In the Doctor Who Magazine comic strip's multi-Doctor story "Time and Time Again", Adric makes a cameo appearance incompetently trying to hit on Ace, and gets threatened with bodily harm.
Igor: I'm killing Ewoks and Gungans! I'm killing Ewoks and Gungans! Carson: Kewl! So what do you think of it? Igor: Explain to me what part of "I'm killing Ewoks and Gungans" was, exactly, hard to understand...
The Dynamite Comics series based on Galactica 1980, which takes place in a different continuity to the original series, pulled this with Doctor Zee, the TV show's fan-despised Teen Genius character. It depicted him as an extremely sinister Mad Scientist who is actually an elderly man in a cloned teenage boy body, and who eventually dies in an undignified manner due to his own foolishness.
Godzilla: Kingdom of Monsters: Girly Yaya, the Lady Gaga Expy who wanted to protect the monsters while showing complete disregard for all the people they killed, is found dead in the ruins of Los Angeles following Godzilla's fight with Anguirus.
Halo: Escalation #16 features Dr. Halsey finally calling Palmer out on her willingness to swallow the UNSC's throwing Halsey under the bus, pointing out that she never could have pulled off the SPARTAN-II project without their approval, and that the job and armor Palmer loves so much would never have existed without Halsey's work.
The spirits are openly unhappy about the new spirit portal, but, despite their grousing, Korra refuses to close it and they concede they have no choice but to accept her decision. Korra even brings up that they were all too happy to keep out of Kuvira's attack on Republic City, which is ultimately what led to the portal's creation. While not quite Laser-Guided Karma, it's satisfying to watch the obnoxious spirits be stuck in a situation that they hate, especially since they honestly can't say they didn't bring it on themselves.
For those who don't like President Raiko, he gets stuck with a 0% Approval Rating, with his numbers in the upcoming election being -3 despite having no opponent. Not only that, the comic seems to intentionally try to make him as unlikable as possible. And come Part 3, he gets replaced as president by Zhu Li.
Les Légendaires: El Diablo is brought back in the "World Without" alternate timeline just to suffer a rather humiliating Curb-Stomp Battle after he tried to double-cross princess Shun-Day.
The Mega Man: Fully Charged comic series delivers one to Breaker Knight; a villain from the cartoon that many fans of the games disliked. The opening issue of the comic revealed that he was detained indefinitely, and he spends the rest of the series in jail.
Mega-Mini was also disliked by fans of the games, and he ends up getting fried and incapacitated for the first half of the story during a battle with the Robot Masters. Crossing over with Rescued from the Scrappy Heap, he ends up getting repaired and upgraded by Dr. Wily, becoming much more helpful and likable than he ever was in the cartoon in the process.
Monica's Gang: Fans' complaints about Milena being a forgettable character are acknowledged in a 2020 comic, in which she teams up with Maggy and Junior to find the boy's pet goat. A Running Gag involves the main duo forgetting who she is and calling her by the wrong name, prompting Milena to inform them that she's been around for over an year.
My Little Pony: Friendship Is Magic (IDW): In the climax of "The Root of the Problem", Well-to-Do uses Bramble as leverage to force Aspen to become a humiliating mascot at the amusement park.
Entresol, Spirou's unpleasant boss at the Moustic Hotel in Hope Despite Everything part 1, met his demise when he kicked a bomb to prove it's non-lethal. Not many fans will miss him because of his rudeness and jerkassness toward everyone. Even the hotel manager and hotel director disliked him.
In Hope Despite Everything, Father André gets his due where he's beaten with a broom for denouncing Spirou to the Nazi. He then exiles himself to the Vatican to avoid prosecution.
Same with the policeman with glasses who harassed Spirou and Fantasio during the Occupation. He's blown apart by a grenade.
During a conversation with Jabba the Hutt, Darth Vader shows that he has the same opinion of Salacious B. Crumb's Annoying Laugh that most viewers and fans do:
Darth Vader: If you value that creature's life, you should tell it to never again do that in my presence.
In Dark Horse's Star Wars Tales anthology, issue #24, there was a story called "Fett Club", which was about Jango Fett offering to train a bunch of new Mandalorians. One of the applicants is a Gungan named Jay-Jay Binks, and Jango shoots him to death as soon as he opens his mouth.
Jango Fett: Seventh rule of Fett Club — No Gungans. Ever!
Patricia ends up thoroughly disliked by the rest of the cast after several Too Dumb to Live actions, and just when things seem to be getting better for her, not only does she lose her new boyfriend at the start of the Prison Massacre, but Patricia herself is unceremoniously killed by The Governor and completely forgotten about by all the other characters afterwards.
for the first issue of Star Wars (Marvel 2015) has the rest of the cast hiding from Jaxxon, a rather hated Canon Foreigner character from the original Marvel Star Wars series.
