Killers or The Killers may be referring to:
- Killers (Album): The 1981 album by Iron Maiden.
- Killers (2010): The action comedy film about assassins, featuring Ashton Kutcher.
- The Killers (Band): The indie rock band from Nevada.
- The Killers (1946): The first film adaptation of Ernest Hemingway's 1927 short story of the same name.
- The Killers (1964): The second film adaptation of the short story, directed by Don Siegel.