- Box Office Bomb: Budget, $40 million. Box office, $26,620,002 (worldwide).
- California Doubling: Germany doubles for Switzerland.
- Completely Different Title: Known in France under the untranslated title A Cure for Life.
- Creator Killer: As a result of a double whammy involving this film as well as The Lone Ranger (2013) (which was an even bigger Box Office Bomb and in fact one of the biggest ever), A Cure for Wellness ended up being the last film in Verbinski's movie career so far. He has yet to direct another feature.
- Fake Nationality:
- British actors Jason Isaacs and Mia Goth play the Swiss Volmer and Hannah.
- Swedish actor Magnus Krepper plays Pieter the Vet, another Swiss character.
- Typecasting: It's not the first time Dane DeHaan plays as a young man with daddy issues.
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