Mr. & Mrs. Smith may refer to:
- Mr. & Mrs. Smith (1941), a screwball comedy film directed by Alfred Hitchcock, starring Robert Montgomery and Carole Lombard
- Mr. & Mrs. Smith (2005), an action comedy film directed by Doug Liman, starring Brad Pitt and Angelina Jolie
- Mr. & Mrs. Smith (2024), an action comedy series starring Donald Glover and Maya Erskine
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