Legion of Super-Heroes: Saturn Girl and Lightning Lad (married and with children), Supergirl and Brainiac 5, Phantom Girl and Ultra Boy, Bouncing Boy and Triplicate Girl/Duo Damsel/Duplicate Damsel (married), Mon-El and Shadow Lass, Karate Kid and Princess Projectra (married)...
Hawkman and Hawkwoman are married. (as in Carter Hall and Shiera Sanders)
Took on a Squicky quality once the Hawkgirl mantle was passed down, as the new one was actually the old one reincarnated into the body of her own niece. Whom Hawkman still tried to pursue a relationship with Because Destiny Says So. Despite being, at least physically, her uncle by marriage.
Additionally, Garth and Tula. Whilst Tula did die during Crisis, the relationship between her and Garth was memorable enough to spread into othercontinuities, resulting into the relationship returning in DC Infinite Frontier
Lucifer has the title character and the succubus Mazikeen. She's perhaps the only entity in all of creation he genuinely cares about, as opposed to manipulating or helping just because he owes someone a favor, and in the book's final issues they undergo a sort of symbolic marriage involving him passing his title of Morningstar to her.
Jean Grey and Cyclops (a.k.a Scott Summers), at least when they're both alive.
Though more on-again off-again, Gambit and Rogue are second only to the above as the iconic X-Men couple. After their surprise wedding, they now headline their own book, Mr. and Mrs. X.
Mystique (AKA Raven Darkholme) and Destiny (AKA Irene Adler). While Mystique has had many flings with different characters throughout the book's history, Destiny is one of the very few people she truly loves and has no animosity towards at any point.
Hank's good friend Clint and his long-time wife Bobbi, albeit not without a lot of trauma. They're now Amicably Divorced, though its not expected to last given they're constantly being teased as about to get back together.
The Incredible Hulk: Bruce Banner and Betty Ross. They're currently on the outs, in the wake of Betty returning from being Mostly Dead.
Spider-Man: Peter Parker and Mary Jane Watson. There's been attempts to break them apart, but inevitably they tend to get back together. Even during the late 2000s/2010s period, they're constantly teased as about to reunite, and various alternate universe stories depict them still together and happy. One of the first things Nick Spencer did after taking over the title from Dan Slott was to officially get Peter and MJ back together.
Sonic and Sally in Sonic the Hedgehog (Archie Comics). Ever since the earliest stories in the comic, the mutual crush between Sonic and Sally has been shown in continual, obvious◊ display◊, despite constant, arguably excessive Will They or Won't They? throughout the history of the comic. In later issues, it was revealed that Sonic has become her◊ consort, and the future stories confirm that they have children and rule Mobius together. However, following the events of the Super Genesis Wave, their relationship was erased from existence, and they seem content to be Just Friends.
Rewind and Chromedome in Transformers: More than Meets the Eye. The exclusive toys sold at Fun Publication even featured them, based on their IDW designs, together.
Lug and Anode, Tailgate and Cyclonus, and Drift and Ratchet eventually join them.
If there are two official couples in the X-Wing Rogue Squadron comics, it's Tycho Celchu/Winter and Nrin/Ibitsam. Both romances are fed out bit by bit for the entire length of the comic's run.