- Self-confessed video game addict Phil Collins played himself in Grand Theft Auto: Vice City Stories.
- Every Grand Theft Auto game from the third onwards features Lazlow Jones as a radio personality (most often associated with talk radio shows, in addition to being the DJ for V-Rock in the Vice City duology), who hosts his own radio show in the real world. In addition, Lazlow is a major figure in the development of the series, being the chief writer in charge of managing the various radio stations that air in-game. He finally makes a physical appearance in Grand Theft Auto V, where he suffers various humiliations from the protagonists.
- In Grand Theft Auto Online during The Cayo Perico Heist update, Dr. Dre, DJ Pooh and Jimmy Lovine appear and attempt to go to the titular island but are unable to attend. Dr. Dre and DJ Pooh later return in The Contract update with Dr. Dre being one of Franklin Clinton's clients and the update focusing on retrieving unreleased songs from Dr. Dre that were stolen.
- Rob Zombie, who provided the soundtrack for Twisted Metal III and 4 appeared as a playable character in Twisted Metal 4. In his ending, his wish is to "let the world hear the wails and war cries of a dead man's soul." He gets it in the form of a clip from one of his music videos.
- Takashi Miike shows up in No More Heroes 2: Desperate Struggle to deliver a Beam katana to Shinobou. He shows up again in No More Heroes III to get Travis out of his grave.
- Art Bell plays himself hosting a fictionalized version of Coast to Coast AM in Prey (2006). It is scripted to play out like real call-in segments of the show would, providing a from-Earth account of the in-game plot developments.
- Burt Reynolds plays himself as the Mayor of Steelport in Saints Row: The Third.
- The same goes for Keith David in Saints Row IV. In the same game, the new gimmick voice is now Nolan North playing himself. A later mission features Roddy Piper as part of a massive reference to They Live!. The game also has Ashly Burch as a DLC homie.
- Nazi Zombies; one of the game modes for Call of Duty: Black Ops, gives us Call of the Dead. Hell yeah we wanna party.
- Lieutenant Colonel Oliver North was brought along to help produce Call of Duty: Black Ops II. He also voices himself in a brief cameo early on in the campaign.
- The birds in Hatoful Boyfriend are stock images, the writer's own photography, and so on. One of the birds, Oko San, is represented with a photo of her own pet bird, Okosan. Unlike the other characters in the game, Oko San is a Partially Civilized Animal rather than a Civilized Animal, and while the others get human portraits, his is just a drawing of a pigeon.
- Some of the later LEGO Adaptation Games feature minifigures based on real people as characters, with their real-life counterparts providing the voices:
- Stan Lee in LEGO Marvel Super Heroes, LEGO Marvel's Avengers, and LEGO Marvel Super Heroes 2.
- Lou Ferrigno in LEGO Marvel's Avengers.
- Adam West, Kevin Smith, and Conan O'Brien in LEGO Batman 3: Beyond Gotham.
- Paul Feig in the LEGO Dimensions Ghostbusters (2016) level pack.
- In Just Cause 3, David Tennant is the voice behind the local Propaganda Machine and it's implied in-game that he might actually be the actor who was kidnapped in-universe.
- Marc Eckō's Getting Up: Contents Under Pressure features cameos from several real-life graffiti artists, who give the player character Trane advice on graffiti techniques.
- The h3h3 DLC in PAYDAY 2 has YouTubers Ethan and Hila Klein playing fictionalized versions of themselves.
- Professional wrestler and avid video game fan Xavier Woods voices his own Bomber counterpart in Super Bomberman R.
- Leisure Suit Larry 7: Love for Sail!: Peggy is listed in the credits as "Herself". She's actually voiced by Mary Kay Bergman, but requested not to be credited due to her foul language.
- Like a Dragon:
- In Yakuza Kiwami, retired two time world judo champion Shinichi Shinohara appears in one sidequest, providing the face and voice of... retired judo champion Shinichi Shinohara.
- During the development of Yakuza: Like a Dragon, Sega held an open audition for the last party member of the Heroes of Tomorrow. The Top 5 all get cast as fictionalized versions of themselves, while the winner gets the added bonus of being an Optional Party Member.
- Winner: Eri Kamataki - President (later Vice-President) of the struggling Ichiban Confections; She plays a major role in the Business Management activity, and acts as Ichiban's secretary. Make enough progress in Business Management, and she will be available as a party member.
- Second Place: Iroha Yanagi - A showgirl at Survive; Ichiban can replay party chats through her.
- Third Place: Sumire Sawa - Ex-delinquent and manager of the Romance Factory. Through her, Ichiban can craft weapons and armor and upgrade specific weapons.
- Fourth Place: Manae Miyakoshi - A receptionist at the Ounabara Vocational School; through her, Ichiban can take courses that, if passed, develop aspects of his personality. This in turn increases his resistance to certain status ailments, unlocks access to certain activities, and allows him to apply for certain jobs.
- Fifth Place: Ririka - An employee at the Ijincho branch of Hello Work; through her, Ichiban and his party can apply for new jobs, change jobs, and select outfits.
- Kei in Like a Dragon: Infinite Wealth and Like a Dragon Gaiden: The Man Who Erased His Name is a Revolve Bar employee played by VTuber and streamer Kson On Air. Kei is effectively Kson playing herself, from being an English potty-mouth, to fangirling over Kiryu Kazuma, to her fondness for pizza, and more.
- Gary Busey and Gary Cole both show up in Hitman (2016) in an Elusive Target mission. A vote was held online to determine which Gary would be the mission's target, with Busey winning the vote.
- Nicolas Cage was added to Dead by Daylight as a playable Survivor in July 2023.
- Charles Martinet serves as the narrator for BIT.TRIP RUNNER's two spinoff titles, with Runner3 also featuring him as a playable character.
- Takahashi Meijin, a former executive at Hudson Soft, appears as the Player Character's commanding officer in Star Gagnant, voiced by himself. Notably, the game features a Button Mashing mechanic, inspired by Takahashi's legendary rapid-tapping capability, having once been able to achieve a 16 Hz tapping rate.
- Used as a gag in the remake of Live A Live. Cube is The Unintelligible (he "speaks" in computer chirps), so his voice actor is listed as "Himself" in the credits.
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