- Actor-Shared Background: Damon Wayans' middle name is Kyle and he also has a son named Junior.
- Completely Different Title: In Germany, it's known as What's Up, Dad? (the title is in English).
- In France, it's known as Ma famille d'abord (My Family First)
- In Italy, it's known as Tutto in famiglia (All in the Family)
- The Danza:
- Kennedy McCulloughnote as Kennedy, Claire's protégé from the Big Sister program in "The Sweet Hairafter".
- Rick Overton as Rick, one of Michael's employees in "Candy Wars".
- Michael Wayans as Mike, one of Junior's friends.note
- Real-Life Relative:
- Ken, Michael's brother who appears in "A Little Romance", is played by Keenen Ivory Wayansnote .
- Damon Wayans' sons Damon Jr. and Michael play friends of Junior's (John and Mike, respectively) and his daughter Cara Mia plays two friends of Claire's (Bre in "Of Breasts and Basketball", and Shante in "He Heard, She Heard" and "The Whole World is Watching").
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