Alpha Flight: The Canadian superhero team has a villain-turned-hero called Diamond Lil —though she does not have superstrength, she effectively hits twice as hard as normal because her fists absorb none of the impact energy. (Given that she's also a six-and-a-half-foot-tall weightlifter, that's gotta hurt.) She's so nigh invulnerable that she has very little sense of touch and sometimes isn't even aware of low-power attacks against her. (She was created, like Bethany of the Next Men below, by John Byrne.)
The Avengers: Ultron, essentially being evil computer software, falls under this, since no matter what, a portion of him always exists in cyberspace. And more importantly, most versions of Ultron are made entirely of adamantium. Destroying him in the first place is an epic challenge.
Avengers: The Initiative: Butterball has a variation on this power; he is completely immutable, and therefore cannot be harmed in any way. This power is apparently all-encompassing, as he has extreme difficulty learning new subjects, can't lose (or gain, for that matter) weight, can't get in shape, etc, etc....
The Awesome Slapstick: Slapstick has been shot with bazookas, burned with fire, zapped with electricity, twisted into a knot, and kicked across New York City with no ill effects. The only thing that can really hurt him is a specific frequency of energy that disrupts the molecular bonds of his electroplasm body, and that only works temporarily.
ClanDestine: Adam Destine is completely invulnerable, as well as being immortal. He can withstand superpowered combat, large-scale explosions, lasers, crashing on Earth from space in a bus with broken windows (albeit with a spaceship engine attached, courtesy of his Gadgeteer Genius son) and who knows what else with nothing more than Clothing Damage. He also apparently doesn't need to eat, drink, or breathe to survive - he once went a decade without doing any of the above, with no ill effects. The power was given to him by his wife, a very powerful genie.
Deadpool has a variation of Wolverine's healing factor that was accidentally super-charged by his own cancer. As such, Deadpool is always healing, no matter what. This has allowed him to effectively regrow limbs and possibly be effectively immortal (one possible timeline had Deadpool trapped in a refrigerator for a thousand years and came out of it with a split personality because he got bored.
Madcap has this as his primary power (his secondary power being inducing euphoria in others). He has been dismembered, decapitated, burned to ash, and even vaporized, yet always managed to regenerate within a few hours at most.
Doctor Strange: Doctor Strange has the unenviable task of fighting various demons, gods, and things that are almost impossible to kill or even hurt. The worst is Shuma-Gorath. It's extremely difficult to even hurt it in the first place, it can recover from just about anything, and if by some miracle someone does slay Shuma-Gorath its power will simply possess its killer and transform him/her into a new Shuma-Gorath! Even Death, as in the Anthropomorphic Personification of death itself, can't permanently kill this monster.
The Eternals: While a lot of superheroic characters have some level of invulnerability, the aptly-named Eternals may stand out for special mention: they possess a "psychic lock" on their molecular structure that allows them to restore virtually any injury they can't flat-out ignore.
While not nearly as durable as Plastic Man, Reed Richards is Made of Rubber and can survive most attacks, at least as long as he sees them coming in time to stretch with the impact.
Galactus's armor is made of a metal-like substance so tough that nearly zero attacks can even scratch it. Galactus himself is somewhere between an Energy Being and an Anthropomorphic Personification, making him immune to physical ailments. His Herald, the Silver Surfer, is a more straightforward case of diamond durability: His skin was designed to easily withstand the rigors of deep space and is virtually indestructible. He's also been shown to have a Healing Factor from time to time. Pretty much every Herald has some version of this. Galactus builds his minions to last.
Ghost Rider. When transformed, he's just bone, hellfire, and a biker outfit. He can take insane amounts of punishment, and only magic attacks can hurt him.
Great Lakes Avengers: Craig Hollis/Mr. Immortal has no special abilities, no power to withstand damage, but if he actually died, he just stood up again three seconds later, fully healed. Since he was a child, he's been haunted by Deathurge, a psychopomp-like being who convinces people to kill themselves, but decided to take Craig in as a sort of adoptive son. It's been said somewhere that he's destined to be the last living creature in the universe. In the GLA miniseries, he's revealed to be "Homo Supreme", one step beyondmutant (which caused Flatman, who'd just come out as gay, to mutter "Always have to one-up me, don't you?").
