In "Lazarus", LX-6, the defective Lex clone, is seen to be bald and wear a metallic breathing mask… coincidentally, making them appear identical to how Bane was later depicted in The Dark Knight Rises.
Cyborg is depicted as a member of the Justice League in this series, as opposed to being a member of the Teen Titans as in most previous continuities. But following DC Comics' New 52Continuity Reboot in 2011, he would eventually be retroactively made into a founding member of the League in the comics as well—even appearing as a member in the 2017 live-action Justice League film.
During the early and middle seasons of the show, it was a fairly common phenomenon for fanfics to feature an original female character who would show up in Smallville, flirt with Clark or other male characters, and subsequently turn out to be Lionel's secret daughter. In Season 10, we learn that Tess Mercer—an original character who arrived in Smallville in S8 and was frequently flirtatious towards Clark and Oliver—was in fact Lionel's secret daughter.
Just as Lana Lang was initially beloved and grew unpopular here, another version of her has suffered a similar popularity shift in Seasons 1-2 of CW's following Superman series, Superman & Lois.
