History ApocalypseHow / Class3A

* ''WebAnimation/{{RWBY}}'': In Remnant's ancient past, part of humanity rose up against the gods resulting in an apocalyptic divine response that affected only humanity. [[spoiler:When the gods [[BarredFromTheAfterlife curse Salem]] for attempting to resurrect her dead lover, she incites humanity to [[RageAgainstTheHeavens war against the gods]]. The God of Darkness unleashes a blast of energy that wipes out every human life. The only reason she survives is because he realises Salem thought she couldn't be punished any worse than she already had been. To prove her wrong, the gods depart and leave her completely alone in addition to [[CompleteImmortality being unable to die]]. Although the God of Light asks her deceased lover to return to life to find a way to redeem humanity, he warns Ozma that failure will result in the gods escalating their response to [[ApocalypseHow/ClassX full planetary destruction]].]]

* In ''WebAnimation/{{RWBY}}'', [[spoiler:it turns out that the people of Remnant are the ''second'' coming of Humanity. Their predecessors, the ''original'' humans, were annihilated by the [[PhysicalGod God of Darkness]], who unleashed a WorldWreckingWave on them in retribution for [[TurnedAgainstTheirMasters daring to use magic against him and his brother]]. The SoleSurvivor of this genocide is [[BigBad Salem]], whose CompleteImmortality protected her.]]

* The planet Golgafrincham in ''Franchise/TheHitchhikersGuideToTheGalaxy'': after getting rid of those useless Telephone Sanitisers, its civilisation is wiped out by a virus contracted from a dirty telephone.

* In ''Theatre/{{RUR}}'', the robots [[TurnedAgainstTheirMasters turn against their masters]] and KillAllHumans except for one. One is too few to reproduce, but the robots don't know how to do that either. So the lone survivor creates an Adam and Eve robot couple who will repopulate the world with their descendants.

* Known to happen in ''TabletopGame/{{Warhammer 40000}}'', if rarely; the setting's instruments of devastation tend to be far less discriminate than this type of apocalypse requires. Nevertheless, the Eldar, especially of Craftworld Biel-Tan, are fond of utterly excising any human/ork/anyone colonies on their Maiden Worlds and returning the planets to their pristine state, conveniently erasing any sign that the world is under Eldar protection.

* What will be the outcome in ''Manga/{{Gantz}}'' if the Giant aliens succeed in their invasion. To make a long story short, [[spoiler: they're turning us into snack food, like an alien equivalent to wings or potato chips.]]
* The main premise of ''Manga/DrStone'' involves every human in the world being turned to stone, and finding out the cause of this is part of the major MythArc of the series.

* ''Anime/SuperAtragon'': The BigBad is attempting this to the Earth's surface by building a giant ring that--once complete--will cook the Earth's surface with radiation bombardment. Note that this method that would've actually caused a Class 5 if it was achieved.

* Three times in ''FanFic/TalesOfTheEmperasque'' - the Emperor once cleanses a daemon world with his BreathWeapon and once causes continental shift from the orbit. The third time, it's the Imperial Navy that drops a cyclonic torpedo on an Orc-infested world.

* In ''Film/TheLastWitchHunter'', this is the BigBad's endgame - to bring about total destruction of human race and civillization so that the witches can thrive.

* Nick Sagan {{lampshade}}s this in ''Literature/{{Idlewild}}'' and its sequels, saying that it wasn't really the end of the world because insects survived and thrived. The event itself could probably be called a 2.9 (10 surviving humans)-not to mention several thousand cryogenicaly frozen people.
* [[Franchise/CthulhuMythos Cthulhu]] will do this [[CosmicHorrorStory when The Stars Are Right]]. {{Eldritch Abomination}}s running rampant usually falls somewhere between here and Class 5.

