throats for 200 years due to a {{Groundhog Day| Loop}} StableTimeLoop. Takano invariably kills Rika, at which point [[PhysicalGod Hanyuu]] pushes the ResetButton, and it [[ItsPersonal gets more personal]] for poor Rika, who is [[FateWorseThanDeath completely conscious of the time loop. Rika only finds out Takano is her Arch Enemy in the second-to-last loop, and Takano is never aware of the loop.]].]]
* In ''VisualNovel/UminekoNoNakuKoroNi'', both Battler and Beatrice, as well as Bernkastel and Lambdadelta have reached this point with each other. [[spoiler:Or have they?]]
* Spike in ''Anime/CowboyBebop'' has EvilCounterpart Vicious. He also has LordErrorProne Andy, who is a mockery of this trope, being a one-shot {{foil}} who's a [[NotSoDifferent near perfect expression of Spike's id]] despite the latter's constant protests to the contrary.
* Negi Springfield in ''MahouSenseiNegima'' has Fate (no, not that [[MagicalGirlLyricalNanoha Fate]]), who seems to go out of his way to make personal attacks on Negi's friends.
** [[SchoolgirlLesbians Setsuna]] has her own Arch Enemy in the [[PsychoLesbian psychotic]] Tsukuyomi.
* Zero and Suzaku in ''Anime/CodeGeass'', though it's another case of moral ambiguity/ideological antagonism. [[spoiler:They eventually get over their issues and honestly work together.]]
** For Lelouch himself, both Charles and Schneizel follow this straight. And maddeningly enough, he has the misfortune [[spoiler:[[EtTuBrute to get sold out to both to them]] after they've already caused him enough grief for several lifetimes]].
* In ''Manga/{{Naruto}}'' it's a little hard to decide, but mostly earlier friends turn into enemies, such as Orochimaru and Jiraiya, or even Naruto and Sasuke (though, the latter is in a quite difficult situation). Also Sasuke considered Itachi his arch-nemesis for a long time [[spoiler:until learing the truth now turns to Naruto and the leaf village]]. Tobi and the Akatsuki to Naruto and his allies.
** The Second Tsuchikage and Second Mizukage had a long-standing grudge, which eventually led to their final battle where both perished.
* In ''Manga/DetectiveConan'' Shinichi's rival might be considered Kaito Kid, wherefore his nemesis is 'the organization' with his most present member Gin.
* Char Aznable and Amuro Ray are perhaps the most iconic throughout the ''Franchise/{{Gundam}}'' fandom. What started out as a professional military rivalry, later turned deeply personal after [[spoiler: the death of Char's assistant Lahlah Sune, whom both men loved, when she attempted to intervene in a battle between the two of them.]] In the end their rivalry leads to a MutualKill in ''CharsCounterattack''.
** ''[[Anime/MobileSuitZetaGundam Zeta Gundam]]'': While Paptimus Scirocco might be the BigBad and Yazan Gable the resident HeroKiller, it's [[StateSec Titans]]' AcePilot and former JerkJock Jerid Messa who is Kamille Bidan's archetypal archnemesis. The two of them essentially go back and forth on killing one another's friends and loved ones (Jerid kills Kamille's mother, girlfriend, and one of his friends; Kamille Jerid's crush, his BigBrotherMentor, his girlfriend, and a truckload of his subordinates), until the rivalry had turned deeply personal, especially on Jerid's part; by the end all he wants is Kamille's head on a pike.
** Judau Ashta and Haman Khan from ''[[Anime/MobileSuitGundamZZ Gundam ZZ]]'' play the trope rather differently from the usual Gundam rivalry. [[DatingCatwoman Haman is in love with Judau, who kind of reciprocates]], but Haman's [[MisanthropeSupreme philosophy of life]] is completely irreconcilable with Judau's idealism. Mutual attraction and [[MindlinkMates a Newtype connection]] between the two, rather than hatred, is what makes their opposition into a personal feud, to the point that when they go looking for a duel, the reaction of their respective crews is to LeaveTheTwoLovebirdsAlone.
*** Contrasting them is the equally twisted relationship between Roux Louka, Judau's [[TheLancer right-hand girl]], and Haman's treacherous subordinate [[TheStarscream Glemmy Toto]]. From shortly after his first appearance, Glemmy becomes obsessed with Roux, stalking her wherever she goes, and doing his best to gain control over her, while Roux alternately manipulates and defies him, using him for information one moment, then trying to kill him the next. Glemmy, in return, begins to subvert Roux's expectations, using her attempts at manipulating him in order to gain advantage over her crewmates. In the end, it's Roux who [[spoiler:kills Glemmy]], who accepts it with grace.
