Richie's desperation to "cure" himself of AIDS before finally getting tested, which involves taking vitamin pills, eating disgusting foods, and at one point even considering drinking battery acid. After receiving the diagnosis he acknowledges that it's a death sentence, and as that realisation dawns on him he crosses the Despair Event Horizon.
Richie's breakdown in the car that he will never do anything. His future and all of his hopes and dreams have been taken away from him.
Colin's descent into dementia as a result of HIV given to him by his landlady’s son.
Colin's AIDS diagnosis, made worse by the fact he feels that he needs to apologise to his mother and deny being "dirty".
Richie's confession that he infected people after knowing he might have the virus, and asking Jill if she now hates him.
Gregory is taken home to Glasgow by his family, seemingly against his will, and dies without ever speaking to the rest of the group. His death is marked by a bonfire in the family garden, with all his clothes, childhood toys, possessions and even photos of him burning. Every trace of Gregory is wiped off the planet.
