The Earl of Lemongrab from does this a lot, especially in his premiere episode "Too Young":
Princess Bubblegum: Yo, Earl! Lemongrab:(from far away) WHAT?! Princess Bubblegum: Hey—you're fired! Ya BUTT! Lemongrab:(from far away) HHHHRRRRRUUURUUUUGGGGHH!!!!!!
In "Wizard Battle", Finn screams so loud at the prospect of Abracadaniel getting a chance to kiss Princess Bubblegum that it turns into a sonic attack that knocks out his opponent, winning Finn the contest.
In episode "A Smith in the Hand" of American Dad!, Stan screams when he first gets his family jewels burnt, and then a second time when he discovers masturbation.
From Animaniacs a Shout-Out most viewers likely missed; in "The Money Song", Dr. Scratchnsniff's face resembles the painting when he first wakes up.
Courage the Cowardly Dog does this a lot, such as Courage after getting stung by bees in "The Magic Tree of Nowhere". The penultimate episode has his ability used as a Chekhov's Skill, as his scream is so loud and long after years of honing it that he's able to shatter the ground beneath his rogues' gallery, sending them toppling down.
In the Earthworm Jim episode Conqueror Worm, Jim eats an entire cup of frozen yogurt in one gulp, which soon causes 'epic' brain freeze. He runs around shrieking so frantically, the camera skips the intermediate steps and immediately zooms out to planet level to show the entire Earth violently shaking.
In "Rambling Ed", Rolf reaches his Rage Breaking Point and shouts "The burden of hospitality is too great for Rolf!!", leading to a Distant Reaction Shot from the other kids.
Stewie screams several times when he walks in on Lois and Peter having sex. The scene then cuts to Mayor West sitting in his office several miles away, where he hears the infant's screeches.
Mayor Adam West: So, it's a shouting match you want, eh, Quahog? Well game on! Aaah aaah aaah aaah aar - I'm beating you!
The season 21 episode "The Munchurian Candidate" has Lois deliver a horrified scream as she witnesses Peter performing oral sex on Babs in a hypnotic trance.
Fry from Futurama Is prone to long, high-pitched screams, most notably in the episode, "Roswell That Ends Well", when the crew travels through time, get stuck in in Roswell, New Mexico, and Fry ends up impregnating his own grandmother. Dr. Zoidberg will occasionally do an epic scream as well, along with Prof. Farnsworth. You could basically say any character voiced by Billy West.
He-Man and the Masters of the Universe (2021): In the "The Tomb of Grayskull", He-Man battles a giant snake summoned by the Sigil of Hssss until it threw him into the air and swallowed him whole. He-Man screams as he ends up falling into a pool of Havoc in the creature's stomach. He embraces the Havoc to escape the snake and destroy the Sigil.
Hercules: The Animated Series, uses screams for comedic purposes quite often. Usually with Hercules who will typically scream as he falls or is sent flying in the air.
A little girl's scream is heard by The Tallest, who are on a spaceship on the other end of the galaxy.
In "Battle of the Planets", when Zim uses Mars as a giant steamroller to flatten Earth. The planet comes down gently and crushes a man's soda can. The man's screams go on for about a minute onscreen without end.
Old Lady Munson from Kid vs. Kat does this by screaming '''BUR. TON. BUR. GER!" in the episode "Something About Fiona" when she sees Coop and Fiona kissing in the door of her house causing her to scream Fiona's name at the top of her lungs.
In an episode of King of the Hill when Bobby joins a modeling agency for overweight boys he shows Hank a bunch of pictures they took of him and when he finds they are going put one of him wearing trapdoor pajamas, holding a tray of cookies, and putting his pinky finger to his mouth in the newspaper Hank lets one out that echos.
Used in Lilo & Stitch when Pleakley and Jumba spend their first night on Earth, and Pleakley discovers a very painful truth about one of the so-called wildlife preserve's inhabitants:
Pleakley: Look! A mosquito has chosen me as her perch. She's so beautiful. Look, another one! And another one! Why, it's a whole flock! They like me! They're nuzzling my flesh with their noses! Now they're... they're...
