Tampering with Food and Drink in Video Games.
- In 2Dark, an alternate way of dealing with Sylvia Scarlett is to place rat poison in her cake before it's sent upstairs through the food elevator. The player can poison her assistant/girlfriend's champagne alongside it as well.
- The online game Allergy Assassin has you play an assassin who specializes in eliminating targets via their allergies. Thus you have to figure out who your target is of the people in the room, what they are eating and what they are allergic to. In most cases, a successful kill has the target's allergy kick in as they eat, causing them to turn purple and pass out. (There are two exceptions where you must slip laxatives into their food so they must run to the bathroom and get attacked by bees or cats.)
- Assassin's Creed:
- In Assassin's Creed, Abu'l Nuqoud poisons the guests at his party with a wine fountain, which he reveals during his "The Reason You Suck" Speech to them before he has his guards starting slaughtering them.
- Assassin's Creed: Brotherhood has Rodrigo Borgia attempt to kill his son Cesare using this method and a poisoned apple, but he wounds up Hoist by His Own Petard when the apples get forced into his mouth instead.
- Baldur's Gate:
- In Baldur's Gate, your party gets poisoned around the time you get into the eponymous city, and you have to do a quest to get an antidote.
- In Baldur's Gate II, when you reach the Asylum, you find out that Yoshimo, or Saemon if you don't have Yoshimo, poisoned your food, enabling Irenicus to capture you.
- Black & White: You can poison a grain pile, like that in a Village Store, by adding a poison mushroom or similar toxin; anyone who eats the food will sicken and potentially die. Although the food looks distinctively green to you, it's undetectable to mortals and NPC gods, making it an A.I. Breaker if you slip it into an enemy village.
- Ceville entails slipping Tabasco sauce into coffee.
- At the end of the Soviet campaign in Command & Conquer: Red Alert, Nadia successfully kills Joseph Stalin by tricking him into drinking a poisoned cup of tea. At an earlier point in the campaign, Marshal Gradenko is killed by the same person in the same way. It even features the same dialogue.
- In The Curse of Monkey Island, you are required to drug yourself by mixing hangover medicine with alcohol.Guybrush: This makes the drink oh so much more appealing.
- Divinity: Original Sin II: In one Sidequest, the player character can Item Craft a special pie with Void-tainted fish, feed it to an assassination target, and Camp a Crapper during the resulting intestinal distress.
- Don't Escape: In the first game, the protagonist can combine meat and poison to make some bait in order to weaken his werewolf side.
- Ether One has this as having happened to a mine warden (he apparently survived, but his incapacitation had severe consequences) when arsenic tablets were substituted for coffee filter cleaning tablets in a coffee machine. Whether or not this was intentional or accidental is unclear (evidence exists for either possibility).
- Final Cut: Death on the Silver Screen: The PC discovers early in the game that her father's death was caused by medication tampering. (The game is set in the 1950s, which might justify the coroner not catching this before her.)
- Final Fantasy XIV: At the end of A Realm Reborn, Sultana Nanamo Ul Namo is apparently killed by poisoned wine, forcing the heroes to flee to Ishgard. Thankfully, as revealed in Heavensward, members of Ul'Dah's Syndicate who had in interest in their city-state not descending into chaos over the Sultana's assassination sabotaged the attempt on her life by switching the poison out for a concoction that instead merely induced a reversible death-like slumber.
- Fire Emblem:
- In Fire Emblem: The Binding Blade, King Zephiel's Start of Darkness was triggered when his father, King Desmond, tried to kill him with a poisoned drink. Zephiel survived, but it is implied that the poisoning changed him for the worse.
- A US commercial for Fire Emblem: The Blazing Blade shows a medieval banquet, during which a man named Dorcas slumps forward, dead. One of the attendees, who'd proclaimed that no one can be trusted, cheerfully admits to poisoning his mutton.
- Free Icecream: In order to get the duster from the killer's cat, you need to feed it a bowl of cat food laced with rat poison.
- In the mission "Did Somebody Say Yoga" in Grand Theft Auto V, Jimmy asks Michael to help him pick up something from Burger Shot, and then gives Michael a milkshake. After a few sips, Michael starts hallucinating, at which point Jimmy pushes him out of the car. Michael has a Mushroom Samba sequence, freefalling from the sky to find his family having left him when he returns home.
- In Harvest Moon DS, you can do this at the Harvest Festival by adding a poisonous toadstool to the town's stew. Usually, doing this will result in the whole town falling ill (as well as making it taste like crap), but if you cultivate a level 99+ toadstool and add it to the stew, the game ends with your character eating the stew, choking, collapsing, and dying, with the same fate suggested to befall the rest of the town.
- In Heroes of Might and Magic III, this is how King Gryphonheart was killed.