** In ''[[Anime/MobileFighterGGundam G Gundam]]'' the Canadian fighter Andrew Graham considers the Russian Fighter Argo Gulski his nemesis because he blames him for his wife's death. Also Domo Kasshu's and Master Asia's difficult relationship might be some kind of arch nemesis.
** In ''[[Anime/MobileSuitGundamWing Gundam Wing]]'' [[TheRival Zechs]] spends too much time on the good side to be this for [[TheHero Heero]] despite their constant battles, but Wufei definitely has one in [[MagnificentBastard Treize]] [[{{Ubermensch}} Kushrenada]].
** Rau Le Creuset of ''[[Anime/MobileSuitGundamSeed Gundam SEED]]'' is the Arch Enemy of Earth Forces' AcePilot Mu La Flaga. Their rivalry goes back to early in the war, and is ''extremely'' personal, even before TheReveal that Le Creuset is [[spoiler: a dying clone of La Flaga's father]]. Early in-show, the Le Creuset team, and especially [[ForgottenChildhoodFriend Athrun Zala]] are set up as the Archenemies of the ''[[CoolShip Archangel]]'', and [[TheHero Kira Yamato]] in particular. By the end they have pulled a HeelFaceTurn and [[spoiler: Le Creuset takes their position as Kira' Arch Enemy]].
** In ''[[Anime/MobileSuitGundamSeedDestiny Gundam SEED Destiny]]'' [[HeroWithAnFInGood Shinn Asuka]] and [[TheDragon Rey Za Burrel]] both consider [[AllLovingHero Kira Yamato]] to be their ArchNemesis, although Kira doesn't necessarily agree. An interesting case in that the arch enemies never so much as knew each other by name, only by the machines that they piloted (and in Shinn's case, recognizing Kira's fighting style after they each got a MidSeasonUpgrade).
** In ''[[Anime/MobileSuitGundam00 Gundam 00]]'' Graham Acre considers Setsuna F. Seiei and his Gundam Exia his arch nemesis for their crimes (though he calls it a special kind of love...) But he's really more TheRival in that regard. A better fit for Setsuna's archnemesis is [[TheSociopath psychopathic]] BloodKnight Ali Al-Saachez for destroying not just his life, but also killing off Lockon Stratos' family as well.
** In ''[[Anime/MobileSuitGundamAge Gundam AGE]]'' [[TheBrute Decil]] [[PsychoForHire Galette]] is Flit Asuno's Arch Enemy starting late in Season 1 and continuing into Season 2. Flit might hate all of the Vagan with a passion, but it takes Decil's return to send him into a murderous enough rage that he sorties himself, while Decil is living for revenge after Flit humiliated him in Season 1's climax.
* Gauron and Sousuke in ''LightNovel/FullMetalPanic!''. The feeling tends to be a ''lot'' more one-sided on Gauron's part, as he makes it his personal mission to put himself in a position where he can constantly antagonize Sousuke. It's so bad, it's to the point where it's suggested that he actually ''[[StalkerWithACrush stalks and watches Sousuke]]'', and purposefully chooses missions that would put him at odds with Sousuke, allowing them to meet again. Sousuke, on the other hand, finds Gauron ''insanely'' annoying, and would really love nothing more than [[WhyWontYouDie for the guy to just go die somewhere]] and leave him alone.
* [[TheHero Red]] and [[TheMafia Giovanni]] in ''Manga/PokemonSpecial'' are the most important. Also Yellow and Lance.
** The [[VideoGame/PokemonGoldAndSilver Johto arc]] has [[AntiHero Silver]] and [[FilleFatale Blue's]] nemesis [[spoiler:Pryce]].
* ''Anime/{{Pokemon}}'' has several examples:
** The original enmity was between Ash and Gary, with Gary rubbing his superiority in Ash's nose and Ash going crazy as he tried to catch up. They eventually buried the hatchet when they finally battled at the Johto League. Although Ash beat Gary, DefeatMeansFriendship and they became friendly rivals afterward.