(Cue Distant Reaction Shot of their campsite near the house as Pleakley screams in pain)
Little Princess: Princess, being four years old, often screams at the top of her lungs when she's scared or frustrated. The Maid also screams like that sometimes, due to being a bit of a Lovable Coward.
In "I Don't Want Help", Princess screams when a spider jumps out.
In "I Don't Want to Go to Bed", the Maid wakes up and screams when she sees that the Princess is not in her bed, because she thinks that the monster the Princess was talking about earlier took her.
In "I Don't Want to Comb My Hair", the Maid and Princess both scream when they see a mouse as they think it's a rat and worry that rats will nest in their hair.
In "What's Wrong with Gilbert?", Princess screams when her teddy bear Gilbert's leg falls off.
In "I Want My Potty", Princess screams while having a tantrum on getting her potty for the first time, because she thinks potties are worse than diapers.
In "I Don't Want to Tidy Up", the Maid screams upon seeing the Princess's poorly-constructed "world" made out of toys as it looks like a mess to her and she's a Neat Freak.
Mrs. Wicket from Mr. Bean: The Animated Series screams constantly a lot to Mr. Bean especially in Homeless episode which she let's go a scream that everyone can be heard.
In "Sonic Rainboom", after Fluttershy's failed attempt at a pep talk, Rainbow Dash screams in panic and starts ranting about how there's no chance she can pull off a Sonic Rainboom and win the Best Young Flyers' Competition.
Parodied in "Green Isn't Your Color", when Fluttershy tries to give a frustrated scream after her modeling job makes her late to her spa day with Rarity.
Fluttershy: I'm so frustrated I could just scream! (long deep breath)Aaaaaaaaaaaaah!
This is King Julien's reaction when his crown gets lost in The Penguins of Madagascar episode "Crown Fools" and his screaming was still heard as the Penguins plan to retrieve it after Maurice tells them about it.
The Simpsons use screams for comedic purposes quite often. Usually with Homer who will typically overreact to something with a high-pitched yell.
A variation appears on the first half of the "Who Shot Mr. Burns"; on realizing that Mr. Burns has forgotten his name yet again despite all his efforts, Homer takes a deep breath and yells a profanity (starts with an "F", the rest is covered by the sound of an organ playing). It's given exactly the same treatment as this trope.
Flanders: Dear lord, that's the loudest profanity I've ever heard!
Subverted in "Mona Leaves-a". Homer arrives in the living room to apologize to his mother for his jerkish behavior to her lately, but then asks her name when she doesn't respond (as she had died). It cuts to the outside of the house, yet Homer says "...Mother?" in the exact same tone and volume as he did before the cutaway point.
Parodied in "Lisa's Sax". Homer wonders if museums have fooseball tables, and then imagines himself playing with Michelangelo's David. After winning, he says "Now who's next?" and the figure in Munch's work appears and shouts "MEEEEEEEEEE!"
South Park's "The Red Badge of Gayness": when Kyle rips the beard off of Cartman's General Robert E. Lee costume, Cartman's scream can be heard all the way to the planet Marklar.
In the Space Goofs episode "Bats in the Belfry", Gorgious screams when he finds out that there are no more food in the refrigerator, as seen here —>
One episode of Spongebob Squarepants does this with Squidward during the episode "Clams", when Spongebob catches his nose, after getting his book, chair, and shirt.
In Teen Titans (2003) Episode "Masks", Starfire and Beast Boy let out shrill screams after Cyborg rips off the adhesive X covering Raven's mouth. Raven screams on the inside but restrains herself to just "Ow."
In one episode of Total Drama Heather screams after her hair gets shaved off and Chris tells her she has to leave the island the scene then cuts to the eliminated campers at the Playa Des Losers Resort all looking up in surprise.
In Wat's Pig, when the invader hits the king in the foot, he lets out a scream of agony that can be heard all the way in Wat's cottage. Wat shrugs, not knowing it was the king screaming let alone his brother.
, Dr. Scratchnsniff's face resembles the painting when he first wakes up.