- Naomi from Harmonic Feedback once got her neglectful dad to watch the first five minutes of CSI with her before he fell asleep.
- Ivy from Things I Should Have Known comments on Facebook that Law & Order: Special Victims Unit is better than the original Law & Order, and another girl agrees but says that CSI is better than either.
- Family Guy: In "Dearly Deported", Stewie tries to find something to watch on television with Isabella's twin sons, Juan and Two. He comes to a show called CSI: Babies, a show about babies freaking out near a dead body. The show freaks Stewie out to the point where he hides in a pillow fort and finds Peter there for the same reason.Stewie: They can't solve this crime, they're just frightened babies! They don't even know it's a crime, they just know their parents aren't there! They're scared and now I'm scared! Turn this off!
- One sketch on MAD is called CSiCarly, which is a crossover between CSI and iCarly.