** Ash later developed a more bitter rivalry with Paul over their methods of training Pokemon. A combination of BreakTheHaughty on Paul's part and Ash eventually beating him in the Sinnoh League again led them to bury the hatchet, and while they didn't exactly become friends afterward, they did develop a new respect for one another.
** Galactic Commander Saturn's Toxicroak to Brock's Croagunk.
** Team Rocket's Meowth feels this way towards ''every'' Persian he comes across.
* Ranma of ''RanmaOneHalf'' had Happosai (outright stated to be Ranma Arch Enemy in the datebook)
* Harima the delinquent in ''SchoolRumble'' had Hanai the class president. Harima's love rival is Karasuma. Eri & Yakumo too.
* Makoto and Jinnai in ''Anime/ElHazardTheMagnificentWorld''.
* In ''Manga/{{Bleach}}'', [[TheLancer Ishida]] originally had MadScientist Mayuri Kurotsuchi as his nemesis, although now that they're on the same side, [[spoiler: Ishida seems to come across as the ButtMonkey victim of Mayuri's [[SociopathicHero sociopathic humor]].]] The protagonist always had at least one mayor [[TheRival rival]] at each point in the story (first Ishida, followed by Renji, Kenpachi, Byakuya, Grimmjow and Ulquiorra).
** We also have The Grand Fisher, the first major antagonist. He went down quickly, but at the time he was Ichigo's archnemesis. He killed Ichigo's mother, the event that changed his life completely. It is because of him that he changes his motivation for fighting hollows, taking it much more seriously. Grand Fisher seems to acknowledge this, seeking out Ichigo as soon as he returns to the human world.
** [[GoodIsNotNice Yamamoto]]'s seems to be [[TheEmperor Yhwach]]. (who could be considered his EvilCounterpart, complete with a NotSoDifferent moment when the latter [[JerkassHasAPoint accuses the former]] of being a RetiredMonster) Notably, Yhwach is the only enemy that Yamamoto doesn't call "child", and he immediately unleashes his [[GodzillaThreshold incredibly destructive]] [[OneWingedAngel Bankai]] as soon as he shows up. The feeling is mutual - they've been at it for at least a millenium and it's pretty obvious that they really hate each other.
* Kimblee to Scar in ''Manga/FullmetalAlchemist'', as well as [[spoiler:Hohenheim to Father]]. Wrath also becomes this to both Greed and Scar.
** Ed and Envy in [[Anime/FullmetalAlchemist the 2003 anime version]], as well as Mustang and Pride.
* ''GunXSword'' - Justifying the DesignatedGirlFight, Carmen 99 and Fasalina are arch enemies. Fasalina is responsible for destroying Carmen's hometown, causing the death of Carmen's best friend from childhood, and Carmen ends up blamed for Fasalina's actions and shunned and exiled from her town.
* Johann vs Tenma in ''Anime/{{Monster}}'', but Nina wants in on it for a [[ItsPersonal good reason]].
* Griffith to Guts in ''{{Berserk}}''. The Skull Knight also has one in Void, the leader of the Godhand.
* Neo Saiba to Taichi Yagami in ''Manga/{{Digimon V-Tamer 01}}''.
* Kyubey to Akemi Homura in ''Anime/PuellaMagiMadokaMagica''. [[spoiler:[[GroundhogDayLoop There are some parallels to]] [[VisualNovel/HigurashiNoNakuKoroNi Takano Miyo and Furude Rika]].]]
* ''Franchise/BlackRockShooter'': The eponymous character versus Dead Master. [[spoiler:Ultimately {{Defied}} in the anime thanks to PowerOfLove.]]
* ''Manga/InuYasha'' and his friends have Naraku.
* In ''{{Durarara}}'', while almost anyone can set off Shizuo's HairTriggerTemper, just ''seeing'' Izaya (and sometimes just hearing his name) is enough to send Shizuo into a homicidal rage. Meanwhile, Izaya screws around with everyone's lives, but that's just because [[ForTheEvulz he likes seeing how they'll react]]; Shizuo's the only person in the world he actually hates.
* In ''Manga/SoulEater'', Medusa is the Arch Enemy of Maka, on Maka's part due to Medusa's connection to [[TheCorruption the black blood]] and [[HeelfaceRevolvingDoor Crona]], and on Medusa's side thanks to Maka's Soul Perception. [[BigBad Asura]] is this [[BigGood Lord Death]] and his DWMA Students, Staff, and many of their allies, including TheHeroine Maka and her friends.