Guardians of the Galaxy: Drax the Destroyer is almost impervious to conventional harm, able to stand up to the likes of Thor without worry. Unfortunately, his main opponent was Thanos, who punches well above Thor's weight classnote In one instance, Thanos managed to shatter Galactus's armor with a sustained assault, though Galactus wasn't physically harmed from the attack, only pissed. For the rare occasions when Drax's body was damaged, he also possesses a low-grade Healing Factor. For the even rarer occasions when his body is completely destroyed, he fortunately combines this with the Body Backup Drive option.
The Incredible Hulk: The Hulk is an extreme example; he is both super tough, invulnerable to all conventional weapons, and has an extremely fast healing factor, so fast that it was not discovered in the continuity until he was wounded while he was slowed down because he was Joe Fixit. Basically, he has shrugged off point blank heavy nuclear weaponry, planet-splitting impacts, solar temperatures, strikes from cosmic entities, has healed within seconds from having over 80% of his flesh repelled off of his body, and one incarnation eventually managed to restore itself from being blown to powder. This even extends to extreme resistance to mind-control or molecular manipulation of his body, and some adaptive evolution to build greater immunity or adapt to hostile environments. Even on those occasions when he is vulnerable enough to have a body part removed, he can either regenerate it or reattach it.
Hulk is resistant to magical attacks as well. The various Ghost Riders using Hellfire on him is nothing but an annoyance. To even make him register damage, the Ghost Rider spirit needed to take over.
Lampshaded in "The Last Titan" wherein the immortal Hulk just keeps on going alone in the wasteland after the rest of humanity destroys itself. (The alien empires were said to host an enormous celebration.)
When Amadeus Cho accused Reed Richards of killing the Hulk, Richards maintained that was impossible, "Because the Hulk doesn't die."
One of the Hulk's enemies is the super intelligent Leader. The Leader uses pink, rubbery biological androids called Humanoids as Mecha-Mooks. They fall into the "made of rubber" category, being resilient and stretchy enough that punching them doesn't do any harm.
Luke Cage: Luke's skin is as hard as metal and his muscle and bone tissues are considerably denser than the tissues of an ordinary human, granting him much greater resistance to physical injury than an ordinary human. He can withstand conventional handgun fire and cannot be cut by any blade forged of conventional material. He can withstand up to one-ton impacts or blasts of 150 pounds of TNT without serious injury, and is highly resistant to extreme temperatures and electrical shocks. He has withstood impacts from superhumans a good deal stronger than him, destructive energy attacks including electricity, and falls from great heights such as ninety story high skyscrapers.
Man-Thing: The Man-Thing is both something of a blob (he's a mass of plant matter with no internal organs to damage), and even if something manages to destroy him, he'll simply regrow from swamp matter back home.
The Mighty Thor: Thor is nigh-invulnerable due to being a literal Physical God, what with being the son of Odin and Gaia. He's one of the few non-cosmic beings in the Marvel universe capable of going toe-to-toe with the Hulk and can survive blows from him, Galactus, and other such powerful beings.
His one-time foe Harald Jaekelsson was so invulnerable that when Thor struck him in the head with Mjolnir it did no damage despite the fact both of Thor's wrists snapped from the force of the blow.
Another foe, Jormungand the Midgard Serpent, is also insanely tough mostly due to being big enough to encircle the Earth. Even Thor can't afford to hold anything back when he's fighting the planet-sized snake.
The titular Space Knights sit somewhere between the lower tiers of this trope and the upper tiers of Super-Toughness. Their cybernetic armor is incredibly durable, and even has a Healing Factor-like self-repairing function, but sufficiently powerful foes can hurt or even kill them. Rom himself has tanked a full-force punch from Gladiator of the Shi'ar Imperial Guard, although he admitted that it did hurt, as well as having been successfully cut by Wolverine's adamantium claws. On the other hand, human weaponry might as well be throwing spitballs at him.
The horror known as Hybrid definitely counts as this trope. Thanks to a combination of Dire Wraith physiology, sorcerous defenses, and implied mutant telekinesis, he effortlessly tanked blasts from Rom's Neutralizer, which can normally one-shot pureblooded Dire Wraiths; if Kitty Pryde of the X-Men hadn't lucked onto a higher setting that simultaneously tore Hybrid apart on a molecular level and banished the scattered molecules into Limbo, Hybrid would have killed Rom and the X-Men. And then Hybrid reconstituted his sundered molecules and returned to the human dimension through sheer force of will. This time, when Rom used his Neutralizer, Hybrid erected a psionic forcefield that held his molecular structure together against any attack; only the heroic intervention of Rogue to sap his psionic energies negated the forcefield and let Rom repeat Hybrid's destruction again. And then he reconstituted himself again in Rom Annual #3, only being killed off for seeming good by Ilyana Rasputin and her magical Soulsword... except it didn't stick, and Hybrid revived himself in X-Man. This time, Nate Grey managed to vaporize him yet again after awakening Jimmy's long-buried benevolent human side. But that didn't stick either, and he came back to terrorize Avengers Academy before they vaporized him yet again.