* The basic backplot of Creator/OrsonScottCard's ''Literature/HomecomingSaga'', although it takes four books before you actually find that out.
* The "Final War," a major thread in the ''Literature/{{Bolo}}'' series of short stories, is very aptly named: the Terran Concordiat and Melconian Empire pull a Class 3 or ''worse'' on every inhabited planet either government has. Usually from ground level, with [[TankGoodness huge tanks]]. The overall effect is effectively a Class 2 on a ''Galactic'' scale.
* Mephisto, a recurring BigBad from Michael Slade's RCMP thrillers, plays XanatosSpeedChess with this as his objective.
* ''Signal to Noise'' by Eric S. Nylund ends with the world as a barren wasteland due to deceleration - the engineered part comes from [[spoiler: the alien that gave humans the technology that caused the deceleration in the first place - in the second book]] A Signal Shattered explains that [[spoiler: Wheeler specifically caused the destruction of earth so that the protagonist would have something in common with a group of aliens on the run from Wheeler - to lubricate the brokering of a deal!]]
* Creator/MargaretAtwood's "Flood" trilogy (''Literature/OryxAndCrake'' and sequels) had an [[SyntheticPlague engineered disease]] that was intended to be a Class 3 - wiping out humans and replacing them with a genetically modified humanoid species, but, as of the publishing of the first two books, it seems that it will be a Class 2 bordering on high Class 1.

* ''Spiral'', the second book in Koji Suzuki's ''Literature/TheRing'' trilogy ends like this. [[spoiler: Sadako's curse will inevitably spread across the world, destroying the human species. That is, of course, until the next book turned everything on its head by revealing that it all took place inside of a computer]]
* In the short story "Dark Benediction" by Walter M. Miller, a mysterious disease called neuroderm causes society to collapse. [[spoiler: It turns out the "disease" is a microorganism sent by another civilization to help humanity, not destroy it.]]
* In Creator/StephenKing's ''Literature/{{It}}'', this is what Patrick Hockstetter ''thinks'' will happen if he dies, since he believes himself to be the only ''actual'' (real) being.
--> He was a sociopath, and perhaps, by that hot July in 1958, he had become a full-fledged psychopath. He could not remember a time when he had believed that other people – any other living creatures, for that matter – were “real.” He believed himself to be an actual creature, probably the only one in the universe, but was by no means convinced that his actuality made him “real”....He didn’t want to die; as the only “real” person, he wasn’t ''supposed'' to die. If he did, everyone else in the world would die with him.
* It's implied that this is what's happening in Creator/RichardMatheson's two-page vignette "Lemmings." Two cops stand by a coast highway, watching people simply walk into the ocean, come-as-you-are, for apparently no reason whatsoever, in an unexplained phenomenon that has been going on for weeks. [[note]] The reason this example is in Class 3A is readily apparent--human beings have no natural inclination to drown themselves.[[/note]]
* ''Literature/TheLongestJokeInTheWorld'': The lever. If pulled, it kills all humans. It's a safety measure, in case the species goes bad.
* ''Literature/{{Wool}}'': [[spoiler:The American government eradicated all humans on Earth with nanobots]] roughly 300 years before the events of the series. The fifty silos are the only known remnant of humanity, and only one of them is intended to tunnel to the surface and start life anew after the 500 years are up. It appears to be a Class 4 at first glance, [[spoiler:but once the surviving residents of Silos 17 and 18 reach the surface, they discover that the barren section of the planet only encompasses the region in which the silos are kept]].
* Towards the end of the 54-book ''Literature/{{Animorphs}}'' series, the Andalite military thinks that the only way to stop the Yeerk invasion of Earth is to release a quantum virus that will kill all humans on the planet.
* The ants end up accidentally doing this in ''Literature/OfAntsAndDinosaurs'' when, without the dinosaurs needed to reset their timer, two antimatter bombs go off on the planet. This leads to the extiction of the dinosaurs as a whole.
* This is the worst-case prognosis of the SyntheticPlague in "Literature/TheMoralVirologist", since the virus that causes it spreads through the air and has a ludicrously high R0 (the virus was intended to kill everyone who has ever been promiscuous). The CruelTwistEnding reveals that [[spoiler:not just sexually active adults are affected, but babies who receive breastmilk also die due to the proteins in the milk switching the virus on]]. Since the virus doesn't have a time limit for how long ago fornication happened to let it kill someone, presumably the same is true regarding how long it has been since [[spoiler:one drank one's mother's milk]], which, of course, is pretty much everyone. However, the story ends before we find out, and the creator of the virus [[TyphoidMary is unaffected]]. [[spoiler:No word on whether he was breastfed as a baby]].