- One of many methods of killing in the Hitman series is to put poison into food or drink that gets delivered to the target/victim. It's such a staple of the franchise that as of Hitman (2016), almost all of the story mission targets can be poisoned, as most of them eat or drink something as a part of their routine around a given part of the map. The recent games also add some variety with the use of emetic poison, which rather than killing people will cause them to go to the nearest bathroom to vomit, thus allowing you to drown them in a toilet.
- Kindergarten:
- Nugget can trick the protagonist into eating a poisoned, well, nugget. Depending on your choices, he can then withhold the antidote until you trick Buggs into eating another, more potent, one.
- Ms. Applegate will serve you a poisoned meal if you have lunch with her after turning down her offer to eliminate Buggs.
- Jade Empire
- During the Imperial Arena questline, a member of the criminal syndicate known as the Guild offers you the chance to poison Crimson Khana. The Closed Fist option is to agree to this, while the Open Palm option is to not only refuse, but warn Khana.
- In an unused ending for Sky, he continues his quest for revenge against the Guild until he ends up drinking poison in his wine.
- In King's Quest III: To Heir Is Human, you defeat Manannan by hiding a crumbled magical cookie in his porridge. When the unsuspecting wizard eats the porridge, the cookie turns him into a cat.
- Magicka: Although this game is usually rather comedic, the Dungeons and Gargoyles DLC plays this trope for horror with the cultists of Old Aldrheim.
- In Mitsumete Knight, Raizze Haimer tries to kill Princess Priscilla by giving her a poisoned drink at the Princess's Birthday Party. Depending on your choices as the main protagonist, the Asian, it ends with either: Priscilla's near-death, the Asian's near-death (as Raizze will give him the antidote), or Raizze spilling the drink to avoid the Asian being accidentally poisoned.
- In Mystery Case Files Ravenhearst, In 1895, Emma falls very sick shortly before leaving England for home. Charles offers to let her stay at his mansion, Ravenhearst, "The House That Love Built", and personally prepares all her meals, in spite of the maid he hires to attend Emma. Through the course of the game, the Master Detective finds evidence that Charles was making Emma sick, and at least some of the poison was being administered through her food.
- While fighting in the major leagues in the Glitz Pit in Paper Mario: The Thousand-Year Door, Mario gets sent two cakes from fans, the second one is laced and was sent by the champion Rawk Hawk. If Mario eats it, his partner will be out for one Glitz Pit match; if Mario avoids it, then another fighter will have eaten it when you get back from your match. It's also heavily implied Rawk Hawk did the same to previous champion Prince Mush prior to their match.
- Pokémon Scarlet and Violet's DLC story introduces Pecharunt, who can use mochi secreted from its poison to bring out a person or Pokemon's inner greed and put them under its control once eaten.
- In the online game Receptionist's Revenge, you play as a disgruntled receptionist getting back at your lazy boss by putting disgusting things in his coffee while he flirts with the hot secretary. If you make it to the end of the game without getting caught, you're rewarded with a "you win" screen that shows your boss throwing up in the toilet.
- A bizarre example occurs in Sam & Max Beyond Time and Space - Night of the Raving Dead: Max, knowing that he will be bitten by a vampire, drinks holy water beforehand, thereby spiking his own blood with vampire poison.
- In Shin Megami Tensei: Strange Journey, you can do this to a boss. Specifically, Horkos periodically summons a Katakirauwa and then eats it a few turns later to recover his HP. However, if you inflict status ailments on the Katakirauwa, and then Horkos eats the afflicted demon, Horkos will contract that same status ailment.
- In Styx: Master of Shadows and Styx: Shards of Darkness, Styx can poison food or water/wine with his bile, which will kill wandering guards just a few seconds after they consume it.
- In Technomage, the player is required to pull a non-lethal variant in one of the early stages. An essential item is stored in a warehouse, which is blocked off by a guard. The trick is to gain some castor oil from another person in the town, and then go to the inn where the guard’s favourite stew is being prepared. They then pour some of the oil into the stew and then receive a batch from the inattentive chef. They go back to the guard and give him the stew, which makes him sick, so he heads to the nearby hospital, leaving the warehouse wide open.
- Yandere Simulator:
- A high biology grade lets Yandere-chan identify poisons which she can swipe and slip into a student's lunch. This allows her to eliminate rivals without drawing suspicion upon herself. However, if Senpai witnesses the death, particularly if the rival is his childhood friend or sister, his sanity will take a huge hit. She can also slip an emetic poison into either the rival's lunch to make her sick and get her alone to murder her out of Senpai's sight or into Senpai's lunch to make him sick and sabotage his budding relationship with the rival. There's also the option of poisoning other people's lunches with the above two and sedatives to get rid of witnesses or something to induce a headache, which will distract the nurse enough for Yan-chan to steal tranquilizer.
- In 1980s Mode, this trope plays a role in two of the 'canon' elimination methods for rivals: Sumiko dies from eating poisoned food, and Ritsuko's food is laced with a sedative which puts her to sleep and leaves her unable to stop Ryoba when Ryoba pushes her into the pool, causing her to drown.