* Alucard and Alexander Anderson from {{Hellsing}}. Both regard the other as a WorthyOpponent.
* In {{HunterxHunter}}, Hisoka is this to Gon. He has an unnerving obssession with Gon and anticipates the day he "ripens to his full potential" just so he can have the chance to fight and possibly kill him. Gon also had a desire to fight Hisoka earlier in the series for hurting his pride.
** Chrollo Lucifer is Kurapica's Arch Enemy, due to being the leader of the group responsible for killing his clan.
** The one person Killua hates and fears more than anyone else is his own older brother Illumi. Illumi is psychotically devoted to Killua and has done some truly awful things to him and to others because of it.
* In ''Manga/JojosBizarreAdventure'', Dio Brando is this to Jonathan Joestar in Part I and arguably to the Joestar bloodline for the rest of the series. Even after he is permanently slain in Part III, the mess he left behind causes trouble for Jonathan's descendants.
* ''OnePiece'': While for the most part subverted due to the ArcVillain formula, there have been exceptions.
** Vivi, who's practically an angel, hates Crocodile with such a passion that he was the only person she has ever expressed the desire to kill. Then again, he's ''more'' than earned her hatred, and that of all of Alabasta for that matter.
*** Luffy, may be one of the most forgiving people in the series (read: Robin), had been aided several of his enemies, including Buggy and Mr. 3, but immediately had his live-and-let-live tendencies shut down the very ''moment'' he met Crocodile again while in Impel Down. Luffy would have never let him out of his cell had it not been for Ivankov.
*** Crocodile himself has [[spoiler:or had]] one in Whitebeard.
** Akainu to Luffy [[spoiler:and the remnants of the Whitebeard Pirates for killing Ace.]]
** Blackbeard to the Whitebeard Pirates for betraying them and killing nakama, [[spoiler:then orchestrating the Marineford war for his own personal gain, thereby indirectly causing Ace's death, and then personally killing (with the help of his crew) Whitebeard himself.]]
** [[spoiler:Law and Doflamingo. To the point that Law is willing to do anything to ensure Doflamingo's death, even at the cost of his own life. Doflamingo, after the last two arcs, has come to hate him just as deeply.]]
*** [[spoiler:Doflamingo is also a personal enemy of the Riku royal family, the previous rulers of Dressrosa. Let's put it this way: what Crocodile did to Vivi and Alabasta was ''nothing'' compared to what Doflamingo did to the Riku family and Dressrosa as a whole.]]
* In ''Anime/FutariWaPrettyCure'', Jaaku King is the ArchEnemy to the Queen of Light.
* In ''Anime/FreshPrettyCure'', Eas was this to Cure Peach [[spoiler:until her HeelFaceTurn]], even if Peach wasn't really aware of it.
* In ''Anime/HeartcatchPrettyCure'', Dark Precure is this to Cure Moonlight. She's an EvilKnockoff who is especially created to defeat Moonlight. Also [[spoiler:[[CainAndAbel Dark Precure is the Cain to Moonlight's Abel]]]].
* Subverted in ''Anime/SuitePrettyCure''. It seems that Mephisto is the ArchEnemy to Aphrodite, but it later turns out that [[spoiler:Mephisto actually is the king of Major Land, Aphrodite's husband and he's brainwashed by the real BigBad Noise]].
* In ''Anime/DokiDokiPrettyCure'', Regina is this to Cure Heart. With a lots of FoeYay. Sadly, both actually love each other (in a platonic way), and Cure Heart wants to ''save'' Regina because [[spoiler:she's brainwashed by her father [[BigBad King Jikochuu]]]], Regina is still a villain.
* In ''Anime/DragonBallZ'', Vegeta is this to Goku until his HeelFaceTurn.
** Near is Mello's Arch Enemy even though they're theoretically on the same side.
* Baikinman from ''Soreike! Franchise/{{Anpanman}}'' is Anpanman's Arch Enemy, who was born to fight Anpanman. However, Anpanman treats him as friendly as anyone else as long as he isn't causing trouble.
* In ''ShakuganNoShana'', Wilhelmina Carmel explicitly refer to Sabrac, The Destructive Blade, as her nemesis.