Symbiotes usually have strong Healing Factors; however they seem to get stronger the more attached they are to their hosts.
Anti-Venom had enough of Eddie Brock's personality that when The Punisher blew his brains out it reassembled them so that he could protect Jenna Cole.
Carnage is even worse. He's still alive after losing his entire lower half at the hands of The Sentry, also recently the symbiote was able to somehow fix his brain after a lobotomy and even more recently he was blown to bits after smothering a bomb designed to kill every non-mutant in New York and came back only slightly weakened. The symbiote just dosen't want to give Cletus up.
Thanos is one of the Titans, a weaker offshoot of Earth's Eternals. Due to the mutation that made him resemble a Deviant he possesses strength and durability far greater than that of any other Titan. And that's before he gets his hands on sources of great power like the Infinity Gems.
Ben Grimm from Ultimate Fantastic Four. Pretty much nothing is capable of seriously hurting him. Even more so after he evolves.
The Ultimates: The Liberators are a deadly group of genetically enhanced Super Soldiers... but Loki is a God. He can completely No-Sell punches from The Hulk and even shrugs off blows from Mjolnir before Odin strips him of his powers.
Ultimate X Men: In Ultimate Wolverine Vs. Hulk, the Hulk rips Logan in half, and throws the lower portion of his body on top of a mountain, necessitating the need for him to climb a mile up with his intestines hanging out of him. Once the remaining issues of Ultimate Wolverine Vs. Hulkwere shipped, readers were treated to an even better sight — Ultimate Nick Fury interrogating Wolverine's disembodied head, with the former surmising Ultimate Wolvie's real mutant power must be to survive anything, as he did things like drop the head into a complete vacuum to see if that would kill him.
The Vision: The Vision covers so many bases at once, it's hard to tell which to mention first. He can control his own density, for starters — meaning that he can be Made of Diamond or an Intangible Man, depending on what would suit his purposes. He's also a synthezoid (read: super-sophisticated android), so he can just replace any parts from attacks (like certain energy attacks or surprise attacks) that get around his density control. Finally, if push came to shove, he potentially could just be uploaded into a new body, much like his father Ultron (noted above).
After Nitro's attack on an Elementary School, only Wolverine's BRAIN hadn't been completely incinerated because of his Made of Diamond skeleton, and he regenerated even when it was completely implausible that he could be ALIVE, let alone able to regenerate. Although that wasn't his Healing Factor. Didn't you know? An angel of death did it. Which is sadly the more reasonable explanation. Anyway... his Healing Factor is back to "normal" after Wolverine had a talk with said angel.
In Uncanny X-Men Annual #11, Wolverine regenerated completely from a single drop of blood. To be fair, his healing factor was supercharged with the power of the Crystal of Ultimate Vision. We don't talk about what happened to the adamantium.
After he was resurrected with the Crystal of Ultimate Vision, he came back as an actual god. He was going to use his power, but then realized that as a man it was not right for him to have that much power, and smashed the Crystal with his claws. Supposedly the implication was that he gave himself adamantium bones with his god-like powers in order to break the Crystal.
Marvel editors continually raise the question with this: If Wolvie's arm or finger gets cut off, could it grow a new Wolverine?
Wolverine has survived direct hits (or near enough) from nuclear weapons, at least once while bonded with a clone of the Venom symbiote in Venom (2003).
Colossus has the superhuman ability to convert the tissue of his entire body into an organic steel-like substance. In his armored form Colossus is invulnerable to most forms of bodily harm. His armor is capable of withstanding ballistic penetration, including that of a 155 millimeter Howitzer shell. He can survive extremes of temperature from 70 degrees above absolute zero (-390 degrees Fahrenheit) to approximately 9000 degrees Fahrenheit. He can survive a collision with a loaded, ten-ton flatbed truck at 100 miles per hour or an explosion of 4500 pounds of TNT. He can also survive falls from great heights while in his armored body. He can now go toe-to-toe with any incarnation of the Hulk (barring the tragedy-enhanced "Green Scar" incarnation from World War Hulk). It should be noted, though, that his nigh invulnerability is only in effect when he's in metal form. If an enemy manages to catch him off-guard in human form, he can be taken down just as easily as any normal human. Well, as easily as any normal human who happens to be about seven feet tall, built like a bear and an extremely experienced hand to hand combatant.