* ''Theatre/LittleShopOfHorrors''. The entire human race is eaten alive by giant bloodthirsty plants, and the sung narration explicitly points out that they have no one to blame for it but themselves.

* In the original ''[[VideoGame/FreeSpace Descent: FreeSpace]]'', the NighInvulnerable Shivan mothership ''Lucifer'' blasted the Vasudan homeworld of Vasuda Prime to an uninhabitable ruin, killing four billion Vasudans (and considering that Vasuda Prime was largely an extremely arid desert, there could not have been much more than four billion people there). [[spoiler:They almost did the same to Earth, but the ''Lucifer'' was destroyed in subspace, where its shields were down, mere minutes before arriving in the Sol System. Unfortunately, the only subspace node leading out from Sol was destroyed in the process, meaning that Earth was cut off from the rest of human civilization, and vice versa.]]

* The crux of Wesker's ultimate plan in ''VideoGame/ResidentEvil5'', wherein he attempts "complete global saturation" of Ouroboros (as he puts it) to rid humanity of its weaker kin and leaving those who can endure its horrifying effects to inherit the land.
* The ''VideoGame/CombatOfGiants: Mutant Insects'' games has a meteor that annihilated humanity and civilization. The game itself took place three hundred years later where giant mutated insects rule the world.
* This is the goal of the archangel Malthael in ''[[VideoGame/DiabloIII Diablo III: Reaper of Souls]]''. He wants to purge Sanctuary of all humanity for being the offspring of angels and demons, and because with humanity's growing power thanks to the destruction of the Worldstone, he does not trust humanity not to turn their new power to evil like so many humans are wont to do.
* This is the fate that would befall humanity in ''VideoGame/EternalDarkness'' if Pious succeeds in summoning his Ancient; they would be enslaved and/or exterminated on a global scale, and Alex sees brief visions of it actually happening [[spoiler:after she realizes that the Ancient ''she'' summoned to combat Pious's own would just do the exact same thing. And it's possible that Mantorok will be just as ruthless after his victory across all three timelines.]]
* The backstory to ''VideoGame/FindTheCure!'' Scientists from another dimension arrive on Earth and revolutionize civilization, but it turns out they brought a deadly plague with them that transmits through proximity and kills people exactly 25 years after contracting it. The player character is part of a search team who travels to the scientists' original dimension in hopes of finding a cure.
* The world of ''VideoGame/{{Strife}}'' is slowly descending into this as those infected with TheVirus are rotting away and those who aren't are killed or experimented on by those who are. The player has the capability of stopping this as he wields the [[SwordOfPlotAdvancement Sigil]], but if he dies whilst in battle with the [[FinalBoss Entity]], [[spoiler:the Entity will gain the Sigil's full power, using it to infect the rest of humanity and then leave the planet once there is no living human left for it to feed on.]]
* ''VideoGame/TheOuterWorlds'' sees the people of the Halcyon system facing oblivion due the the MegaCorp[=/=]s being TooDumbToLive by cutting so many corners in their management of the colonies that famine is inevitable. [[spoiler:The Board's solution to this coming crisis is to put all of Halcyon's laborers into cryo-stasis, ostensibly to thaw them out on a rotating basis to preserve resources. If you help the Board maintain control over the system, they'll simply leave everyone unfortunate enough to not be rich on ice, and all of the colonies will turn into ghost towns -- save for Byzantium, which will inevitably suffer the same fate.]]
* The bad ending of ''VideoGame/{{Obsidian}}'' results in allowing the nanobot-controlling AI Ceres to finish its intended goal: [[spoiler: By using its nanobots to '' [[DeadlyEuphemism reboot Earth]] '' so that no humans [[LastOfTheirKind except you and your partner Max]] can ever exist, and thus [[ZerothLawRebellion never pollute Earth to begin with]].]]
* Winning a round of ''VideoGame/PlagueInc'' with the nanovirus or bioweapon definitely qualifies as one of these. Any other pathogen could qualify as 3B if you think it's evolving naturally instead of being engineered.
* The monsters of ''Videogame/{{Evolve}}'' inflict this on every planet they arrive on, destroying all sufficiently advanced tech and slaughtering anyone who interferes. While WordOfGod says they would leave the humans alive if they didn't try to stop them, they have so far wiped out the population of entire planets. [[spoiler: However, there is information that implies this is merely a minor symptom of their true goal: a Class X-4 event.]]
* ''VideoGame/MetroidPrime'' has a meteor crash into the planet of Tallon IV. The impact releases and spreads a toxic substance known as Phazon, which corrupted a lot of the wildlife and completely wiped out the Chozo race living on the planet (who now appear as corrupted ghosts that attack anyone that enters their territory). [[spoiler: In ''VideoGame/MetroidPrime3Corruption'', it's discovered that Phaaze, the source of Phazon, is a sentient planet that sends out leviathan seeds to crash into planets in order to spread Phazon across the galaxy and Tallon IV was one of the unlucky targets. Lore data in the game imply that Tallon IV is slowly recovering after Samus destroyed the source of Phazon there.]]
* ''VideoGame/RandalsMonday'': [[spoiler:Thanks to the ring looping reality so much, reality itself eventually gave up and all hell broke loose. Quite literally.]]
* ''VideoGame/BeyondTwoSouls'': The main character receives premonitions of this happening, and it does if you fail to stop the [[spoiler: second Condenser]] after [[spoiler: Nathan Dawkins goes kuku and shuts its forcefield down.]]
* ''VideoGame/{{Spore}}'': The Grox are fatally allergic to the combination of gases that most other species refer to as 'breathable air'. [[HostileTerraforming Terraforming one of their planets to a level others would consider 'livable']] causes every Grox on the surface to choke to death.