* Seto Kaiba in ''Anime/YuGiOh'' might qualify, though he could also be considered a rival to Yugi. He even invokes this trope in the [[WebVideo/YuGiOhTheAbridgedSeries abridged series]]:
--> Kaiba: After all, he's my arch rival. The [[Franchise/SherlockHolmes Sherlock Holmes to my Moriarty]], the [[Manga/{{Akira}} Kaneda to my Tetsuo]], the [[Anime/SpeedRacer Speed Racer to my Racer X]]. I could go on but I won't.
** [[TheSociopath Yami Bakura]] is this to Yami Yugi.
* ''VisualNovel/HigurashiNoNakuKoroNi'' [[spoiler: has Furude Rika and Miyo Takano, who have been at each others' throats for 200 years due to a {{Groundhog Day| Loop}} StableTimeLoop. Takano invariably kills Rika, at which point [[PhysicalGod Hanyuu]] pushes the ResetButton, and it [[ItsPersonal gets more personal]] for poor Rika, who is [[FateWorseThanDeath completely conscious of the time loop. Rika only finds out Takano is her Arch Enemy in the second-to-last loop, and Takano is never aware of the loop.]].]]
* In ''VisualNovel/UminekoNoNakuKoroNi'', both Battler and Beatrice, as well as Bernkastel and Lambdadelta have reached this point with each other. [[spoiler:Or have they?]]
* Spike in ''Anime/CowboyBebop'' has EvilCounterpart Vicious. He also has LordErrorProne Andy, who is a mockery of this trope, being a one-shot {{foil}} who's a [[NotSoDifferent near perfect expression of Spike's id]] despite the latter's constant protests to the contrary.
* Negi Springfield in ''MahouSenseiNegima'' has Fate (no, not that [[MagicalGirlLyricalNanoha Fate]]), who seems to go out of his way to make personal attacks on Negi's friends.
** [[SchoolgirlLesbians Setsuna]] has her own Arch Enemy in the [[PsychoLesbian psychotic]] Tsukuyomi.
* Zero and Suzaku in ''Anime/CodeGeass'', though it's another case of moral ambiguity/ideological antagonism. [[spoiler:They eventually get over their issues and honestly work together.]]
** For Lelouch himself, both Charles and Schneizel follow this straight. And maddeningly enough, he has the misfortune [[spoiler:[[EtTuBrute to get sold out to both to them]] after they've already caused him enough grief for several lifetimes]].
* In ''Manga/{{Naruto}}'' it's a little hard to decide, but mostly earlier friends turn into enemies, such as Orochimaru and Jiraiya, or even Naruto and Sasuke (though, the latter is in a quite difficult situation). Also Sasuke considered Itachi his arch-nemesis for a long time [[spoiler:until learing the truth now turns to Naruto and the leaf village]]. Tobi and the Akatsuki to Naruto and his allies.
** The Second Tsuchikage and Second Mizukage had a long-standing grudge, which eventually led to their final battle where both perished.
* In ''Manga/DetectiveConan'' Shinichi's rival might be considered Kaito Kid, wherefore his nemesis is 'the organization' with his most present member Gin.
* Char Aznable and Amuro Ray are perhaps the most iconic throughout the ''Franchise/{{Gundam}}'' fandom. What started out as a professional military rivalry, later turned deeply personal after [[spoiler: the death of Char's assistant Lahlah Sune, whom both men loved, when she attempted to intervene in a battle between the two of them.]] In the end their rivalry leads to a MutualKill in ''CharsCounterattack''.
** ''[[Anime/MobileSuitZetaGundam Zeta Gundam]]'': While Paptimus Scirocco might be the BigBad and Yazan Gable the resident HeroKiller, it's [[StateSec Titans]]' AcePilot and former JerkJock Jerid Messa who is Kamille Bidan's archetypal archnemesis. The two of them essentially go back and forth on killing one another's friends and loved ones (Jerid kills Kamille's mother, girlfriend, and one of his friends; Kamille Jerid's crush, his BigBrotherMentor, his girlfriend, and a truckload of his subordinates), until the rivalry had turned deeply personal, especially on Jerid's part; by the end all he wants is Kamille's head on a pike.
** Judau Ashta and Haman Khan from ''[[Anime/MobileSuitGundamZZ Gundam ZZ]]'' play the trope rather differently from the usual Gundam rivalry. [[DatingCatwoman Haman is in love with Judau, who kind of reciprocates]], but Haman's [[MisanthropeSupreme philosophy of life]] is completely irreconcilable with Judau's idealism. Mutual attraction and [[MindlinkMates a Newtype connection]] between the two, rather than hatred, is what makes their opposition into a personal feud, to the point that when they go looking for a duel, the reaction of their respective crews is to LeaveTheTwoLovebirdsAlone.
