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  • Yukie Tezuka in Alive: The Final Evolution was, for reasons that weren't her alien-possession superpower because she only got that a couple of years ago, at least three times older than she looked, and a serial terrible mother. She'd come along and dump a new kid on the half-grown-up ones every so often, but when she appears in the story she's turned into a good mother due to the influence of the alien parasite, and is living with what may just be one of her clutches, five 'children' ranging from nine to nineteen and having nothing in common with one another. These include a shy, bald martial artist with lightning powers, a Wild Child speedster girl in Converse, and a hacker who smokes a lot.
    • According to an omake, some of her children were balding by the time the sylph bought the farm. But that's an omake.
  • Barron from Bakugan Battle Brawlers certainly qualifies. He's eager to move out of his parents' house because there's no room left.
  • In Berserk, Casca mentioned in her backstory that she was one of six siblings. When you look more deeply into it, her family's situation serves as a deconstruction, as she grew up very poor and her village often suffered from food shortages and death from starvation. As Casca herself mentioned that it was odd that no one in her family starved to death, it begs to question how much longer her family could have survived having to feed eight members, so this might have prompted her parents' decision into selling their youngest girl-child into servitude when a rich noble passes by their village. Of course, her parents' decision is also laced with Fridge Horror, since it turned out that the noble didn't exactly want young Casca as a typical servant.
  • Bleach:
    • Jushiro Ukitake is the eldest of eight children and uses his position as Captain of the 13th Division to support all of them.
    • Soifon had five older brothers, all of whom died before they achieved anything meaningful.
  • In Castle Town Dandelion, the king have 9 children.
  • In A Centaur's Life, Manami Mitama's family just manages to qualify since she's the oldest of five daughters (three of them being identical triplets). Since her mother presumably passed away, she usually has her hands full looking after her four younger sisters.
  • Code Geass:
    • Eight of Lelouch's siblings have parts in the story from minor roles (Guinevere and Carline) to moderate (Odysseus and Clovis) to major (Nunnally, Euphemia, Cornelia and Schneizel). Lelouch was the 11th born and 17th in the line of succession at the time of his mother's death, so he had at least 10 elder siblings at that point, with the possibility of still more being born in the seven years between then and the start of the main story. The exact number of children fathered by Charles Zi Britannia on his 108 wives is never stated, but since Nunnally, Lelouch's full blooded younger sibling, was 87th in line to the thronenote , he may have close to or over 100 children.
    • While it doesn't happen for tragic reasons Shirley in an image spot in side material imagines having nine sons. All of whom, naturally, look like Lelouch.
  • The Wong-Chang-Lee brothers (and sister May) from Daphne in the Brilliant Blue are all siblings by one Mother. "I am the son of our mother's 4th Husband..."
  • Oz, the demon king of Hell in the manga The Demon Ororon, has seven sons, of whom only four are named: Othello, Oscar, Olga, and the titular Ororon.
  • In Demon Slayer: Kimetsu no Yaiba, main character Tanjiro is introduced as being the eldest of six siblings. Unfortunately, he and his younger sister Nezuko are now the only ones left alive after the rest of their family was killed by a demon.
  • Fullmetal Alchemist:
    • Ling Yao and Mei Chang's father, the Emperor of Xing, has 43 children.
    • Olivier Mira Armstrong is the eldest of five siblings; little brother Alex, fourth out of the five, is the only brother.
    • At the end of the series, Ed and Winry are the parents of two children, and Word of God says they go on to have several.
  • The Nezu siblings in Gakuen Babysitters amount to six, who all look extremely alike and have a shared theme in their names. Chuukichi Nezu, the member of the family who's seen most often, is the second oldest.
  • Girls und Panzer das Finale: in teh second episode it is revealed that Momo Kawashima actually has four younger siblings, a fact unknown to anyone before this.
  • Go! Go! Itsutsugo Land is a rare case, as it centers on a family of quintuplets (3 boys and 2 girls).
  • In House of the Sun, Oda has six sisters.
  • In Hunter × Hunter, the Zoldyck family has four sons (Illumi, Milluki, Killua, and Kalluto) and a daughter (Alluka).
  • Even though Ueda from Japan, Inc. says he has eight siblings, seven of whom are sisters, we only directly meet him.
  • In K-On! High School, Nao Okuda is the eldest of five. The last four are quadruplets. Sumire was not expecting this when she went to visit.
  • Lucy-May of the Southern Rainbow: Lucy May is one of five siblings (six if you count the deceased sister from the Phyllis Piddington novel it was based on).
  • Lyrical Nanoha has the twelve Numbers, all of them are sisters (though only some of them are related biologically). Technically, Subaru and Ginga are also counted as well, since they are the prototypes.
  • Max and Milia Jenius of Macross have seven natural daughters and adopted another. The only ones who have appeared in the actual anime are Komilia (the oldest, who appeared as an infant/toddler in the original series), Mylene (the youngest, who was one of the protagonists of Macross 7), and Emilia (the fifth daughter, who was featured in The Galaxy's Calling Me!). No news on how many grandchildren they have aside for Mirage.
  • In Magi: Labyrinth of Magic, it's justified for royal families to have harems to ensure the birth of male heirs. Not including Hakuei and Hakuryuu who were adopted into their uncle's family after he became emperor, the Kou siblings are ten children in total.