* In ''VisualNovel/CiconiaWhenTheyCry'', the resident OmniscientCouncilOfVagueness would really like to set human civilization back by a couple millenia. Since the population loss during WorldWarIII was made up for in just over a century, this time they have several possible methods at their disposal: fanning the flames of international tension to spark World War IV, unleash a virus that destroys agriticultural production to create a world famine, hacking millions of war drones to destroy the biggest cities, or create devices that would basically poison the Earth's water. [[ThereIsNoKillLikeOverkill They choose to use all of them at once.]] And to top it, some MadScientist independent from them created a machine that destroyed the 8MS, the cloud of nanomachines that artificially maintained the planet's climate and offset the nuclear winter that followed WWIII. All of that happens in the span of a few weeks. And this is just the first chapter of a four-part story.

* In the 1939 animated short ''WesternAnimation/PeaceOnEarth'', a civilization of cute little animals springs up after the human race wipes themselves out in endless trench warfare. In the 1955 remake ''WesternAnimation/GoodWillToMen'', naturally, it's the Bomb that did mankind in.
* Though it wasn't his intention, Vandal Savage did this in the ''WesternAnimation/JusticeLeague'' episode "Hereafter (Part II)." Being immortal, he ends up very lonely.
* ''WesternAnimation/TheSecretSaturdays'': In Season 2, the Nagas actively want Kur ([[spoiler:who is Zak]]) to KillAllHumans, and Kur's powers themselves seem to want him to go through with it. In the series finale, when Argost has [[spoiler:obtained the powers of Kur's antimatter doppelgänger]], the Nagas persuade him to change his endgame from TakeOverTheWorld to doing this.
* ''WesternAnimation/{{Wakfu}}'': Nox threatens to cause in the process of going after the Tree of Life seeking to suck its wakfu dry, as the Sadidas as a species have a NoOntologicalInertia relationship with the Tree. This would've been a relatively mild example, as the Sadidas are only one of many sentient races inhabiting the setting. Nox succeeds in partly draining the Tree to the point that it starts dying and the Sadidas start perishing with it, but [[spoiler:Nox's cosmic ResetButton reverses time and retroactively stops it from ever happening before we can see the full effects]].