*** Contrasting them is the equally twisted relationship between Roux Louka, Judau's [[TheLancer right-hand girl]], and Haman's treacherous subordinate [[TheStarscream Glemmy Toto]]. From shortly after his first appearance, Glemmy becomes obsessed with Roux, stalking her wherever she goes, and doing his best to gain control over her, while Roux alternately manipulates and defies him, using him for information one moment, then trying to kill him the next. Glemmy, in return, begins to subvert Roux's expectations, using her attempts at manipulating him in order to gain advantage over her crewmates. In the end, it's Roux who [[spoiler:kills Glemmy]], who accepts it with grace.
** In ''[[Anime/MobileFighterGGundam G Gundam]]'' the Canadian fighter Andrew Graham considers the Russian Fighter Argo Gulski his nemesis because he blames him for his wife's death. Also Domo Kasshu's and Master Asia's difficult relationship might be some kind of arch nemesis.
** In ''[[Anime/MobileSuitGundamWing Gundam Wing]]'' [[TheRival Zechs]] spends too much time on the good side to be this for [[TheHero Heero]] despite their constant battles, but Wufei definitely has one in [[MagnificentBastard Treize]] [[{{Ubermensch}} Kushrenada]].
** Rau Le Creuset of ''[[Anime/MobileSuitGundamSeed Gundam SEED]]'' is the Arch Enemy of Earth Forces' AcePilot Mu La Flaga. Their rivalry goes back to early in the war, and is ''extremely'' personal, even before TheReveal that Le Creuset is [[spoiler: a dying clone of La Flaga's father]]. Early in-show, the Le Creuset team, and especially [[ForgottenChildhoodFriend Athrun Zala]] are set up as the Archenemies of the ''[[CoolShip Archangel]]'', and [[TheHero Kira Yamato]] in particular. By the end they have pulled a HeelFaceTurn and [[spoiler: Le Creuset takes their position as Kira' Arch Enemy]].
** In ''[[Anime/MobileSuitGundamSeedDestiny Gundam SEED Destiny]]'' [[HeroWithAnFInGood Shinn Asuka]] and [[TheDragon Rey Za Burrel]] both consider [[AllLovingHero Kira Yamato]] to be their ArchNemesis, although Kira doesn't necessarily agree. An interesting case in that the arch enemies never so much as knew each other by name, only by the machines that they piloted (and in Shinn's case, recognizing Kira's fighting style after they each got a MidSeasonUpgrade).
** In ''[[Anime/MobileSuitGundam00 Gundam 00]]'' Graham Acre considers Setsuna F. Seiei and his Gundam Exia his arch nemesis for their crimes (though he calls it a special kind of love...) But he's really more TheRival in that regard. A better fit for Setsuna's archnemesis is [[TheSociopath psychopathic]] BloodKnight Ali Al-Saachez for destroying not just his life, but also killing off Lockon Stratos' family as well.
** In ''[[Anime/MobileSuitGundamAge Gundam AGE]]'' [[TheBrute Decil]] [[PsychoForHire Galette]] is Flit Asuno's Arch Enemy starting late in Season 1 and continuing into Season 2. Flit might hate all of the Vagan with a passion, but it takes Decil's return to send him into a murderous enough rage that he sorties himself, while Decil is living for revenge after Flit humiliated him in Season 1's climax.
* Gauron and Sousuke in ''LightNovel/FullMetalPanic!''. The feeling tends to be a ''lot'' more one-sided on Gauron's part, as he makes it his personal mission to put himself in a position where he can constantly antagonize Sousuke. It's so bad, it's to the point where it's suggested that he actually ''[[StalkerWithACrush stalks and watches Sousuke]]'', and purposefully chooses missions that would put him at odds with Sousuke, allowing them to meet again. Sousuke, on the other hand, finds Gauron ''insanely'' annoying, and would really love nothing more than [[WhyWontYouDie for the guy to just go die somewhere]] and leave him alone.
* [[TheHero Red]] and [[TheMafia Giovanni]] in ''Manga/PokemonSpecial'' are the most important. Also Yellow and Lance.
