The Adventures of Dr. McNinja plays with this, and plays it for laughs. The Doc has no trouble killing guards and mooks. In one comic, there's a guard happily strolling around thinking of his family, when he gets his neck snapped, and the Doctor misunderstands what he was talking about it. When the Doc kills a bunch of Ninja mooks, the mother of one of them calls him out on it... at the funeral for The Doc's mentor who the ninja mooks had ruthlessly gunned down. Despite this he still has nightmares about killing all those people.
A Beginner's Guide to the End of the Universe: Many of the hostile creatures, especially the void beasts and the clockwork halberdiers, are rather weak and quickly cease to pose a meaningful threat the Everyman and his allies except in numbers. In battle, they usually fall quickly and often and mostly serve to distract him or to provide backup for stronger creatures.
Blitzcrafter: The soldiers seem to exist only for two reasons: To look menacing and betray the shiny outside of the city, and to be mowed down in mass by the main character.
Commedia 2X00 has Dottore's island-fortress-lab patrolled by a few different species of robot mook, but the most common seems to be the Nonny: an armless Shyguy wearing a Guy Fawkes mask, speaking entirely in the words "hey" and "nonny". Arlecchino remarks to one that they seem harmless, and it responds by grabbing him with tentacles out of the eye-holes on the mask.
Cry 'Havoc': The Sudanese rebels are fought and annihilated seemingly just to prove how dangerous the mercenaries are. The plot only really starts once they are all killed.
Darken: Inverted when the Hero Antagonist is forced to leave behind a squad of well-meaning but thoroughly outclassed soldiers to slow down the high-level Villain Protagonists while he tries to keep an evil artifact out of their grasp. They don't even provide much of a delay.
Soldier: T-turn back! The forces of the Light stand strong before you! Mink: Looks like they stand whimpering before us.
In El Goonish Shive, the not-really-flaming fire summons fulfill this role. They are so harmless to Greg and Grace that they use them as training dummies to teach Grace a sleeper hold.
Erfworld is set in a RPG Mechanics 'Verse that revolves around warfare, where most people and creatures (except a few special ones like casters and heirs) are literally created to fill this role. Parson has little Heroic BSoD when he realises that he killed around a small nation worth of soldiers. While others think of them as mere units, Parson considers them real people.
Goblins is actually an attempt to explore the other side of this trope by starting off in a goblin battle camp, with a handful of goblins guarding a chest, and what happens when an adventuring party stumbles upon them. The surviving goblins become adventurers, and attempt to change their lives, making the Always Chaotic Evil Elite Guards into mooks.
Homestuck: The Underlings are entities created by Sburb, a reality-altering game, to serve as foes of various levels of challenge for players drawn into it. The best matches for this trope are the Imps, who are by a wide margin the most numerous, most widespread and least powerful kind, posing a serious threat only in numbers and often not even then.
Deconstructed with the villains' goblinoid armies. Their creator god didn't care much about them, they're common low-level XP fodder for other races, and the ostensibly holy Paladins massacred them with glee, provoking Redcloak's mission to help the new Goblin god take over the world and create a better future for goblinoids. This is a point of tension between him and the Big Bad Xykon, who doesn't give a hoot about anyone's life, goblin or otherwise.
Xykon: Sacrificing minions: is there any problem it can't solve?
Redcloak himself has a Villainous BSoD when he realizes his Fantastic Racism against hobgoblins has led him to treat many of his own followers as expendable, just like Xykon does.
Twisted Tropes: The strip shows Luke decapitate a Stormtrooper while yawning and wondering where they even come from. A Goomba comes out from the helmet.
Ziggy Pig and Silly Seal (2022): Ziggy recruits a gang of inept criminal henchmen to help in his plan. They all wear domino masks, yellow shirts, and blue pants and caps.
has Dottore's island-fortress-lab patrolled by a few different species of robot mook, but the most common seems to be the Nonny: an armless Shyguy wearing a Guy Fawkes mask, speaking entirely in the words "hey" and "nonny". Arlecchino remarks to one that they seem harmless, and it responds by grabbing him with tentacles out of the eye-holes on the mask.