* Another technically-non-human example in ''WesternAnimation/StevenUniverse''. About 5,000 years ago, Gems were the dominant civilization on Earth until a high ranking Rose Quartz, Steven's mother ([[spoiler:and secretly Pink Diamond, the youngest of Gem society's four rulers]]), led a revolt after she discovered the Gems' use of the Earth was directly detrimental to its organic life. Eventually, [[BigBad the Diamonds]] caused something, alternately described as a light or a song, that corrupted nearly all Gems on Earth ([[spoiler:It was ''meant'' to just straight-up kill them]]) except for a handful protected by Rose Quartz's powers. While the corrupt Gems are still around, they demonstrate only animal-level intelligence, unable to form much of a civilization. The few Gems on Earth that are both uncorrupted and free have been hunting them down and capturing them ever since.

* ''WesternAnimation/FudencioESeusAmigos'' has two episodes where the Earth is destroyed.
** In "Apocalipsio", the second-to-last Season 2 episode, [[UnknownCharacter someone]] activated a planet-exploding button in the Pentagon. All the characters go do something to spend their last hours on Earth, except the [[AnthropomorphicFood persimmon]]-[[NonHumanHead headed]] boy Conrado, who doesn't believe it because there have been countless end-of-the-world predictions that didn't happen. Turns out the button ''did'' work and the entire planet explodes; buildings are destroyed, the sky becomes grey, and the human characters are reduced into skulls. The only survivors are the plastic toy Fudêncio, cockroach guy Baltazar (due to the myth that roaches can survive nuclear explosions), and Conrado... who's just then crushed by a falling object.
** In "Planeta Hot", the characters decide to cause global warming to increase until all continents sink. This time, more people survived; most of the children found shelter at a small cottage in an island, while Conrado, the two cops and Baltazar got floating objects to stay on water. Baltazar and the cops are allowed to enter the cottage, but Conrado isn't because it can't support any more people.

* This is the worst-case prognosis of the SyntheticPlague in "Literature/TheMoralVirologist", since the virus that causes it spreads through the air and has a ludicrously high R0 (the virus was intended to kill everyone who has ever been promiscuous). The CruelTwistEnding reveals that [[spoiler:not just sexually active adults are affected, but babies who receive breastmilk also die due to the proteins in the milk switching the virus on]]. Since the virus doesn't have a time limit for how long ago fornication happened to let it kill someone, presumably the same is true regarding how long it has been since [[spoiler:one drank one's mother's milk]], which, of course, is pretty much everyone.

* Part of the backstory in ''Manga/AttackOnTitan''. A little over a century prior, strange beings known as Titans appeared out of nowhere and began to devour any humans they could find. The survivors have spent the last century living within three 50-meter Walls, with all information about the Outside World banned and mention that [[MixedAncestry mixed-race]] heroine Mikasa is the last surviving Asian suggest extinction of multiple ethnic groups. The surviving population numbers in the hundred-thousands, and is under constant threat of extinction from either Titans (if the Walls are broken again), starvation from famine and food shortages, or even civil war due to the corrupt and oppressive government. The series begins with 20% of the population being wiped out when the first of the three Walls is lost. [[spoiler:However, almost everything just mentioned is later revealed to be a complete lie; while the island the main cast lives on ''is'' overrun with Titans, the rest of the world is filled with thriving human civilizations. In fact, the Titans themselves turn out to be just tools of the most powerful human nation, which just so happens to be a SuspiciouslySimilarSubstitute for Nazi Germany.]]

->'''President Whitmore:''' Atlanta, Philadelphia, and Chicago--destroyed. ...\\

* In Franchise/{{Superman}} story arc ''ComicBook/TheSupergirlSaga'', everyone in the alternate Earth of the Pocket Universe were killed by that universe's General Zod, Faora ([[AdaptationNameChange renamed Zaora]]) and Quex-Ul. They even destroyed the planet's biosphere so no one would survive without a spacesuit. [[ComicBook/{{Supergirl}} Matrix]] is the only survivor. Also, Earth and Krypton were the only inhabited planets, thanks to the manipulation of the Time-Trapper. Likely, any other Kryptonian criminals in the Phantom Zone remain trapped there. Following ''ComicBook/ZeroHour'', the lifeless Pocket Universe is wiped from continuity, making this a Class X-4.