** The [[VideoGame/PokemonGoldAndSilver Johto arc]] has [[AntiHero Silver]] and [[FilleFatale Blue's]] nemesis [[spoiler:Pryce]].
* ''Anime/{{Pokemon}}'' has several examples:
** The original enmity was between Ash and Gary, with Gary rubbing his superiority in Ash's nose and Ash going crazy as he tried to catch up. They eventually buried the hatchet when they finally battled at the Johto League. Although Ash beat Gary, DefeatMeansFriendship and they became friendly rivals afterward.
** Ash later developed a more bitter rivalry with Paul over their methods of training Pokemon. A combination of BreakTheHaughty on Paul's part and Ash eventually beating him in the Sinnoh League again led them to bury the hatchet, and while they didn't exactly become friends afterward, they did develop a new respect for one another.
** Galactic Commander Saturn's Toxicroak to Brock's Croagunk.
** Team Rocket's Meowth feels this way towards ''every'' Persian he comes across.
* Ranma of ''RanmaOneHalf'' had Happosai (outright stated to be Ranma Arch Enemy in the datebook)
* Harima the delinquent in ''SchoolRumble'' had Hanai the class president. Harima's love rival is Karasuma. Eri & Yakumo too.
* Makoto and Jinnai in ''Anime/ElHazardTheMagnificentWorld''.
* In ''Manga/{{Bleach}}'', [[TheLancer Ishida]] originally had MadScientist Mayuri Kurotsuchi as his nemesis, although now that they're on the same side, [[spoiler: Ishida seems to come across as the ButtMonkey victim of Mayuri's [[SociopathicHero sociopathic humor]].]] The protagonist always had at least one mayor [[TheRival rival]] at each point in the story (first Ishida, followed by Renji, Kenpachi, Byakuya, Grimmjow and Ulquiorra).
** We also have The Grand Fisher, the first major antagonist. He went down quickly, but at the time he was Ichigo's archnemesis. He killed Ichigo's mother, the event that changed his life completely. It is because of him that he changes his motivation for fighting hollows, taking it much more seriously. Grand Fisher seems to acknowledge this, seeking out Ichigo as soon as he returns to the human world.
** [[GoodIsNotNice Yamamoto]]'s seems to be [[TheEmperor Yhwach]]. (who could be considered his EvilCounterpart, complete with a NotSoDifferent moment when the latter [[JerkassHasAPoint accuses the former]] of being a RetiredMonster) Notably, Yhwach is the only enemy that Yamamoto doesn't call "child", and he immediately unleashes his [[GodzillaThreshold incredibly destructive]] [[OneWingedAngel Bankai]] as soon as he shows up. The feeling is mutual - they've been at it for at least a millenium and it's pretty obvious that they really hate each other.
* Kimblee to Scar in ''Manga/FullmetalAlchemist'', as well as [[spoiler:Hohenheim to Father]]. Wrath also becomes this to both Greed and Scar.
** Ed and Envy in [[Anime/FullmetalAlchemist the 2003 anime version]], as well as Mustang and Pride.
* ''GunXSword'' - Justifying the DesignatedGirlFight, Carmen 99 and Fasalina are arch enemies. Fasalina is responsible for destroying Carmen's hometown, causing the death of Carmen's best friend from childhood, and Carmen ends up blamed for Fasalina's actions and shunned and exiled from her town.
* Johann vs Tenma in ''Anime/{{Monster}}'', but Nina wants in on it for a [[ItsPersonal good reason]].
* Griffith to Guts in ''{{Berserk}}''. The Skull Knight also has one in Void, the leader of the Godhand.
* Neo Saiba to Taichi Yagami in ''Manga/{{Digimon V-Tamer 01}}''.
* Kyubey to Akemi Homura in ''Anime/PuellaMagiMadokaMagica''. [[spoiler:[[GroundhogDayLoop There are some parallels to]] [[VisualNovel/HigurashiNoNakuKoroNi Takano Miyo and Furude Rika]].]]
* ''Franchise/BlackRockShooter'': The eponymous character versus Dead Master. [[spoiler:Ultimately {{Defied}} in the anime thanks to PowerOfLove.]]
* ''Manga/InuYasha'' and his friends have Naraku.
