Those who have been Conditioned to Accept Horror in Anime and Manga.
- Hansel and Gretel of Black Lagoon end up as Creepy Twins due to this trope.
- Honestly, most of the cast could be considered this. You’d have to be to survive even a day in Roanapur.
- Hibiki from Bloody Monday Season 2 is perfectly understanding about the possibility of dying and being replaced because not only has she been trained to be a perfect agent since childhood, she also has seven identical clones and all of them were specifically bred for spying.
- In Code Geass, Emperor Charles invokes the trope, believing the people will accept what they are forced into when given enough time. Lelouch defies this trope, saying that time will never happen and proves it.
- DARLING in the FRANXX: Zero Two has been a prized military asset of APE and sent to fight on the front lines for so long that she has no regard for human life or her own, since they all exist to fight and die and become a statistic anyway. Heck, even when her beloved is dying, perhaps the one person she unambiguously cares about, she hardly bats an eye at it because, to her, it's just a fact of life that everyone dies.
- In Endride, assassins like Mischa are kidnapped as children, emotionally broken and then brainwashed in order to become more effective killers for their owners.
- The "normal" people from Miyu's homeworld in Fate/kaleid liner PRISMA☆ILLYA. Illya comes to this realization when she realizes both of them automatically go "people can't fly" despite the magic they've seen. "The Ainsworths have taken their wings."
- Gunslinger Girl used this as an early conceit. The girls are very sweet and can pass for normal in public, but they cannot comprehend the idea that there's anything morose or negative in the fact that they must kill people on command, most of the time without knowing why. This is best summed up in an early story where Rico realizes she must kill a busboy she befriended earlier because he's a witness. At first it seems like she's hesitating for human reasons, but it turns out that she was trying to remember the words "I'm sorry". That she had to kill him was never a doubt in her mind.
- I Got My Wish and Reincarnated as the Villainess (Last Boss)!: Having spent her last life under the shadow of death—specifically, what's usually read as a severe heart defect—leaves Elizabeth unfazed by some of the horrors she faces in her new life such as the prevailing Fantastic Racism and Abusive Parents. She outright said these are still an improvement to her past life, when moving around was a health hazard. While self-imposed, her training has also caused her to shrug off harassment and getting chewed out, as it isn't as bad compared to some of the monsters she has faced.
- Inuyasha: All of the protagonists, sans Kagome, count to varying degrees. Miroku and Sango are so used to the mass destruction of their era that, while they're sympathetic to the loss of entire villages, they're also pragmatic about not being able to do much about it. Inuyasha takes the cake, considering that, in Episode 9, he thought nothing of stopping for a meal break in the middle of a corpse-strewn battlefield.
- In Kill la Kill Mako Mankanshoku lived her life almost as if she was blissfully unawares that’s her school is essentially a fascist dictatorship where she’s forced to live in the slums and any misbehavior is punishable by death. Her friendship with Ryuko makes her only SLIGHTLY more aware of the world around her.
- The main characters and most of the community in Made in Abyss. The value, both financial and military, of objects found in the titular Eldritch Location results in the society on its fringes training orphans to mine its shallower depths. The community accepts this, despite the fact that many of the children are orphans because of the Abyss. By the time children are old enough to reach the deeper layers, they're supposed to be able to deal with the horrors and insanity that exist in the dark below.
- Fate Testarossa in the first season of Magical Girl Lyrical Nanoha seemed to genuinely believe that her mother's abuse of her was a good enough substitute for parental affection, because she has never actually experienced the latter (other than in Alicia's memories). So much, she even defended her mother's actions to her familiar Arf. It takes many years for Lindy to "decondition" her to accept real tenderness without tensing up.
- Played for Laughs in Mission: Yozakura Family. The Yozakuras are so hard on Taiyo that he's desensitized to most everyday thrills. For instance, when he and Mutsumi ride a roller coaster, he ends up falling asleep because it's relaxing compared to his daily training and frequent missions.
- Rei in Neon Genesis Evangelion. Her character relationship arc with Shinji is based largely on how he questions why she feels this is necessary. Mostly it's the fault of Shinji's dad.
- Overlord (2012):
- Victim, the eight floor guardian, is a weird critter resembling a floating fetus with a halo and a cutesy voice, whose shtick is that when he dies (and he's purposefully easy to kill), the invaders are hit with all sorts of horrible status debuffs. This was all well and good when he was just an NPC, but now that he's an actual sentient being, he's downright eager to be killed in defense of Nazarick, no matter how much Ainz apologizes and promises to resurrect him afterwards.
- Tsuare was forced to work as a prostitute in a brothel that throws the girls out when they're used up and caters to clients who like getting violent. When Sebas rescues her despite orders not to get noticed, Ainz decides to ensure that Sebas' loyalty is unchanged and orders him to kill her. She's so happy that he rescued her from that hellhole that she smiles at him and shows no resistance as he prepares to kill her in a single punch. Fortunately Cocytus blocks the punch, allowing him to determine that Sebas had every intention of killing Tsuare as ordered. This reassures the other guardians that Sebas isn't going rogue, and the matter is dropped and Tsuare is allowed to live at Nazarick as a maid.
- The main character of PandoraHearts can accept anything life throws at him — death, being thrown into an extra-dimensional hell/prison, stuff like that. Most disturbingly, he actually conditioned himself into this as opposed to the usual premise of it having been performed by morally dubious characters. Naturally, this creeps the heck out of his friends.
- In Puella Magi Madoka Magica, several of the witches, their barriers and imagery are rather creepy. However, veteran Puella Magi enter barriers day after day, and are unfazed by this. A good example is Yachiyo Nanami, a veteran from Magia Record: Puella Magi Madoka Magica Side Story. Special shoutout goes to Homura, who - after Sayaka and Madoka cowered before the sight of Mami dying gruesomely, - defeats Charlotte like she was just another conquered castle. Explanation: Homura is a Time Master, who's Save Scumming here.
- In Episode 5 of SHWD, Koga is stunned to learn that a SHWD employee went berserk during a disposal and killed 5 of his teammates after forgetting to take his suppression drug. What horrifies her more is how nonchalant her fellow employees are about the matter, with one even mentioning that cases like this used to be a lot more common.