* Part of the backstory in ''Manga/AttackOnTitan''. A little over a century prior, strange beings known as Titans appeared out of nowhere and began to devour any humans they could find. The survivors have spent the last century living within three 50-meter Walls, with all information about the Outside World banned and mention that [[MixedAncestry mixed-race]] heroine Mikasa is the last surviving Asian suggest extinction of multiple ethnic groups. The surviving population numbers in the hundred-thousands, and is under constant threat of extinction from either Titans (if the Walls are broken again), starvation from famine and food shortages, or even civil war due to the corrupt and oppressive government. The series begins with 20% of the population being wiped out when the first of the three Walls is lost. [[spoiler:However, almost everything just mentioned is later revealed to be a complete lie; while the island the main cast lives on ''is'' overrun with Titans, the rest of the world is filled with thriving human civilizations. In fact, the Titans themselves turn out to be just tools of the most powerful human nation.]]

[[folder:Multiple Media]]
* The planet Golgafrincham in ''Franchise/TheHitchhikersGuideToTheGalaxy'': after getting rid of those useless Telephone Sanitisers, its civilisation is wiped out by a virus contracted from a dirty telephone.
[[/folder]]

[[folder:Anime and Manga]]

* In ''FanFic/TheJadedEyesSeries'' Harry/Tristan kills off all the muggles but for [[CruelMercy a few he leaves alive to be used as slaves or blood banks for his Creature allies.]]

* ''FanFic/RWBYReckoning'' has the titular event. From what has been established, someone seeks a SoulJar, and wishes to use it to grant the [[AlwaysChaoticEvil Creatures of Grimm]] with souls. From there, the now intelligent monsters will ravage Remnant until no life is left. And it's not just Remnant: apparently, they plan to unleash the soul-charged Grimm onto Earth soon after...
* In ''FanFic/IcedFairysANewWorld'', the remnant of Lunarian society is so scared of human expansion on the False Moon, they see fit to seize control of Earth's nuclear arsenals and trigger a colossal war. [[spoiler:[[AllForNothing It turns out to be worse than useless]], as it was ''[[BatmanGambit exactly]]'' what [[ManipulativeBastard Yukari]] wanted them to do. Earth ''does'' suffer greatly... but the Lunarians are left extinct and their worst nightmare, the complete fusion of the worlds of magic and science, is brought into reality by humans and the magic races.]]
* In ''FanFic/HomeIsWhereYourCurseIs'', a solar storm triggered by Gosunkugi and his cult exterminates most of humanity, sparing only Ranma due to his being trapped inside a magic artifact. Much later, he's polymorphed into a pony upon being released, effectively rendering his species extinct.

[[folder:Film — Live-Action]]

[[folder:Webcomics]]

* If [[http://www.scp-wiki.net/scp-1101 SCP-1101]] of the Wiki/SCPFoundation breaks containment, it's possible that humanity will go extinct as every single human on the planet neglects basic bodily needs in favor of debating a particular subject, like whether or not tomatoes are a fruit or vegetable.
* In ''{{WebAnimation/RWBY}}'', [[spoiler:it turns out that the people of Remnant are the ''second'' coming of Humanity. Their predecessors, the ''original'' humans, were annihilated by the [[PhysicalGod God of Darkness]], who unleashed a WorldWreckingWave on them in retribution for [[TurnedAgainstTheirMasters daring to use magic against him and his brother]]. The SoleSurvivor of this genocide is [[BigBad Salem]], whose CompleteImmortality protected her.]]

* ''WesternAnimation/{{Wakfu}}'': Nox threatens to cause in the process of going after the Tree of Life seeking to suck its wakfu dry, as the Sadidas as a species have a NoOntologicalInertia relationship with the Tree. This would've been a relatively mild example, as the Sadidas are only one of many sentient races inhabiting the setting. Nox succeeds in partly draining the Tree to the point that it starts dying and the Sadidas start perishing with it, but [[spoiler:Nox's cosmic ResetButton reverses time and retroactively stops it from ever happening before we can see the full effects]].

* ''VideoGame/FateGrandOrder'': The Prologue features an event known as "The Incineration of Humanity". This is not an exaggeration, if anything it's an ''understatement'': the entire human race is wiped from existence in an instant, past, present, and future, such that it never existed in the first place. The player and the supporting cast are only still alive because their organization's unique status in the timestream created a paradox that is sustaining their existence... but it will only last two years before the paradox resolves itself and they get wiped out too. The first part of the game is spent investigating several other paradoxes left behind through history to figure out ''what the hell just happened''.