  • Hanako from Massugu ni Ikou is a pedigree Kishu who mentions having dozens of half-siblings throughout Japan. She worries that her boyfriend Mametarou is one of them, despite the fact Mametarou is obviously a mutt.
  • Degwin Zabi of Mobile Suit Gundam has five children. The second eldest son, Salso, was assassinated by a car bomb before the series started. His third son, Dozle, is the only one who is married with a daughter who becomes the Sole Survivor of the clan after end of the One Year War and is one of the protagonists in Gundam Unicorn.
  • Mobile Suit Gundam Wing's Quatre Raberba Winner has 29 sisters. Justified as the sisters are all but stated to be Gattaca Babies. The novel Frozen Teardrop reveals he has a thirtieth sister (who's actually his clone), Katherine.
  • My Roommate is a Cat: Hiroto is the oldest of five siblings, three of whom Subaru had never met before Hiroto took them to his house to see Haru.
  • In Nagasarete Airantou Mei-Mei is the yongest of a 23-sibling group, and the only one that isn't a twin or a tripplet. Five of her elder siblings are girls.
  • Nausicaä of the Valley of the Wind is the youngest of nine siblings, and, thanks to the toxic environment, the only one to live to adulthood.
  • In Ojamajo Doremi, we have Doremi, Aiko and Hazuki's friend Itoko Yamada, a girl with at least five other siblings. There's a Yamada brother/sister in each grade: One's a first-grader, another is a second-grader, and so forth.
  • Baku's family in the anime Onegai My Melody: the sibs actually have numbers as names.
  • One Piece:
    • All pirates under Whitebeard's command are his adopted sons, and he has over 100 of them. Even pirates from his alliance call him father and he considers him as sons, meaning that he has at least more than 1,000 or 10,000 sons.
    • As far as biological children go, Big Mom has 85 children (46 sons and 39 daughters) with 43 husbands - giving birth once a year from the time she was eighteen to the time she was sixty. Of those 43 births, there was one set of decuplets (ten children at once), one set of quintuplets, two sets of quadruplets, six sets of triplets and eleven sets of twins, totaling sixty-three out of the eighty-five. Plus twenty-two single births. All the rest of her crew and some other residents of Totto Land call her Mama too, regardless of whether they're related or not.
  • Classic manga/anime example is Osomatsu-kun and its sequel Osomatsu-san, which center around identical sextuplets.
  • In Otomen, Juta has nine other siblings, of which he is the eldest. The primary reason of him moonlighting as a manga author is actually to financially support his siblings, since his parents have wilfully decided to go for a world tour all by themselves.
  • Pokémon: The Series:
    • Brock and his siblings. Brock, himself, his younger brother, Forrest, and the others; Salvadore, Yolanda, Tommy, Cindy, Suzie, Timmy, Billy and Tilly, the latter two being toddler-aged twins.
    • In Japanese, the younger 9 all have number-based names.
    • All of the Officer Jennys and the Nurse Joys that Ash and his friends meet in a region are all sisters from two families.
  • Pretty Cure:
    • Nao Midorikawa/Cure March from Smile Pretty Cure! has five younger siblings. Given how other Pretty Cures tend to either be only children or have a maximum of two siblings, this is quite an achievement. Also, a sixth sibling is born in episode 42.
    • Erena Amamiya/Cure Soleil from Star★Twinkle Pretty Cure also has five younger siblings who she often has to look after.
  • Kanae Kotonami of Skip Beat! never visits her home because she has ten siblings (some with their own children!) and two sisters-in-law who live under the same roof as her parents. The chaos is too much for her to handle, and she doesn't like her coworkers thinking she grew up poor or unsophisticated. A full roster of everyone living in her parents' house includes: Kanae's older sister (with three children of her own), Kanae's oldest brother (with his wife and two children), Kanae's other older brother (with his wife and their baby), and Kanae's seven younger brothers and sisters.
  • Meow from Space☆Dandy has six younger siblings back on his home planet of Betelgeuse.
  • Millie Thompson from Trigun has at least three older sisters, three older brothers, and several younger siblings. The actual number of siblings she has is not very clear, particularly in the anime. At one point she proclaims to Wolfwood she has ten brothers and sisters - and as she drops her pudding to hold her fingers up, he mutters, "Lemme guess, you're the youngest", to which she responds with an astonished, "How did you know?!?" But when she writes a letter to her family, she only counts off six siblings before getting into names, and Meryl implies that the named people are her nieces and nephews.
  • The Secret Garden: Susan Sowerby is the mother of twelve children (though the only ones named are Martha and Dickon). There's no father in the picture, which implies she's a widow, he left or they were a result of a one night stand.
  • Ringo in Spellbound! Magical Princess Lil'Pri has seven younger identical brothers named, interestingly enough, after the days of the week. Coincidentally, Ringo is the one that transforms into Snow White.
  • Bu-Ling Huang in Tokyo Mew Mew is the oldest of six. In the 2002 anime, they're a set of identical quadruplets with one extra, while in the manga and the 2022 reboot they're fraternal quintuplets.
  • At first, Touta Konoe of UQ Holder! seems like an only child, but then he meets a girl named Cutlass that claims to be his sister... It's revealed that they're both clones of Negi and Asuna, the protagonists of Negima! Magister Negi Magi, with Touta being the successful clone and Cutlass the failure. Moreover, Cutlass is identified as "Experiment Number 17", meaning there are at least 16 other clone siblings, and likely a great deal more than that.

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