Iceman in his living ice form. In that state, you can blow a hole through his chest, shatter him into a million pieces, melt him, evaporate him... it doesn't matter. His body will always re-form itself. The only way to harm him is via psychic attack or catching him in his normal form.
Another invulnerable mutant is the Blob that is a very large guy with that name — who has stood up to everything from Wolverine's claws, to flamethrowers, to the Hulk's punches. Though not, apparently, Wolverine's head-banging in a certain 2009 movie... though this is probably because in the comics his head was always vulnerable compared to the rest of his body. He's generally more vulnerable to sensory assaults - Banshee once stunned the Blob with his Sonic Scream, while both the Hulk and Sleepwalker exploited his blubber. The Hulk stretched the Blob like a piece of taffy, while Sleepwalker used his warp vision to wrap a steel girder around the Blob and squeeze him. In both cases, it was pretty painful.
Juggernaut. It's almost impossible to inflict even minor damage on him, he quickly regenerates in the rare cases (almost always involving magic) that somebody can can hurt him, and once he gets up some steam, he just plows right through any obstacle in his way. At full power, Juggernaut has a force field that he can summon at-will just inches away from himself. One time, a demon mystically melted his flesh and organs... and Juggernaut's bones still kept moving forward. The demon was literally too stunned to do anything about that. He's practically a Physical God, as he is an avatar of Cyttorak, an evil god thing.
Emma Frost is LITERALLY Made of Diamond. One of her powers is to take on a diamond form, while losing her psionic powers in the process. This can of course be reverted.
Before Emma, Penance of Generation X was as hard as diamond, and she couldn't turn it off.
In one future, Emma Frost and Scott Summers' daughter, Ruby, has a similar ability. Contrary to the name, it is just as much diamond as her mother. The red hue is due to her father's powers.
From New Mutants to X-Force to X-Men, Sam "Cannonball" Guthrie's power renders him Nigh Invulnerable (as he repeatedly says himself), but only when he's "blasting" — which is to say using his pyro-plasmodic forcefield in flight. And as if that didn't do it, he's supposedly also an External (an immortal mutant). This has since been quietly ignored.
Cell, one of The Morlocks from X-Men-related comics, is a giant single-cell organism, meaning he can regenerate any damage done to him at all and absorb organic matter for nourishment. Basically the only catch to this is that he can't digest inorganic objects, meaning he had a bullet stuck harmlessly in his head for a while. His teammates Shatter and Litterbug, however, were just super-tough; Shatter was made of some kind of super dense obsidian-like rock, while Litterbug had a layered, chitinous exoskeleton.
The X-Men foe Apocalypse is usually nigh invulnerable (his first powerless child incarnation was an exception) thanks to a combination of his original mutant powers and Celestial technology. Any time he is killed, his followers Clan Akkaba take steps to ensure his rebirth.
Nate Grey, the Age of Apocalypse version of Cable, Apocalypse's eternal foe, was also functionally invulnerable, once boasting that "My body's only vulnerable until my mind decides otherwise." As a psychic so powerful that he was a functional Reality Warper, considering his track record of tanking punches from Captain Britain and Colossus when caught off-guard, with only instinctive telekinesis protecting him, as well as first resurrecting himself through sheer willpower, and later transmuting himself into energy and merging with all of humanity at once to poison the well for an alien race that wanted to eat the Earth, before repeatedly recreating and dispersing himself at will, once Faking the Dead, he had a point. Honestly, until he fried his nerves overdoing it with his powers, there was no really conceivable way to make him stay dead - if someone killed him, he'd probably just come back with his full powers and a bad mood. As it was, he did get them back, and effectively became a living reality.
Short-term X-Man Paulie Provenzano had Nigh-Invulnerability as his mutant power, but it came with the limitation that he had to be able to be generally aware of the attack. He learned of this limitation when he made the mistake of taunting Northstar with a homophobic slur, which resulted in the speedster punching him so fast he couldn't even register it.
X-Men: Red character Orrdon the Omega Rocket riffs on Cannonball's catchphrase by claiming to be fully invulnerable when he's blasting. But not, as it turns out, from the inside.