* In ''{{Durarara}}'', while almost anyone can set off Shizuo's HairTriggerTemper, just ''seeing'' Izaya (and sometimes just hearing his name) is enough to send Shizuo into a homicidal rage. Meanwhile, Izaya screws around with everyone's lives, but that's just because [[ForTheEvulz he likes seeing how they'll react]]; Shizuo's the only person in the world he actually hates.
* In ''Manga/SoulEater'', Medusa is the Arch Enemy of Maka, on Maka's part due to Medusa's connection to [[TheCorruption the black blood]] and [[HeelfaceRevolvingDoor Crona]], and on Medusa's side thanks to Maka's Soul Perception. [[BigBad Asura]] is this [[BigGood Lord Death]] and his DWMA Students, Staff, and many of their allies, including TheHeroine Maka and her friends.
* Alucard and Alexander Anderson from {{Hellsing}}. Both regard the other as a WorthyOpponent.
* In {{HunterxHunter}}, Hisoka is this to Gon. He has an unnerving obssession with Gon and anticipates the day he "ripens to his full potential" just so he can have the chance to fight and possibly kill him. Gon also had a desire to fight Hisoka earlier in the series for hurting his pride.
** Chrollo Lucifer is Kurapica's Arch Enemy, due to being the leader of the group responsible for killing his clan.
** The one person Killua hates and fears more than anyone else is his own older brother Illumi. Illumi is psychotically devoted to Killua and has done some truly awful things to him and to others because of it.
* In ''Manga/JojosBizarreAdventure'', Dio Brando is this to Jonathan Joestar in Part I and arguably to the Joestar bloodline for the rest of the series. Even after he is permanently slain in Part III, the mess he left behind causes trouble for Jonathan's descendants.
* ''OnePiece'': While for the most part subverted due to the ArcVillain formula, there have been exceptions.
** Vivi, who's practically an angel, hates Crocodile with such a passion that he was the only person she has ever expressed the desire to kill. Then again, he's ''more'' than earned her hatred, and that of all of Alabasta for that matter.
*** Luffy, may be one of the most forgiving people in the series (read: Robin), had been aided several of his enemies, including Buggy and Mr. 3, but immediately had his live-and-let-live tendencies shut down the very ''moment'' he met Crocodile again while in Impel Down. Luffy would have never let him out of his cell had it not been for Ivankov.
*** Crocodile himself has [[spoiler:or had]] one in Whitebeard.
** Akainu to Luffy [[spoiler:and the remnants of the Whitebeard Pirates for killing Ace.]]
** Blackbeard to the Whitebeard Pirates for betraying them and killing nakama, [[spoiler:then orchestrating the Marineford war for his own personal gain, thereby indirectly causing Ace's death, and then personally killing (with the help of his crew) Whitebeard himself.]]
** [[spoiler:Law and Doflamingo. To the point that Law is willing to do anything to ensure Doflamingo's death, even at the cost of his own life. Doflamingo, after the last two arcs, has come to hate him just as deeply.]]
*** [[spoiler:Doflamingo is also a personal enemy of the Riku royal family, the previous rulers of Dressrosa. Let's put it this way: what Crocodile did to Vivi and Alabasta was ''nothing'' compared to what Doflamingo did to the Riku family and Dressrosa as a whole.]]
* In ''Anime/FutariWaPrettyCure'', Jaaku King is the ArchEnemy to the Queen of Light.
* In ''Anime/FreshPrettyCure'', Eas was this to Cure Peach [[spoiler:until her HeelFaceTurn]], even if Peach wasn't really aware of it.
* In ''Anime/HeartcatchPrettyCure'', Dark Precure is this to Cure Moonlight. She's an EvilKnockoff who is especially created to defeat Moonlight. Also [[spoiler:[[CainAndAbel Dark Precure is the Cain to Moonlight's Abel]]]].
* Subverted in ''Anime/SuitePrettyCure''. It seems that Mephisto is the ArchEnemy to Aphrodite, but it later turns out that [[spoiler:Mephisto actually is the king of Major Land, Aphrodite's husband and he's brainwashed by the real BigBad Noise]].
* In ''Anime/DokiDokiPrettyCure'', Regina is this to Cure Heart. With a lots of FoeYay. Sadly, both actually love each other (in a platonic way), and Cure Heart wants to ''save'' Regina because [[spoiler:she's brainwashed by her father [[BigBad King Jikochuu]]]], Regina is still a villain.
* In ''Anime/DragonBallZ'', Vegeta is this to Goku until his HeelFaceTurn.
