History AdaptationDeviation / ResidentEvil2Remake

* The Plastic Explosives item is used to demolish a broken doorway from the chopper crash in the original in order to gain access to Chief Iron's office, while the remake instead has the protagonists using it to unblock the way leading to the Medallion on the precinct's third floor.

* The locations of many of the weapons have been changed so that they can be found in roughly the same areas regardless of if you're playing as Leon or Claire, in either the A or B scenario. The most egregious example of this is how the Spark Shot and Flamethrower have been changed from the original. Whereas both are found in separate areas of NEST in the classic, the Spark Shot on the body of a zombie and the Flamethrower in a locker, the remake puts both of them in a specialized holding area in the sewers that must be unlocked via SolveTheSoupCans. To make matters more confusing, both are found in the same room, on the same plaque, [[AdaptationInducedPlotHole despite both scenarios are supposed to be running concurrently in a single timeline]].

* Ada's injury changes between games. The original had her being slashed by G and her injury could be seen on her arm. The remake has her falling into a pit and her leg gets pierced by broken glass. Leon tends to her wound while he didn't do so in the original.

Several alterations have been made to the original game. However, unlike the remake of the original ''VideoGame/{{Resident Evil|1}}'', which more or less supplanted the first game's story by introducing new plot threads, here the narrative changes are more self-contained, and don't add onto or contradict with anything that takes place afterward in ''Franchise/ResidentEvil'' canon in any significant ways.

* Ada's "looking for my boyfriend" cover story is replaced with her [[ImpersonatingAnOfficer pretending to be an FBI agent]] who's going after Annette Birkin to get dirt on Umbrella. This also leads to her AdaptaionalPersonalityChange as well; whereas the original Ada played up her seductiveness and use of emotional manipulation to meet her goals, remake Ada leans heavily into a colder and more professional attitude with little tolerance for anything that gets in her way.

* Ada's "looking for my boyfriend" cover story is replaced with her [[ImpersonatingAnOfficer pretending to be an FBI agent]] who's going after Annette Birkin to get dirt on Umbrella.

* The remake has Sherry being captured and held hostage by Chief Irons while Claire fights her way through the city to rescue her. Sherry and Irons never interacted in the original game and Irons only makes a passing mention of Sherry during his final conversation with Claire.

* The ending was given a slight change. In the original, Leon says it's time for them to go and take out Umbrella (Leon B), while Claire's ending has her wanting to continue her mission to find Chris (Claire B). The remake has the ending the same for both characters and it has them wandering down a highway, waving at a passing truck and them being flipped off by the the driver. Leon and Claire then decide they'll do whatever it takes to prevent another viral outbreak, while Sherry proposes that the two should adopt her and get a puppy.

* The way Leon and Claire learn about how the town came to be infected and how William infected himself after getting shot are changed as well. In the original, [[JustBetweenYouAndMe Annette told various characters how the spill happened, how William was attacked, and that he injected himself with the G-virus.]] This made no sense, since she was trying to protect the G-virus. Here, since she is trying to destroy it, she doesn't make small talk with anyone save just before the G3 fight when Claire/Leon pointedly ask her what is going on after finding out for themselves via USS videotapes how the T-virus leaked and how William was cut down and connecting the dots themselves.

* Claire and Leon don't meet in a restaurant in Raccoon City. Instead, they encounter each other at a gas station on the outskirts of the city, and head into the city proper together. In addition, there's no zombie in the backseat of their cruiser. They instead are split up when their cop car comes upon a barricade, electing to go on foot to the RPD, when suddenly their cruiser is attacked by zombies on both sides, and a tanker truck bears down on them and crashes.

* Leon gets shot by [[spoiler:Annette]] before fighting the giant SewerGator in the original, whereas the remake reverses this order of events. This makes better sense as the gunshot wound would likely get infected (with regular infection) if Leon fights the gator with it in a damp sewer. Making it so that he gets shot after tumbling around in dirty water to kill the gator would solve this issue.

* Annette has been made slightly more sympathetic; rather than callously ignoring Sherry in favor of her research, her motive is now trying to put an end to her husband in his now monstrous form before he causes an epidemic. Accordingly, rather than approaching William's G 2 form and getting butchered, she instead tries to help Claire/Leon take him down (using a flare gun converted into a miniature grenade launcher) and is attacked when he turns out to be NotQuiteDead.

* The self destruct sequence was completely revamped. The original gave you five minutes to escape and the escape route you took was based on what scenario you played; scenario A leads you to a room where you fought G one last time while waiting for the elevator to come up and then said elevator took you to the train platform. Scenario B has you take the main elevator directly to the train station, turn on power for the train, and then have a final bout with Mr. X before boarding the train and then fighting G one last time. The remake doubles the escape timer to 10 minutes since you have to go through a few areas before reaching the train. Likewise, no matter which run you play on, Leon will always fight Mr. X near the end and Claire has to deal with G. While the original gave the scenario B character a rocket launcher to finish off Mr. X, the remake makes it a Leon exclusive weapon for his campaign while Claire gets a minigun for hers. The 2nd run character still fights G on the train.

* William Birkin's start of his G-Virus mutation has several differences between versions. The original had him barely alive with Annette seeing him dying and running off to get him treated. In the remake, Annette walks in after William injected the virus into himself and he starts to walk away while his whole body twitches. Annette raises a gun on him but can't bring herself to shoot her husband.
* Elliot Edward was given a drastically different design and his death was also changed between games. The original game had him as an overweight cop who almost looked like Chief Irons. Elliot dies by two zombies he tries to shoot with his machine gun and his weapon arcs up as he is tackled, causing it to shoot at the helicopter pilot nearby and making him crash into the group. The remake has Elliot with a slimmer build and he dies from a zombie chewing off his legs as Claire or Leon drag him from under the shutter door.

* William Birkin's start of his G-Virus mutation has several differences between versions. The original had him barely alive with Annette seeing him dying and running off to get him treated. In the remake, Annette walks in after William injected the virus into himself and he starts to walk away while his whole body twitches. Annette raises a gun on him but can't bring herself to shoot her husband.

** Speaking of the letter, it's made to be more a subtle code. He's comically pretending to not take the mansion murders seriously and instead enjoy a vacation. But the mention of "a really big Umbrella" should tip his fellow S.T.A.R.S. members, his sister, and fans of the first game off about his true intentions. He says Barry shouldn't come with him because it would upset his family if he does, I.E. he needs to stay and keep his family safe from the evil company.

* In the original's B scenario, Mr. X would appear after you powered the elevator leading to the laboratory. Looking at the security console would show Mr. X making his entrance before he destroys the camera. The remake moved this scene to the police station where the 2nd run character looking at the main hall's computer can see Mr. X approaching the camera and destroying it.

* The joint plugs used in scenario B of the original game were used to give the train area power. In the remake, the plugs not only appear in the train area to power the train, but also appear in Leon's scenario to power an elevator that takes him to the train. The plugs in the remake were also combined into one item but still takes up two slots.