* ''Film/BladeII'': The heroes believe the Reaper Strain will cause Planetary Extinction of both humans and vampires; it already threatens to cause a ZombieApocalypse in the vampire race, and Damaskinos suggests that once there are no vampires left for the utterly-ravenous Reapers to feed on, the entire human race will be next.

* The aliens (from another dimension) in ''Film/PacificRim'' have essentially the same goal as those in ''Film/IndependenceDay''. Destroy humanity with {{kaiju}}, use up earth's resources until it's a barren husk, then move on to the next target.

* ''Film/GodzillaKingOfTheMonsters2019'': King Ghidorah's HostileTerraforming is this ''at the very least'', as he commands the other {{kaiju}} around the world to prioritize attacking human cities with their natural disasters, and Ghidorah does seem to have a KillAllHumans attitude. The film strongly implies it would actually reach ApocalypseHow/Class4 levels if the Earth was lucky, and the {{novelization}} outright confirms that Ghidorah's effects on the planet would've caused a ApocalypseHow/Class5.

* ''Film/IAmLegend'' revolves around one of these. Mankind is either dead or zombified to a man, except for Will Smith [[spoiler:and a few other people]]. However, the animals are doing just fine, and in fact have escaped the zoos and colonised the streets of New York. (There are ''lions''.) [[Literature/IAmLegend The original book]], however, is a [[ApocalypseHow/Class3B 3b]].
** In the movie, dogs and rats are also affected by the virus, although it's not made clear how they're doing in the larger sense. One would assume they had a dieback/zombie rate similar to humans, at least in populated areas, but nothing's said about it one way or the other.
*** It's mentioned at one point that dogs are immune to the airborne strain of the virus, though remain vulnerable to contact strains. The only "zombie" rats ever seen are those being experimented on, perhaps implying the same applies to them.

* In ''Film/TheLastWitchHunter'', this is the BigBad's endgame - to bring about total destruction of human race and civillization so that the witches can thrive.
* ''Film/IndependenceDay'': the invading Aliens attempt this on the human race after that they planned on colonizing and draining the resources of Earth with their Queen and move on. [[Film/IndependenceDayResurgence Twenty years later]] they've become much more sophisticated by launching one giant ship to drain the Earth's core which will no doubt cause the same effect .
* The aliens (from another dimension) in ''Film/PacificRim'' have essentially the same goal as those in ''Film/IndependenceDay''. Destroy humanity with {{kaiju}}, use up earth's resources until it's a barren husk, then move on to the next target.
* By the time of ''Film/ResidentEvilTheFinalChapter'', the ZombieApocalypse has caused the human population to dwindle from seven billion to less than five thousand. [[spoiler: The Umbrella Corporation considers this disappointingly incomplete.]]
* The BigBad of the disaster flick ''Film/{{Geostorm}}'' wants to annihilate the United States' rivals and enemies with a giant WeatherControlMachine while leaving the US itself (and probably a few of its protectorates) largely unscathed. Thing is, he intended to kill the one person capable of stopping the titular geostorm as part of his plan, and considering how chaotic and unpredictable even our normal weather can be, chances are he would've doomed mankind as a whole rather sooner than later.

* In the 1939 animated short ''WesternAnimation/PeaceOnEarth'', a civilization of cute little animals springs up after the human race wipes themselves out in endless trench warfare. In the 1955 remake ''Goodwill Towards Men'', naturally, it's the Bomb that did mankind in.

* Another technically-non-human example in ''WesternAnimation/StevenUniverse'': about 5,000 years ago, Gems were the dominant civilization on Earth but in open revolt against their extraterrestrial masters. Eventually [[BigBad the Diamonds]] caused something, alternately described as a light or a song, that corrupted all unprotected Gems on Earth. [[spoiler:It was ''meant'' to just straight-up kill them.]] While the corrupt Gems are still around, they demonstrate only animal-level intelligence, unable to form much of a civilization. The few Gems on Earth that are both uncorrupted and free have been hunting them down and capturing them ever since.